1. Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model.
- Author
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Wang S-y, Tan X, Liu Z-q, Ma H, Liu T-b, Yang Y-q, Ying Y, Gao R-y, Zhang D-z, Ma Y-f, Chen K, Lin L, Jiang Z-h, and Yu J-l
- Subjects
- Animals, Mice, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents pharmacology, Pseudomonas aeruginosa, Pseudomonas Phages genetics, Bacteriophages, Pseudomonas Infections therapy, Pseudomonas Infections microbiology
- Abstract
Importance: Phage therapy is gaining traction as an alternative to antibiotics due to the rise of multi-drug-resistant (MDR) bacteria. This study assessed the pharmacokinetics and safety of PA_LZ7, a phage targeting MDR Pseudomonas aeruginosa , in mice. After intravenous administration, the phage showed an exponential decay in plasma and its concentration dropped significantly within 24 h for all dosage groups. Although there was a temporary increase in certain plasma cytokines and spleen weight at higher dosages, no significant toxicity was observed. Therefore, PA_LZ7 shows potential as an effective and safe candidate for future phage therapy against MDR P. aeruginosa infections., Competing Interests: The authors declare no conflict of interest.
- Published
- 2024
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