1. pH-responsive oxygen self-sufficient smart nanoplatform for enhanced tumor chemotherapy and photodynamic therapy.
- Author
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Liu X, Wang X, Zang D, Chang Y, Su W, Li G, Zhang J, Yang P, Ma X, and Guo Y
- Subjects
- Hydrogen-Ion Concentration, Animals, Humans, Mice, Silicon Dioxide chemistry, Chitosan chemistry, Drug Liberation, Catalase metabolism, Catalase chemistry, Cell Survival drug effects, Drug Screening Assays, Antitumor, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Particle Size, Tumor Microenvironment drug effects, Antibiotics, Antineoplastic pharmacology, Antibiotics, Antineoplastic chemistry, Antibiotics, Antineoplastic administration & dosage, Drug Carriers chemistry, Surface Properties, Cell Line, Tumor, Mice, Inbred BALB C, Cell Proliferation drug effects, Photochemotherapy, Doxorubicin pharmacology, Doxorubicin chemistry, Nanoparticles chemistry, Oxygen chemistry, Oxygen metabolism, Chlorophyllides, Porphyrins chemistry, Porphyrins pharmacology, Photosensitizing Agents chemistry, Photosensitizing Agents pharmacology
- Abstract
Premature drug release in chemotherapy and hypoxic conditions in photodynamic therapy (PDT) are perplexing problems in tumor treatment. Thus, it is of great significance to develop the novel therapeutic system with controllable drug release and effective oxygen generation. Herein, a pH-responsive oxygen self-sufficient smart nanoplatform (named DHCCC), integrating hollow mesoporous silica nanoparticles (HMSNs), chitosan (CS), doxorubicin hydrochloride (DOX), chlorin e6 (Ce6) and catalase (CAT), is fabricated to enhance the tumor therapeutic efficacy efficiently through avoiding premature drug release and mitigating hypoxia of tumor microenvironment (TME). The drug DOX can be efficiently loaded into the HMSNs with large cavity and be controllable released because of the pH responsiveness of CS to the weak acidic TME, thereby elevating the chemotherapy efficacy. Meanwhile, CAT can catalyze the decomposition of endogenous hydrogen peroxide in situ generating oxygen to alleviate the hypoxia and enhance the PDT efficiency considerably. In vitro and in vivo results demonstrate that the combined chemo-photodynamic therapy based on the DHCCC nanoplatform exerts more effective antitumor efficacy than chemotherapy or PDT alone. The current study provides a promising inspiration to construct the pH-responsive oxygen self-sufficient smart nanomedicine with potentials to prevent premature drug leakage and overcome hypoxia for efficient tumor therapy., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.) more...
- Published
- 2024
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