34 results on '"Wang, Wei-Liang"'
Search Results
2. [Analysis of Change and Driving Factors of River Environmental Quality in China from 2002 to 2020].
- Author
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Yang CX, Xue Y, Gao C, Wan ZH, Wang XN, Liu YL, Liu L, Liu CQ, and Wang WL
- Abstract
According to the river environmental quality, pollutant emission, and investment in environmental pollution control from 2002-2020, the change law and driving factors of river environmental quality in China were evaluated using canonical correlation analysis and the Spearman correlation coefficient to analyze the influence between environmental and pollutant emission/investment in environmental pollution control. The results indicated that the river environmental quality was improved significantly based on the proportion of Class Ⅰ-Ⅲ increasing from 29.1% to 87.4% and the proportion of inferior Class Ⅴ decreasing from 40.9% to 0.2% from 2002-2020. The emission of wastewater and domestic wastewater increased from 4.395×10
10 tons and 2.323×1010 tons to 8.491×1010 tons and 6.598×1010 tons, respectively. However, emissions of industrial wastewater decreased from 2.072×1010 tons to 1.680×1010 tons. Investment in environmental pollution control increased from 110.66 billion yuan to 1063.89 billion yuan. The proportion of Class Ⅰ-Ⅲ in seven major river basins, river basins in Zhejiang and Fujian, southwest river basins, and northwest river basins showed a negative correlation for industrial pollutant emissions and a positive correlation for investment in environmental pollution control. The primary measure for the seven major river basins, river basins in Zhejiang and Fujian, and northwest river basins cut down the industrial pollutant emissions, in the order of COD>NH4 + -N>total wastewater. The primary measure for southwest river basins increased the investment in environmental pollution control, in the order of industrial investment in environmental pollution control>urban environmental infrastructure construction investment and environmental protection investment in construction projects. These results can provide theoretical and policy suggestions for the improvement of river environmental quality during the "14th Five-Year Plan" period.- Published
- 2023
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3. Erythema multiforme-like drug eruption associated with dupilumab treatment: Report of an unusual case.
- Author
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Long XH, Jiang HS, Lai JD, Liu YH, and Wang WL
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- Humans, Antibodies, Monoclonal, Humanized adverse effects, Erythema Multiforme chemically induced, Erythema Multiforme diagnosis, Drug Eruptions diagnosis, Drug Eruptions etiology
- Published
- 2022
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4. Correction to: Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia.
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Wang WL, Zhou YQ, Chai NN, Li GH, and Liu DW
- Published
- 2021
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5. Preparation and Characterization of Phosphoric Acid-Modified Biochar Nanomaterials with Highly Efficient Adsorption and Photodegradation Ability.
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Yang CX, Zhu Q, Dong WP, Fan YQ, and Wang WL
- Abstract
Phosphoric acid-modified biochar (PMBC) was prepared using biochar (BC) as the carbon source and phosphoric acid as the activating agent. The PMBC exhibited an ordered vessel structure after deashing treatment, but the sidewalls became much rougher, the polarity (O/C atomic ratio of BC = 0.2320 and O/C atomic ratio of PMBC = 0.1604) decreased, and the isoelectric points (PI of BC = 5.22 and PI of PMBC = 5.51) and specific surface area (SSA of BC = 55.322 m
2 /g and SSA of PMBC = 62.285 m2 /g) increased. The adsorption characterization of the removal of sulfadiazine (SDZ) from PMBC was studied. The adsorption of SDZ by PMBC was in accordance with the Langmuir isotherm model and the pseudo-second-order kinetics model, and the adsorption thermodynamics were shown as Gibbs free energy < 0, an enthalpy change of 19.157 kJ/mol, and an entropy change of 0.0718 kJ/(K·mol). The adsorption of SDZ by PMBC was a complicated monolayer adsorption that was spontaneous, irreversible, and endothermic, and physical adsorption and chemical adsorption occurred simultaneously. The adsorption process was controlled by microporous capture, electrostatic interactions, hydrogen-bond interactions, and π-π interactions. PMBC@TiO2 photocatalysts with different mass ratios between TiO2 and PMBC were prepared via the in situ sol-gel method. PMBC@TiO2 exhibited both an ordered vessel structure (PMBC) and irregular particles (TiO2 ), and it was linked via Ti-O-C bonds. The optimal mass ratio between TiO2 and PMBC was 3:1. The removal of SDZ via PMBC@TiO2 was dependent on the coupling of adsorption and photocatalysis. The PMBC-enhanced photocatalytic performance of PMBC@TiO2 resulted in a higher absorption of UV and visible light, greater generation of reactive oxygen species, high levels of adsorption of SDZ on PMBC, and the conjugated structure and oxygen-containing functional groups that promoted the separation efficiency of the hole-electron pairs.- Published
- 2021
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6. Process in medication self-management: The perspective of Chinese patients with schizophrenia.
- Author
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Qin L, Wang WL, Zhou YQ, and Li YL
- Subjects
- China, Family, Humans, Antipsychotic Agents therapeutic use, Psychiatry, Schizophrenia drug therapy
- Abstract
This study aimed to explore the medication self-management experience of Chinese patients with schizophrenia who are prescribed antipsychotics. Grounded theory methodology was used to guide the research. Semistructured and in-depth interviews with 17 patients with schizophrenia were conducted and analysed. The six categories identified in this study portray an evolving journey for participants, from initially obeying the orders of psychiatrists or family members to actively engaging in medication management. Six main categories emerged from the data: (i) obeying the orders; (ii) perceiving the changes; (iii) appraising the changes; (iv) making some adjustments; (v) generating insight into medication-taking; and (vi) transcending themselves. The findings from the study indicate that the participants' experience antipsychotic management is complex and that the medication self-management behaviour trajectory is a continuous, dynamic, and progressive process. Health care professionals should identify the characteristics of medication self-management behaviour changes in patients with schizophrenia according to their actual situation and provide correct, timely and adequate guidance for patients., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
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7. Sleep disturbance and quality of life in clinically stable inpatients with schizophrenia in rural China.
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Wang WL, Zhou YQ, Chai NN, and Li GH
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- Adult, China epidemiology, Cross-Sectional Studies, Female, Humans, Male, Rural Population, Quality of Life psychology, Schizophrenia complications, Sleep Wake Disorders epidemiology
- Abstract
Background: Studies have identified numerous factors that may affect the sleep quality and quality of life (QOL) in outpatients with schizophrenia. However, the clinically stable inpatients who represent a large proportion of the population with schizophrenia in China have not received enough attention. The present study was performed to explore the sociodemographic and clinical correlates of sleep disturbance and QOL in clinically stable inpatients with schizophrenia in rural China., Methods: A cross-sectional study was designed, and 207 clinically stable inpatients with schizophrenia were selected from Chifeng Anding Hospital, located in Inner Mongolia Autonomous Region, in northern China. All subjects were interviewed by the same investigator using standardized assessment instruments. QOL and sleep disturbance were measured using the Schizophrenia Quality of Life Scale (SQLS) and Pittsburgh Sleep Quality Index (PSQI), respectively. Univariate and multiple regression analyses were used to identify the factors influencing sleep disturbance and QOL. Antipsychotics taken by individuals were converted into olanzapine equivalent doses as the main confounding factor to be controlled., Results: The prevalence of sleep disturbance was 58%, and sleep disturbance was significantly associated with depression (OR 1.33, 95% CI 1.17-1.52) and coping mechanisms (OR 0.95, 95% CI 0.91-0.98). We observed large differences between the sexes: the QOL of male inpatients with schizophrenia was substantially better than that of female inpatients, with a standard coefficient of 0.19 ± 1.62. Other factors related to QOL were depression (0.42 ± 0.30), hope (- 0.21 ± 0.19), general psychopathology symptoms (0.21 ± 0.24) and personal and social performance (- 0.12 ± 0.07)., Conclusions: The depressive symptoms of inpatients with schizophrenia should receive more attention. More targeted interventions, such as the early identification and treatment of depression, should be promptly administered to improve the patient's hospitalization experience.
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- 2020
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8. Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia.
- Author
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Wang WL, Zhou YQ, Chai NN, Li GH, and Liu DW
- Subjects
- Depression, Female, Hope, Humans, Male, Quality of Life, Surveys and Questionnaires, Resilience, Psychological, Schizophrenia
- Abstract
Background: The underlying mechanism between hope and quality of life is as yet unknown. We aim to examine the potential mediating effect of depression and resilience and the moderated effect of sex in this well-established association., Methods: Two hundred seven patients diagnosed with schizophrenia were administered a questionnaire battery that measured hope, depression, resilience and QOL. A multiple mediation model was used to examine the mediating effect of resilience and depression on the association between hope and QOL. A subgroup analysis was performed and a moderated mediation model was examined to find and test the moderated effect of sex on the mediation model. We used Mplus to perform moderation and mediation analyses so that the mediators and moderator could function together in the same model., Result: Sex was the moderator on the direct path between hope and QOL. The relationship between hope and QOL was mediated by resilience and depression in both sexes. When compared with female patients, the effect of hope on QOL was completely mediated by resilience and depression in males. In female patients, the model was partially mediated, and the direct effect of hope on QOL was significantly negatively correlated with the level of hope., Conclusion: We present a conceptual model containing the mediated effects of resilience and depression and the moderated effect of sex between hope and QOL, which we believe facilitates the understanding of these associations. This model should be useful in the formulation of strategies to improve QOL.
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- 2020
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9. Cross-cultural adaptation and psychometric properties of the Chinese version of the Functional Remission of General Schizophrenia (FROGS) scale and the four-item version (mini-FROGS) among people with schizophrenia.
- Author
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Wang WL, Zhou YQ, Mao YY, and Qu P
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- Adult, China, Culture, Female, Humans, Male, Middle Aged, Psychometrics instrumentation, Psychometrics methods, Remission Induction, Reproducibility of Results, Schizophrenia therapy, Outcome Assessment, Health Care standards, Psychiatric Status Rating Scales standards, Psychometrics standards, Schizophrenia physiopathology
- Abstract
Objective: This study was designed to verify the cross-cultural psychometric properties of the Functional Remission of General Schizophrenia (FROGS) scale and the four-item version (mini-FROGS) in Chinese schizophrenic individuals., Methods: Item clustering analysis was used to show the clustering relationship among items. Confirmatory factor analysis (CFA) was used to test the structural validity of the scale. The Global Assessment of Functioning (GAF) was used as a criterion to test convergent validity. The receiver operating characteristic curve (ROC) and the area under the ROC curve (ROC-AUC) were calculated to test the sensitivity and specificity of FROGS and mini-FROGS for functional assessment. Fifty participants were randomly selected for retest at two-month intervals., Results: A total of 228 schizophrenia individuals were enrolled in our study. The results of the item clustering analysis and CFA supported the 3-factor structure of the original scale, and all items, except for the item "absence of antisocial or violent", showed good psychometric characteristics. The correlated coefficients between FROGS and mini-FROGS with the GAF were excellent (FROGS: r = 0.74, p<0.01; mini-FROGS: r = 0.65, p<0.01). The retest showed that the scale had good stability and validity over time (ICC = 0.856; 95% CI = 0.701∼0.941). Both mini-FROGS and FROGS had good sensitivity and specificity for the measurement of social function (mini-FROGS: ROC-AUC = 84.3% (76.9%-91.6%), and FROGS: ROC-AUC = 89.2% (83.0%-95.4%)), and there was no difference between the two versions of ROC-AUC (P = 0.154)., Conclusion: The results of our study showed that the Chinese version of FROGS and mini-FROGS had good psychometric properties for assessing the social function of people with schizophrenia in China. In particular, the mini-FROGS version was better used in the clinical setting because of its convenience and efficiency., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2020
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10. [Effect of perioperative dexamethasone on nausea, vomiting and pain after total knee arthroplasty].
- Author
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Liu M, Zhou RC, Zhou XS, Liu LL, Wang WL, Cai CY, and Wu LF
- Subjects
- Aged, Dexamethasone, Female, Humans, Male, Nausea, Pain, Postoperative, Vomiting, Arthroplasty, Replacement, Knee
- Abstract
Objective: To investigate the effect of perioperative dexamethasone on nausea, vomiting and pain after unilateral total knee arthroplasty and to evaluate its safety., Methods: From February 2014 to June 2016, 100 patients with unilateral advanced osteoarthritis treated by total knee arthroplasty were divided into two groups: 50 patients in dexamethasone group including 27 males and 23 females, aged (72.30±7.02) years, were given intravenous drip of dexamethasone 10 mg before operation; 50 patients in saline group, including 26 males and 24 females, aged (71.30±6.08) years, were given the same amount of saline at the corresponding time. The VAS scores of pain at rest and at 45 degrees of knee flexion were recorded at 2, 4, 6, 8, 12, 24, 36 and 48 h after operation. Vomiting, antiemetic drugs and opioids were recorded at 0 to 24 h and 24 to 48 h after operation. The side effects and complications were recorded., Results: All the 100 patients were followed up for an average of 14.5 months. VAS score of pain at rest in dexamethasone group was lower than that in saline group at 8, 24 and 48 h after operation ( P <0.05); VAS score of dexamethasone group at 45 degrees after knee flexion was lower than that of saline group at 8 and 48 h after operation( P <0.05); VAS score of dexamethasone group at rest and 45 degrees after knee flexion was lower than that of saline group( P <0.05). The dosage of opioids and total opioids in dexamethasone group was lower than that in saline group at 0 to 24 h, 24 to 48 h after operation ( P <0.05). The proportion of nausea and vomiting occurred at 0 to 24 h and 24 to 48 h after operation, and the proportion of antiemetic required at 0 to 24 h after operation had statistical significance between two groups( P <0.05). The total antiemetic dosage of dexamethasone group was less than that of saline group( P <0.05). As of the last follow-up, no complications such as infection, gastrointestinal ulcer and bleeding occurred in the two groups., Conclusions: Preoperative systemic application of dexamethasone can effectively reduce pain and nausea and vomiting after TKA without increasing postoperative complications., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© 2019 by the China Journal of Orthopaedics and Traumatology Press.)
- Published
- 2019
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11. [Finite element analysis of anterior ring injuries in unstable pelvic fractures treated by different methods].
- Author
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Liu M, Zhou XS, Wang JC, Liu LL, Wang WL, Cai CY, and Yang GJ
- Subjects
- Bone Screws, Finite Element Analysis, Fracture Fixation, Internal, Humans, Fractures, Bone, Pelvic Bones
- Abstract
Objective: To compare the biomechanical stability of different fixation methods for anterior ring injury of unstable pelvic fractures, and to provide reference for clinical treatment., Methods: An unstable pelvic fracture model (Tile C) with one side of the sacroiliac joint dislocation and the pubic rami fracture was constructed via three-dimensional finite element analysis. Five different fixation methods were used in the front, and the rear was fixed with sacroiliac screws. The von Mises stress and strain distributions of different combinations of fixation methods were analyzed under mimicking standing conditions., Results: After being loaded with 500 N vertically, the maximum stress in the anterior fracture was 3.56 MPa in anterior pelvic external fixation (AEF) group, the total displacement and the vertical displacement of the Y axis at the sacroiliac joint and the fracture were not more than 1.5 mm. The maximum stress at fixation, the front of the fracture and sacroiliac joints in the anterior pelvic subcutaneous approach(APA) group and AEF, was significantly higher than anterior modified Stoppa approach(ASA) group, anterior pelvic Ilioinguinal approach (AIA) group, and canulated screw fixation(CSF) group. The total displacement and the vertical displacement of the Y axis at the sacroiliac joint and the fracture in APA group and AEF group were also greater than the other three groups., Conclusions: Anterior ring injury of unstable pelvic fractures can be significantly improved after the fixation of the implants in the five combined methods. However, overall biomechanical properties of ASA, AIA and CSF group are superior to APA and AEF group., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© 2019 by the China Journal of Orthopaedics and Traumatology Press.)
- Published
- 2019
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12. [Clinical effect of superselective arterial embolization for the treatment of massive haemorrhage from pelvic fracture].
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Lin ZQ, Ye XZ, Wang WL, Zhu GQ, Xie BJ, and Liu LL
- Subjects
- Adult, Aged, Feasibility Studies, Female, Hemorrhage etiology, Humans, Male, Middle Aged, Treatment Outcome, Young Adult, Embolization, Therapeutic methods, Fractures, Bone complications, Hemorrhage therapy, Pelvic Bones injuries
- Abstract
Objective: To investigate feasibility and curative effect of superselective arterial embolization for the treatment of massive haemorrhage from pelvic fracture., Methods: From March 2008 to February 2016, clinical data of 65 patients with massive haemorrhage from pelvic fracture were collected and analyzed, and patients were divided into non-embolic and embolic group according to whether perform vascular thrombosis. Thirty-three patients were in non-embolic group including 26 males and 7 females aged from 21 to 64 years old with an average of(39.2±5.7) years old, the time from injury to operation ranged from 1.1 to 4.8 h with an average of (2.2±0.4) h; 12 cases were type B and 21 cases were type C according to AO/Tile classification; injury severity score (ISS) ranged from 25 to 42 with an average of (37.7±7.5); shock index score ranged from 1.7 to 2.4 with an average of 2.1±0.3; treated with blood transfusion and fluid infusion. Thirty-two patients in embolic group, including 25 males and 7 females aged from 22 to 65 years old with an average of(38.1±4.5) years old; the time from injury to operation ranged from 1.2 to 4.8 h with an average of (2.1± 0.5) h; 14 cases were type B and 18 cases were type C according to AO/Tile classification; ISS ranged from 26 to 43 with an average of 38.9±4.5; shock index score ranged from 1.6 to 2.4 with an average of 2.2±0.2; treated by blood transfusion and fluid infusion with superselective arterial embolization. Blood transfusion volume, fluid infusion volume, shock correction time and survival rate were observed and compared, effective rate of hemostasis and postoperative complications were compared., Results: Thirty-seven artery were injured in embolic group, hemostasis were controlled at 3 h after operation, and hemodynamics turned to stable. There were significant difference in blood transfusion volume, fluid infusion volume, shock correction time between non-embolic and embolic group, and embolic group performed better. Survival rate in embolic group was also better than that of non-embolic group, and had significant difference. While there was obvious differences in complications(χ²=4.03, P =0.045)., Conclusions: Superselective arterial embolization for massive haemorrhage from pelvic fracture could effective hemostasis, reduce blood transfusion and fluid infusion volume and occurrence rate of shock, moreover improve survival rate and deserves promotion., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
- Published
- 2017
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13. [Expert consensus on the design and implementation of clinical safety centralized monitoring study of Chinese medical injection].
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Zhang JH, Ren JT, Hu JQ, Xie YM, Song HB, Zhu MJ, Gao R, Wang Z, Zheng WK, Li XL, Jiang M, Huang YH, Lu F, He LY, Lian WX, Yang ZQ, Yuan WA, Hu SY, Wang BH, Wang WL, Ren DQ, and Zhang BL
- Subjects
- China, Consensus, Drug-Related Side Effects and Adverse Reactions, Drugs, Chinese Herbal adverse effects, Drugs, Chinese Herbal standards, Humans, Injections, Quality Control, Medicine, Chinese Traditional standards, Product Surveillance, Postmarketing
- Abstract
Along with the increase of clinical application, the safety of traditional Chinese medicine gained more and more attentions. In particular, the safety evaluation of Chinese medical injections has become a mandatory task should be completed by pharmaceutical companies under the supervision of China Food and Drug Administration(CFDA). Due to the weak foundation of previous studies, the safety issues of Chinese medical injections have not been fully understood, and lack of scientific and rational risk management programs. Clinical safety centralized monitoring(CSCM) is an important method for post-market safety evaluation of Chinese medicine. Due to the lack of appropriate norms and procedures, the quality of similar research is uneven, and the results vary. Combined with practical experience with experts' suggestions, we developed this expert consensus on the design and implementation of CSCM from three stages (design, implementation and report) with 20 technical points, which will provide technical support for future CSCM studies., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)
- Published
- 2017
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14. Band Gap Engineering of Two-Dimensional Nitrogene.
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Li JS, Wang WL, and Yao DX
- Abstract
In our previous study, we have predicted the novel two-dimensional honeycomb monolayers of pnictogen. In particular, the structure and properties of the honeycomb monolayer of nitrogen, which we call nitrogene, are very unusual. In this paper, we make an in-depth investigation of its electronic structure. We find that the band structure of nitrogene can be engineered in several ways: controlling the stacking of monolayers, application of biaxial tensile strain, and application of perpendicular electric field. The band gap of nitrogene is found to decrease with the increasing number of layers. The perpendicular electric field can also reduce the band gap when it is larger than 0.18 V/Å, and the gap closes at 0.35 V/Å. A nearly linear dependence of the gap on the electric field is found during the process. Application of biaxial strain can decrease the band gap as well, and eventually closes the gap. After the gap-closing, we find six inequivalent Dirac points in the Brillouin zone under the strain between 17% and 28%, and the nitrogene monolayer becomes a Dirac semimetal. These findings suggest that the electronic structure of nitrogene can be modified by several techniques, which makes it a promising candidate for electronic devices.
- Published
- 2016
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15. Analysis of the relationship between economic growth and industrial pollution in Zaozhuang, China-based on the hypothesis of the environmental Kuznets curve.
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Liu XH, Wang WL, Lu SY, Wang YF, and Ren Z
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- Biological Oxygen Demand Analysis, China, Environment, Gross Domestic Product, Industrial Waste economics, Industry economics, Models, Theoretical, Wastewater analysis, Wastewater economics, Water Pollutants, Chemical analysis, Water Quality, Economic Development, Industrial Waste statistics & numerical data, Industry statistics & numerical data, Wastewater statistics & numerical data
- Abstract
In Zaozhuang, economic development affects the discharge amount of industrial wastewater, chemical oxygen demand (COD), and ammonia nitrogen (NH3-N). To reveal the trend of water environmental quality related to the economy in Zaozhuang, this paper simulated the relationships between industrial wastewater discharge, COD, NH3-N load, and gross domestic product (GDP) per capita for Zaozhuang (2002-2012) using environmental Kuznets curve (EKC) models. The results showed that the added value of industrial GDP, the per capita GDP, and wastewater emission had average annual growth rates of 16.62, 16.19, and 17.89 %, respectively, from 2002 to 2012, while COD and NH3-N emission in 2012, compared with 2002, showed average annual decreases of 10.70 and 31.12 %, respectively. The export of EKC models revealed that industrial wastewater discharge had a typical inverted-U-shaped relationship with per capita GDP. However, both COD and NH3-N showed the binding curve of the left side of the "U" curve and left side U-shaped curve. The economy in Zaozhuang had been at the "fast-growing" stage, with low environmental pollution according to the industrial pollution level. In recent years, Zaozhuang has abated these heavy-pollution industries emphatically, so pollutants have been greatly reduced. Thus, Zaozhuang industrial wastewater treatment has been quite effective, with water quality improved significantly. The EKC models provided scientific evidence for estimating industrial wastewater discharge, COD, and NH3-N load as well as their changeable trends for Zaozhuang from an economic perspective.
- Published
- 2016
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16. Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects.
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Sheng L, Qu Y, Yan J, Liu GY, Wang WL, Wang YJ, Wang HY, Zhang MQ, Lu C, Liu Y, Jia JY, Hu CY, Li XN, Yu C, and Xu HR
- Subjects
- Aged, Aged, 80 and over, Alkaloids administration & dosage, Asian People, Body Height, Body Weight, Creatinine urine, Female, Humans, Male, Middle Aged, Nonlinear Dynamics, Sesquiterpenes administration & dosage, Sex Characteristics, Aging blood, Alkaloids blood, Alkaloids pharmacokinetics, Models, Biological, Sesquiterpenes blood, Sesquiterpenes pharmacokinetics
- Abstract
Aim: Our preliminary results show that huperzine A, an acetylcholinesterase inhibitor used to treat Alzheimer's disease (AD) patients in China, exhibits different pharmacokinetic features in elderly and young healthy subjects. However, its pharmacokinetic data in elderly subjects remains unavailable to date. Thus, we developed a population pharmacokinetic (PPK) model of huperzine A in elderly Chinese people, and identified the covariate affecting its pharmacokinetics for optimal individual administration., Methods: A total of 341 serum huperzine A concentration records was obtained from 2 completed clinical trials (14 elderly healthy subjects in a phase I pharmacokinetic study; 35 elderly AD patients in a phase II study). Population pharmacokinetic analysis was performed using the non-linear mixed-effect modeling software Phoenix NLME1.1.1. The effects of age, gender, body weight, height, creatinine, endogenous creatinine clearance rate as well as drugs administered concomitantly were analyzed. Bootstrap and visual predictive checks were used simultaneously to validate the final population pharmacokinetics models., Results: The plasma concentration-time profile of huperzine A was best described by a one-compartment model with first-order absorption and elimination. Age was identified as the covariate having significant influence on huperzine A clearance. The final PPK model of huperzine A was: CL (L/h)=2.4649(*)(age/86)((-3.3856)), Ka=0.6750 h(-1), V (L)=104.216. The final PPK model was demonstrated to be suitable and effective by the bootstrap and visual predictive checks., Conclusion: A PPK model of huperzine A in elderly Chinese subjects is established, which can be used to predict PPK parameters of huperzine A in the treatment of elderly AD patients.
- Published
- 2016
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17. Cross-linked versus conventional polyethylene for total knee arthroplasty: a meta-analysis.
- Author
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Yu BF, Yang GJ, Wang WL, Zhang L, and Lin XP
- Subjects
- Arthroplasty, Replacement, Knee adverse effects, Arthroplasty, Replacement, Knee methods, Cross-Linking Reagents, Humans, Osteolysis etiology, Prosthesis Design, Prosthesis Failure, Reoperation statistics & numerical data, Arthroplasty, Replacement, Knee instrumentation, Knee Prosthesis, Polyethylene chemistry
- Abstract
Background: Highly cross-linked polyethylene (HXLPE) has been reported as an effective material for decreasing polyethylene wear and osteolysis in total knee arthroplasty (TKA). Because no single study to date has been large enough to definitively determine the benefit of HXLPE in TKA, we conducted a meta-analysis to pool the results from randomized controlled trials (RCTs) and non-RCTs to make such a determination., Methods: Potential candidate articles were identified by searching the Cochrane Library, Medline (1966-2015.10), PubMed (1966-2015.10), Embase (1980-2015.10), ScienceDirect (1985-2015.10), and other databases. "Gray studies" were identified from the included articles' reference lists. Pooled data were analyzed using RevMan 5.1., Results: Three RCTs and three non-RCTs were included in the meta-analysis. There were no significant differences between the groups in the total number of reoperations (P = 0.11), reoperations for prosthesis loosening (P = 0.08), radiolucent line (P = 0.20), osteolysis (P = 0.38), prosthesis loosening (P = 0.10), and mechanical failures related to the tibial polyethylene (P = 1.00). Similarly, no significant differences between the two groups were found in postoperative total knee score (P = 0.18) or functional score (P = 0.23)., Conclusions: The meta-analysis showed that compared with conventional polyethylene, HXLPE did not improve the clinical and radiographic outcomes in mid-term follow-up after TKA. Additional high-quality multicenter prospective RCTs with good design, large study populations and long-term follow-up will be necessary to further clarify the effect of HXLPE in TKA.
- Published
- 2016
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18. Polyethylene glycol modification decreases the cardiac toxicity of carbonaceous dots in mouse and zebrafish models.
- Author
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Chen JT, Sun HQ, Wang WL, Xu WM, He Q, Shen S, Qian J, and Gao HL
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- Animals, Animals, Genetically Modified, Carbon administration & dosage, Disease Models, Animal, Heart embryology, Heart physiology, Heart Defects, Congenital chemically induced, Heart Rate drug effects, Male, Mice, Nanostructures administration & dosage, Nanostructures ultrastructure, Polyethylene Glycols administration & dosage, Zebrafish, Carbon chemistry, Carbon toxicity, Cardiotoxicity prevention & control, Heart drug effects, Nanostructures chemistry, Nanostructures toxicity, Polyethylene Glycols chemistry, Polyethylene Glycols pharmacology
- Abstract
Aim: Carbonaceous dots (CDs), which have been used for diagnosis, drug delivery and gene delivery, are accumulated in heart at high concentrations. To improve their biocompatibility, polyethylene glycol-modified CDs (PEG-CDs) were prepared. In this study we compared the cardiac toxicity of CDs and PEG-CDs in mouse and zebrafish models., Methods: Mice were intravenously treated with CDs (size: 4.9 nm, 5 mg·kg(-1)·d(-1)) or PEG-CDs (size: 8.3 nm, 5 mg·kg(-1)·d(-1)) for 21 d. Their blood biochemistry indices, ECG, and histological examination were examined for evaluation of cardiac toxicity. CDs or PEG-CDs was added in incubator of cmlc2 transgenic Zebrafish embryos at 6 hpf, and the shape and size of embryos' hearts were observed at 48 hpf using a fluorescent microscope. Furthermore, whole-mount in situ hybridization was used to examine the expression of early cardiac marker gene (clml2) at 48 hpf., Results: Administration of CDs or PEG-CDs in mice caused mild, but statistically insignificant reduction in serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels detected at 7 d, which were returned to the respective control levels at 21 d. Neither CDs nor PEG-CDs caused significant changes in the morphology of heart cells. Administration of CDs, but not PEG-CDs, in mice caused marked increase of heart rate. Both CDs and PEG-CDs did not affect other ECG parameters. In the zebrafish embryos, addition of CDs (20 μg/mL) caused heart development delay, whereas addition of CDs (80 μg/mL) led to heart malformation. In contrast, PEG-CDs caused considerably small changes in heart development, which was consistent with the results from the in situ hybridization experiments., Conclusion: CDs causes greater cardiac toxicity, especially regarding heart development. Polyethylene glycol modification can attenuate the cardiac toxicity of CDs.
- Published
- 2015
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19. [Treatment of patellar fractures with cable through the bone and Kirschner with a hole in the tail].
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Sun Xiao-liang, Yang GJ, Zhang L, Wang WL, and Xie BJ
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- Adult, Aged, Aged, 80 and over, Bone Wires, Female, Follow-Up Studies, Fracture Fixation, Internal instrumentation, Fracture Fixation, Internal methods, Humans, Male, Middle Aged, Treatment Outcome, Young Adult, Fractures, Bone surgery, Patella injuries, Patella surgery
- Abstract
Objective: To study clinical effects of a new internal fixation by using a cable through the bone and Kirschner with a hole in the tail, for the treatment of patellar fractures., Methods: From May 2012 to July 2013, thirty-four patients with patellar fractures were treated with cable through the bone and Kirschner with a hole in the tail. All the patients had close fracture,including 12 transverse fractures and 22 comminuted fractures. There were 18 males and 16 females, ranging in age from 26 to 81 years old, with an average of (46.0 ± 3.0) years old. After open reduction, two appropriate length of Kirschner with a hole in the tail were driven into the patella as perpendicular to the fracture line or the major fragments as possible. A transverse bone tunnel was then drilled with a Kirschner at one side of the patella. Then the cable, which was successively pulled through the bone tunnel and the hole of Kirschner, was crossed in a figure-eight over the anterior of the patella, tightened and fixated by special instruments. The Kirschner was clipped off on the edge of the hole. If it was a comminuted fracture, another cable was used to fasten the patella with cerclage. Postoperative evaluation was based on Bostman., Results: All the patients were followed up, and the duration ranged from 12 to 26 months, with a mean of (16.0 ± 2.0) months. Fractures healed in all the cases without such complications as infection, loosening of Kirschner and cable loop, and skin irritation. According to the Böstman score system, 33 cases got an excellent result, and 1 good., Conclusion: The cable through the bone and Kirschner with a hole in the tail is a simple, stable and effective method for the treatment of patellar fractures, especially the transverse fractures, with earlier knee exercise and fewer complications.
- Published
- 2015
20. Two-Dimensional Pnictogen Honeycomb Lattice: Structure, On-Site Spin-Orbit Coupling and Spin Polarization.
- Author
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Lee J, Tian WC, Wang WL, and Yao DX
- Abstract
Because of its novel physical properties, two-dimensional materials have attracted great attention. From first-principle calculations and vibration frequencies analysis, we predict a new family of two-dimensional materials based on the idea of octet stability: honeycomb lattices of pnictogens (N, P, As, Sb, Bi). The buckled structures of materials come from the sp(3) hybridization. These materials have indirect band gap ranging from 0.43 eV to 3.7 eV. From the analysis of projected density of states, we argue that the s and p orbitals together are sufficient to describe the electronic structure under tight-binding model, and the tight-binding parameters are obtained by fitting the band structures to first-principle results. Surprisingly large on-site spin-orbit coupling is found for all the pnictogen lattices except nitrogen. Investigation on the electronic structures of both zigzag and armchair nanoribbons reveals the possible existence of spin-polarized ferromagnetic edge states in some cases, which are rare in one-dimensional systems. These edge states and magnetism may exist under the condition of high vacuum and low temperature. This new family of materials would have promising applications in electronics, optics, sensors, and solar cells.
- Published
- 2015
- Full Text
- View/download PDF
21. Coordinated response of photosynthesis, carbon assimilation, and triacylglycerol accumulation to nitrogen starvation in the marine microalgae Isochrysis zhangjiangensis (Haptophyta).
- Author
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Wang HT, Meng YY, Cao XP, Ai JN, Zhou JN, Xue S, and Wang WL
- Subjects
- Aquatic Organisms drug effects, Biomass, Carbon Cycle drug effects, Carbon Dioxide metabolism, Fatty Acids metabolism, Haptophyta cytology, Haptophyta drug effects, Haptophyta growth & development, Microalgae cytology, Microalgae drug effects, Microalgae growth & development, Photosystem II Protein Complex metabolism, Aquatic Organisms metabolism, Carbon metabolism, Haptophyta metabolism, Microalgae metabolism, Nitrogen pharmacology, Photosynthesis drug effects, Triglycerides metabolism
- Abstract
The photosynthetic performance, carbon assimilation, and triacylglycerol accumulation of Isochrysis zhangjiangensis under nitrogen-deplete conditions were studied to understand the intrinsic correlations between them. The nitrogen-deplete period was divided into two stages based on the photosynthetic parameters. During the first stage, carbon assimilation was not reduced compared with that under favorable conditions. The marked increase in triacylglycerols and the variation in the fatty acid profile suggested that triacylglycerols were mainly derived from de novo synthesized acyl groups. In the second stage, the triacylglycerol content continued increasing while the carbohydrate content decreased from 44.0% to 26.3%. These results indicated that the intracellular conversion of carbohydrates to triacylglycerols occurred. Thus, we propose that sustainable carbon assimilation and incremental triacylglycerol production can be achieved by supplying appropriate amounts of nitrogen in medium to protect the photosynthetic process from severe damage using the photosynthetic parameters as indicators., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
22. Identification of carbohydrates as the major carbon sink of the marine microalga Isochrysis zhangjiangensis (Haptophyta) and optimization of its productivity by nitrogen manipulation.
- Author
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Wang HT, Yao CH, Ai JN, Cao XP, Xue S, and Wang WL
- Subjects
- Chromatography, High Pressure Liquid, Haptophyta cytology, Haptophyta metabolism, Microalgae cytology, Microalgae metabolism, Nitrates metabolism, Photosystem II Protein Complex metabolism, Biofuels, Bioreactors, Carbon Sequestration physiology, Glucose physiology, Haptophyta physiology, Microalgae physiology, Nitrogen metabolism
- Abstract
Microalgae represent a potential feedstock for biofuel production. During cultivation under nitrogen-depleted conditions, carbohydrates, rather than neutral lipids, were the major carbon sink of the marine microalga Isochrysis zhangjiangensis (Haptophyta). Carbohydrates reached maximum levels of 21.2 pg cell(-1) on day 5, which was an increase of more than 7-fold from day 1, while neutral lipids simultaneously increased 1.9-fold from 4.0 to 7.6 pg cell(-1) during the ten-day nitrogen-depleted cultivation. The carbohydrate productivity of I. zhangjiangensis was improved by optimization of the nitrate supply mode. The maximum carbohydrate concentration was 0.95 g L(-1) under batch cultivation, with an initial nitrogen concentration of 31.0 mg L(-1), which was 2.4-fold greater than that achieved under nitrogen-depleted conditions. High performance liquid chromatography (HPLC) analysis showed that the accumulated carbohydrate in I. zhangjiangensis was composed of glucose. These results show that I. zhangjiangensis represents an ideal carbohydrate-enriched bioresource for biofuel production., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
23. Effects of Pb(Ⅱ) exposure on Chlorella protothecoides and Chlorella vulgaris growth, malondialdehyde, and photosynthesis-related gene transcription.
- Author
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Xiong B, Zhang W, Chen L, Lin KF, Guo MJ, Wang WL, Cui XH, Bi HS, and Wang B
- Subjects
- Chlorella physiology, Chlorella vulgaris drug effects, Chlorella vulgaris physiology, Chlorophyll analogs & derivatives, Chlorophyll metabolism, Chlorophyll A, Oxidation-Reduction, Photosynthesis genetics, Species Specificity, Chlorella drug effects, Environmental Pollutants toxicity, Lead toxicity, Malondialdehyde metabolism, Photosynthesis drug effects, Transcription, Genetic drug effects
- Abstract
Greater exposure to Pb(Ⅱ) increases the likelihood of harmful effects in the environment. In this study, the aquatic unicellular alga Chlorella protothecoides (C. protothecoides) and Chlorella vulgaris (C. vulgaris) were chosen to assess the acute and chronic toxicity of Pb(Ⅱ) exposure. Results of the observations show dose-response relationships could be clearly observed between Pb(Ⅱ) concentration and percentage inhibition (PI). Exposure to Pb(Ⅱ) increased malondialdehyde (MDA) content by up to 4.22 times compared with the control, suggesting that there was some oxidative damage. ANOVA analysis shows that Pb(Ⅱ) decreased chlorophyll (chl) content, indicating marked concentration-dependent relationships, and the lowest levels of chl a, chl b, and total-chl were 14.53, 18.80, and 17.95% of the controls, respectively. A real-time PCR assay suggests the changes in transcript abundances of three photosynthetic-related genes. After 120 h exposure Pb(Ⅱ) reduced the transcript abundance of rbcL, psaB, and psbC, and the relative abundances of the three genes of C. protothecoides and C. vulgaris in response to Pb(Ⅱ) were 54.66-98.59, 51.68-95.59, 37.89-95.48, 36.04-94.94, 41.19-91.20, and 58.75-96.80% of those of the controls, respectively. As for 28 d treatments, the three genes displayed similar inhibitory trend. This research provides a basic understanding of Pb(Ⅱ) toxicity to aquatic organisms., (Copyright © 2013 Wiley Periodicals, Inc.)
- Published
- 2014
- Full Text
- View/download PDF
24. [Fluorescent carbon dots and the application in biomedicine].
- Author
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Zhang S, Gao HL, Shen S, Wang WL, and Qian J
- Subjects
- Carbon chemistry, Fluorescent Dyes chemistry, Nanostructures chemistry, Quantum Dots chemistry
- Abstract
As a new type of carbon nanomaterials, fluorescent carbon dots (fluorescent CDs) have many advantages when compared with the traditional fluorescent probes. They are photoluminescence stable and resistance to photo bleaching. Moreover, they are excellent in biocompatibility, low-toxic and easy to modify. All these above make them a promising optical image material as a probe in optical image. This article reviews structure, the common carbon sources, the preparation methods, and the light-emitting principles of the carbon dots. We also introduce the research progress of fluorescent carbon dots in biomedicine, and the problems need to be resolved in the study of fluorescent CDs.
- Published
- 2014
25. [Headles cannulated screw for the treatment of Freiberg disease].
- Author
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Li CH, Lin GM, and Wang WL
- Subjects
- Female, Fracture Fixation, Internal methods, Humans, Metatarsus surgery, Osteochondritis surgery, Young Adult, Bone Screws statistics & numerical data, Foot Diseases surgery, Fracture Fixation, Internal instrumentation, Internal Fixators statistics & numerical data, Metatarsus abnormalities, Osteochondritis congenital
- Published
- 2013
26. Rational design of carbon and TiO2 assembly materials: covered or strewn, which is better for photocatalysis?
- Author
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Cui GW, Wang WL, Ma MY, Zhang M, Xia XY, Han FY, Shi XF, Zhao YQ, Dong YB, and Tang B
- Subjects
- Catalysis, Methylene Blue chemistry, Microscopy, Electron, Scanning, Nanostructures ultrastructure, Photolysis, Titanium radiation effects, Water Pollutants, Chemical chemistry, Carbon chemistry, Nanostructures chemistry, Titanium chemistry
- Abstract
The rational design of carbonaceous hybrid nanostructures is very important for obtaining high photoactivity. TiO2 particles strewn with an optimal quantity of carbon nanodots have a much higher photoactivity than that of TiO2 covered with a carbon layer, showing the importance of carbon morphology in the photocatalysis of carbonaceous hybrid nanostructures.
- Published
- 2013
- Full Text
- View/download PDF
27. [Treatment of type C pelvic fracture with Stoppa approach and posterior percutaneous plate fixation].
- Author
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Zhou DB, Yang GJ, Wang WL, Li YJ, Pan ZP, Lin XP, and Jiang WH
- Subjects
- Adult, Female, Fracture Fixation, Internal adverse effects, Humans, Male, Middle Aged, Pelvic Bones surgery, Bone Plates, Fracture Fixation, Internal methods, Fractures, Bone surgery, Pelvic Bones injuries
- Abstract
Objective: To explore the clinical effects of Stoppa approach and posterior percutaneous plate in treating type C pelvic fracture., Methods: From June 2009 to July 2011,16 patients with type C pelvic fracture were treated with reconstruction plate fixation in Stoppa approach for anterior lesions combined with posterior percutaneous plate fixation for posterior lesions.There were 11 males and 5 females,with an average age of 38.8 years (ranged, 22 to 59 years). According to the Tile classification,10 cases belonged to C1,4 belonged to C2,2 belonged to C3. Tometta and Majeed score standards were used to evaluate clinical results., Results: Sixteen patients were followed up from 4 to 13 months with an average of 7.3 months. Operative time was from 80 to 140 min with an average of 100 min;blood loss volume was from 200 to 500 ml with an average of 280 ml; and the healing time of fracture was from 12 to 16 months with an average of 14 months. According to the Tometta score classification, 9 cases got excellent results, 6 good, 1 fair. According to the Majeed score classification, 9 cases obtained excellent results, 5 good, 2 fair., Conclusion: Reconstruction plate fixation in Stoppa approach for anterior lesions combined with posterior percutaneous plate fixation for posterior lesions is an ideal minimally invasive operation in treaing type C pelvic fracture. It can early exercise and has the advandages of small trauma, safe operaton,less complication, stable fixation.
- Published
- 2013
28. [Case-control study on the reconstruction of near distal tendo achillis rupture by suture anchors and traditional steel wire].
- Author
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Xie BJ, Wang WL, Yang GJ, Lin GM, Pan ZP, and Liu LL
- Subjects
- Achilles Tendon diagnostic imaging, Adolescent, Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Radiography, Retrospective Studies, Rupture surgery, Achilles Tendon injuries, Achilles Tendon surgery, Bone Wires, Plastic Surgery Procedures methods, Suture Anchors
- Abstract
Objective: To compare the curative effects of newly suture anchors and traditional steel wire for the reconstruction of near distal tendo achillis rupture., Methods: The clinical data of 56 patients with near distal tendo achillis rupture from June 2007 to February 2011 were retrospectively analyzed. Among 31 patients receiving reconstruction by suture anchors, 22 patients were male and 9 patients were female, with a mean age of 35.5 years (ranging from 16 to 52 years ). Among 25 patients treated with traditional steel wire, 19 patients were male and 6 patients were female, with a mean age of 37.6 years (ranging from 22 to 53 years). The different rehabilitation was conducted for every patient at different times after operation. The position of suture anchor and steel wire were recorded. The clinical data such as operative time, complications of the surgery and the function of stendo achillis were analyzed. The healing of stendo achillis and functional recovery were assessed by Arner-Lindholm standard., Results: All the patients were followed up with an average during of 24.2 months. There were no intraoperative injuries on blood vessels, nerve and tendon. The average operative time and postoperative complications of suture anchors were lower than there of the traditional steel wire (t = 8.75, P = 0.00; Chi2 = 5.42, P = 0.02). The functional recovery of tendo achillis repaired by suture anchors was better than that in the group of traditional steel wire (Chi2 = 7.65, P = 0.02)., Conclusion: Compared to the traditional steel wire, suture anchor demonstrate the superior performance on repairing rupture of the near distal tendo achillis, which is a reliable and effective treatment methods.
- Published
- 2011
29. [Case-control study on transcatheter artery embolization for massive bleeding due to pelvic fractures].
- Author
-
Lin ZQ, Wang WL, Yang GJ, Zhu GQ, Xie BJ, and Liu LL
- Subjects
- Adult, Case-Control Studies, Female, Fractures, Bone therapy, Humans, Male, Middle Aged, Embolization, Therapeutic methods, Fractures, Bone complications, Hemorrhage therapy, Pelvic Bones injuries
- Abstract
Objective: To investigate the techniques and curative effects of transcatheter artery embolization (TAE) for massive bleeding due to pelvic fractures., Methods: The clinical data of 92 patients with haemorrhage due to pelvic fractures from March 1998 to February 2008 were retrospectively analyzed. Among 53 patients treated conservatively such as massive transfusion and fluid infusion in the control group, 43 patients were male and 10 patients were female, ranging in age from 27 to 61 years, averaged (37.2 +/- 5.7) years. Among 39 patients who were hemodynamically unstable or had evidences of ongoing hemorrhage required TAE, 26 patients were male and 13 patients were female, ranging in age from 26 to 62 years, with a mean age of (35.3 +/- 9.5) years. The clinical date such as blood or fluid transfusion volume, shock redress time and survival rate were compared between the two groups. The hemostatic efficiency and complications of the surgery were also analyzed., Results: The average hemostasis time of TAE group was 2 hours. There were no intraoperative injuries of blood vessels, nerve or vital organs. Three patients had lower limbs numbness and 5 patients had gluteal skin redness after the operation. The blood transfusion or fluid infusion volume, shock redress time and survival rate were all significantly better than those in the conservative group., Conclusions: TAE is an early,rapid and effective method in controlling haemorrhage due to pelvic fractures.
- Published
- 2010
30. [Therapeutic effects of suture anchors for the reconstruction of distal tendo achillis rupture].
- Author
-
Liu LL, Xie BJ, Wang WL, Dai MH, Yang GJ, and Tang CX
- Subjects
- Adolescent, Adult, Female, Foreign-Body Reaction etiology, Humans, Male, Middle Aged, Plastic Surgery Procedures instrumentation, Retrospective Studies, Suture Anchors, Tendon Injuries complications, Tendon Injuries immunology, Tenodesis instrumentation, Treatment Outcome, Young Adult, Plastic Surgery Procedures methods, Tendon Injuries surgery, Tenodesis methods
- Abstract
Objective: To investigate the techniques and therapeutic effects of suture anchors for the reconstruction of distal tendo achillis rupture., Methods: The clinical data of 16 patients of distal tendo achillis rupture repaired with suture anchors from June 2005 to August 2008 were retrospectively analyzed. Among them, there were 13 males and 3 females with a mean age of 33.5 years (ranged from 17 to 46 years). The postoperative rehabilitation was conducted for every patient. The operation time, position of suture anchor and complications of the surgery were analyzed. The healing of stendo achillis and functional recovery were assessed by Arner-Lindholm standard., Results: All the patients were followed up for an average of 13.2 months. There were no complications of foreign-body reaction or re-rupture. The average operation time was 35.5 minute. There was no intraoperative injuries of blood vessels, nerves or tendons. A total of 19 suture anchors were used, and only 1 anchor was displaced. The functional recovery of tendo achillis was rated as excellent in 13 cases,good in 2 cases, bad in 1 case. All patients were satisfied with the effects on their current work and life. And no displacement of anchors was found in radiographic films., Conclusion: Repairing of the distal tendo achillis rupture with suture anchors can make operation simple and quick, rigid fixation, less complications, and provide good therapeutic effects.
- Published
- 2010
31. [Improved EPSTR for prevention of dislocation after total hip arthroplasty].
- Author
-
Li Q, Zhang LC, Yang GJ, Cai CY, Tang CX, Wang WL, and Lin LX
- Subjects
- Aged, Aged, 80 and over, Female, Hip Prosthesis, Humans, Male, Middle Aged, Prosthesis Failure, Treatment Outcome, Arthroplasty, Replacement, Hip adverse effects, Femoral Neck Fractures surgery, Femur Head Necrosis surgery, Hip Dislocation prevention & control, Osteoarthritis surgery
- Abstract
Objective: To explore the effect of improved EPSTR on prevention of dislocation after total hip arthroplasty., Methods: From January 2006 to May 2007, the posterior structures were repaired using improved EPSTR in 85 cases (87 hips) of total hip arthroplasty, which involved 39 males and 46 females, with an average age of 69.5 years (range, from 62 to 85 years). Fifty-eight cases were of fresh femoral neck fracture, 25 cases were of aseptic necrosis of femoral head, 3 cases were of osteoarthritis, 1 case was of a internal fixation failure of femoral intertrochanteric fracture., Results: All 85 cases were followed up for 8-24 months (average 15 months). None of these 85 patients had posterior dislocation, external rotation contracture and greater trochanter fracture. The Harris score at the 6th month postoperatively was 89.2 +/- 4.5., Conclusion: Improved EPSTR is an effective, simple and timesaving method in prevention of dislocation after total hip arthroplasty, it has clinical application value.
- Published
- 2009
32. [Prevention of prothesis dislocation after the revision of total hip arthroplasty].
- Author
-
Li YJ, Zhang LC, Yang GJ, Zhang CC, Wang WL, Lin RX, and Cai CY
- Subjects
- Aged, Female, Follow-Up Studies, Hip diagnostic imaging, Humans, Male, Middle Aged, Postoperative Complications, Radiography, Retrospective Studies, Arthroplasty, Replacement, Hip instrumentation, Hip surgery, Hip Dislocation prevention & control, Hip Prosthesis adverse effects, Prosthesis Failure
- Abstract
Objective: To explore the role of reconstruction of the posterior capsule and external rotators in prevention of postoperative dislocation in total hip arthroplasty revision following the posterolateral approach., Methods: Forty-five patients (47 hips) with the mean age of 65 years (55 to 78 years)of failed total hip arthroplasty were revised following the posterolateral approach. Posterior capsule was sutured to the anterosuperior portion of the capsule from where it had been detached, and the external rotators were then reattached to the soft tissue at the tip of the greater trochanter using 1.0 silk suture in surgery. The dislocation rate and risk factors were reviewed retrospectively to determine if closing the posterior capsule resulted in fewer dislocations. The femoral prosthesis and acetabular prosthesis were revised in 29 patients (31 hips), the liner was exchanged in 5 patients (5 hips), and the acetabular prosthesis or femoral components were revised in 10 patients (10 hips) and one patient (one hip) respectively. The procedure was the patient's first revision in 29 patients (30 hips), the second revision in 15 patients (16 hips), and the third revision in one patient(one hip). Radiographic evaluation included lower limb discrepancy, acetabular phase, femoral offset, anteversion angle, prosthetic loosening before and after revision. Function evaluation based on Harris score system., Results: All patients were followed up with an average of 2.7 years. None of the patients sustained dislocation or infection, except one patient felt the anterior instability but without dislocation, X-ray revealed the acetabular component was in excessively anteversion. Lower leg discrepancy, acetabular abduction, anteversion femoral offest and collodiaphyseal angle were restored to normal level after operation on the basis of X-ray. One of the acetabular components and one of the femoral components were loose without dislocation. The Harris hip score improved from (49.13 +/- 15.53) points preoperatively to (83.59 +/- 6.93) points at the final follow-up (P < 0.05). According to Harris functional evaluation, 36 hip got an excellent result, 5 good, 5 fair and 1 bad., Conclusion: The historically high dislocation rate with the posterolateral approach for total hip arthroplasty revision can be reduced by careful soft tissue balancing,correction of implant alignment, meticulously closure of the posterior capsule, and reattaching the external rotators.
- Published
- 2008
33. [Expressions of MIP-1alpha, MCP-1 and their receptors CCR-1, CCR-2 in chronic myeloid leukemia cells].
- Author
-
Wang WL, Shen T, Hui YR, Gu XC, and Li RS
- Subjects
- Chemokine CCL2 genetics, Chemokine CCL3, Chemokine CCL4, Humans, Macrophage Inflammatory Proteins genetics, Receptors, CCR1, Receptors, CCR2, Receptors, Chemokine genetics, Tumor Cells, Cultured, Chemokine CCL2 biosynthesis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive metabolism, Macrophage Inflammatory Proteins biosynthesis, Receptors, Chemokine biosynthesis
- Abstract
This study was aimed to explore the expression of MIP-1alpha, MCP-1 and their receptors CCR-1, CCR-2 in bcr/abl fusion gene positive CML cells, and to study the effects of P210(bcr/abl) fusion protein tyrosine kinase on expression of MIP-1alpha, MCP-1 and their receptors CCR-1, CCR-2 mRNAs in chronic myeloid leukemia cells. The expression levels of MIP-1alpha, MCP-1 and their receptors CCR-1, CCR-2 mRNA were detected by semi-quantitative RT-PCR in bcr/abl negative cells, bcr/abl positive cells, and P210(bcr/abl)-Rb-C-Box positive cells. The results showed that MIP-1alpha and CCR-1 mRNAs were expressed in bcr/abl negative cells, but not in positive cells. Both MCP-1 and CCR-2 mRNA cannot be detected in both bcr/abl positive and negative cells. After inhibiting P210(bcr/abl) tyrosine kinase activity by Rb-C-Box, expressions of MIP-1alpha and CCR-1 mRNAs were restored to normal (similar to P210(bcr/abl) negative cells). It is concluded that P210(bcr/abl) fusion protein inhibits the expression of MIP-1alpha and CCR-1 in chronic myeloid leukemia cells, but does not inhibit MCP-1 and CCR-2 mRNA expressions in these leukemia cells.
- Published
- 2006
34. [Effects of bcr/abl fusion gene on expression of beta1 integrin and L-selectin in mouse chronic myeloid leukemia cells].
- Author
-
Wang WL, Shen T, Hui YR, Gu XC, and Li RS
- Subjects
- Animals, Cell Line, Tumor, Genes, Retinoblastoma genetics, Mice, RNA, Messenger genetics, Transfection, Fusion Proteins, bcr-abl genetics, Gene Expression Regulation, Leukemic, Integrin beta1 genetics, L-Selectin genetics, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
- Abstract
Objectives: To explore the effects of p210 bcr/abl fusion gene on expression of beta1 integrin and L-selectin mRNAs in mouse chronic myeloid leukemia (CML) cells., Methods: Comparisons of beta1 integrin and L-selectin mRNA levels among p210 bcr/abl negative, p210 bcr/abl positive, and p210 bcr/abl-Rb-C-Box positive cells were undertaken by quantity RT-PCR., Results: In p210 bcr/abl positive cells, L-selectin mRNA level was decreased, but beta1 integrin mRNA expression had no change as compared to those in p210 bcr/abl negative cells. When inhibition of bcr-abl tyrosine kinase activity by Rb-C-Box, the L-selectin mRNA expression restored to normal (similar to p210 bcr/abl negative cells)., Conclusion: p210 bcr/abl oncoprotein inhibits expression of L-selectin mRNA, but not of beta1 integrin mRNA.
- Published
- 2003
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