1. Ischemia-Modified Albumin and Antioxidant Protection in Newborns with Asphyxia of Varying Severity.
- Author
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Delsuz SF, Shalina RI, Karaganova EY, Kurtser MA, Babenkova IV, Teselkin YO, Osipov AN, and Vladimirov YA
- Subjects
- Child, Humans, Infant, Newborn, Biomarkers, Asphyxia, Case-Control Studies, Oxidative Stress, Serum Albumin, Antioxidants therapeutic use
- Abstract
The content of ischemia-modified albumin (IMA), serum albumin, and antioxidant capacity of blood serum was studied in healthy newborns and in newborns with moderate and severe asphyxia on days 1-2 and 3-4 of the postnatal period. Changes in these indicators were found in both groups of newborns with birth asphyxia in comparison with the group of healthy newborns and were more pronounced in children with severe asphyxia. An increase in the IMA level (by 1.6 times; p<0.001) and antioxidant capacity of blood serum (by 2.4 times; p<0.001) and a decrease in serum albumin content (by 1.5 times; p<0.001) were found in severe asphyxia on days 1-2. Analysis of changes in these indicators by days 3-4 allows to talk about a decrease in the intensity of free-radical reactions in newborns with birth asphyxia during complex therapy., (© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
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