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In this paper, a dual-polarized Huygens unit is proposed, which has a double-layer metallic pattern etched on both sides of one dielectric substrate. Induced magnetism enables the structure to support Huygens' resonance, thus obtaining nearly complete available transmission phase coverage. By optimizing the structural parameters, a better transmission performance can be achieved. When the Huygens metasurface was used for the design of a meta-lens, good radiation performance was exhibited, with a maximum gain of 31.15 dBi at 28 GHz, an aperture efficiency of 42.7% and a 3 dB gain bandwidth of 26.4 GHz to 30 GHz (12.86%). Due to its excellent radiation performance and very simple fabrication, this Huygens meta-lens has important applications in millimeter-wave communication systems.

Background: Pancreatic cancer (PC) is a highly lethal malignancy regarding digestive system, which is the fourth leading factor of cancer-related mortalities in the globe. Prognosis is poor due to diagnosis at advanced disease stage, low rates of surgical resection, and resistance to traditional radiotherapy and chemotherapy. In order to develop novel therapeutic strategies, further elucidation of the molecular mechanisms underlying PC chemoresistance is required. Ribosomal RNA biogenesis has been implicated in tumorigenesis. Small nucleolar RNAs (snoRNAs) is responsible for post-transcriptional modifications of ribosomal RNAs during biogenesis, which have been identified as potential markers of various cancers. Here, we investigate the U3 snoRNA-associated protein RRP9/U3-55 K along with its role in the development of PC and gemcitabine resistance., Methods: qRT-PCR, western blot and immunohistochemical staining assays were employed to detect RRP9 expression in human PC tissue samples and cell lines. RRP9-overexpression and siRNA-RRP9 plasmids were constructed to test the effects of RRP9 overexpression and knockdown on cell viability investigated by MTT assay, colony formation, and apoptosis measured by FACS and western blot assays. Immunoprecipitation and immunofluorescence staining were utilized to demonstrate a relationship between RRP9 and IGF2BP1. A subcutaneous xenograft tumor model was elucidated in BALB/c nude mice to examine the RRP9 role in PC in vivo., Results: Significantly elevated RRP9 expression was observed in PC tissues than normal tissues, which was negatively correlated with patient prognosis. We found that RRP9 promoted gemcitabine resistance in PC in vivo and in vitro. Mechanistically, RRP9 activated AKT signaling pathway through interacting with DNA binding region of IGF2BP1 in PC cells, thereby promoting PC progression, and inducing gemcitabine resistance through a reduction in DNA damage and inhibition of apoptosis. Treatment with a combination of the AKT inhibitor MK-2206 and gemcitabine significantly inhibited tumor proliferation induced by overexpression of RRP9 in vitro and in vivo., Conclusions: Our data reveal that RRP9 has a critical function to induce gemcitabine chemoresistance in PC through the IGF2BP1/AKT signaling pathway activation, which might be a candidate to sensitize PC cells to gemcitabine. Video abstract., (© 2022. The Author(s).)

We propose a bi-layer transmissive metasurface to obtain linear-to-circular polarization conversion in a wideband. The unit cell of each metasurface layer, which has identical configuration, consists of a Jerusalem-cross-like resonator and a metal strip. A universal equivalent circuit model is employed to guide the design of the polarizer. By analyzing the circuit parameters of the equivalent circuit, four metal strips are symmetrically inserted in each unit cell to broaden the bandwidth of linear-to-circular polarization conversion. Numerical and experimental results show that the polarizer can convert a linearly polarized wave into a circularly polarized wave in a wideband from 6.1 GHz to 12.6 GHz. Compared to the reported designs, the proposed polarization converter has advantages of ultrathin thickness and ultrawideband, and hence can be used in many applications, such as antennas and remote sensors.

Ceramide synthases (CerSs) catalyze the formation of ceramides from sphingoid bases and acyl-CoA substrates. Increasing evidence suggests that cancer cells generally exhibit altered sphingolipid metabolism in the tumorigenesis of multiple cancers. However, there is no evidence that CerSs are associated with pancreatic ductal carcinoma (PDAC). In the present study, we examined CerS expression in clinical tissue and conducted data mining to investigate the clinical significance of CerSs in the TCGA-PAAD database. We found that high CerS6 expression positively correlated with progression and predicted worse prognosis in PDAC patients, establishing CerS6 as a potential biomarker for PDAC. Furthermore, CerS6 promoted cell proliferation, colony formation and invasion by producing C16-ceramide and was required for tumor formation. Mechanistically, AKT1 interacted with and phosphorylated FOXP3 at S418, which decreased the binding of FOXP3 to the CERS6 promoter and in turn induced CerS6 expression by reconstituting an activated state on the CERS6 promoter. The AKT1/FOXP3 axis mediated the CerS6 expression and promoted p53 mutant pancreatic tumorigenesis by producing excessive C16-ceramide, which induced the accumulation of mutant p53. Thus, our study explores the relationship between PI3K/AKT signaling and sphingolipid metabolism, revealing an oncogenic role for CerS6, which may represent a potential target for PDAC treatment., (Copyright © 2021. Published by Elsevier B.V.)

Edge states in photonic heterostructures composed of metal layers and all-dielectric one-dimensional photonic crystals (1DPCs) will shift toward short wavelengths (blueshift) with the increase in the incident angle for both transverses magnetic (TM) and transverse electric (TE) polarizations. However, we achieve redshift edge states for TM polarization and blueshift edge states for TE polarization in heterostructures composed of metal layers and 1DPCs containing layered hyperbolic metamaterials. Owing to the opposite wavelength shift of the edge states for two orthogonal polarizations, the ellipsometric phase will change dramatically around the edge state wavelength in a broad angle range. Based on this wide-angle phase singularity property, we propose a biosensor which can work with high refractive index resolution in a broad angle range.

We theoretically and experimentally investigate the wide-angle perfect absorptance in a photonic heterostructure composed of a metal film and a truncated photonic crystal (PC) with layered hyperbolic metamaterials (HMMs) in the near ultraviolet and visible regions. The wide-angle perfect optical absorption depends on the dispersionless Tamm plasmon polarition (TPP) under TM polarization, which originates from reflection phase compensation condition between the metal and the truncated PC with HMMs. Our experimental results show nearly perfect absorptance over 0.91 in an angle range of 0-45 degree, which facilitates the design of perfect optical absorbers working in a wide angle range.

The polarization controlled optical signal routing has many important applications in photonics such as polarization beam splitter. By using two-dimensional transmission lines with lumped elements, we experimentally demonstrate the selective excitation of guided modes in waveguides composed of two kinds of single-negative metamaterials. A localized, circularly polarized emitter placed near the interface of the two kinds of single-negative metamaterials only couples with one guided mode with a specific propagating direction determined by the polarization handedness of the source. Moreover, this optical spin-orbit locking phenomenon, also called the photonic spin Hall effect, is robust against interface fluctuations, which may be very useful in the manipulation of electromagnetic signals.

We propose a topological description for gaps of one-dimensional symmetric all-dielectric photonic crystals (PCs). It is shown that, in the propagating direction, the effective electromagnetic parameters of PCs can be derived from one unit cell with mirror symmetry. Besides, at the frequencies of gaps, these symmetric PCs can be described as photonic insulators with effective negative permittivity or negative permeability. Moreover, based on the mapping of Maxwell's equations to the Dirac equation and the band inversion achieved by tuning the material and structural parameters, we demonstrate that the gaps of PCs with effective negative permittivity or negative permeability possess different topological orders. Lastly, we show that a bound state is robust against the disorder under a zero-average-effective-mass condition in a heterostructure made of two PCs with different topological orders.

We propose a scheme for subwavelength electromagnetic switch by employing nonlinear meta-atom. Bistable response is conceptually demonstrated on a microwave transmission line, which is side-coupled to a varactor-loaded split ring resonator acting as a nonlinear meta-atom. Calculations and experiments show that by applying conductive coupling instead of near-field interaction between the transmission line and the nonlinear meta-atom, switch performances are improved. The switch threshold of low to -5.8 dBm and the transmission contrast of up to 4.0 dB between the two bistable states were achieved. Subwavelength size of our switch should be useful for miniaturization of integrated optical nanocircuits.

We theoretically investigate the feasibility of constructing compact and highly efficient all-optical diodes (AODs) based on light tunneling mechanism in heterostructures. Due to light tunneling behaviors in heterostructures with one-dimensional photonic crystals (1D PC) and lossy metallic film, not only very large nonlinear permittivity of metal can be utilized sufficiently but also the structures with strongly nonreciprocal electric field distributions can be constructed. Finally we design a composite structure consisting of 1D PC-metal heterostructures to achieve the optimal unidirectional light transmission with 0.984 transmission contrasts, 42% transmission and 0.93 GW/cm(2) operating light power at working wavelength 557.2nm.

Different discrete soliton states in optical waveguide lattices are studied theoretically for the different external conditions such as the biased field, lattice spacing and the position of the input pulse. It is demonstrated that the discrete solitons can be formed in an appropriate biased field and exhibit different discrete properties in different biased field. The results also indicate that lattice spacing and the position of input pulse can affect apparently the discreteness of discrete solitons. If changing the ratio of the waist width of input beam to lattice period, the discrete solitons will be excited in more or less channels. In addition, the increase of lattice intensity almost does not affect the propagation behavior of soliton.