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Background: The types of growth hormone-secreting pituitary adenomas are diverse, we have found that there are significant differences in clinical features and prognosis between PIT-1 single-cell spectrum growth hormone adenomas and growth hormone phenotypic polyhormonal adenomas., Methods: This study examined a cohort of 193 patients with growth hormone-secreting pituitary adenoma (GHPA), stratifying them into two groups: PIT-1 single transcription factor positive growth hormone adenoma (STF-GHPA) and Multiple transcription factor-positive growth hormone-secreting adenomas (MTF-GHPA). The objective was to compare these two groups' clinical characteristics. Within the MTF-GHPA group, we further subtyped them based on transcription factors to evaluate potential variations in clinical manifestations. Logistic regression analyses were employed to develop a risk factor model for investigating factors influencing hormone remission., Results: There were no statistically significant differences in terms of age, gender, serum GH, and IGF-1 levels between patients diagnosed with MTF-GHPA and STF-GHPA. However, patients with MTF-GHPA exhibited a higher proportion of hypopituitarism compared to those with STF-GHPA. Furthermore, MTF-GHPA were characterized by smaller tumor size and less invasiveness, as indicated by lower Knosp classes. However, patients with MTF-GHPA have a lower rate of hormonal remission (30.8%) and more postoperative complications (31.0%), which means that STF-GHPA (hormonal remission:71.6%; postoperative complications:13.4%) has a better endocrine outcome than MTF-GHPA patients. Between the PIT-1 + SF-1+ and PIT-1 + TPIT+ subtypes within MTF-GHPA, significant differences were also observed in tumor size, endocrine outcomes, and postoperative complications. Risk factors influencing hormonal remission for GHPA included preoperative GH level, primary/recurrent, extent of resection, and transcription factor expression., Conclusion: Co-expression of multiple transcription factors is an important factor associated with clinical behavior and endocrine outcomes in patients with GHPA., Competing Interests: Compliance with ethical standards. Conflict of interest: The authors declare no competing interests. Ethical approval: This study was approved by the ethics committee of Beijing Tiantan Hospital, Capital Medical University (KY2022-209-02). Informed consent was obtained from all individual participants included in the study. This study was performed in line with the principles of the Declaration of Helsinki., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Deep vein thrombosis (DVT) in patients undergoing endoscopic endonasal surgery remains underexplored, despite its potential impact on postoperative recovery. This study aimed to develop and validate a predictive nomogram for assessing the risk of lower-limb DVT in such patients without chemoprophylaxis. A retrospective analysis was conducted on 935 patients with postoperative lower-limb vein ultrasonography. Clinical data, including potential risk factors, were used to construct a predictive model via multivariate logistic regression analysis. The resulting nomogram was validated using an independent cohort and evaluated through concordance index (C-index), calibration plots, and decision curve analysis. The incidence of postoperative DVT was 28.9%, with most cases being distal (27.2%). Significant predictors included older age, intraoperative bleeding, female gender, prolonged surgery duration, elevated postoperative APTT and D-dimer levels, and disturbance of consciousness. The nomogram demonstrated good predictive performance, with C-index values of 0.81 in the training cohort and 0.75 in the validation cohort. Calibration and decision curve analyses confirmed the model's clinical applicability. This nomogram offers a practical tool for individualized DVT risk assessment in patients undergoing endoscopic endonasal surgery, facilitating more targeted prophylactic measures., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)

Cybervictimization and cyberbullying are serious public health issues. Parental monitoring serves as a protective factor, reducing adolescents' risk of cybervictimization and cyberbullying. However, no study has systematically explored the interplay between parental monitoring, cybervictimization and cyberbullying at within-person processes, the mediating mechanisms between them, and the moderator of sex among Chinese adolescents. This study followed 2407 Chinese adolescents (50.23% girl, M age  = 12.75, SD = 0.58 at baseline) from seven schools over three time points across one year. Random intercept cross-lagged models were employed to investigate the dynamic links among parental monitoring, deviant peer affiliation, cybervictimization and cyberbullying. Results indicated significant associations among these variables at the between-person level. At the within-person level, parental monitoring, deviant peer affiliation, and cybervictimization were reciprocally predictable. Parental monitoring and deviant peer affiliation predicted cyberbullying, but cyberbullying did not predict parental monitoring or deviant peer affiliation. Additionally, parental monitoring indirectly predicted cybervictimization but not cyberbullying through deviant peer affiliation. Sex differences were observed in the longitudinal associations. The present study provides valuable insights into the relations among parental monitoring, deviant peer affiliation, cybervictimization and cyberbullying from a developmental perspective, offering a new scientific basis for interventions targeting adolescents' involvement in cyberbullying., Competing Interests: Compliance with Ethical Standards. Conflict of interest: The authors declare no competing interests. Ethical Approval: All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by Shanxi University Ethics Committee in Taiyuan, China. Informed Consent: Informed consent was obtained from all individual participants included in the study., (© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Adolescence is usually the beginning of externalizing problems. At the same time, as adolescents mature it drives changes in teacher-student relationships. Even though bidirectional associations between teacher-student relationships and cyberbullying perpetration exist, studies examining this link at the within-person level are lacking. This longitudinal study tested the process of influence between teacher-student relationships and cyberbullying perpetration and examined whether teacher-student relationships predicted cyberbullying perpetration by using the random-intercept cross-lagged model. Participants included 2,407 Chinese adolescents (50.23% girl, M age = 12.75, SD = 0.58 at baseline) from seven schools at three-time points with one-year intervals. Results showed that initial levels and changes of teacher-student relationships significantly predicted cyberbullying perpetration. The relation between teacher-student relationships and cyberbullying perpetration was stable over time at the within-person level, but not at the between-person level. Furthermore, self-esteem significantly predicted cyberbullying perpetration at the between-person level, but not at the within-person level. The results indicate that adolescents with higher teacher-student relationships compared to their own average, tended to be those who later experienced lower cyberbullying perpetration and vice versa. Low self-esteem is not a risk factor for cyberbullying perpetration at the within-person level., Competing Interests: Compliance with Ethical Standards. Conflict of Interest: The authors declare no competing interests. Ethical Approval: All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by Shanxi University Ethics Committee in Taiyuan, China. Informed Consent: Informed consent was obtained from all individual participants included in the study., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

When making risky choices in social contexts, humans typically combine social information with individual preferences about the options at stake. It remains unknown how such decisions are made when these preferences are inaccessible or disrupted, as might be the case for individuals confronting novel options or experiencing cognitive impairment. Thus, we examined participants with lesions in insular or dorsal anterior cingulate cortex, key regions implicated in risky decision-making, as they played a gambling task where choices were made both alone and after observing others' choices. Participants in both lesion groups showed disrupted use of standard utility-based computations about risky options. For socially situated decisions, these participants showed increased conformity with the choices of others, independent from social utility-based computations. These findings suggest that in social contexts, following others' choices may be a heuristic for decision-making when utility-based risk processing is disrupted., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Orloff et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Based on the general aggression model, the current study examined the mediating role of moral disengagement in the association between sensation seeking and cyberbullying perpetration and the moderating role of perceived social support. A total of 2,286 Chinese adolescents aged 11-16 years completed the questionnaires regarding sensation seeking, cyberbullying perpetration, moral disengagement, and perceived social support. After gender and age were controlled, sensation seeking was significantly and positively associated with cyberbullying perpetration and this relationship was partially mediated by moral disengagement. Moderated mediation analysis further indicated that perceived social support moderated the relationship between sensation seeking and moral disengagement as well as sensation seeking and cyberbullying perpetration. These two relationships became weaker for adolescents with high perceived social support. Specifically, adolescents with higher levels of sensation seeking were more likely to develop moral disengagement and further engaged in cyberbullying perpetration, when they perceived less social support., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Leaf senescence following heading in rice is subject to rigorous regulation, with many of the underlying control mechanisms remaining largely unknown. In this study, we identified a novel gene, OsMESL, which exerts a positive regulatory effect on leaf senescence in rice. The T-DNA insertion mutant known as osmesl and RNA interference plants displayed a phenotype characterized by stay-green after heading. Genetic analysis indicated that the mutant phenotype could be rescued through complementation, while the overexpression of OsMESL accelerated leaf senescence after heading, underscoring OsMESL's positive regulatory role in rice leaf senescence. Subsequent investigations revealed that OsMESL modulates the process of cell death by influencing the stability of its interacting protein, the cell death suppressor OsBI-1, thereby governing leaf senescence. Furthermore, the leaves of the osmesl mutant exhibited a delayed reduction in photosynthesis, along with increased grain length and 1000-grain weight. In conclusion, we identified OsMESL as a novel positive regulator of leaf senescence in rice, which likely participates in leaf senescence through the mediation of cell death by OsBI-1, resulting in the phenotype of stay-green in the osmesl mutant after heading., Competing Interests: Declaration of Competing Interest The authors declare no competing interests., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Intraventricular tumors frequently provoke alterations in ventricular morphology. This study aims to quantificational assess perioperative dynamic fluctuations in the cerebrospinal fluid (CSF) volume within the lateral ventricles of patients harboring lateral ventricular tumors. A retrospective review encompassing 90 patients who underwent surgical intervention for lateral ventricular tumors at our institution was undertaken. Comprehensive observations at multiple perioperative time points were conducted, and LVCV analyses were performed to delineate the longitudinal dynamic alterations in ventricular morphology. Additionally, LVCV measurements were juxtaposed with data from 19 healthy subjects to stratify patients into two cohorts: those exhibiting preoperative increased LVCV and those without such changes. After surgical excision of intraventricular tumors, alterations in LVCV were compared between these cohorts, with a factor analysis undertaken specifically among patients demonstrating increased LVCV to elucidate potential influencing variables. 40 patients (44.4%) diagnosed with intraventricular tumors presenting with enlarged preoperative LVCV [74.6 (49.3-101.8) cm 3 ] compared with the normal subject group, and the LVCV demonstrated a significant postoperative [41.3 (27.6-67.5) cm 3 ] reduction in 3 months (p < 0.001). Meanwhile, 50 patients (55.6%) without LVCV enlargement [14.5 (8.1-21.0) cm 3 ] experienced a notable increase following surgery in 3 months [20.2 (14.1-33.3) cm 3 , p = 0.002]. Preoperative increased LVCV is an important factor leading to the increased LVCV postoperatively (p = 0.022, OR = 26.239), however, compared to healthy subjects, both groups exhibited a trend toward normalization of LVCV value postoperatively (p = 0.165, p = 0.072, respectively). Following appropriate surgical excision of the tumor, the preoperative increased LVCV associated with intraventricular tumors does not hinder the normalization trend of ventricular morphology. Not all ventricular dilation requires preventive long-term external ventricular drainage and aggressive ventriculoperitoneal shunt treatment., Competing Interests: Declarations Competing interests The authors declare no competing interests., (© 2024. The Author(s).)

Zinc ion hybrid capacitors (ZIHCs) show promise for large-scale energy storage because of their low cost, highly intrinsic safety, and eco-friendliness. However, their energy density has been limited by the lack of advanced cathodes. Herein, a high-capacity cathode material named N-doped porous carbon (CFeN-2) is introduced for ZIHCs. CFeN-2, synthesized through the annealing of coal pitch with FeCl 3 ·6H 2 O as a catalytic activator and melamine as a nitrogen source, exhibits significant N content (10.95 wt%), a large surface area (1037.66 m 2 g -1 ), abundant lattice defects and ultrahigh microporosity. These characteristics, validated through theoretical simulations and experimental tests, enable a dual-ion energy storage mechanism involving Zn 2+ ions and CF 3 SO 3 - anions for CFeN-2. When used as a cathode in ZIHCs, CFeN-2 achieves a high-energy density of 142.5 W h kg -1 and a high-power density of 9500.1 W kg -1 . Furthermore, using CFeN-2 ZIHCs demonstrate exceptional performance with 77% capacity retention and nearly 100% coulombic efficiency after 10 000 cycles at 10 A g -1 , showcasing substantially superior performance to current ZIHCs. This study offers a pathway for developing high-energy and high-power cathodes derived from coal pitch carbon for ZIHC applications., (© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

Based on general strain theory, the current study examined whether bullying victimization was significantly related to adolescents' non-suicidal self-injury and whether negation emotions mediated this association and submissive behavior moderated this mediation process. A total of 1,984 adolescents completed a series of anonymous questionnaires regarding bullying victimization, negative emotions, non-suicidal self-injury, and submissive behavior. Results showed that bullying victimization was significantly and positively associated with non-suicidal self-injury and this relation was partially mediated by negative emotions. Submissive behavior moderated the relation between bullying victimization and non-suicidal self-injury as well as negation emotions and non-suicidal self-injury. Specifically, the victims of bullying with high submissive behavior were more likely to develop non-suicidal self-injury. Adolescents who had higher negative emotions were at greater risk of engaging in non-suicidal self-injury when they also had high submissive behavior. The positive association between negative emotions and non-suicidal self-injury was stronger in females than males., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Bystanders are the most common role that adolescents play in bullying episodes, they have considerable influence on the formation of the victim's experience and the perpetrator's behavior. Based on the social-cognitive model, the current study examined the mediating role of moral disengagement in the association between callous-unemotional traits and bystander behavior and the moderating roles of moral identity and perceived social support. Participants included 2,286 Chinese adolescents aged 11-16 years (49.3% boys; M age  = 13.46, SD age  = 0.93). The study showed callous-unemotional traits were significantly and positively associated with bystander behavior and this relation was partially mediated by moral disengagement. Moral identity moderated the relation between callous-unemotional traits and moral disengagement as well as callous-unemotional traits and bystander behavior. Perceived social support moderated in the direct and indirect associations between callous-unemotional traits and bystander behavior via moral disengagement. The relation between callous-unemotional traits and moral disengagement and the relation between callous-unemotional traits and bystander behavior became weaker for adolescents with high perceived social support. Surprisingly, the relation between moral disengagement and bystander behavior became stronger for adolescents with a high level of perceived social support. The results supported two specific patterns of perceived social support: stress-buffering and reverse stress-buffering. The present study contributes to our understanding of the key mechanisms underlying the association between callous-unemotional traits and adolescents' bystander behavior., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Telekinesis, as commonly portrayed in science fiction literature and cinema, is a super power wherein users control and manipulate objects absent in physical interaction. In real world, enhancing human-robot interaction needs the synthesis of human intuitive processes with robotic arm. This paper introduces a robotic teleoperation system achieving the essence of telekinetic operations, combining the profound capabilities of augmented reality (AR) with the robotic arm operations. Utilizing AR, the proposed methodology offers operators with a visual feedback, facilitating a level of control surpassing the capacities of natural interfaces. By using AR-driven visual recognition, this system achieves operations in a virtual environment, subsequently actualized in the real world through the robotic arm. Through multiple experiments, we found that the system has a small margin of error in telekinesis operations, meeting the needs of remote operation. Furthermore, our system can operate on objects in the real world. These experiments underscore the capability of the remote control system to assist humans in accomplishing a wider range of tasks through the integration of AR and robotic arms, providing a natural human-robot interaction approach., Competing Interests: Competing interests: The authors declare that they have no competing interests., (Copyright © 2024 Xingchao Wang et al.)

Objective: Despite pituitary neuroendocrine tumor (PitNET) being extra-axial tumors without direct damage to brain tissue, patients with PitNET exhibit neuropsychological impairments. However, it remains unclear whether there are neuropsychological differences between PitNET and intra-axial tumors that directly destroy the brain parenchyma. This prospective study aims to clarify this distinction to inform decision-making for intracranial tumors of diverse origins., Methods: A total of 146 patients with PitNET, 74 patients with glioma representing intra-axial tumors, and 52 age-, sex-, and education-matched healthy controls were recruited. All patients received standard treatment and postoperative rehabilitation. Clinical data were meticulously collected, and neuropsychological tests were administered to all participants both before and 3 months after surgery., Results: Both PitNET and glioma patients experience the dual burden of cognitive and affective deficits. However, the feature of these deficits differs substantially. In PitNET patients, the deficits are relatively mild and focal, whereas in glioma patients, they are severe and extensive. Specifically, PitNET patients exhibit deficits in memory, anxiety, and negative affect. In contrast, glioma patients display deficits in executive function, attention, anxiety, positive/negative affect, and empathy. Notably, except for persistent memory deficits, the majority of neuropsychological scores declines in PitNET patients are restorable and can reach improvement within a short period after standard surgical therapy and perioperative management. Conversely, glioma patients not only fail to show improvements but also demonstrate worsening in terms of general cognition and memory postoperatively., Interpretation: As an extra-axial tumor, PitNET may exhibit distinctive cognitive and affective functioning compared to intra-axial tumors, highlighting the need for specific treatment approaches for PitNET patients., (© 2024 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)

The rational construction of amorphous-crystalline heterointerface can effectively improve the activity and stability of hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Herein, RuO 2 /Co 3 O 4 (RCO) amorphous-crystalline heterointerface is prepared via oxidation method. The optimal RCO-10 exhibits low overpotentials of 57 and 231 mV for HER and OER at 10 mA cm -2 , respectively. Experimental characterization and density functional theory (DFT) results show that the optimized electronic structure and surface reconstruction endow RCO-10 with excellent catalytic activity. DFT results show that electrons transfer from RuO 2 to Co 3 O 4 through the amorphous-crystalline heterointerface, achieving electron redistribution and moving the d-band center upward, which optimizes the adsorption free energy of the hydrogen reaction intermediate. Moreover, the reconstructed Ru/Co(OH) 2 during the HER process has low hydrogen adsorption free energy to enhance HER activity. The reconstructed RuO 2 /CoOOH during the OER process has a low energy barrier for the elementary reaction (O*→*OOH) to enhance OER activity. Furthermore, RCO-10 requires only 1.50 V to drive 10 mA cm -2 and maintains stability over 200 h for overall water splitting. Meanwhile, RCO-10 displays stability for 48 h in alkaline solutions containing 0.5 M NaCl. The amorphous-crystalline heterointerface may bring new breakthroughs in the design of efficient and stable catalysts., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Objective: To investigate the visual outcomes and optimal timing for repeat surgery in cases of postoperative hematoma following transsphenoidal surgery for pituitary neuroendocrine tumors (PitNETs)., Methods: A retrospective study was conducted on 28 patients who developed evident postoperative hematoma out of a total of 9,010 patients. The hematomas were classified into three types based on their CT appearance. Type 1a - mild high density with no tension, Type 1b - thin-layer high density; Type 2a - solid high density with large empty cavities, Type 2b - solid high density with small empty cavities; Type 3 -solid high density with no cavity showing high tension. Patient data were collected for analysis., Results: The study cohort comprised 10 female and 18 male patients, with a mean age of 51.5±11.9 years. Most patients presented with large adenomas (median diameter 36mm). Postoperative visual sight improved in 12 patients, remained stable in 11 patients, and worsened in 5 patients. Notably, no patients experienced worsened visual sight beyond twenty-four hours after the operation. Among the five patients with visual deterioration, four had CT type 3 hematoma (4/6, 66.7%), and one had CT type 2b hematoma (1/9, 11.1%). Patients in the type 3 CT group were significantly more prone to experience visual deterioration compared to those in the type 2 group (odds ratio [OR] 2.154 [95% CI 1.858-611.014], P=.027). Four patients underwent repeat surgery after visual deterioration, resulting in visual improvement following a prolonged recovery period. Postoperative hematoma had limited impact on pituitary dysfunction and hyponatremia., Conclusion: Our study reveals a significant association between postoperative hematoma CT types and visual deterioration. For patients with stable visual sight and type 1 or 2a hematoma, conservative strategies may be considered. Conversely, type 2b and 3 patients are at higher risk of visual deterioration, especially within the first 24 hours after the operation. Consequently, early reoperation before vision worsens may be a prudent approach to reduce risks and improve visual outcomes, particularly in type 3 patients., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

Parental phubbing, as a new risk factor for adolescents' healthy development, has been noticed by scholars. However, few studies have clarified the associations between parental phubbing and adolescents' proactive and reactive aggression and the potential mediating mechanisms. To address the gaps, the current study explored the longitudinal associations among parental phubbing, self-esteem, and adolescents' proactive and reactive aggression by using the parallel process latent growth curve model and the cross-lagged panel model. The current study involved 2407 Chinese adolescents (girls were 1202, M age  = 12.75, SD = 0.58 at baseline, range = 11-16). Results indicated that parental phubbing significantly positively predicted adolescents' reactive aggression but not proactive aggression. Self-esteem significantly predicted the adolescents' reactive and proactive aggression. Self-esteem significantly mediated the associations between parental phubbing and adolescents' proactive and reactive aggression, respectively. These findings suggest that intervening with parental phubbing is a promising way to reduce adolescents' reactive aggression, and promoting adolescents' self-esteem is an effective approach to prevent their proactive and reactive aggression., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Background and Objectives: Lineage-based classification has critical clinical implications in pituitary neuroendocrine tumor (PitNET). As the most prevalent subtype of multilineage PitNET, PitNET originating from both pituitary-specific positive transcription factor 1 (Pit1) and steroidogenic factor-1 (SF1) lineages (Pit1/SF1-adenoma) is expected to exhibit rich and varied clinical behaviors. A comprehensive understanding of the clinical and pathological characteristics of Pit1/SF1-adenoma will provide mechanistic insight and influence the prognosis and treatment of PitNET., Methods: A retrospective study was conducted by reviewing 57 cases of Pit1/SF1-adenoma between 2018 and 2022. We also included 88 cases of PitNET arising from Pit1 cell lineage (Pit1-adenoma) and 70 cases of PitNET arising from SF1 cell lineage (SF1-adenoma) as controls. Comprehensive data, including demographic, symptom, endocrinal, radiological, surgical, pathological, and prognostic information, were systematically collected. All specimens were immunostained for pituitary transcription factors (PTFs) and pituitary hormones., Results: The detection rate was 8.0% for Pit1/SF1-adenoma within PitNET surgical specimens. Pit1/SF1-adenoma displayed a male predominance, with the mean diagnosis age falling between Pit1-adenoma and SF1-adenoma. The endocrine activity of Pit1/SF1-adenoma was lower than Pit1-adenoma but higher than SF1-adenoma. Pit1/SF1-adenoma had a higher incidence of cavernous sinus invasion (56.1%) than both Pit1-adenoma (38.6%, P = .039) and SF1-adenoma (27.1%, P = .001). Furthermore, Pit1/SF1-adenoma showed more postoperative complications than Pit1-adenoma (29.8% vs 8.0%, P = .001). Nonfunctional Pit1/SF1-adenoma had a higher radiological tumor recurrence rate than nonfunctional SF1-adenoma (34.8% vs 10.9%, P = .021). Notably, the immunostaining pattern was diverse in Pit1/SF1-adenoma, with various combinations of staining intensity for PTFs and 15 combinations for 6 pituitary hormones. Intriguingly, various PTFs combinations had no different impact on the outcome of Pit1/SF1-adenoma., Conclusion: Pit1/SF1-adenoma represents a unique pathological subtype of PitNET, characterized by distinctive clinical behaviors. Identifying Pit1/SF1-adenoma can facilitate more precise management of PitNET by the practical use of Pit1/SF1 immunostaining., (Copyright © Congress of Neurological Surgeons 2024. All rights reserved.)

Background: NF2-schwannomatosis (NF2) is an autosomal dominant disorder prone to hearing loss. Auditory brainstem implants (ABIs) offer a promising solution for hearing rehabilitation in NF2., Objective: To synthesize existing literature on ABI implantation in NF2, focusing on audiological outcomes and ABI-related complications., Methods: The systematic review followed PRISMA guidelines and was registered in the PROSPERO database (CRD42022362155). Relevant studies were identified by searching PubMed, EMBASE, CENTRAL, CMB, and CNKI from inception to August 2023. Data on environmental sound discrimination, open-set discrimination, closed-set discrimination, and ABI-related complications were extracted and subjected to meta-analysis. Publication bias was evaluated using funnel plots and Egger's test., Results: Thirty-three studies were included. The pooled estimate was 58% (95% CI 49-66%) for environmental sound discrimination and 55% (95% CI 40-69%) for closed-set discrimination. Regarding open-set discrimination, the pooled estimates were 30% (95% CI 19-42%) for sound only, 46% (95% CI 37-54%) for lip-reading only, and 63% (95% CI 55-70%) for sound plus lip-reading. The pooled occurrence of ABI-related complications was 33% (95% CI 15-52%)., Conclusion: This meta-analysis underscores the effectiveness and safety of ABIs in NF2, providing valuable insights for evidence-based decision-making and hearing rehabilitation strategies.

Objective: The current study explored whether agreeableness predicted cyberbullying perpetration across 3 years and extended previous studies by exploring the mediating effect of moral disengagement and the moderating effects of empathy and gender., Method: The participants included 2407 adolescents from 7 middle schools in China. They were recruited to complete the Big Five Personality Inventory, Bullying Scale and Empathy Scale at Time 1, Moral Disengagement Scale at Time 1 and Time 2, and Cyberbullying Perpetration Scale at Time 1, Time 2, and Time 3., Results: Agreeableness at Time 1 predicted cyberbullying perpetration at Time 3 and moral disengagement at Time 2 mediated this relationship. The relationship between moral disengagement at Time 2 and cyberbullying perpetration at Time 3 was stronger for low cognitive empathy adolescents than high cognitive empathy adolescents at Time 1. The relationship between agreeableness at Time 1 and cyberbullying perpetration adolescents at Time 3 was stronger for low affective empathy than high affective empathy adolescents at Time 1. The link between moral disengagement at Time 2 and cyberbullying perpetration at Time 3 was weaker for females than males., Conclusions: Low agreeableness adolescents are more likely to use moral disengagement, which in turn leads to more cyberbullying perpetration., (© 2023 Wiley Periodicals LLC.)

Designing efficient catalysts to promote the electrochemical oxidation of anodes is the core of the development of electrochemical synthesis technologies, such as HER and CO 2 RR. Here, a novel vacuum induction strategy is used to synthesize nickel boride/nickel (Ni 3 B/Ni) heterostructure catalyst for electrochemical oxidation of methanol into formic acid. The catalyst has extremely high reactivity (only 146.9 mV overpotential at 10 mA cm -2 , the maximum current density reaches 555.70 mA mg -1 and 443.87 mA cm -2 ), ultra-high selectivity (Faraday efficiency of methanol conversion to formic acid is close to 100%), and ultra-long life (over 50 h at 100 mA cm -2 ). In-suit electrochemical impedance spectroscopy proved that MeOH is oxidized first and inhibits the phase transition of the electrocatalyst to the high-valent electrooxidation products, which not only enables the high selectivity of MeOH oxidation but also ensures high stability of the catalyst. The mechanism studies by density functional theory calculations show that the potential determining step, the formation of *CH 2 O, occurs most favorably in the Ni 3 B/Ni heterostructure. These results provide references for the development of MeOH oxidation catalysts with high activity, high stability, high selectivity, and low cost., (© 2023 Wiley-VCH GmbH.)

20-inch Large area photomultiplier tube based on microchannel plate (MCP-PMT) is newly developed in China. It is widely used in high energy detection experiments such as Jiangmen Underground Neutrino Observatory (JUNO), China JinPing underground Laboratory (CJPL) and Large High Altitude Air Shower Observatory (LHAASO). To overcome the poor time performance of the existing MCP-PMT, a new design of large area MCP-PMT is proposed in this paper. Three-dimensional models are developed in CST Studio Suite to validate its feasibility. Effects of the size and bias voltage of the focusing electrodes and MCP configuration on the collection efficiency (CE) and time performance are studied in detail using the finite integral technique and Monte Carlo method. Based on the simulation results, the optimized operating and geometry parameters are chosen. Results show that the mean ratio of photoelectrons landing on the MCP active area is 97.5%. The acceptance fraction of the impinging photoelectrons is close to 100% due to the emission of multiple secondary electrons when hitting the MCP top surface. The mean transit time spread (TTS) of the photoelectrons from the photocathode is 1.48 ns., (© 2023. The Author(s).)

Potassium (K) metal is considered one of the most promising anodes for potassium metal batteries (PMBs) because of its abundant and low-cost advantages but suffers from serious dendritic growth and parasitic reactions, resulting in poor cyclability, low Coulombic efficiency (CE), and safety concerns. In this work, we report a localized high-concentration electrolyte (LHCE) consisting of potassium bis(fluorosulfonyl)imide (KFSI) in a cosolvent of 1,2-dimethoxyethane (DME) and 1,1,2,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (TTE) to solve the problems of PMBs. TTE as a diluent not only endows LHCE with advantages of low viscosity, good wettability, and improved conductivity but also solves the dendrite problem pertaining to K metal anodes. Using the formulation of LHCE, a CE of 98% during 800 cycles in the K||Cu cell and extremely stable cycling of over 2000 h in the K||K symmetric cell are achieved at a current density of 0.1 mA cm -2 . In addition, the LHCE shows good compatibility with a Prussian Blue cathode, allowing almost 99% CE for the K||KFe II Fe III (CN) 6 full cell during 100 cycles. This promising electrolyte design realizes high-safety and energy-dense PMBs.

Background: Adult posterior fossa ependymomas (PF-EPN) with preoperative cerebrospinal metastases are extremely rare. Only 3 cases have been reported in previous literature., Case Presentation: A case of a 32-year-old male patient complained of headaches for three months. Pure tone audiometry showed a slight decrease in bilateral hearing. Auditory evoked potential indicated that the hearing on the left was slightly weaker than that on the right. Magnetic resonance imaging (MRI) revealed a primary tumor arising within the fourth ventricle and metastasizing to bilateral cerebellopontine angle (CPA), the third ventricle, the left lateral ventricle, T1, L1-2 and L5. A gross total resection (GTR) was performed on the lesion located in the left CPA. The histological examination showed a papillary ependymoma (WHO grade II). Immunohistochemical staining for H3K27me3 showed that nuclear positivity in more than 80% of cells. No NF2 mutation was observed. No progression was found during a 24-month follow-up., Conclusions: Our data indicate that preoperative multiple metastases in adult PF-EPN are extremely rare. This kind of disease usually has a low WHO grade and a favorable prognosis. GTR should be achieved when feasible and patients need a long-term follow-up with MRI.

Adolescents with negative student-student relationships are at increased risk for bullying perpetration. Moral disengagement has been well documented as one of the main examined predictive variables of bullying perpetration. However, few studies have examined the mechanism of moral disengagement in the association between student-student relationship and adolescents' bullying perpetration. The present study examined the bidirectional associations among student-student relationship, moral disengagement, and bullying perpetration. Moreover, the present study tested the longitudinal mediating effect of moral disengagement and the moderating effect of gender. Participants were 2,407 Chinese adolescents ( M age = 12.75, SD = .58 at baseline). The cross-lagged panel model (CLPM) revealed that prior student-student relationship was associated with later bullying perpetration (β T1→T2 = -.11 and β T2→T3 = -.12), prior student-student relationship was associated with later moral disengagement (β T1→T2 = -.15 and β T2→T3 = -.10), and prior moral disengagement was associated with later bullying perpetration (β T1→T2 = .22 and β T2→T3 = .10). Furthermore, moral disengagement at Time 2 significantly mediated the association between student-student relationship at Time 1 and bullying perpetration at Time 3 (β = -.015). Gender moderated the mediating effect of moral disengagement. These findings highlight the importance of student-student relationship and moral disengagement in antibullying intervention programs. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Ultrafast microchannel plate (MCP) photomultiplier tubes are under active development. To obtain high gain, high spatial resolution, and good time performance, we comprehensively investigate the effects of the gap distances and voltages from cathode to MCP in and MCP out to anode in a systematic study using the finite integral technique and Monte Carlo method. A three-dimensional model is introduced to simplify the calculations. From the simulation results, a short gap distance and high gap voltage were determined to achieve good time performance, high spatial resolution, and high gain.

Serious capacity and voltage degradation of Li-rich layered oxides (LLOs) caused by severe interfacial side reactions (ISR), structural instability, and transition metal (TM) dissolution during charge/discharge need to be urgently resolved. Here, it is proposed for the inaugural time that the confinement effect of PO 4 3- dilutes the LiMn 6 superstructure units on the surface of LLOs, while deriving a stable interface with phosphate compounds and spinel species. Combining theoretical calculations, diffraction, spectroscopy, and micrography, an in-depth investigation of the mechanism is performed. The results show that the modified LLO exhibits excellent anionic/cationic redox reversibility and ultra-high cycling stability. The capacity retention is increased from 72.4% to 95.4%, and the voltage decay is suppressed from 2.48 to 1.29 mV cycle -1 after 300 cycles at 1 C. It also has stable long cycling performance, with capacity retention improved from 40.2% to 81.9% after 500 cycles at 2 C. The excellent electrochemical performance is attributed to the diluted superstructure units on the surface of LLO inhibiting the TM migration in the intralayer and interlayer. Moreover, the stable interfacial layers alleviate the occurrence of ISR and TM dissolution. Therefore, this strategy can give some important insights into the development of highly stable LLOs., (© 2023 Wiley-VCH GmbH.)

Objective: In the present study, we evaluate the characteristics of cognitive and affective function in patients with somatotroph adenomas (SAs) that secrete excess growth hormone and the effects of surgical intervention., Methods: We conducted a prospective longitudinal study, recruiting 27 patients with SAs, 29 patients with nonfunctional pituitary adenomas (NFPAs) as the lesion control group, and 24 healthy participants as the healthy controls (HCs). These three groups were matched for sex, age, and years of education. We performed multidimensional cognitive function and neuropsychological assessments 1-2 days before endoscopic endonasal transsphenoidal surgery and at 3 months postoperatively. The Mini-mental state examination, Montreal cognitive assessment, Frontal assessment battery, Trail making test, and Digit span test were used to assess multidimensional cognitive function, including general intelligence, frontal lobe function, executive function, and memory. The Hamilton anxiety scale, Beck depression inventory, and Positive and Negative Affect Schedule scale were used for the neuropsychological assessment, including anxiety, depressed mood, and positive and negative emotions., Results: Compared with the HCs, the patients with SAs showed poor performance in the memory (P = 0.009) and anxiety (P = 0.013) assessments. However, no statistically significant difference was observed between patients with SAs and NFPAs for either cognitive function or effective performance. Moreover, patients with SAs did not show significant changes in cognition and affective behavior after surgery. In contrast, patients with NFPAs displayed significant improvements in memory (P = 0.015), executive function (P < 0.001), and anxiety mood (P = 0.001) performance postoperatively., Conclusions: Patients with SAs showed specific cognitive deficits and abnormal moods, which might be attributed to the overproduction of growth hormone. However, surgical intervention had a limited effect on improving the impaired cognitive function and abnormal moods in patients with SAs at short-term follow-up., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Background: Frequent fungal diseases tend to lead to severe losses in rice production. As a main component of the fungal cell wall, glucan plays an important role in the growth and development of fungi. Glucanase can inhibit the growth of fungi by breaking glycosidic bonds, and may be a promising target for developing rice varieties with broad-spectrum disease resistance., Results: We transferred a codon-optimized β-1,6-glucanase gene (GluM) from myxobacteria into the japonica rice variety Zhonghua11 (ZH11), and obtained a large number of individual transgenic plants with GluM overexpression. Based on molecular analysis, three single-copy homozygous lines with GluM overexpression were selected for assessment of fungal disease resistance at the T 3 generation. Compared with that of the recipient cultivar ZH11, the area of rice blast lesion in transgenic rice was reduced by 82.71%; that of sheath blight lesion was decreased by 35.76%-43.67%; the sheath blight resistance in the field was enhanced by an average of 0.75 grade over 3 years; and the incidence of diseased panicles due to rice false smut was decreased by 65.79%. More importantly, there was no obvious loss of yield (without a significant effect on agronomic traits). Furthermore, plants overexpressing a β-1,6-glucanase gene showed higher disease resistance than rice plants overexpressing a β-1,3-glucanase gene derived from tobacco., Conclusion: The β-1,6-glucanase gene GluM can confer broad-spectrum disease resistance to rice, providing an environmentally friendly alternative way to effectively manage fungal pathogens in rice production. © 2023 Society of Chemical Industry., (© 2023 Society of Chemical Industry.)

Cybervictimization has been shown to relate to suicidal ideation. However, few studies have fully clarified the directionality of this relationship, and little is known about the potential mediating and moderating mechanisms of this relationship. To address these gaps, the current study tested bidirectional relationships among cybervictimization, hopelessness, and suicidal ideation across three years using a cross-lagged design and examined whether these relationships varied by openness, family socioeconomic status, perceived economic stress, and sex. A total of 2,407 Chinese adolescents (50.23% female, M age  = 12.75, SD = 0.58 at baseline) from seven schools participated in the present study. The results indicated that cybervictimization was related to hopelessness and suicidal ideation. There was a vicious cycle between cybervictimization and hopelessness after controlling the effects of cyberbullying at T1. There were significant reciprocal relationships between hopelessness and suicidal ideation. Hopelessness at T2 mediated the relationship between cybervictimization at T1 and suicidal ideation at T3. Openness moderated the relationships among cybervictimization, hopelessness, and suicidal ideation. Family socioeconomic status, perceived economic stress, and sex did not play a moderating role. These findings will help to understand that intervening with hopelessness is a promising way to reduce adolescents' cybervictimization and suicidal ideation, and promoting adolescents' openness is an effective approach to alleviate the negative outcome of cybervictimization., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Linguistic communication is often regarded as an action that serves a function to convey the speaker's goal to the addressee. Here, with an functional magnetic resonance imaging (fMRI) study and a lesion study, we demonstrated that communicative functions are represented in the human premotor cortex. Participants read scripts involving 2 interlocutors. Each script contained a critical sentence said by the speaker with a communicative function of either making a Promise, a Request, or a Reply to the addressee's query. With various preceding contexts, the critical sentences were supposed to induce neural activities associated with communicative functions rather than specific actions literally described by these sentences. The fMRI results showed that the premotor cortex contained more information, as revealed by multivariate analyses, on communicative functions and relevant interlocutors' attitudes than the perisylvian language regions. The lesion study results showed that, relative to healthy controls, the understanding of communicative functions was impaired in patients with lesions in the premotor cortex, whereas no reliable difference was observed between the healthy controls and patients with lesions in other brain regions. These findings convergently suggest the crucial role of the premotor cortex in representing the functions of linguistic communications, supporting that linguistic communication can be seen as an action., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Parenting is an important factor affecting teenagers' gratitude, but few studies have deeply examined the impact of specific parenting behavior on teenagers' gratitude. In this study, 357 high school students were tested by questionnaires to examine the mechanism of parental rejection on adolescents' gratitude. Results showed that (1) parental rejection significantly and negatively predicted adolescents' gratitude, and that (2) after controlling for gender and age, parental rejection would indirectly impact adolescents' gratitude through responsibility and belief in a just world, respectively. These results suggested that responsibility and belief in a just world were important factors in reducing the negative effect of parental rejection on teenagers' gratitude.

In adolescence, individuals are at high risk for cyberbullying perpetration. Although the role of trait anger in cyberbullying perpetration has attracted attention in the research literature, it is unclear the temporal sequence between trait anger and adolescents' cyberbullying perpetration and whether stressful environments could interact synergistically with trait anger to create a profile of the particularly severe risk to adolescents' cyberbullying perpetration. This study contributed to existing knowledge by examining the longitudinal and reciprocal relationships between trait anger and cyberbullying perpetration and exploring whether peer pressure and family economic stress would moderate these relationships across 2 years (3 time points) with a cohort of Chinese adolescents ( N = 2,407, M age = 12.75 at baseline). The cross-lagged model revealed that prior trait anger was associated with later self-reported cyberbullying perpetration (β T1 → T2 = 0.09 and β T2 → T3 = 0.10), whereas earlier self-reported cyberbullying perpetration was not associated with subsequent trait anger. Peer pressure moderated the link between trait anger and self-reported cyberbullying perpetration. Family economic stress did not play a moderating role in the link between trait anger and self-reported cyberbullying perpetration. Findings suggest that cyberbullying perpetration prevention and intervention programs should attach importance to adolescents' trait anger and the way of getting along with their peers. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Purpose: Brain structural remodeling alters related brain function. However, few studies have assessed morphological alterations of unilateral vestibular schwannoma (VS) patients. Therefore, this study examined the characteristics of brain structural remodeling in unilateral VS patients., Methods: We recruited 39 patients with unilateral VS (19 left, 20 right) and 24 matched normal controls (NCs). We obtained brain structural imaging data using 3T T1-weighted anatomical and diffusion tensor imaging scans. Then, we evaluated both gray and white matter (WM) changes using FreeSurfer software and tract-based spatial statistics, respectively. Furthermore, we constructed a structural covariance network to assess brain structural network properties and the connectivity strength between brain regions., Results: Compared with NCs, VS patients showed cortical thickening in non-auditory areas (e.g., the left precuneus), especially left VS patients, along with reduced cortical thickness in the right superior temporal gyrus (auditory areas). VS patients also showed increased fractional anisotropy in extensive non-auditory-related WM (e.g., the superior longitudinal fasciculus), especially right VS patients. Both left and right VS patients showed increased small-worldness (more efficient information transfer). Left VS patients had a single reduced-connectivity subnetwork in contralateral temporal regions (right-side auditory areas), but increased connectivity between some non-auditory regions (e.g., left precuneus and left temporal pole)., Conclusion: VS patients exhibited greater morphological alterations in non-auditory than auditory areas, with structural reductions seen in related auditory areas and a compensatory increase in non-auditory areas. Left and right VS patients show differential patterns of brain structural remodeling. These findings provide a new perspective on the treatment and postoperative rehabilitation of VS., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Objective: There are few published data concerning pituitary adenomas (PAs) derived from multiple lineages. In this study the authors aimed to determine the clinicopathological characteristics and prognostic profiles of PAs with multiple cell lineage combinations (PAwMCs)., Methods: The authors reviewed data on 723 patients with PAs who had undergone surgery between 2018 and 2021 and identified 93 cases (12.9%) of PAwMC. They collected detailed data on these cases, including clinical information, pathological features, and prognosis. From among 589 cases of PAs with only one cell lineage (PAwOCs), they randomly selected 100 cases to investigate differences between the two tumors. To enable investigation of the characteristics of different subgroups, they further subclassified PAwMCs into 4 groups according to the following specified combinations of pituitary-associated transcription factors: group A, immunopositive for pituitary-specific positive transcription factor 1 (Pit1) and steroidogenic factor 1 (SF1); group B, immunopositive for Pit1 and T-box transcription factor (Tpit); group C, immunopositive for SF1 and Tpit; and group D, immunopositive for Pit1, SF1, and Tpit., Results: Compared with PAwOC, PAwMC was more often associated with hormone hypersecretion (31.0% vs 50.0%, p = 0.037) and had worse short-term prognoses with lower complete response rates (58.7% vs 30.0%, p = 0.026) and more postoperative complications (19.4% vs 35.9%, p = 0.041). Each of the 4 PAwMC subgroups had its own clinical features. Overall, PAwMCs displayed more neurological manifestations than evidence of hypersecretion, which may be attributable to a disparity between pituitary-associated transcription factors and endocrine-related manifestations. Moreover, multiple cell lineages, tumor size (p = 0.011), and Knosp grade (p = 0.013) were all found to be critical predictors of the prognosis of PAwMC., Conclusions: The authors described a special subtype of PAs, which derived from multiple lineages. They found a unique effect of the combination of distinct cell lineages on PAs and present detailed clinicopathological and prognostic profiles of these special PAs. These data will contribute to a more comprehensive view of PAs and assist in the selection of treatment.

Background: Parental phubbing is defined as the phenomenon that parents ignore their children when they are paying more attention to smartphones. The present study aimed to test bidirectional relationships among parental phubbing, problematic smartphone use, and learning burnout. We also extended previous studies to examine the mediating role of problematic smartphone use in the relationship between parental phubbing and learning burnout., Methods: Using a cross-lagged panel model, we recruited 2260 Chinese adolescents (50.35 % girls, M age  = 12.76, SD = 0.58 at baseline) across two years. Descriptive statistics, a cross-lagged panel analysis, a mediation model, and a multiple group analysis were estimated in the current study., Results: Parental phubbing was associated with problematic smartphone use, and there were bidirectional associations between problematic smartphone use and learning burnout as well as between parental phubbing and learning burnout. Problematic smartphone use significantly mediated the relationship between parental phubbing and learning burnout. There were no gender differences among parental phubbing, problematic smartphone use, and learning burnout., Limitations: The current study only used two-time points to measure variables. Additionally, this study measured adolescents' perceived parental phubbing instead of the actual phubbing behavior., Conclusion: It is important to consider the influences of parental phubbing in order to decrease adolescents' problematic smartphone use and learning burnout. Furthermore, there is a vicious circle between PSU and learning burnout. Interventions need to reduce problematic smartphone use and learning burnout simultaneously., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Parental phubbing refers to a phenomenon in which parents are distracted by their smartphones when they interact with their children. It has become a common concern and linked to adolescents' internalizing and externalizing behavior problems. However, much remains unclear about reciprocal associations among parental phubbing, self-esteem, and suicidal ideation and the potential mechanisms underlying these associations. To address these gaps, the current study tested bidirectional relationships among parental phubbing, self-esteem, and suicidal ideation, as well as the mediating role of self-esteem. In addition, the present study examined whether these relationships varied by extraversion, gender, and perceived economic stress across three time points using a cross-lagged design. A total of 2407 Chinese adolescents (50.23% girls, M age  = 12.75, SD = 0.58 at baseline) participated in the study. The results showed that parental phubbing was associated with self-esteem as well as with suicidal ideation, and there were bidirectional relationships between self-esteem and suicidal ideation. Self-esteem significantly mediated the association between parental phubbing and suicidal ideation. Extraversion moderated the link between parental phubbing and suicidal ideation as well as self-esteem and suicidal ideation during the first year. Gender and perceived economic stress did not play a moderating role. The results indicate that parental phubbing is a new risk factor for adolescents' suicidal ideation. Parents concerned about adolescents' self-esteem and suicidal ideation should focus on minimizing the frequency of smartphone use and teach adolescents some social skills to seek more sources of social support., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

A growing body of research has documented that childhood maltreatment is associated with increased risk of child aggression. However, little is known about the mediating and moderating mechanisms underlying the relationships between childhood maltreatment and reactive and proactive functions of aggression. Therefore, the present study examined whether callous-unemotional traits mediated the relationships between childhood maltreatment and two subtypes of aggression and whether these mediating processes were moderated by friendship quality. A cross-sectional study was conducted among 2407 adolescents between 11 and 16 years ( M age = 12.75, SD = .58) in Shanxi province, China. Participants filled out questionnaires regarding childhood maltreatment, callous-unemotional traits, aggression, and friendship quality. The results indicated that childhood maltreatment was significantly and positively associated with proactive and reactive aggression, and these relationships were partially mediated by callous-unemotional traits after controlling for demographic variables. Friendship quality moderated the relationship between childhood maltreatment and proactive aggression as well as callous-unemotional traits and proactive aggression. These relationships became weaker for adolescents with high levels of friendship quality. Friendship quality did not moderate the effects of childhood maltreatment and callous-unemotional traits on reactive aggression.

The present study sought to examine whether parental phubbing was significantly related to children's social withdrawal and aggression, and determine whether positive and negative parenting behaviors mediated this association. We further examined whether parents' gender moderated the direct and indirect relationships between parental phubbing and children's social withdrawal and aggression. The participants included 465 Chinese fathers and mothers from different families, and each father or mother had one child from preschool and early school aged 4-10 years. They completed the measures regarding their experience with parental phubbing, positive and negative parenting behaviors, and children's social withdrawal and aggression. Results showed that parental phubbing was positively related to children's social withdrawal and aggression. Positive and negative parenting behaviors significantly mediated the associations between parental phubbing and children's social withdrawal and aggression. Furthermore, parents' gender moderated the relationships between parental phubbing and children's social withdrawal and aggression. Specifically, in the mediating model of positive parenting behavior, the pathways from parental phubbing to children's social withdrawal and parental phubbing to children's aggression were significantly different. In the mediating model of negative behavior, the pathway from negative parenting behavior to children's social withdrawal was significantly different.

Biomass as a carbon material source is the characteristic of green chemistry. Herein, a series of hierarchical P-doped cotton stalk carbon materials (HPCSCMs) were prepared from cheap and abundant biowaste cotton stalk. These materials possess a surface area of 3463.14 m 2 g -1 and hierarchical pores. As lithium-ion battery (LIB) anodes, the samples exhibit 1100 mAh g -1 at 0.1 A g -1 after 100 cycles and hold 419 mAh g -1 at 1 A g -1 after 1000 cycles, with nearly 100% capacity retention. After HPCSCMs are loaded with sulfur (S/HPCSCMs), the samples (S/HPCSCMs-2) deliver a discharge capacity of 413 mAh g -1 at 0.1 A g -1 after 100 cycles as lithium-sulfur (Li-S) battery cathodes. This excellent electrochemical performance can be attributed to P in carbon networks, which not only provides more active sites, but also improves electrical conductivity.

Cyberbullying perpetration (CP) is a common and devastating network deviation behavior. Some parenting factors for CP have been identified, but few studies have examined the correlation between perceived maternal/paternal acceptance (PMA/PPA) and CP, and the mediating and moderating mechanisms underlying this relation are also largely unknown. Thus, by using a cross-sectional designed questionnaire survey of 4,206 adolescents ( M = 16.41 years, SD = 0.77), the current study examined the relationship between PMA/PPA and CP, as well as the mediating effect of materialism and the moderating effects of father/mother-child attachment anxiety and attachment avoidance in this relation. The results showed that PMA/PPA was protective factors of CP. The moderated mediation models showed that materialism played a partial mediation role in the relationship between PMA/PPA and CP. Moreover, the direct association of PMA/PPA with CP was exacerbated by stronger father/mother-child attachment anxiety, in contrast, it was weakened by stronger father/mother-child attachment avoidance. Besides, both father/mother-child attachment anxiety and father/mother-child attachment avoidance strengthened the direct relationship between materialism and CP, and further strengthened the indirect association of PMA/PPA with CP. This study highlighted the importance of uncovering the link between perceived parental acceptance and adolescents' CP and emphasized the underlying mechanisms, which are of great significance for the prevention and intervention of adolescents' CP.

Transition metal oxides (TMOs) hold great potential for lithium-ion batteries (LIBs) on account of the high theoretical capacity. Unfortunately, the unfavorable volume expansion and low intrinsic electronic conductivity of TMOs lead to irreversible structural degradation, disordered particle agglomeration, and sluggish electrochemical reaction kinetics, which result in perishing rate capability and long-term stability. This work reports an Fe 2 O 3 /MoO 3 @NG heterostructure composite for LIBs through the uniform growth of Fe 2 O 3 /MoO 3 heterostructure quantum dots (HQDs) on the N-doped rGO (NG). Due to the synergistic effects of the "couple tree"-type heterostructures constructed by Fe 2 O 3 and MoO 3 with NG, Fe 2 O 3 /MoO 3 @NG delivers a prominent rate performance (322 mA h g -1 at 20 A g -1 , 5.0 times higher than that of Fe 2 O 3 @NG) and long-term cycle stability (433.5 mA h g -1 after 1700 cycles at 10 A g -1 ). Theoretical calculations elucidate that the strong covalent Fe-O-Mo, Mo-N, and Fe-N bonds weaken the diffusion energy barrier and promote the Li + -ion reaction to Fe 2 O 3 /MoO 3 @NG, thereby facilitating the structural stability, pseudocapacitance contribution, and electrochemical reaction kinetics. This work may provide a feasible strategy to promote the practical application of TMO-based LIBs.

A new large area photomultiplier tube based on the microchannel plates (MCP-PMT) with high collection efficiency (CE) and good time performance is proposed in this paper. A novel focusing system with two cylindrical and a conical barrels is designed to generate the accelerating and focusing electric field. A three-dimensional model is developed by CST Studio Suite to validate its feasibility. Finite Integral Technique and Monte Carlo method are combined to simulate the process. Results predict that CE of the novel MCP-PMT is expected to be 100%. TTS of the photoelectrons from the whole photocathode achieves 1.2 ns. Differ from other large area PMTs, it performs well in the geomagnetic field.

The optimization work of a newly proposed 20-in. photomultiplier tube based on dynode and microchannel plates (Dynode-MCP-PMT) are conducted in this paper. Three-dimensional models are developed in CST STUDIO SUITE to systematically investigate the effects of the size and bias voltage of the two focusing electrodes, dynode and the glass envelop handle based on the Finite Integral Technique and Monte Carlo method. Results predict that the collection efficiency and the transit time spread of the optimized design are substantially improved which are 100% and 3.7 ns., (© 2022. The Author(s).)

Previous studies have found some risk factors of cyberbullying. However, little is known about how mother phubbing may influence adolescent cyberbullying, and the mediating and moderating mechanisms underlying this relationship. "Phubbing," which is a portmanteau of "phone" and "subbing," refers to snubbing other people and focus on smartphones in social interactions. This study examined whether mother phubbing, which refers to being phubbed by one's mother, would be positively related to adolescent cyberbullying, whether perceived mother acceptance would mediate the relationship between mother phubbing and adolescent cyberbullying, and whether emotional stability would moderate the pathways between mother phubbing and adolescent cyberbullying. The sample consisted of 4,213 Chinese senior high school students (mean age 16.41 years, SD = 0.77, 53% were female). Participants completed measurements regarding mother phubbing, cyberbullying, perceived mother acceptance, and emotional stability. The results indicated that mother phubbing was positively related to cyberbullying, which was mediated by perceived mother acceptance. Further, moderated mediation analyses showed that emotional stability moderated the direct path between mother phubbing and cyberbullying and the indirect path between mother phubbing and perceived mother acceptance. This study highlighted the harmful impact of mother phubbing on adolescents by showing a positive association between mother phubbing and adolescent cyberbullying, as well as the underlying mechanisms between mother phubbing and adolescent cyberbullying.

Although trait anger has been shown to play an important role in cyberbullying perpetration, little is known about mediating and moderating mechanisms underlying this relationship. In the present study, we examined whether moral disengagement mediated the relationship between trait anger and cyberbullying perpetration, and whether this mediating process was moderated by empathy. Four hundred and fifty-five Chinese adolescents completed the measures of trait anger, moral disengagement, cyberbullying perpetration, and empathy. The results indicated that trait anger was significantly and positively associated with cyberbullying perpetration and this relationship was partially mediated by moral disengagement. Moderated mediation analysis further indicated that empathy moderated the relationship between moral disengagement and cyberbullying perpetration. This relationship became weaker for adolescents with higher levels of empathy. Results highlight the significance of identifying the mechanisms that moderate the mediated paths between trait anger and adolescents' cyberbullying perpetration.

Considering the prevalence of cyberbullying, the current study explores the factors associated with its perpetration. Using self-determination theory, the association of parental psychological control (PPC) with cyberbullying perpetration was examined. To explore this influencing mechanism further, psychological reactance (PRt) and materialism were examined as two mediators in this relationship. Moreover, according to the diathesis-stress model and cognitive model of resilience, psychological resilience (PRl) was examined as a moderator in the direct and indirect link between PPC and cyberbullying perpetration. To test our expectations, 804 adolescents ( M = 13.12, SD = 1.16) participated in the current study using a cross-sectional design and multiple questionnaires, namely, the Chinese version of the Parental Control Questionnaire, Revised Cyber Bullying Inventory, Hong Psychological Reactance Scale, Material Values Scale for Children, and Resilience Scale for Chinese Adolescents. Correlation analysis indicated that PPC, PRt, materialism, and cyberbullying perpetration were significantly and positively correlated, and were significantly and negatively related to PRl. Moderated mediation analysis revealed that PRt and materialism played multiple mediating roles in the relationship between PPC and cyberbullying perpetration. Multiple mediation analysis indicated that PRl weakened the direct associations of PPC, PRt, and materialism with cyberbullying perpetration, further alleviating the indirect and direct associations of PPC with cyberbullying perpetration, supporting the moderated mediation model. Specifically, adolescents high in PPC were more likely to have stronger PRt and materialistic values, which further triggered cyberbullying perpetration. PRl can protect adolescents high in PPC from cyberbullying perpetration via weakening the direct and indirect associations of PPC with cyberbullying.

Background: Colony stimulating factor 1 receptor (CSF-1R) is a single channel III transmembrane receptor tyrosine kinase (RTK) and plays an important role in immune regulation and the development of various cancer types. The expression of CSF-1R in colon adenocarcinoma (COAD) and its prognostic value remain incompletely understood. Therefore, we aim to explore the prognostic value of CSF-1R in COAD and its relationship with tumor immunity., Methods: CSF-1R expression in a COAD cohort containing 103 patients was examined using immunohistochemistry (IHC). The relationship between CSF-1R expression and clinicopathological parameters and prognosis was evaluated. Dual immunofluorescence staining was conducted to determine the localization of CSF-1R in COAD tissues. Univariate and multivariate Cox regression analysis were performed to evaluate independent prognostic factors. Transcriptomic profiles of CSF-1R high and CSF-1R low tumor-associated macrophages (TAMs) were investigated. Gene enrichment analysis was used to explore the signal pathways related to CSF-1R. In addition, the relationship between CSF-1R in tumor microenvironment (TME) and tumor immunity was also studied., Results: IHC analysis showed that CSF-1R was overexpressed in COAD, and higher expression was associated with shorter overall survival (OS). Immunofluorescence staining showed that CSF-1R was co-localized with macrophage marker CD68. Univariate and multivariate Cox regression analysis showed that CSF-1R was an independent prognostic factor for COAD. The results of gene enrichment analysis showed that CSF-1R was involved in tumor immune response and regulation of TME. In addition, CSF-1R was significantly correlated with TME, immune cell infiltration, TMB, MSI, Neoantigen, and immune checkpoint molecules., Conclusion: CSF-1R can serve as an independent prognostic factor of COAD and promising immunotherapeutic target of COAD., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Wang, Zhang, Hu and Qian.)

Although childhood maltreatment has been shown to play an important role in adolescent cyberbullying perpetration, little is known about mediating and moderating mechanisms underlying this relationship. The current study investigated the mediating role of callous-unemotional (CU) traits in the association between childhood maltreatment and adolescent cyberbullying perpetration, as well as the moderating role of perceived social support. A total of 2,407 Chinese adolescents (aged 11-16 years, M age = 12.75 years, SD = 0.58) completed the measures of childhood maltreatment, CU traits, cyberbullying perpetration, and perceived social support. The results showed that CU traits partially mediated the relationship between childhood maltreatment and adolescent cyberbullying perpetration. Furthermore, perceived social support moderated the relationship between childhood maltreatment and CU traits, as well as CU traits and cyberbullying perpetration. Specifically, childhood maltreatment had a greater impact on CU traits for adolescents with higher levels of perceived social support and the predictive function of CU traits on cyberbullying perpetration was stronger for adolescents with low levels of perceived social support.

The current study sought to examine whether parental phubbing was significantly related to adolescents' cyberbullying perpetration and if moral disengagement mediated this relationship. We further examined whether online disinhibition moderated the direct and indirect relationships between parental phubbing and adolescents' cyberbullying perpetration. The participants included 2,407 adolescents from seven middle schools in China who completed the questionnaires regarding their experience with parental phubbing, moral disengagement, cyberbullying perpetration, and online disinhibition. Results indicated that adolescents with a high level of parental phubbing were likely to cyberbully others. Moral disengagement significantly mediated the relationship between parental phubbing and adolescents' cyberbullying perpetration. Furthermore, online disinhibition moderated the indirect relationship between parental phubbing and adolescents' cyberbullying perpetration. Specifically, the paths from parental phubbing to moral disengagement and from moral disengagement to cyberbullying perpetration became strengthened when adolescents experienced high levels of online disinhibition.