1. Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica.
- Author
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Tingjun C, Zhaohui L, Zhaocai J, Zihao L, Quangang X, Dehui H, Qing L, and Shihui W
- Subjects
- Adult, Analysis of Variance, Brain pathology, Enzyme-Linked Immunosorbent Assay, Evoked Potentials, Visual physiology, Female, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Myelitis cerebrospinal fluid, Myelitis complications, Neurologic Examination, Neuromyelitis Optica cerebrospinal fluid, Optic Neuritis complications, Optic Neuritis pathology, ROC Curve, Severity of Illness Index, Syndrome, Chemokine CXCL12 cerebrospinal fluid, Chemokines, CXC cerebrospinal fluid, Myelitis pathology, Neuromyelitis Optica pathology, Optic Neuritis cerebrospinal fluid, Platelet-Derived Growth Factor cerebrospinal fluid
- Abstract
The CXC chemokines (CXC-motif ligand 12 and CXC-motif ligand 14) and platelet-derived growth factor are suggested to modulate remyelination in the course of many demyelinating diseases. The present study compared the difference in the brain levels of these chemokines between patients with idiopathic demyelinating optic neuritis (IDON) and neuromyelitis optica (NMO) by measuring their concentrations in the cerebrospinal fluid using an enzyme linked immunosorbent assay. Our data indicate that the prognosis of neuritis depends on the remyelinating process that is impaired due to decreased chemokines. The much lower levels of chemokines would specifically indicate the severe neuritis, such as NMO., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2015
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