1. The relationship between serum fibrinogen-like protein 2 concentrations and 30-day mortality of patients with traumatic brain injury.
- Author
-
Chen TJ, Ji MX, Tao ZQ, Fu QY, Xiong K, and Cheng B
- Subjects
- Adolescent, Adult, Aged, Brain Injuries, Traumatic diagnosis, Female, Glasgow Coma Scale, Humans, Male, Middle Aged, Prognosis, Young Adult, Brain Injuries, Traumatic blood, Brain Injuries, Traumatic mortality, Fibrinogen metabolism
- Abstract
Background: Fibrinogen-like protein 2 (FGL2) is an inflammatory procoagulant protein. We discerned the impact of serum FGL2 on trauma severity and 30-day mortality in patients with traumatic brain injury (TBI)., Methods: A total of 114 severe TBI patients were subjected to assessment of trauma severity using the Glasgow coma scale (GCS). Measurement of the serum concentrations of FGL2 was done. 114 matched control subjects for their age and sex were included for comparison of serum concentration of FGL2., Results: The concentration of FGL2 was dramatically increased in the patients as compared with the control subjects. FGL2 concentration was inversely correlated with GCS score among the patients. The non-survivors within 30 days exhibited substantially higher FGL2 concentrations than the alive. FGL2 concentrations discriminated the patients at risk of 30-day death with significantly high area under receiver operating characteristic curve. Serum FGL2 emerged as an independent predictor for mortality and overall survival at 30 days after head trauma., Conclusions: Serum FGL2 is a promising biomarker for assessing the severity and prognosis in severe TBI., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF