42 results on '"Vale, Justin"'
Search Results
2. Proving the Effectiveness of the Fundamentals of Robotic Surgery (FRS) Skills Curriculum: A Single-blinded, Multispecialty, Multi-institutional Randomized Control Trial.
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Satava RM, Stefanidis D, Levy JS, Smith R, Martin JR, Monfared S, Timsina LR, Darzi AW, Moglia A, Brand TC, Dorin RP, Dumon KR, Francone TD, Georgiou E, Goh AC, Marcet JE, Martino MA, Sudan R, Vale J, and Gallagher AG
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- Analysis of Variance, Curriculum, Female, Humans, Male, Risk Assessment, Single-Blind Method, Treatment Outcome, Clinical Competence, Computer Simulation, Robotic Surgical Procedures education, Simulation Training methods, Specialties, Surgical education
- Abstract
Objective: To demonstrate the noninferiority of the fundamentals of robotic surgery (FRS) skills curriculum over current training paradigms and identify an ideal training platform., Summary Background Data: There is currently no validated, uniformly accepted curriculum for training in robotic surgery skills., Methods: Single-blinded parallel-group randomized trial at 12 international American College of Surgeons (ACS) Accredited Education Institutes (AEI). Thirty-three robotic surgery experts and 123 inexperienced surgical trainees were enrolled between April 2015 and November 2016. Benchmarks (proficiency levels) on the 7 FRS Dome tasks were established based on expert performance. Participants were then randomly assigned to 4 training groups: Dome (n = 29), dV-Trainer (n = 30), and DVSS (n = 32) that trained to benchmarks and control (n = 32) that trained using locally available robotic skills curricula. The primary outcome was participant performance after training based on task errors and duration on 5 basic robotic tasks (knot tying, continuous suturing, cutting, dissection, and vessel coagulation) using an avian tissue model (transfer-test). Secondary outcomes included cognitive test scores, GEARS ratings, and robot familiarity checklist scores., Results: All groups demonstrated significant performance improvement after skills training (P < 0.01). Participating residents and fellows performed tasks faster (DOME and DVSS groups) and with fewer errors than controls (DOME group; P < 0.01). Inter-rater reliability was high for the checklist scores (0.82-0.97) but moderate for GEARS ratings (0.40-0.67)., Conclusions: We provide evidence of effectiveness for the FRS curriculum by demonstrating better performance of those trained following FRS compared with controls on a transfer test. We therefore argue for its implementation across training programs before surgeons apply these skills clinically.
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- 2020
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3. Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A population-based analysis.
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Tan WS, Trinh QD, Hayn MH, Marchese M, Lipsitz SR, Nabi J, Kilbridge KL, Vale JA, Khoubehi B, Kibel AS, Sun M, Chang SL, and Sammon JD
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- Carcinoma, Renal Cell pathology, Female, Humans, Kidney Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Survival Rate, Time Factors, Carcinoma, Renal Cell mortality, Carcinoma, Renal Cell surgery, Kidney Neoplasms mortality, Kidney Neoplasms surgery, Nephrectomy, Time-to-Treatment statistics & numerical data
- Abstract
Objectives: Early surgical resection remains the recommended treatment option for most small renal mass (≤4 cm). We examined the long-term overall survival (OS) of patients managed with delayed and immediate nephrectomy of cT1a renal cancer., Patient and Methods: We utilized the National Cancer Database (2005-2010) to identify 14,677 patients (immediate nephrectomy: 14,050 patients vs. late nephrectomy: 627 patients) aged <70 years with Charlson Comorbidity Index 0 and cT1aN0M0 renal cell carcinoma. Immediate nephrectomy and late nephrectomy were defined as nephrectomy performed <30 days and >180 days from diagnosis, respectively. Inverse probability of treatment weighting-adjusted Kaplan-Meier curves and Cox proportional hazards regression analyses were used to compare OS of patients in the 2 treatment arms. Influence of patient age and Charlson Comorbidity Index on treatment effect was tested by interactions. Sensitivity analysis was performed to explore the outcome of delaying nephrectomy for >12 months., Results: Median patient age was 55 years with a median follow-up of 82.5 months. Inverse probability of treatment weighting-adjusted Kaplan-Meier curves suggest no significant difference between treatment arms (immediate nephrectomy [<30 days] vs. delayed nephrectomy [>180 days]) (Hazard ratio 0.96; 95% confidence interval 0.73-1.26; P = 0.77). This outcome was consistent between all patients regardless of age (P = 0.48). Sensitivity analysis reports no difference in OS even if nephrectomy was delayed by >12 months (P = 0.60)., Conclusions: We report that delayed and immediate nephrectomy for cT1a renal cell carcinoma confers comparable long-term OS. These findings suggest that a period of observation of between 6 and 12 months is safe to allow identification of renal masses, which will benefit from surgical resection., (Copyright © 2019 Elsevier Inc. All rights reserved.)
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- 2020
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4. Traumatic renal injury in a UK major trauma centre - current management strategies and the role of early re-imaging.
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Aldiwani M, Georgiades F, Omar I, Angel-Scott H, Tharakan T, Vale J, and Mayer E
- Abstract
Objectives: To analyse the contemporary management of renal injuries in a UK major trauma centre and to evaluate the utility and value of re-imaging., Patients and Methods: The prospectively maintained 'Trauma Audit and Research Network' database was interrogated to identify patients with urinary tract injuries between January 2014 and December 2017. Patients' records and imaging were reviewed to identify injury grades, interventions, outcomes, and follow-up., Results: Renal injury was identified in 90 patients (79 males and 11 females). The mean (sd; range) age was 35.5 (17.4; 1.5-94) years. Most of the renal traumas were caused by blunt mechanisms (74%). The overall severity of injuries was: 18 (20%) Grade I, 19 (21%) Grade II, 27 (30%) Grade III, 22 (24%) Grade IV, and four (4%) Grade V. Most patients (84%) were managed conservatively. Early intervention (<24 h) was performed in 14 patients (16%) for renal injuries. Most of these patients were managed by interventional radiology techniques (nine of 14). Only two patients required an emergency nephrectomy, both of whom died from extensive polytrauma. In all, 19 patients underwent laparotomy for other injuries and did not require renal exploration. The overall 30-day mortality was 13%. Re-imaging was performed in 66% of patients at an average time of 3.4 days from initial scan. The majority of re-imaging was planned (49 patients) and 12% of these scans demonstrated a relevant finding (urinoma, pseudoaneurysm) that altered management in three of the 49 patients (6.1%)., Conclusion: Non-operative management is the mainstay for all grades of injury. Haemodynamic instability and persistent urine leak are primary indications for intervention. Open surgical management is uncommon. Repeat imaging after injury is advocated for stable patients with high-grade renal injuries (Grade III-V), although more research is needed to determine the optimal timing., (© 2019 The Authors BJU International © 2019 BJU International Published by John Wiley & Sons Ltd.)
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- 2019
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5. Patient-Specific Simulation of Pneumoperitoneum for Laparoscopic Surgical Planning.
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Dawda S, Camara M, Pratt P, Vale J, Darzi A, and Mayer E
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- Animals, Insufflation, Reproducibility of Results, Surgical Instruments, Swine, Tomography, X-Ray Computed, Laparoscopy methods, Pneumoperitoneum, Artificial methods, Preoperative Care methods
- Abstract
Gas insufflation in laparoscopy deforms the abdomen and stretches the overlying skin. This limits the use of surgical image-guidance technologies and challenges the appropriate placement of trocars, which influences the operative ease and potential quality of laparoscopic surgery. This work describes the development of a platform that simulates pneumoperitoneum in a patient-specific manner, using preoperative CT scans as input data. This aims to provide a more realistic representation of the intraoperative scenario and guide trocar positioning to optimize the ergonomics of laparoscopic instrumentation. The simulation was developed by generating 3D reconstructions of insufflated and deflated porcine CT scans and simulating an artificial pneumoperitoneum on the deflated model. Simulation parameters were optimized by minimizing the discrepancy between the simulated pneumoperitoneum and the ground truth model extracted from insufflated porcine scans. Insufflation modeling in humans was investigated by correlating the simulation's output to real post-insufflation measurements obtained from patients in theatre. The simulation returned an average error of 7.26 mm and 10.5 mm in the most and least accurate datasets respectively. In context of the initial discrepancy without simulation (23.8 mm and 19.6 mm), the methods proposed here provide a significantly improved picture of the intraoperative scenario. The framework was also demonstrated capable of simulating pneumoperitoneum in humans. This study proposes a method for realistically simulating pneumoperitoneum to achieve optimal ergonomics during laparoscopy. Although further studies to validate the simulation in humans are needed, there is the opportunity to provide a more realistic, interactive simulation platform for future image-guided minimally invasive surgery.
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- 2019
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6. Evaluating the impact of image guidance in the surgical setting: a systematic review.
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Dilley J, Camara M, Omar I, Carter A, Pratt P, Vale J, Darzi A, and Mayer EK
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- Data Accuracy, Humans, Translational Research, Biomedical methods, Translational Research, Biomedical standards, Outcome Assessment, Health Care methods, Surgery, Computer-Assisted economics, Surgery, Computer-Assisted methods, Surgery, Computer-Assisted trends
- Abstract
Background: Image guidance has been clinically available for over a period of 20 years. Although research increasingly has a translational emphasis, overall the clinical uptake of image guidance systems in surgery remains low. The objective of this review was to establish the metrics used to report on the impact of surgical image guidance systems used in a clinical setting., Methods: A systematic review of the literature was carried out on all relevant publications between January 2000 and April 2016. Ovid MEDLINE and Embase databases were searched using a title strategy. Reported outcome metrics were grouped into clinically relevant domains and subsequent sub-categories for analysis., Results: In total, 232 publications were eligible for inclusion. Analysis showed that clinical outcomes and system interaction were consistently reported. However, metrics focusing on surgeon, patient and economic impact were reported less often. No increase in the quality of reporting was observed during the study time period, associated with study design, or when the clinical setting involved a surgical specialty that had been using image guidance for longer., Conclusions: Publications reporting on the clinical use of image guidance systems are evaluating traditional surgical outcomes and neglecting important human and economic factors, which are pertinent to the uptake, diffusion and sustainability of image-guided surgery. A framework is proposed to assist researchers in providing comprehensive evaluation metrics, which should also be considered in the design phase. Use of these would help demonstrate the impact in the clinical setting leading to increased clinical integration of image guidance systems.
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- 2019
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7. Using preoperative imaging for intraoperative guidance: a case of mistaken identity.
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Hughes-Hallett A, Pratt P, Mayer E, Clark M, Vale J, and Darzi A
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- Algorithms, Humans, Image Enhancement methods, Imaging, Three-Dimensional methods, Kidney diagnostic imaging, Kidney Neoplasms pathology, Nephrectomy, Observer Variation, Predictive Value of Tests, Preoperative Period, Reproducibility of Results, Software, Tomography, X-Ray Computed, Image Interpretation, Computer-Assisted methods, Kidney Neoplasms diagnostic imaging, Kidney Neoplasms surgery, Pattern Recognition, Automated methods, Surgery, Computer-Assisted methods
- Abstract
Background: Surgical image guidance systems to date have tended to rely on reconstructions of preoperative datasets. This paper assesses the accuracy of these reconstructions to establish whether they are appropriate for use in image guidance platforms., Methods: Nine raters (two experts in image interpretation and preparation, three in image interpretation, and four in neither interpretation nor preparation) were asked to perform a segmentation of ten renal tumours (four cystic and six solid tumours). These segmentations were compared with a gold standard consensus segmentation generated using a previously validated algorithm., Results: Average sensitivity and positive predictive value (PPV) were 0.902 and 0.891, respectively. When assessing for variability between raters, significant differences were seen in the PPV, sensitivity and incursions and excursions from consensus tumour boundary., Conclusions: This paper has demonstrated that the interpretation required for the segmentation of preoperative imaging of renal tumours introduces significant inconsistency and inaccuracy. Copyright © 2015 John Wiley & Sons, Ltd., (Copyright © 2015 John Wiley & Sons, Ltd.)
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- 2016
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8. Assessing the impact of mass media public health campaigns. Be Clear on Cancer 'blood in pee': a case in point.
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Hughes-Hallett A, Browne D, Mensah E, Vale J, and Mayer E
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- Early Detection of Cancer, Humans, Kidney Neoplasms prevention & control, Patient Education as Topic methods, Referral and Consultation statistics & numerical data, Retrospective Studies, Carcinoma, Renal Cell prevention & control, Carcinoma, Transitional Cell prevention & control, Health Promotion methods, Hematuria etiology, Mass Media, Urologic Neoplasms prevention & control
- Abstract
Objectives: To assess the impact on suspected cancer referral burden and new cancer diagnosis of Public Health England's recent Be Clear on Cancer 'blood in pee' mass media campaign., Methods: A retrospective cohort study design was used. For two distinct time periods, August 2012 to May 2013 and August 2013 to May 2014, all referrals of patients deemed to be at risk of urological cancer by the referring primary healthcare physician to Imperial College NHS Healthcare Trust were screened. Data were collected on age and sex and whether the referral was for visible haematuria, non-visible haematuria or other suspected urological cancer. In addition to referral data, hospital episode data for all new renal cell (RCC) and upper and lower tract transitional cell carcinoma (TCC), as well as testicular and prostate cancer diagnoses for the same time periods were obtained., Results: Over the campaign period and the subsequent 3 months, the number of haematuria referrals increased by 92% (P = 0.013) when compared with the same period a year earlier. This increase in referrals was not associated with a significant corresponding rise in cancer diagnosis; instead changes of 26.8% (P = 0.56) and -3.3% (P = 0.84) were seen in RCC and TCC, respectively., Conclusions: This study has shown that the Be Clear on Cancer 'blood in pee' mass media campaign significantly increased the number of new suspected cancer referrals, but there was no significant change in the diagnosis of target cancers across a large catchment. Mass media campaigns are expensive, require significant planning and appropriate implementation and, while the findings of this study do not challenge their fundamental objective, more work needs to be done to understand why no significant change in target cancers was observed. Further consideration should also be given to the increased referral burden that results from these campaigns, such that pre-emptive strategies, including educational and process mapping, across primary and secondary care can be implemented., (© 2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd.)
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- 2016
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9. Robust ultrasound probe tracking: initial clinical experiences during robot-assisted partial nephrectomy.
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Pratt P, Jaeger A, Hughes-Hallett A, Mayer E, Vale J, Darzi A, Peters T, and Yang GZ
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- Aged, Female, Humans, Microsurgery methods, Kidney Neoplasms surgery, Nephrectomy methods, Robotic Surgical Procedures, Surgery, Computer-Assisted methods, Ultrasonography, Interventional methods
- Abstract
Purpose: In order to assist in the identification of renal vasculature and tumour boundaries in robot-assisted partial nephrectomy, robust ultrasound probe calibration and tracking methods are introduced. Contemporaneous image guidance during these crucial stages of the procedure should ultimately lead to improved safety and quality of outcome for the patient, through reduced positive margin rates, segmental clamping, shorter ischaemic times and nephron-sparing resection., Methods: Small KeyDot markers with circular dot patterns are attached to a miniature pickup ultrasound probe. Generic probe calibration is superseded by a more robust scheme based on a sequence of physical transducer measurements. Motion prediction combined with a reduced region-of-interest in the endoscopic video feed facilitates real-time tracking and registration performance at full HD resolutions., Results: Quantitative analysis confirms that circular dot patterns result in an improved translational and rotational working envelope, in comparison with the previous chessboard pattern implementation. Furthermore, increased robustness is observed with respect to prevailing illumination levels and out-of-focus images due to relatively small endoscopic depths of field., Conclusion: Circular dot patterns should be employed in this context as they result in improved performance and robustness. This facilitates clinical usage and interpretation of the combined video and ultrasound overlay. The efficacy of the overall system is demonstrated in the first human clinical case.
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- 2015
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10. Inattention blindness in surgery.
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Hughes-Hallett A, Mayer EK, Marcus HJ, Pratt P, Mason S, Darzi AW, and Vale JA
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- Adult, Burnout, Professional physiopathology, Burnout, Professional psychology, Female, Humans, Male, Pilot Projects, Video Recording, Attention, Burnout, Professional etiology, Clinical Competence, Cognition physiology, Surgeons psychology, Surgical Procedures, Operative standards, Workload psychology
- Abstract
Background: Inattention blindness (IB) can be defined as the failure to perceive an unexpected object when attention is focussed on another object or task. The principal aim of this study was to determine the effect of cognitive load and surgical image guidance on operative IB., Methods: Using a randomised control study design, participants were allocated to a high or low cognitive load group and subsequently to one of three augmented reality (AR) image guidance groups (no guidance, wireframe overlay and solid overlay). Randomised participants watched a segment of video from a robotic partial nephrectomy. Those in the high cognitive load groups were asked to keep a count of instrument movements, while those in the low cognitive load groups were only asked to watch the video. Two foreign bodies were visible within the operative scene: a swab, within the periphery of vision; and a suture, in the centre of the operative scene. Once the participants had finished watching the video, they were asked to report whether they had observed a swab or suture., Results: The overall level of prompted inattention blindness was 74 and 10 % for the swab and suture, respectively. Significantly higher levels of IB for the swab were seen in the high versus the low cognitive load groups, but not for the suture (8 vs. 47 %, p < 0.001 and 90 vs. 91 %, p = 1.000, for swab and suture, respectively). No significant difference was seen between image guidance groups for attention of the swab or suture (29 vs. 20 %, p = 0.520 and 22 vs. 22 %, p = 1.000, respectively)., Conclusions: The overall effect of IB on operative practice appeared to be significant, within the context of this study. When examining for the effects of AR image guidance and cognitive load on IB, only the latter was found to have significance.
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- 2015
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11. Editorial Comment to Feasibility and accuracy of computational robot-assisted partial nephrectomy planning by virtual partial nephrectomy analysis.
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Hughes-Hallett A, Vale J, and Mayer E
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- Female, Humans, Male, Imaging, Three-Dimensional, Kidney Neoplasms surgery, Nephrectomy methods, Robotic Surgical Procedures methods, Surgery, Computer-Assisted methods
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- 2015
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12. Three-dimensional printing in urological surgery: what are the possibilities?
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Yu AW, Abboudi H, Mayer E, and Vale J
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- Animals, Humans, Printing, Three-Dimensional, Urologic Surgical Procedures
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- 2015
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13. The current and future use of imaging in urological robotic surgery: a survey of the European Association of Robotic Urological Surgeons.
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Hughes-Hallett A, Mayer EK, Pratt P, Mottrie A, Darzi A, and Vale J
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- Cystectomy methods, Cystectomy trends, Europe, Female, Humans, Male, Nephrectomy methods, Nephrectomy trends, Prostatectomy methods, Prostatectomy trends, Societies, Medical, Surgery, Computer-Assisted trends, Surveys and Questionnaires, Robotic Surgical Procedures methods, Robotic Surgical Procedures trends, Surgery, Computer-Assisted methods, Urologic Surgical Procedures methods, Urologic Surgical Procedures trends
- Abstract
Background: With the development of novel augmented reality operating platforms the way surgeons utilise imaging as a real-time adjunct to surgical technique is changing., Methods: A questionnaire was distributed via the European Robotic Urological Society mailing list. The questionnaire had three themes: surgeon demographics, current use of imaging and potential uses of an augmented reality operating environment in robotic urological surgery., Results: 117 of the 239 respondents (48.9%) were independently practising robotic surgeons. 74% of surgeons reported having imaging available in theatre for prostatectomy 97% for robotic partial nephrectomy and 95% cystectomy. 87% felt there was a role for augmented reality as a navigation tool in robotic surgery., Conclusions: This survey has revealed the contemporary robotic surgeon to be comfortable in the use of imaging for intraoperative planning it also suggests that there is a desire for augmented reality platforms within the urological community., (Copyright © 2014 John Wiley & Sons, Ltd.)
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- 2015
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14. Management of erectile dysfunction post-radical prostatectomy.
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Saleh A, Abboudi H, Ghazal-Aswad M, Mayer EK, and Vale JA
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Radical prostatectomy is a commonly performed procedure for the treatment of localized prostate cancer. One of the long-term complications is erectile dysfunction. There is little consensus on the optimal management; however, it is agreed that treatment must be prompt to prevent fibrosis and increase oxygenation of penile tissue. It is vital that patient expectations are discussed, a realistic time frame of treatment provided, and treatment started as close to the prostatectomy as possible. Current treatment regimens rely on phosphodiesterase 5 inhibitors as a first-line therapy, with vacuum erection devices and intraurethral suppositories of alprostadil as possible treatment combination options. With nonresponders to these therapies, intracavernosal injections are resorted to. As a final measure, patients undergo the highly invasive penile prosthesis implantation. There is no uniform, objective treatment program for erectile dysfunction post-radical prostatectomy. Management plans are based on poorly conducted and often underpowered studies in combination with physician and patient preferences. They involve the aforementioned drugs and treatment methods in different sequences and doses. Prospective treatments include dietary supplements and gene therapy, which have shown promise with there proposed mechanisms of improving erectile function but are yet to be applied successfully in human patients.
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- 2015
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15. Difference between actual vs. pathology prostate weight in TURP and radical robotic-assisted prostatectomy specimen.
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Lukacs S, Vale J, and Mazaris E
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- Aged, Humans, Male, Middle Aged, Organ Size drug effects, Prospective Studies, Prostate surgery, Reference Values, Reproducibility of Results, Time Factors, Tissue Fixation methods, Treatment Outcome, Fixatives pharmacology, Formaldehyde pharmacology, Prostate drug effects, Prostate pathology, Robotic Surgical Procedures methods, Transurethral Resection of Prostate methods
- Abstract
Introduction: To investigate and highlight the effect of formaldehyde induced weight reduction in transurethral resection of prostate (TURP) and radical robotically-assisted prostatectomy (RALP) specimen as a result of standard chemical fixation., Materials and Methods: 51 patients were recruited from January 2013 to June 2013 who either underwent a TURP (n=26) or RALP (n=25). Data was collected prospectively by the operating surgeon who measured the native, unfixed histology specimen directly after operation. The specimens were fixed in 10% Formaldehyde Solution BP and sent to the pathology laboratory where after sufficient fixation period was re-weighed., Results: Overall mean age 64.78 years, TURP mean age 68.31 years RALP mean age 61.12 years. We found that the overall prostatic specimen (n=51) weight loss after fixation was a mean of 11.20% (3.78 grams) (p ≤ 0.0001). Subgroup analysis of the native TURP chips mean weight was 16.15 grams and formalin treated mean weight was 14.00 grams (p ≤ 0.0001). Therefore, TURP chips had a mean of 13.32 % (2.15 grams) weight loss during chemical fixation. RALP subgroup unfixed specimen mean weight was 52.08 grams and formalin treated mean weight was 42.60 grams (p ≤ 0.0001), a 19.32 % (9.48 grams) mean weight reduction., Conclusion: It has not been known that prostatic chips and whole human radical prostatectomy specimen undergo a significant weight reduction. The practical significance of the accurate prostate weight in patient management may be limited, however, it is agreed that this should be recorded correctly, as data is potential interest for research purposes and vital for precise documentation.
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- 2014
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16. Quantifying innovation in surgery.
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Hughes-Hallett A, Mayer EK, Marcus HJ, Cundy TP, Pratt PJ, Parston G, Vale JA, and Darzi AW
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- Humans, Diffusion of Innovation, Surgical Procedures, Operative trends
- Abstract
Objectives: The objectives of this study were to assess the applicability of patents and publications as metrics of surgical technology and innovation; evaluate the historical relationship between patents and publications; develop a methodology that can be used to determine the rate of innovation growth in any given health care technology., Background: The study of health care innovation represents an emerging academic field, yet it is limited by a lack of valid scientific methods for quantitative analysis. This article explores and cross-validates 2 innovation metrics using surgical technology as an exemplar., Methods: Electronic patenting databases and the MEDLINE database were searched between 1980 and 2010 for "surgeon" OR "surgical" OR "surgery." Resulting patent codes were grouped into technology clusters. Growth curves were plotted for these technology clusters to establish the rate and characteristics of growth., Results: The initial search retrieved 52,046 patents and 1,801,075 publications. The top performing technology cluster of the last 30 years was minimally invasive surgery. Robotic surgery, surgical staplers, and image guidance were the most emergent technology clusters. When examining the growth curves for these clusters they were found to follow an S-shaped pattern of growth, with the emergent technologies lying on the exponential phases of their respective growth curves. In addition, publication and patent counts were closely correlated in areas of technology expansion., Conclusions: This article demonstrates the utility of publically available patent and publication data to quantify innovations within surgical technology and proposes a novel methodology for assessing and forecasting areas of technological innovation.
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- 2014
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17. Image guidance for all--TilePro display of 3-dimensionally reconstructed images in robotic partial nephrectomy.
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Hughes-Hallett A, Pratt P, Mayer E, Martin S, Darzi A, and Vale J
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- Cross-Over Studies, Humans, Imaging, Three-Dimensional, Nephrectomy methods, Robotics, Software, Surgery, Computer-Assisted
- Abstract
Objective: To determine the feasibility of a novel low-barrier-to-entry image guidance system., Methods: Initially a randomized crossover study was performed to establish the interface (iPad or 3-dimensional mouse) that minimized both the amount of time required to perform a manual image registration and the error of that registration. A subsequent clinical feasibility study was undertaken on 5 patients undergoing robot-assisted partial nephrectomy. Randomized crossover study primary outcomes were time to task completion, NASA-Task Load Index score, and alignment error (translational and rotational). The Mann-Whitney U test was used to compare groups. Surgeon feedback was sought when assessing the system in a clinical setting., Results: In the initial randomized crossover study, the iPad-based system was able to achieve adequate alignment accuracy (Frobenius norm of 0.3; total error of 20.8 mm) in significantly less time (33 seconds; P<.01) than the 3-dimensional mouse interface. The platform received good feedback from the operating surgeon in all instances with the surgeon commenting particularly on the improved appreciation of hilar vascular anatomy., Conclusion: In this study, we have demonstrated the feasibility of a "low-barrier-to-entry" image guidance system in a clinical setting. The system was able to achieve swift and sufficiently accurate alignment, with little impact on the surgical workflow., (Copyright © 2014 Elsevier Inc. All rights reserved.)
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- 2014
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18. Reply: To PMID 24857271.
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Hughes-Hallett A, Pratt P, Mayer E, Martin S, Darzi A, and Vale J
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- Humans, Imaging, Three-Dimensional, Nephrectomy methods, Robotics, Software, Surgery, Computer-Assisted
- Published
- 2014
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19. Editorial comment.
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Mayer EK and Vale JA
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- Humans, Male, Health Care Costs, Operative Time, Prostatectomy economics, Prostatectomy methods, Prostatic Neoplasms surgery
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- 2014
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20. Intraoperative ultrasound overlay in robot-assisted partial nephrectomy: first clinical experience.
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Hughes-Hallett A, Pratt P, Mayer E, Di Marco A, Yang GZ, Vale J, and Darzi A
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- Equipment Design, Humans, Intraoperative Care methods, Nephrectomy methods, Robotics, Ultrasonography, Interventional instrumentation
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- 2014
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21. Augmented reality partial nephrectomy: examining the current status and future perspectives.
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Hughes-Hallett A, Mayer EK, Marcus HJ, Cundy TP, Pratt PJ, Darzi AW, and Vale JA
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- Forecasting, Humans, Robotics, Surgery, Computer-Assisted, Nephrectomy methods, Nephrectomy trends
- Abstract
A minimal access approach to partial nephrectomy has historically been under-utilized, but is now becoming more popular with the growth of robot-assisted laparoscopy. One of the criticisms of minimal access partial nephrectomy is the loss of haptic feedback. Augmented reality operating environments are forecast to play a major enabling role in the future of minimal access partial nephrectomy by integrating enhanced visual information to supplement this loss of haptic sensation. In this article, we systematically examine the current status of augmented reality in partial nephrectomy by identifying existing research challenges and exploring future agendas for this technology to achieve wider clinical translation., (Copyright © 2014 Elsevier Inc. All rights reserved.)
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- 2014
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22. Image-guided robotic interventions for prostate cancer.
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Sridhar AN, Hughes-Hallett A, Mayer EK, Pratt PJ, Edwards PJ, Yang GZ, Darzi AW, and Vale JA
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- Animals, Humans, Male, Prostatectomy standards, Robotics standards, Surgery, Computer-Assisted standards, Ultrasonography, Interventional standards, Prostatectomy methods, Prostatic Neoplasms diagnostic imaging, Prostatic Neoplasms surgery, Robotics methods, Surgery, Computer-Assisted methods, Ultrasonography, Interventional methods
- Abstract
Robotic prostatectomy is a common surgical treatment for men with prostate cancer, with some studies estimating that 80% of prostatectomies now performed in the USA are done so robotically. Despite the technical advantages offered by robotic systems, functional and oncological outcomes of prostatectomy can still be improved further. Alternative minimally invasive treatments that have also adopted robotic platforms include brachytherapy and high-intensity focused ultrasonography (HIFU). These techniques require real-time image guidance--such as ultrasonography or MRI--to be truly effective; issues with software compatibility as well as image registration and tracking currently limit such technologies. However, image-guided robotics is a fast-growing area of research that combines the improved ergonomics of robotic systems with the improved visualization of modern imaging modalities. Although the benefits of a real-time image-guided robotic system to improve the precision of surgical interventions are being realized, the clinical usefulness of many of these systems remains to be seen.
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- 2013
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23. Editorial comment.
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Mayer EK and Vale JA
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- Humans, Carcinoma, Renal Cell physiopathology, Carcinoma, Renal Cell surgery, Kidney Neoplasms physiopathology, Kidney Neoplasms surgery, Nephrectomy methods
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- 2012
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24. An effective visualisation and registration system for image-guided robotic partial nephrectomy.
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Pratt P, Mayer E, Vale J, Cohen D, Edwards E, Darzi A, and Yang GZ
- Abstract
Robotic partial nephrectomy is presently the fastest-growing robotic surgical procedure, and in comparison to traditional techniques it offers reduced tissue trauma and likelihood of post-operative infection, while hastening recovery time and improving cosmesis. It is also an ideal candidate for image guidance technology since soft tissue deformation, while still present, is localised and less problematic compared to other surgical procedures. This work describes the implementation and ongoing development of an effective image guidance system that aims to address some of the remaining challenges in this area. Specific innovations include the introduction of an intuitive, partially automated registration interface, and the use of a hardware platform that makes sophisticated augmented reality overlays practical in real time. Results and examples of image augmentation are presented from both retrospective and live cases. Quantitative analysis of registration error verifies that the proposed registration technique is appropriate for the chosen image guidance targets.
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- 2012
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25. A Case of Squamous Cell Carcinoma of the Renal Pelvis in association with Schistosoma hematobium.
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Khan MA, Kar A, Walker MM, Lloyd J, Vale JA, and Mayer EK
- Abstract
A 72-year-old man presented with painless frank haematuria. Investigations included intravenous urogram and abdominal/pelvic CT which revealed a marked focal thickening of the wall of the inferior aspect of the left renal pelvis extending into the lower pole calyx and into the pelviureteric junction resulting in left hydronephrosis. Urine cytology demonstrated clusters of malignant keratinised squamous cells and schistosome ova. He underwent left laparoscopic radical nephroureterectomy and histology revealed moderately differentiated keratinising squamous cell carcinoma in the renal pelvis.
- Published
- 2012
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26. Primary renal embryonal rhabdomyosarcoma in adults: a case report and review of the literature.
- Author
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Fanous RN, Mayer EK, Vale J, Lloyd J, and Walker MM
- Abstract
Adult renal rhabdomyosarcoma is a rare subtype of renal sarcoma. We present a case of a renal mass treated with radical nephrectomy that subsequently was shown to be renal rhabdomyosarcoma. We discuss the clinical presentation, imaging findings, and histology for this case and review the available literature.
- Published
- 2012
- Full Text
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27. "An Unusual Urological Tumour": Above the Collar and below the Belt.
- Author
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Mayer EK, Undre S, Cohen DC, Walker MM, Vale JA, and Patel A
- Abstract
Bladder lymphomas are rarely primary tumours and more commonly associated with systemic lymphoma, either as nonlocalised bladder lymphoma or as secondary bladder lymphoma. Primary bladder lymphomas (PBL) tend to be low-grade mucosa-associated lymphoid tissue (MALT) type, contrasting with diffuse large cell or follicular centre cell types more commonly seen in secondary bladder lymphoma. Bladder involvement by systemic lymphoma infers poor prognosis and patients often have no localising symptoms (typically a postmortem diagnosis). Other treatments are preferred over surgery for all bladder lymphomas, except where diagnosis is uncertain or for relief of irritative bladder symptoms. We describe a unique case of systemic high-grade B-cell lymphoma with simultaneous cutaneous renal and bladder lesions at presentation.
- Published
- 2012
- Full Text
- View/download PDF
28. The volume-outcome relationship for radical cystectomy in England: an analysis of outcomes other than mortality.
- Author
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Mayer EK, Bottle A, Aylin P, Darzi AW, Athanasiou T, and Vale JA
- Subjects
- England, Humans, Cystectomy statistics & numerical data, Outcome Assessment, Health Care
- Abstract
Objective: •To evaluate the volume-outcome relationship for radical cystectomy in England using outcomes other than mortality., Patients and Methods: •Patients undergoing an elective radical cystectomy were extracted from administrative hospital data for financial years 2000/1 to 2006/7. •Institutional and surgeon volume was assessed against postoperative re-intervention, postoperative complications and emergency readmission within 28 days, using a set of models accounting for patient case-mix, the 'clustered' nature of the data and structural and process of care measures., Results: •In the final model, the odds of re-intervention within 14 and 30 days of operation for medium-volume institutions compared to low-volume institutions were found to be 63% (odds ratio, OR, 1.63; 95% CI 1.15-2.32; P= 0.01) and 52% (OR, 1.52; 95% CI, 1.13-2.04; P= 0.01) higher, respectively. •In the summary of adjusted probabilities, low-volume institutions appeared to have a lower re-intervention rate than both medium- and high-volume institutions. •By contrast, high-volume surgeons were associated with a reduced odds (OR, 0.68; 95% CI, 0.51-0.91; P= 0.01) of early re-intervention (within 14 days) compared to low-volume surgeons. •This surgeon volume-outcome effect became apparent only after adjusting for the influence of the institution and structural and process of care confounders. •There was no statistically significant relationship between volume and complication or readmission rates., Conclusions: •Radical cystectomy measures of re-intervention rates can be used as outcome measures to discern differences across institutional or surgeon volume providers when the institutional and surgeon volume are co-examined and adjustment for structural and process of care confounders is performed. •The finding of a lower risk of re-intervention in low-volume institutions needs to be explored further., (© 2011 THE AUTHORS. BJU INTERNATIONAL © 2011 BJU INTERNATIONAL.)
- Published
- 2011
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29. What is the role of risk-adjusted funnel plots in the analysis of radical cystectomy volume-outcome relationships?
- Author
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Mayer EK, Bottle A, Aylin P, Darzi AW, Vale JA, and Athanasiou T
- Subjects
- Cystectomy mortality, Cystectomy standards, Data Collection standards, England, Humans, Outcome Assessment, Health Care statistics & numerical data, Publication Bias, Reoperation statistics & numerical data, Time Factors, Urinary Bladder Neoplasms mortality, Cystectomy statistics & numerical data, Health Facility Size statistics & numerical data, Models, Statistical, Risk Adjustment methods, Urinary Bladder Neoplasms surgery
- Abstract
Objective: • To explore whether risk-adjusted funnel plots are a useful adjunct to analyse volume-outcome data and to further facilitate our understanding of institutional performance data by combining funnel-plot methodology with an incremental statistical modelling approach., Patients and Methods: • Risk-adjusted funnel plots were generated for mortality and re-intervention rates after elective radical cystectomy using administrative data from NHS Hospital Trusts between 2000/01 and 2006/07. Trusts were divided into volume tertiles based on their average annual cystectomy rate. • A funnel plot was produced for each of the following four incremental statistical models: model one (no adjustment), model two (adjusted for patient case mix variables), model three (case mix and 'clustering' of patients) and model four (additional adjustment for institutional structural and process-of-care variables)., Results: • In the final complex model (model four), no Trusts had abnormally high mortality or re-intervention rates. • Comparison of the funnel plots showed the importance of adjusting for certain confounding factors, such as the surgeon, at the institutional level, before they could be labelled as having truly outlying performance., Conclusion: • Risk-adjusted funnel plots have a useful role to play as a component of a methodological framework for investigating the volume-outcome relationship at the institutional level. They can act as a complementary method of validating data by displaying disaggregated outcomes at provider level and account for unmeasured confounders, so reducing the opportunity for spurious labelling of outliers., (© 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL.)
- Published
- 2011
- Full Text
- View/download PDF
30. Effectiveness of procedural simulation in urology: a systematic review.
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Ahmed K, Jawad M, Abboudi M, Gavazzi A, Darzi A, Athanasiou T, Vale J, Khan MS, and Dasgupta P
- Subjects
- Cadaver, Computer Simulation, Models, Anatomic, Models, Animal, Education, Medical methods, Urology education
- Abstract
Purpose: We analyzed studies validating the effectiveness and deficiencies of simulation for training and assessment in urology. We documented simulation types (synthetic, virtual reality and animal models), participant experience level and tasks performed. The feasibility, validity, cost-effectiveness, reliability and educational impact of the simulators were also evaluated., Materials and Methods: The MEDLINE®, EMBASE™ and PsycINFO® databases were systematically searched until September 2010. References from retrieved articles were reviewed to broaden the search., Results: The study included case reports, case series and empirical studies of training and assessment in urology using procedural simulation. The model name, training tasks, participant level, training duration and evaluation scoring were extracted from each study. We also extracted data on face, content and construct validity. Most studies suitably addressed content, construct and face validation as well as the feasibility, educational impact and cost-effectiveness of simulation models. Synthetic, animal and virtual reality models were demonstrated to be effective training and assessment tools for junior trainees. Few investigators looked at the transferability of skills from simulation to real patients., Conclusions: Current simulation models are valid and reliable for the initial phase of training and assessment. For advanced and specialist level skill acquisition animal models can be used but availability is limited due to supply shortages and ethical restrictions. More research is needed to validate simulated environments for senior trainees and specialists., (Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
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31. Leadership in urology education.
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Ahmed K, Vale J, Dasgupta P, and Khan MS
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- Humans, Education, Medical, Graduate organization & administration, Leadership, Urology education
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- 2010
- Full Text
- View/download PDF
32. A persistent bladder erosion with ureteric involvement following mesh augmented repair of cystocele.
- Author
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Derpapas A, Digesu GA, Panayi D, Vale J, and Khullar V
- Subjects
- Cystectomy, Equipment Failure, Female, Humans, Middle Aged, Recurrence, Treatment Outcome, Ureter surgery, Cystocele surgery, Foreign-Body Migration surgery, Surgical Mesh adverse effects, Urinary Bladder surgery
- Abstract
We present a case of a 57-year-old woman who sustained bladder erosion with extension to the left ureter after a mesh-augmented recurrent cystocele repair. The persistence of the eroding mesh eventually necessitated a partial cystectomy and distal left ureterectomy, using a Boari flap technique., (Copyright 2010 Mosby, Inc. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
33. The volume-mortality relation for radical cystectomy in England: retrospective analysis of hospital episode statistics.
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Mayer EK, Bottle A, Darzi AW, Athanasiou T, and Vale JA
- Subjects
- Aged, England epidemiology, Epidemiologic Methods, Female, Hospitalization statistics & numerical data, Humans, Male, Treatment Outcome, Urinary Bladder Neoplasms mortality, Cystectomy mortality, Cystectomy statistics & numerical data, Health Facility Size statistics & numerical data, Urinary Bladder Neoplasms surgery
- Abstract
Objectives: To investigate the relation between volume and mortality after adjustment for case mix for radical cystectomy in the English healthcare setting using improved statistical methodology, taking into account the institutional and surgeon volume effects and institutional structural and process of care factors., Design: Retrospective analysis of hospital episode statistics using multilevel modelling., Setting: English hospitals carrying out radical cystectomy in the seven financial years 2000/1 to 2006/7., Participants: Patients with a primary diagnosis of cancer undergoing an inpatient elective cystectomy., Main Outcome Measure: Mortality within 30 days of cystectomy., Results: Compared with low volume institutions, medium volume ones had a significantly higher odds of in-hospital and total mortality: odds ratio 1.72 (95% confidence interval 1.00 to 2.98, P=0.05) and 1.82 (1.08 to 3.06, P=0.02). This was only seen in the final model, which included adjustment for structural and processes of care factors. The surgeon volume-mortality relation showed weak evidence of reduced odds of in-hospital mortality (by 35%) for the high volume surgeons, although this did not reach statistical significance at the 5% level., Conclusions: The relation between case volume and mortality after radical cystectomy for bladder cancer became evident only after adjustment for structural and process of care factors, including staffing levels of nurses and junior doctors, in addition to case mix. At least for this relatively uncommon procedure, adjusting for these confounders when examining the volume-outcome relation is critical before considering centralisation of care to a few specialist institutions. Outcomes other than mortality, such as functional morbidity and disease recurrence may ultimately influence towards centralising care.
- Published
- 2010
- Full Text
- View/download PDF
34. Technique for urethral eversion and vesico-urethral anastomosis: application to robot-assisted laparoscopic prostatectomy.
- Author
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Karim O, Mayer E, Kucheria R, Hrouda D, and Vale J
- Subjects
- Anastomosis, Surgical, Humans, Laparoscopy, Male, Prostatectomy adverse effects, Robotics, Medical Illustration, Prostatectomy methods, Prostatic Neoplasms surgery, Suture Techniques, Urethra surgery, Urinary Bladder surgery
- Published
- 2010
- Full Text
- View/download PDF
35. Provision of radical pelvic urological surgery in England, and compliance with improving outcomes guidance.
- Author
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Mayer EK, Bottle A, Darzi AW, Athanasiou T, and Vale JA
- Subjects
- Aged, England epidemiology, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Outcome Assessment, Health Care, Prostatic Diseases epidemiology, Treatment Outcome, Urinary Bladder Diseases epidemiology, Cystectomy statistics & numerical data, Guideline Adherence, Practice Guidelines as Topic, Prostatectomy statistics & numerical data, Prostatic Diseases surgery, Urinary Bladder Diseases surgery
- Abstract
Objective: To investigate compliance with Improving Outcomes Guidance (IOG) for radical pelvic surgery in England, and explore the pattern of service provision for radical cystectomy (RC) and radical prostatectomy (RP) before and after the introduction of IOG., Methods: For the period 2000/01-2006/07, all admissions for RC and RP were extracted from Hospital Episode Statistics (HES). At the institutional level, the numbers of RC and RP cases were combined to assess adherence to IOG. The IOG catchment populations for each institution were calculated by linking HES data to census ward population data. The pattern of service provision for RC and RP was independently assessed by assigning institutions into low-, medium- and high-volume groups of roughly equal volumes a priori, based on the ascending order of annual RC or RP rate, respectively. For RC it was also possible to explore the between-institution referral activity for RC by identifying the 'final endoscopic bladder procedure' that occurred immediately before the RC for each patient. This gave an indication of where the diagnosis and decision for RC had been made., Results: The percentage of institutions achieving the recommended IOG minimal case volume of 50 per year increased significantly between 2000/01 and 2006/07 (36% in odds per year, P < 0.001; odds ratio 1.36, 95% confidence interval 1.24-1.50), although absolute numbers remained relatively low (34% in 2006/07). Only one institution had a catchment population greater than the recommended 1 million. The total number of institutions performing RC decreased significantly over the years (P = 0.03), whereas for RP the decrease was not significant (P = 0.6). The decrease reflected a decline in the number of low-volume institutions, both for RC and RP, although this decline was not more than expected by chance. There had been a significant increase in the percentage of patients referred to another provider for their RC, from 5.5% in 2000/01 to 19.6% in 2006/07 (28% rise in odds per year, P < 0.001: odds ratio 1.28, 95% confidence interval 1.23-1.33)., Conclusion: There was evidence of centralization of radical pelvic urological surgery, although it is only relatively recently that this seems to have taken place with any certainty. The absolute numbers of providers achieving the IOG minimum caseload standard was relatively low. What impact this has had, if any, on the quality of patient care is yet to be fully determined.
- Published
- 2009
- Full Text
- View/download PDF
36. Appraising the quality of care in surgery.
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Mayer EK, Chow A, Vale JA, and Athanasiou T
- Subjects
- Benchmarking, Critical Pathways, Data Interpretation, Statistical, Efficiency, Humans, Outcome and Process Assessment, Health Care, Patient Satisfaction, Quality of Life, General Surgery standards, Quality Assurance, Health Care methods, Quality of Health Care
- Abstract
There is currently no validated measurement system available for quality of care assessment in surgery despite all of the inherent benefits of such an approach. A structured quality framework needs to be developed and incorporate measures that are truly reflective of several important dimensions of care within the entire treatment episode. Presently this has been only partially addressed. These measures of quality can be categorized into clinical pathway measures (structure of care, process of care, outcome of care, and economic measures of care) and patient-reported measures (patient-reported treatment outcomes, health-related quality of life measures, and patient satisfaction). Combining these measures to create an overall composite quality score can be made feasible only if it is supported by the use of robust statistical methodology. It is important to use appropriate display of performance data to facilitate provider engagement in quality improvement initiatives. This article was designed to present such a structured approach of a quality framework, which is required to appraise the quality of care in surgery to enhance future quality improvement programmes.
- Published
- 2009
- Full Text
- View/download PDF
37. Assessing the quality of the volume-outcome relationship in uro-oncology.
- Author
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Mayer EK, Purkayastha S, Athanasiou T, Darzi A, and Vale JA
- Subjects
- Cystectomy statistics & numerical data, Humans, Nephrectomy statistics & numerical data, Prostatectomy statistics & numerical data, Risk Factors, Workload, Cystectomy standards, Nephrectomy standards, Outcome and Process Assessment, Health Care, Prostatectomy standards, Urologic Neoplasms surgery
- Abstract
Objective: To assess systematically the quality of evidence for the volume-outcome relationship in uro-oncology, and thus facilitate the formulating of health policy within this speciality, as 'Implementation of Improving Outcome Guidance' has led to centralization of uro-oncology based on published studies that have supported a 'higher volume-better outcome' relationship, but improved awareness of methodological drawbacks in health service research has questioned the strength of this proposed volume-outcome relationship., Methods: We systematically searched previous relevant reports and extracted all articles from 1980 onwards assessing the volume-outcome relationship for cystectomy, prostatectomy and nephrectomy at the institution and/or surgeon level. Studies were assessed for their methodological quality using a previously validated rating system. Where possible, meta-analytical methods were used to calculate overall differences in outcome measures between low and high volume healthcare providers., Results: In all, 22 studies were included in the final analysis; 19 of these were published in the last 5 years. Only four studies appropriately explored the effect of both the institution and surgeon volume on outcome measures. Mortality and length of stay were the most frequently measured outcomes. The median total quality scores within each of the operation types were 8.5, 9 and 8 for cystectomy, prostatectomy and nephrectomy, respectively (possible maximum score 18). Random-effects modelling showed a higher risk of mortality in low-volume institutions than in higher-volume institutions for both cystectomy and nephrectomy (odds ratio 1.88, 95% confidence interval 1.54-2.29, and 1.28, 1.10-1.49, respectively)., Conclusion: The methodological quality of volume-outcome research as applied to cystectomy, prostatectomy and nephrectomy is only modest at best. Accepting several limitations, pooled analysis confirms a higher-volume, lower-mortality relationship for cystectomy and nephrectomy. Future research should focus on the development of a quality framework with a validated scoring system for the bench-marking of data to improve validity and facilitate rational policy-making within the speciality of uro-oncology.
- Published
- 2009
- Full Text
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38. Using routine data to define clinical case-mix and compare hospital outcomes in urology.
- Author
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Mason A, Goldacre MJ, Bettley G, Vale J, and Joyce A
- Subjects
- Diagnosis-Related Groups, Hospital Mortality, Humans, Medical Record Linkage, Outcome Assessment, Health Care statistics & numerical data, Patient Admission statistics & numerical data, Urologic Surgical Procedures statistics & numerical data, Outcome Assessment, Health Care standards
- Published
- 2006
- Full Text
- View/download PDF
39. British Urological Foundation preceptorships to the Cleveland Clinic.
- Author
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Vale J
- Subjects
- Humans, International Cooperation, Ohio, Surveys and Questionnaires, Foundations, Laparoscopy, Preceptorship organization & administration, Urology education
- Published
- 2005
- Full Text
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40. Medical writing.
- Author
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Grange RI, Vale J, Williams G, and Whitfield HN
- Subjects
- Authorship, Ethics, Language, Peer Review, Periodicals as Topic, Urology, Writing
- Published
- 2004
- Full Text
- View/download PDF
41. Testicular leydig cell tumor presenting as primary infertility.
- Author
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Markou A, Vale J, Vadgama B, Walker M, and Franks S
- Abstract
A 29-year old male and his wife presented with an 18 month history of primary infertility. History and initial investigations suggested no major female pathologic component but a semen analysis revealed azoospermia. There was no history of any sexual dysfunction and neither partner was receiving any medication. Clinical examination revealed normal secondary sexual characteristics. Both testicles were of normal consistency with a volume of approximately 15 ml but a 4 x 2 cm mass was palpable at the lower pole of the left testis. Laboratory investigations revealed: serum testosterone 37.1 nmol/l (NV:10.0-38.0 nmol/l), LH<0.3 U/L (NV:3.0-12.0 U/L), and FSH <0.1 IU/L (NV:3.0-11.0 U/L). Serum b-HCG, aFP, LDH, oestradiol and inhibin levels were within the normal range. A repeated semen analysis confirmed azoospermia. Testicular ultrasound demonstrated a well-defined hypoechoic mass, measuring 31 x 23 x 17 mm and containing several flecks of calcification, arising from the lower pole of the left testis. A left orchidectomy was performed. Macroscopical histopathological examination revealed a single firm dark brown nodule 2.8 cm in diameter arising from the lower pole of the testis. The tumor distended the capsule of the testis without extending through it. Microscopical examination was consistent with a Leydig cell tumor. Computerised tomography of the chest, abdomen and pelvis was normal. Six months later, laboratory investigations revealed a serum testosterone of 14.3 nmol/l, an LH of 5.4 U/L and an FSH of 4.3 U/L, respectively. A repeated semen analysis was normal: volume 1.8 ml(2-10 ml), count 124 x 10(6) (20-350 x 10(6)), motility 80%(>60%), abnormal forms <15%(<15%). Three months later his wife was pregnant. In summary, our patient presented with azoospermia, secondary to a Leydig cell tumor, which was reversible after removal of the tumor.
- Published
- 2002
- Full Text
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42. Editor's Comment.
- Author
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Whitfield H, Vale J, and Taylor S
- Subjects
- United Kingdom, Urology, Bibliometrics, Periodicals as Topic statistics & numerical data, Publishing statistics & numerical data
- Published
- 2002
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