1. Efficacy evaluation, active ingredients, and multitarget exploration of herbal medicine.
- Author
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Ren JL, Yang L, Qiu S, Zhang AH, and Wang XJ
- Subjects
- Humans, Metabolomics methods, Drugs, Chinese Herbal pharmacology, Drugs, Chinese Herbal therapeutic use, Plants, Medicinal
- Abstract
Evidence shows that herbal medicine (HM) could be beneficial for the treatment of various diseases. However, complexities present in HM due to the unclear bioactive compounds, mechanisms of action, undetermined targets for therapy, and nonspecific features for metabolism, are currently an obstacle for the progression of novel drug discovery. Metabolomics could be a potential tool to overcome these issues and for the understanding of HM from a small-molecule metabolism level. The chinmedomics-based metabolomics method assesses the overall metabolism of organisms with a holistic view and shows great potential for understanding metabolic pathways, evaluating curative effects, clarifying mechanisms, discovering active ingredients, and precision medicine. This review focuses on the efficacy evaluation, active ingredient discovery, and target exploration of HM based on metabolomics and chinmedomics., Competing Interests: Declaration of interests The authors have no interests to declare. Author Contributions J.R. and A.-H.Z. contributed to the framework design of the manuscript. J.R., L.Y., S.Q., A.-H.Z., and X.-J.W. were responsible for the analysis and interpretation of the manuscript; J.R. and A.-H.Z. wrote, reviewed, and/or revised the manuscript; J.R. prepared the figures; A.-H.Z. communicated with the editors., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Published
- 2023
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