1. Association between irritable temperament and glucose metabolism in the left insula and the right cerebellum.
- Author
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Muronaga M, Hirakawa H, Terao T, Izumi T, Satoh M, and Kohno K
- Subjects
- Humans, Male, Female, Adult, Young Adult, Middle Aged, Cerebral Cortex diagnostic imaging, Cerebral Cortex metabolism, Temperament physiology, Positron-Emission Tomography, Fluorodeoxyglucose F18, Cerebellum diagnostic imaging, Cerebellum metabolism, Glucose metabolism, Insular Cortex diagnostic imaging, Insular Cortex metabolism
- Abstract
Introduction: Affective temperaments are assumed to have biological and neural bases. In the present study, we analyzed
18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) images of healthy participants to explore the neural basis of affective temperaments., Method: We utilized data of affective temperament measured by the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire and18 F-FDG PET images of healthy participants from two of our previous studies. A multiple regression analysis was performed to assess the association between18 F-FDG uptake and temperament scores using Statistical Parametric Mapping 12., Results: The final sample included 62 healthy participants. Whole-brain analysis revealed a cluster of18 F-FDG uptake that was significantly and positively associated with irritable temperament scores in the right cerebellum (Crus II, VIII, and IX). After further adjustment for the other four temperament scores, whole-brain analysis revealed a cluster of18 F-FDG uptake significantly and positively associated with irritable temperament scores in the left insula and right cerebellum (Crus II, VIII, and IX). However, no significant association was found between18 F-FDG uptake and the other four temperaments (depressive, cyclothymic, hyperthymic, and anxious)., Conclusions: The left insula and right cerebellum of the cerebrocerebellar circuit may be one of the neural bases of irritable temperament., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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