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Competing Interests: Declaration of interests We declare no competing interests.

The stability and resilience of the Earth system and human well-being are inseparably linked 1-3 , yet their interdependencies are generally under-recognized; consequently, they are often treated independently 4,5 . Here, we use modelling and literature assessment to quantify safe and just Earth system boundaries (ESBs) for climate, the biosphere, water and nutrient cycles, and aerosols at global and subglobal scales. We propose ESBs for maintaining the resilience and stability of the Earth system (safe ESBs) and minimizing exposure to significant harm to humans from Earth system change (a necessary but not sufficient condition for justice) 4 . The stricter of the safe or just boundaries sets the integrated safe and just ESB. Our findings show that justice considerations constrain the integrated ESBs more than safety considerations for climate and atmospheric aerosol loading. Seven of eight globally quantified safe and just ESBs and at least two regional safe and just ESBs in over half of global land area are already exceeded. We propose that our assessment provides a quantitative foundation for safeguarding the global commons for all people now and into the future., (© 2023. The Author(s).)

Climate records of ratios of stable water isotopes of oxygen (δ 18 O) are used to reconstruct the past Indian monsoon precipitation. Identifying the sources of water vapor is important in understanding the role of monsoonal circulation in the δ 18 O values, to aid in monsoon reconstructions. Here, using an isotope-enabled Earth system model, we estimate the contributions of oceanic and terrestrial water vapor sources to two major precipitation seasons in India-the Southwest monsoon and the Northeast monsoon, and their effects on the δ 18 O in precipitation (δ 18 O p ). We find that the two monsoon seasons have different dominant sources of water vapor because of the reversal in atmospheric circulation. While Indian Ocean regions, Arabian Sea, and recycling are the major sources of the Southwest monsoon precipitation, North Pacific Ocean and recycling are two crucial sources of Northeast monsoon precipitation. The δ 18 O p of the Southwest monsoon precipitation is determined by contributions from the Indian Ocean sources and recycling. Despite reduced precipitation, more negative δ 18 O p values are simulated in the Northeast monsoon season due to larger negative δ 18 O p contributions from the North Pacific. Our results imply that changes in atmospheric circulation and water vapor sources in past climates can influence climate reconstructions using δ 18 O., (© 2023. The Author(s).)

Background and Aim: Increased demand for metal-free restorations in posterior areas has increased the focus on zirconia restorations because of its advantages in excellent mechanical properties, patient comfort, and acceptance. Although all-ceramic crowns have better biocompatibility and esthetic properties, there are some clinical reasons for the fracture of the veneer or the core materials in the posterior region. This study aims at comparing the influence of zirconia coping designs on the fracture resistance of all-ceramic crowns., Materials and Methods: A total of 32 zirconia copings ( n = 8 for each group) were designed and fabricated based on the marginal collar height of zirconia coping. The groups were the following: Group 1: 0.0 mm zirconia coping; Group 2: 0.5 mm collar; Group 3: 1.0 mm collar; and Group 4: 1.5 mm collar. All these zirconia copings were veneered with porcelain. Master die with cemented ceramic-layered zirconia copings was tested using Universal testing machine. Data obtained were statistically evaluated by one-way analysis of variance and post hoc test., Results: There was statistically significant difference between the groups with P < 0.001. Group 4 has the highest strength (3318.89 ± 395.67) followed by Group 3 (2910.0 ± 219.22), then Group 1 (2320.02 ± 547.36) that is the control group and the least strength with Group 2 (2286.59 ± 496.66)., Conclusion: On the basis of the results obtained from this study, it can be concluded that, the more the height of the zirconia collar, the higher the fracture strength of the all-ceramic crowns. Thus ceramic-layered zirconia coping design with 1.5 mm marginal collar height is recommended for functional long life, at least in the posterior higher load-bearing areas with lesser esthetic demands., Competing Interests: There are no conflicts of interest., (Copyright: © 2020 Journal of Pharmacy and Bioallied Sciences.)