1. Preparation of nano-hydroxyapatite/chitosan/tilapia skin peptides hydrogels and its burn wound treatment.
- Author
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Qianqian O, Songzhi K, Yongmei H, Xianghong J, Sidong L, Puwang L, and Hui L
- Subjects
- Animals, Anti-Infective Agents pharmacology, Bandages, Burns pathology, Collagen chemistry, Escherichia coli drug effects, Human Umbilical Vein Endothelial Cells drug effects, Human Umbilical Vein Endothelial Cells metabolism, Humans, Microbial Sensitivity Tests, Peptides chemical synthesis, Rabbits, STAT3 Transcription Factor metabolism, Staphylococcus aureus drug effects, Tilapia, Vascular Endothelial Growth Factor A metabolism, Burns therapy, Chitosan chemistry, Durapatite chemistry, Hydrogels chemistry, Nanoparticles chemistry, Peptides pharmacology, Skin chemistry, Wound Healing drug effects
- Abstract
There is an urgent need for wound dressings to treat partial-thickness burns. Hydrogels are a promising material that can maintain hydration to promote necrotic tissue removal. Tilapia peptides (TP) and hydroxyapatite (HA) were incorporated into chitosan system to prepare new types of hydrogels. The hydrogels were cross-linking by tannin (TA), which were developed to promote rapid wound healing in a New Zealand rabbit partial-thickness burn model. Nanohydroxyapatite (NHA) was synthesized by coprecipitation method, which made hydrogels have a highly porous structure comprised of interconnected pores, excellent water absorption and low hemolysis. Besides, the hydrogels showed excellent antimicrobial activities against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), as well as the cytocompatibility on endothelial cells. Moreover, the hydrogels promoted epithelial and dermal regeneration, reduce the expression of TNF-α and IL-6 and promote the skin regeneration by enhancing expression of collagen, STAT3, and VEGF., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2021. Published by Elsevier B.V.)
- Published
- 2021
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