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The biomechanical properties of cells and tissues play an important role in our fundamental understanding of the structures and functions of biological systems at both the cellular and subcellular levels. Recently, Brillouin microscopy, which offers a label-free spectroscopic means of assessing viscoelastic properties in vivo, has emerged as a powerful way to interrogate those properties on a microscopic level in living tissues. However, susceptibility to photodamage and photobleaching, particularly when high-intensity laser beams are used to induce Brillouin scattering, poses a significant challenge. This article introduces a transformative approach designed to mitigate photodamage in biological and biomedical studies, enabling nondestructive, label-free assessments of mechanical properties in live biological samples. By leveraging quantum-light-enhanced stimulated Brillouin scattering (SBS) imaging contrast, the signal-to-noise ratio is significantly elevated, thereby increasing sample viability and extending interrogation times without compromising the integrity of living samples. The tangible impact of this methodology is evidenced by a notable three-fold increase in sample viability observed after subjecting the samples to three hours of continuous squeezed-light illumination, surpassing the traditional coherent light-based approaches. The quantum-enhanced SBS imaging holds promise across diverse fields, such as cancer biology and neuroscience where preserving sample vitality is of paramount significance. By mitigating concerns regarding photodamage and photobleaching associated with high-intensity lasers, this technological breakthrough expands our horizons for exploring the mechanical properties of live biological systems, paving the way for an era of research and clinical applications., Competing Interests: Competing interests statement:The authors declare no competing interest.

Stimulated Brillouin scattering (SBS) microscopy is a nonlinear all-optical imaging method that provides mechanical contrast based on the interaction of laser radiation and acoustical vibrational modes. Featuring high mechanical specificity and sensitivity, three-dimensional sectioning, and practical imaging times, SBS microscopy with (quasi) continuous wave excitation is rapidly advancing as a promising imaging tool for label-free visualization of viscoelastic information of materials and living biological systems. In this article, we introduce the theory of SBS microscopy and review the current state-of-the-art as well as recent innovations, including different approaches to system designs and data analysis. In particular, various performance parameters of SBS microscopy and its applications in the life sciences are described and discussed. Future perspectives for SBS microscopy are also presented., (© 2024 The Author(s). Published by IOP Publishing Ltd.)

A multimode optical fiber supports excitation and propagation of a pure single optical mode, i.e., the field pattern that satisfies the boundary conditions and does not change along the fiber. When two counterpropagating pure optical modes are excited, they could interact through the stimulated Brillouin scattering (SBS) process. Here, we present a simple theoretical formalism describing SBS interaction between two individual optical modes selectively excited in an acoustically isotropic multimode optical fiber. Employing a weakly guiding step-index fiber approach, we have built an analytical expression for the spatial distribution of the sound field amplitude in the fiber core and explored the features of SBS gain spectra, describing the interaction between modes of different orders. In this way, we give a clear insight into the sound propagation effects accompanying SBS in multimode optical fibers, and demonstrate their specific contributions to the SBS gain spectrum.

Brillouin microscopy based on spontaneous Brillouin scattering has emerged as a unique elastography technique because of its merit of non-contact, label-free, and high-resolution mechanical imaging of biological cell and tissue. Recently, several new optical modalities based on stimulated Brillouin scattering have been developed for biomechanical research. As the scattering efficiency of the stimulated process is much higher than its counterpart in the spontaneous process, stimulated Brillouin-based methods have the potential to significantly improve the speed and spectral resolution of existing Brillouin microscopy. Here, we review the ongoing technological advancements of three methods, including continuous wave stimulated Brillouin microscopy, impulsive stimulated Brillouin microscopy, and laser-induced picosecond ultrasonics. We describe the physical principle, the representative instrumentation, and biological application of each method. We further discuss the current limitations as well as the challenges for translating these methods into a visible biomedical instrument for biophysics and mechanobiology., Competing Interests: Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

We experimentally demonstrate a fiber laser with different linewidths based on self-injection locking (SIL) and the stimulated Brillouin scattering effect. Based on the homemade fiber laser, the error origin, resolution, and applicable range of delayed self-heterodyne interferometry (DSHI), self-correlation envelope linewidth detection (SCELD) and Voigt fitting are investigated numerically and experimentally. The selection of the linewidth measuring method should meet the following conclusions: an approximately Lorentzian self-heterodyne spectrum without the pedestal and high-intensity sinusoidal jitter is a prerequisite for DSHI; the SCELD needs a suitable length of delay fiber for eliminating flicker noise and dark noise of the electrical spectrum analyzer; a non-Lorentzian self-heterodyne spectrum without a pedestal is an indispensable element for Voigt fitting. According to the experimental results, the laser Lorentzian linewidth of SIL changes from 1.7 kHz to 587 Hz under different injection powers. When the Brillouin erbium fiber laser is utilized, the Lorentzian linewidth is measured to be 60 ± 5 Hz.

Nonlinear distortion for single-sideband (SSB) signals will significantly reduce the performance of Kramers-Kronig (KK) receiver-based optical transmission. In this work, we present a proof-of-concept study of stimulated Brillouin scattering (SBS)-induced nonlinear distortion for 10 Gbaud and 28 Gbaud SSB QAM16 transmission over 80 km standard single mode fiber (SSMF) based on a KK receiver. Significantly reduced bit error rate (BER) has been experimentally observed due to the SBS and the threshold of SBS at about 7 dBm is detected for such an 80 km SSMF link. With left sideband (LSB) modulation of SSB, together with optical filtering, reduced SBS nonlinear distortion has been achieved with ~2 dB power tolerance improvement. The results reveal an important issue of SBS-induced nonlinear distortion, which would be of great significance for KK receiver-based optical transmission applications.

Distributed optical fiber sensing technology has been widely applied in the areas of infrastructure health monitoring, national defense security, etc. The long-range high-spatial-resolution Brillouin optical correlation domain analysis (BOCDA) has extensive development and application prospects. In this paper, long-range BOCDAs are introduced and summarized. Several creative methods underpinning measurement range enlargement, including the interval enhancement of the adjacent correlation peak (CP), improvements in the signal-to-noise ratio, and the concurrent interrogation of multiple CPs, are discussed and experimentally verified, respectively. The main drawbacks in the present BOCDA schemes and avenues for future research and development have also been prospected.

Stimulated Brillouin scattering (SBS) is useful, among others for generating slow light, sensing and amplification. SBS was previously viewed as a poor method due to the limitation on optical power in high-powered photonic applications. However, considering the many possible applications using SBS, it is now of interest to enhance SBS in areas of Brillouin frequency shift together with Brillouin Gain. A numerical model, using a fully vectorial approach, by employing the finite element method, was developed to investigate methods for enhancing SBS in optical fiber. This paper describes the method related to the numerical model and discusses the analysis between the interactions of longitudinal, shear and hybrid acoustic modes; and optical modes in optical fiber. Two case studies were used to demonstrate this. Based on this numerical model, we report the influence of core radius, clad radius and effective refractive index on the Brillouin frequency shift and gain. We observe the difference of Brillouin shift frequency between a normal silica optical fiber and that of a microfiber - a uniformed silica fiber of a much smaller core and cladding dimensions where nonlinearities are higher. Also observed, the different core radii used and their respective Brillouin shift. For future work, the COMSOL model can also be used for the following areas of research, including simulating "surface Brillouin shift" and also to provide in-sights to the Brillouin shift frequency vB of various structures of waveguides, e.g circular, and triangular, and also to examine specialty fibers, e.g. Thulium and Chalcogenide doped fibers, and their effects on Brillouin shift frequency., Competing Interests: No competing interests were disclosed., (Copyright: © 2022 Yeap SH et al.)

As one of the most consolidated distributed fiber sensors based on stimulated Brillouin scattering, the Brillouin optical time-domain analyzer (BOTDA) has been developed for decades. Despite the commercial availability and outstanding progresses which has been achieved, the intrinsic Lorentzian gain spectrum restricts the sensing performance from possible further enhancements and hence limits the field of validity of the technique. In this paper, the novel method of engineering the gain spectral properties of the Brillouin scattering and its application on static and dynamic BOTDA sensors will be reviewed. Such a spectral property engineering has not only provided improvements to BOTDA, but also might open a new way to enhance the performance of all kinds of distributed Brillouin fiber sensors.

Over the past three decades, extensive research activity on Brillouin scattering-based distributed optical fiber sensors has led to the availability of commercial instruments capable of measuring the static temperature/strain distribution over kilometer distances and with high spatial resolution, with applications typically covering structural and environmental monitoring. At the same time, the interest in dynamic measurements has rapidly grown due to the relevant number of applications which could benefit from this technology, including structural analysis for defect identification, vibration detection, railway traffic monitoring, shock events detection, and so on. In this paper, we present an overview of the recent advances in Brillouin-based distributed optical fiber sensors for dynamic sensing. The aspects of the Brillouin scattering process relevant in distributed dynamic measurements are analyzed, and the different techniques are compared in terms of performance and hardware complexity.

Nonlinear frequency generation requires high intensity density which is usually achieved with pulsed laser sources, anomalous dispersion, high nonlinear coefficients or long interaction lengths. Whispering gallery mode microresonators (WGMRs) are photonic devices that enhance nonlinear interactions and can be exploited for continuous wave (CW) nonlinear frequency conversion, due to their capability of confine light for long time periods in a very small volume, even though in the normal dispersion regime. All signals must be resonant with the cavity. Here, we present a review of nonlinear optical processes in glass microspherical cavities, hollow and solid.

In this article, we demonstrate the noise reduction and signal to noise ratio (SNR) enhancement in Brillouin optical time-domain analyzers (BOTDA). The results show that, although the main noise contribution comes from the Brillouin interaction itself, a simple low pass filtering on the detected radio frequency (RF) signal reduces remarkably the noise level of the BOTDA traces. The corresponding SNR enhancement depends on the employed cut-off frequency of the low pass filter. Due to the enhancement of the SNR, a mitigation of the standard deviation error of the Brillouin frequency shift (BFS) has been demonstrated. However, RF filters with low cut-off frequency could lead to distortions on the trace signals and therefore detection errors on a non-uniform BFS. The trade-off between the noise reduction and the signal distortion as well as an optimal cut-off frequency are discussed in detail.

We present, to our knowledge for the first time, a 100-km Brillouin Optical Frequency-Domain Analysis (BOFDA) employing a 200-km fiber loop. Compared to our previous publication, enhanced sensor length, sensor accuracy and spatial resolution are presented. The performance improvements are achieved by applying distributed Raman amplification (DRA) and a digital high-pass filter. We report on temperature measurements over sensing distances of 75 km and 100 km both with a 12.5-m spatial resolution. Temperature changes of 5 ° C have been measured along 75 km sensing fiber. A temperature change of 30 ° C has been detected at 99.5 km.

Vegetable oils provide high nutritional value in the human diet. Specifically, extra virgin olive oil (EVOO) possesses a higher price than that of other vegetable oils. Adulteration of pure EVOO with other types of vegetable oils has attracted increasing attentions. In this work, a stimulated Brillouin scattering (SBS) combined with visible absorption spectroscopy method is proposed for authentication of vegetable oils and detection of olive oil adulteration. The results provided here have demonstrated that the different vegetable oils and adulteration oils exhibit significant differences in normalized absorbance values of two relevant wavelengths (455 and 670 nm) and frequency shifts of SBS. The normalized absorbance values of all spectra at the two relevant wavelengths of 670 nm and 455 nm linearly decrease with the increase of the adulteration concentration. The Brillouin frequency shifts exponentially increase with the increase of the adulteration concentration. Due to non-destructive and requiring no sample pretreatment procedure, this method can be effectively employed for authentication and detection of oils adulteration., (Copyright © 2018 Elsevier B.V. All rights reserved.)

In this paper perfluorinated graded-index polymer optical fibers are characterized with respect to the influence of relative humidity changes on spectral transmission absorption and Rayleigh backscattering. The hygroscopic and thermal expansion coefficient of the fiber are determined to be C H E = (7.4 ± 0.1) · 10 - 6 %r.h. -1 and C T E = (22.7 ± 0.3) · 10 - 6 K -1 , respectively. The influence of humidity on the Brillouin backscattering power and linewidth are presented for the first time to our knowledge. The Brillouin backscattering power at a pump wavelength of 1319 nm is affected by temperature and humidity. The Brillouin linewidth is observed to be a function of temperature but not of humidity. The strain coefficient of the BFS is determined to be C S = (-146.5 ± 0.9) MHz/% for a wavelength of 1319 nm within a strain range from 0.1% to 1.5%. The obtained results demonstrate that the humidity-induced Brillouin frequency shift is predominantly caused by the swelling of the fiber over-cladding that leads to fiber straining.

Brillouin-Enhanced Four-Wave-Mixing techniques, which couple four optical beams through Brillouin nonlinearity, have gained popularity in the 1980's largely owing to their phase conjugation properties. Experiments were mainly conducted in liquid cells. The interest in Brillouin-Enhanced Four-Wave-Mixing has reawakened in the 2000's, following the quest for dynamically reconfigurable gratings in optical fibers. Termed Brillouin Dynamic Grating this time around, it is, in fact, an acoustic wave, optically generated by stimulated Brillouin scattering process between two pump waves. The acoustic wave either carries the coherent information encoded by the pump beams, or in the case of sensing applications, its properties are determined by the environmental parameters. This information, in turn, is imparted to the third phase-matched optical probe wave through the elasto-optic effect. Over the last decade, this mechanism allowed for the realization of many all-optical signal processing functions and has proven instrumental in distributed sensing applications. This paper describes the basics, as well as the state of the art, of BDG-based applications in optical fibers. It also surveys the efforts being done to carry over these concepts to the photonic chip level.

We demonstrate (and are the first to do so) 63 km Brillouin Optical Frequency-Domain Analysis (BOFDA) for temperature and strain monitoring using a 100 km fiber loop. The use of BOFDA for long-range applications can be considered a novel approach, as previous investigations focused on the utilization of Brillouin Optical Time-Domain Reflectometry and Analysis (BOTDR and BOTDA, respectively). At 51.7 km, a 100 m hotspot (37 ∘ C) was detected without using distributed Raman amplification or image processing.

In the distributed optical fiber sensing (DOFS) domain, simultaneous measurement of vibration and temperature/strain based on Rayleigh scattering and Brillouin scattering in fiber could have wide applications. However, there are certain challenges for the case of ultra-long sensing range, including the interplay of different scattering mechanisms, the interaction of two types of sensing signals, and the competition of pump power. In this paper, a hybrid DOFS system, which can simultaneously measure temperature/strain and vibration over 150 km, is elaborately designed via integrating the Brillouin optical time-domain analyzer (BOTDA) and phase-sensitive optical time-domain reflectometry (Ф-OTDR). Distributed Raman and Brillouin amplifications, frequency division multiplexing (FDM), wavelength division multiplexing (WDM), and time division multiplexing (TDM) are delicately fused to accommodate ultra-long-distance BOTDA and Ф-OTDR. Consequently, the sensing range of the hybrid system is 150.62 km, and the spatial resolution of BOTDA and Ф-OTDR are 9 m and 30 m, respectively. The measurement uncertainty of the BOTDA is ± 0.82 MHz. To the best of our knowledge, this is the first time that such hybrid DOFS is realized with a hundred-kilometer length scale., Competing Interests: The authors declare no conflict of interest.

Distributed fiber sensing possesses the unique ability to measure the distributed profile of an environmental quantity along many tens of kilometers with spatial resolutions in the meter or even centimeter scale. This feature enables distributed sensors to provide a large number of resolved points using a single optical fiber. However, in current systems, this number has remained constrained to a few hundreds of thousands due to the finite signal-to-noise ratio (SNR) of the measurements, which imposes significant challenges in the development of more performing sensors. Here, we propose and experimentally demonstrate an ultimately optimized distributed fiber sensor capable of resolving 2100000 independent points, which corresponds to a one-order-of-magnitude improvement compared to the state-of-the-art. Using a Brillouin distributed fiber sensor based on phase-modulation correlation-domain analysis combined with temporal gating of the pump and time-domain acquisition, a spatial resolution of 8.3 mm is demonstrated over a distance of 17.5 km. The sensor design addresses the most relevant factors impacting the SNR and the performance of medium-to-long range sensors as well as of sub-meter spatial resolution schemes. This step record in the number of resolved points could be reached due to two theoretical models proposed and experimentally validated in this study: one model describes the spatial resolution of the system and its relation with the sampling interval, and the other describes the amplitude response of the sensor, providing an accurate estimation of the SNR of the measurements.

Optical fibers, the enablers of the Internet, are being used in an ever more diverse array of applications. Many of the rapidly growing deployments of fibers are in high-power and, particularly, high power-per-unit-bandwidth systems where well-known optical nonlinearities have historically not been especially consequential in limiting overall performance. Today, however, nominally weak effects, most notably stimulated Brillouin scattering (SBS) and stimulated Raman scattering (SRS) are among the principal phenomena restricting continued scaling to higher optical power levels. In order to address these limitations, the optical fiber community has focused dominantly on geometry-related solutions such as large mode area (LMA) designs. Since such scattering, and all other linear and nonlinear optical phenomena including higher order mode instability (HOMI), are fundamentally materials-based in origin, this paper unapologetically advocates material solutions to present and future performance limitations. As such, this paper represents a 'call to arms' for material scientists and engineers to engage in this opportunity to drive the future development of optical fibers that address many of the grand engineering challenges of our day.