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Background: Household air pollution (HAP) from biomass fuel combustion remains a leading environmental risk factor for morbidity worldwide., Objective: Measure the effect of liquefied petroleum gas (LPG) interventions on HAP exposures in Puno, Peru., Methods: We conducted a 1-y randomized controlled trial followed by a 1-y pragmatic crossover trial in 180 women age 25-64 y. During the first year, intervention participants received a free LPG stove, continuous fuel delivery, and regular behavioral messaging, whereas controls continued their biomass cooking practices. During the second year, control participants received a free LPG stove, regular behavioral messaging, and vouchers to obtain LPG tanks from a nearby distributor, whereas fuel distribution stopped for intervention participants. We collected 48-h kitchen area concentrations and personal exposures to fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μ m ( PM 2.5 ), black carbon (BC), and carbon monoxide (CO) at baseline and 3-, 6-, 12-, 18-, and 24-months post randomization., Results: Baseline mean  [ ± standard deviation  ( SD ) ] PM 2.5 (kitchen area concentrations 1,220 ± 1,010 vs. 1,190 ± 880   μ g / m 3 ; personal exposure 126 ± 214 vs. 104 ± 100   μ g / m 3 ), CO (kitchen 53 ± 49 vs. 50 ± 41  ppm ; personal 7 ± 8 vs. 7 ± 8  ppm ), and BC (kitchen 180 ± 120 vs. 210 ± 150   μ g / m 3 ; personal 19 ± 16 vs. 21 ± 22   μ g / m 3 ) were similar between control and intervention participants. Intervention participants had consistently lower mean  ( ± SD ) concentrations at the 12-month visit for kitchen ( 41 ± 59   μ g / m 3 , 3 ± 6   μ g / m 3 , and 8 ± 13  ppm ) and personal exposures ( 26 ± 34   μ g / m 3 , 2 ± 3   μ g / m 3 , and 3 ± 4  ppm ) to PM 2.5 , BC, and CO when compared to controls during the first year. In the second year, we observed comparable HAP reductions among controls after the voucher-based intervention for LPG fuel was implemented (24-month visit PM 2.5 , BC, and CO kitchen mean concentrations of 34 ± 74   μ g / m 3 , 3 ± 5   μ g / m 3 , and 6 ± 6  ppm and personal exposures of 17 ± 15   μ g / m 3 , 2 ± 2   μ g / m 3 , and 3 ± 4  ppm , respectively), and average reductions were present among intervention participants even after free fuel distribution stopped (24-month visit PM 2.5 , BC, and CO kitchen mean concentrations of 561 ± 1,251   μ g / m 3 , 82 ± 124   μ g / m 3 , and 23 ± 28  ppm and personal exposures of 35 ± 38   μ g / m 3 , 6 ± 6   μ g / m 3 , and 4 ± 5  ppm , respectively)., Discussion: Both home delivery and voucher-based provision of free LPG over a 1-y period, in combination with provision of a free LPG stove and longitudinal behavioral messaging, reduced HAP to levels below 24-h World Health Organization air quality guidelines. Moreover, the effects of the intervention on HAP persisted for a year after fuel delivery stopped. Such strategies could be applied in LPG programs to reduce HAP and potentially improve health. https://doi.org/10.1289/EHP10054.

Background: Low- and middle-income countries (LMICs) account for >90% of deaths and illness episodes related to COPD; however, this condition is commonly underdiagnosed in these settings. Case-finding instruments for COPD may improve diagnosis and identify individuals that need treatment, but few have been validated in resource-limited settings., Methods: We conducted a population-based cross-sectional study in Uganda to assess the diagnostic accuracy of a respiratory symptom, exposure and functional questionnaire in combination with peak expiratory flow for COPD diagnosis using post-bronchodilator FEV 1 /FVC z-score below the 5th percentile as the gold standard. We included locally relevant exposure questions and statistical learning techniques to identify the most important risk factors for COPD. We used 80% of the data to develop the case-finding instrument and validated it in the remaining 20%. We evaluated for calibration and discrimination using standard approaches. The final score, COLA (COPD in LMICs Assessment), included seven questions, age and pre-bronchodilator peak expiratory flow., Results: We analyzed data from 1,173 participants (average age 47 years, 46.9% male, 4.5% with COPD) with acceptable and reproducible spirometry. The seven questions yielded a cross-validated area-under-the-curve [AUC] of 0.68 (95% CI 0.61-0.75) with higher scores conferring greater odds of COPD. The inclusion of peak expiratory flow and age improved prediction in a validation sample (AUC=0.83, 95% CI 0.78-0.88) with a positive predictive value of 50% and a negative predictive value of 96%. The final instrument (COLA) included seven questions, age and pre-bronchodilator peak expiratory flow., Conclusion: COLA predicted COPD in urban and rural settings in Uganda has high calibration and discrimination, and could serve as a simple, low-cost screening tool in resource-limited settings., Competing Interests: Dr Robert A Wise reports personal fees from GSK, Novartis, AstraZeneca, Merck, Anapsysbio, Kikiksa, Kinevant, Galderma, Chimerx, and AbbVie, outside the submitted work. Professor John R Hursts report grants, personal fees, non-financial support from AstraZeneca, Boehringer Ingelheim, Chiesi, and Novartis  that make medicines to treat COPD, outside the submitted work. The authors report no other conflicts of interest in this work., (© 2020 Siddharthan et al.)