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The Anthropocene is characterized by dramatic ecosystem changes driven by human activities. The impact of these activities can be assessed by different geochemical and paleontological proxies. However, each of these proxies provides only a fragmentary insight into the effects of anthropogenic impacts. It is highly challenging to reconstruct, with a holistic view, the state of the ecosystems from the preindustrial period to the present day, covering all biological components, from prokaryotes to multicellular eukaryotes. Here, we used sedimentary ancient DNA (sedaDNA) archives encompassing all trophic levels of biodiversity to reconstruct the two century-natural history in Bagnoli-Coroglio (Gulf of Pozzuoli, Tyrrhenian Sea), one of the most polluted marine-coastal sites in Europe. The site was characterized by seagrass meadows and high eukaryotic diversity until the beginning of the 20th century. Then, the ecosystem completely changed, with seagrasses and associated fauna as well as diverse groups of planktonic and benthic protists being replaced by low diversity biota dominated by dinophyceans and infaunal metazoan species. The sedaDNA analysis revealed a five-phase evolution of the area, where changes appear as the result of a multi-level cascade effect of impacts associated with industrial activities, urbanization, water circulation and land-use changes. The sedaDNA allowed to infer reference conditions that must be considered when restoration actions are to be implemented., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)

In this study, site-specific natural background levels (NBLs) were determined for 18 elements (Al, As, Be, Cd, Co, Cu, Cr, Fe, Hg, K, Mn, Mo, Ni, Pb, Tl, U, V, and Zn) in two sediment cores collected offshore the Bagnoli-Coroglio brownfield site (Gulf of Pozzuoli, southern Italy) to accurately assess the degree of contamination and the historical trends in Heavy Metals (HMs) enrichment. This objective was pursued taking in account the high temporal and spatial variability of the geochemical properties of the area due to the local geothermal activity. Moreover, the temporal variation of Polycyclic Aromatic Hydrocarbons (PAHs) was investigated. 226 Ra was used as an extraordinary marker to confirm 210 Pb dating. It especially allowed defining the geochronological framework of the sediment core closer the brownfield up to around 1500, providing compelling support to correlate the investigated elements' occurrences with natural geogenic dynamic. Sediment samples were accurately dated and analyzed for chemical and particle size composition. The contamination factor (Cf) and the pollution load index (PLI) showed very high enrichment of Cd, Cu, Hg, Pb, and Zn. The contamination profiles of HMs and PAHs follow the same pattern in both sediment cores, increasing from deep to upper layers. The highest contamination levels for HMs and PAHs were observed between 10 and 30 cm, corresponding to the periods of most intense industrial activity. Decreasing trends of pollutants were observed in the surface layers (0-10 cm), probably affected by a natural attenuation process due to the cessation of industrial activities., (© 2022. The Author(s).)

Coastal lagoons are important but sensitive environments, being transitional zones between land and sea. The Khnifiss lagoon is the most important desert wetland in Morocco, but little data have been produced concerning heavy metal geochemistry and enrichments in the sediments. Therefore, 26 surface sediments (15 intertidal and 11 subtidal) and 2 sediment cores were collected in 2016 and analyzed for a selection of heavy metals. The data were processed to assess the degree of contamination and the corresponding potential ecological risk, using several accumulation/enrichment indices, and the singular and multi-metal risk indices. Mean concentrations in the bottom layers of the two cores, dating from a pre-industrial age according to geochronological analysis, were used as the local geochemical background. The resulting values were on the whole lower than those reported for other areas of the northeastern coast of Morocco. Multivariate statistics were also applied to better understand relationships among variables (metals and other geochemical parameters) and to reveal similarities among sample groups. The results showed that, although the lagoon is not yet affected by significant anthropogenic influences, small enrichments can be recognized, especially for Ni and Cd. The cause may be related to the proximity to the main national highway, the vehicles and machinery used in the saltworks located in the area, and the small harbors used principally for fishing. In addition, industrial emissions from the Atlantic coast of Morocco and adjacent countries can be reasonably attributed as additional contributors to the enrichments. In terms of potential ecological risk, Cd shows the greatest impact compared to the other metals investigated., (© 2022. The Author(s).)

Isotopic composition of mercury (Hg) in marine organisms and sediment cores was used to identify sources and reconstruct historical trends of contamination in the coastal-marine area of Rosignano Solvay (Italy), affected by Hg pollution from a chlor-alkali plant on the near land. Sediments show a wide range of Hg concentration and Hg isotope signatures. Particularly, coupled Hg concentration and δ 202 Hg values trace inputs from different sources. The two depth-profiles clearly indicate three distinct periods: "pre-industrial" (before 1941), "industrial" (between 1941 and 2007) and "post-industrial" (after 2007) ages. This is also corroborated by sediment chronology, using 210 Pb dating method, validated through 137 Cs. Marine organisms are characterized by Hg isotope signatures comparable to "post-industrial" surface sediments. Notably, specimens of Mullus spp. evidence isotope composition comparable to the "industrial" sediments, thus suggesting a still active role of those sediments as source of Hg for the benthic fish compartment. The small amount of MIF and the Δ 199 Hg/Δ 201 Hg ratio recorded in organisms are reasonably consistent with limited processes of MMHg demethylation in the water column., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

210 Pb and 137 Cs vertical profiles in coastal sediments are studied using a sedimentation-mixing model. The cores were sampled in a complex coastal area characterized by the presence of different impact sources and environmental uses (riverine inputs, commercial and military harbour, marine protected area) in the Eastern Ligurian Sea, Italy. The analysis of accumulation and dispersion processes is performed using a numerical advection and diffusion model, in terms of the independent variables - time and mass depth. The flux of 210 Pb is considered in steady state while the time dependent input flux of 137 Cs is estimated from the concentration of this radionuclide in seawater, starting from observed data from 1960 to date. Differently from the atmospheric fallout distribution, this input function contains, at least partly, the contribution that still continues to reach the sediment in the last 25 years as a result of coastal and riverine input. The analysis highlights some features obscured in experimental data, and allows comparison of the effects of different scenarios. The specific effect of a pulsed input is discussed by analysing the effects of the Chernobyl event. The effects of mass flux in non-steady state are also considered: we observe that since the pulsed inputs in 137 Cs are now too old, a strong superficial mixing and a time-variable flux produce similar profiles for both radionuclides. Hence, the general environmental knowledge of the area remains the main instrument to fully define the active processes in some cores., (Copyright © 2019. Published by Elsevier Ltd.)

In continental margins, canyons appear to act as natural conduits of sediments and organic matter from the shelf to deep basins, providing an efficient physical pathway for transport and accumulation of particles with their associated land-produced contaminants. However, these mechanisms have not been yet sufficiently explored by geochemical markers. The continental slope of the south Sardinia has been used as a natural laboratory for investigating mechanisms and times of transfer dynamics of contaminants from land to sea and from shelf to deep sea through an articulated system of submarine canyons. Here, dynamics of contaminants have been investigated in a pilot area of the central Mediterranean basin (Gulf of Cagliari, S Sardinia) where important industrial plants are sited since beginning of the last century. Five sediment cores dated by 210 Pb and 137 Cs reveal: i) a complex dynamics of organic and inorganic contaminants from point source areas on land to the deep sea and ii) a crucial role played by canyons and bottom morphology as primary pathway conveying sediments and associated contaminants from sources to very far deep sea environments. In particular, this study provides new integrated tools to properly understand mechanisms of connection between coastal sectors and deep sea. This is challenging mostly in regions where coastal pollution could represent critical threats for larger areas of the Mediterranean Sea., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Background: The present analysis focuses on real-world data of Everolimus-Exemestane in advanced HR+ve, HER2-ve elderly breast cancer patients (aged 65 years) included in the EVA study, with unique findings in those aged 70 years., Methods: Data are collected from clinical records and analysed according to age cut-off (< 65 years; 65 - 69 years and {greater than or equal to} 70 years). Relationship of analyzed variables with response were tested by mean of a Mantel-Haenszel chi square test. Time to event analysis was described by Kaplan Meier approach and association with baseline characteristics was analysed by stratified log-rank test and proportional hazard model., Results: From July 2013 to December 2015, the EVA study enrolled overall 404 pts. 154 patients out of 404 (38,1%) were aged {greater than or equal to} 65 years, of whom 87 were {greater than or equal to} 70 years. Median duration of EVE treatment was 28.5 weeks (95% CI 19.0 - 33.8) in patients aged 65-69 years and 24,4 weeks (95% CI 19,2 - 33,2) in those aged {greater than or equal to} 70 years. Fewer patients aged 65 years received the highest EVE Dose-Intensity (>7.5 mg/day) in comparison to younger patients (49,6% vs. 66,8%). Grade 3-4 toxicities occurred to 55 patients (35,7%), mainly stomatitis (10,9%), rash (5,8%) and non-infectious pneumonitis (NIP) (3,6%). Some toxicities, such as weight loss and anaemia were peculiarly observed in patients aged {greater than or equal to} 70 years. Five treatment-related deaths were collected (3,2%)., Conclusions: EVE-EXE combination remains one of the potential treatments in HR+ patients also for elderly ones., Competing Interests: CONFLICTS OF INTEREST The Authors declare that they have no conflicts of interest.

Settling fluxes and sediment accumulation rates in coastal Tema Harbour (Ghana) were investigated by the combined analyses of results in sediment traps and sediment cores. Sediment traps were deployed at 5 stations within the Tema Harbour at two sampling depths and were retrieved every two weeks till the end of 12weeks to estimate the Settling Fluxes (SFs). Four sediment cores from the harbour were analysed for their radioactivity ( 7 Be, 234 Th, 210 Pb, 212 Pb, 226 Ra, 40 K and 137 Cs) profiles to quantify Sediment Accumulation Rates (SARs). The sediment cores exhibited variable bulk density profiles, indicating highly dynamic and non-steady sedimentation conditions. 7 Be-derived gross-estimates of very recent SARs using the constant flux-constant sedimentation (CF-CS) model were in the range of 2.5-9.0g·cm -2 ·y -1 . These values were much lower than the estimated average SFs (15.2-53.8g·cm -2 ·y -1 ), indicating sediment resuspension plays an important role. On a decadal time scale, conventional 210 Pb sediment dating models did not allow any estimation of SARs in the Tema Harbour. Thus, the 210 Pb-based TERESA model was applied to depict a reliable scenario for sedimentation with time-averaged SARs in the range of 1.4-3.0g·cm -2 ·y -1 and fluxes of matter contributed by the marine inflow and local sources. Sediment accretion rates of 1.7-3cm·y -1 were also inferred, which may pose a moderate problem of sustainability for the Tema Harbour. This study reveals how the geochemical behaviour of different radionuclides with Gamma spectrometry in the marine environment can be used to obtain reliable information on the complex dynamics of Suspended Particulate Matter (SPM), even in a very disturbed and anthropic environment as a coastal harbour area where (1) conventional 210 Pb-based dating methods fail and (2) the use of sediment traps and 234 Th and 7 Be profiles in sediment cores show serious constraints., (Copyright © 2017 Elsevier B.V. All rights reserved.)