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This paper presents the results of tests on the railway disc brake with regard to the weight wear of friction pads. The tests were carried out at a certified brake test bench where the friction-mechanical characteristics of the railway brake were determined. The test stand was additionally equipped with a thermal imaging camera to observe the contact between the brake pads and the brake disc. The scientific goal of the test is to evaluate the relationship between the weight wear of friction pads and the quantities characterizing the braking process. The quantities characterizing the braking process included pad-to-disc contact area, friction pad thickness, pad-to-disc pressure, and braking speed. A regression model to estimate the friction pad wear on the basis of a single braking with the given input quantities was determined. The greatest influence on the increase in weight wear of friction pads has the braking velocity, which was confirmed by the value of the correlation coefficient of the regression model at value 0.81. The pressure of the friction pad to the disc and the friction pad thickness do not have a significant effect on the weight wear described by the regression model, and the obtained correlation coefficient for these parameters was lower than the value of 0.2.

The article presents the results of friction and vibroacoustic tests of a railway disc brake carried out on a brake stand. The vibration signal generated by the friction linings provides information on their wear and offers evaluation of the braking process, i.e., changes in the average friction coefficient. The algorithm presents simple regression linear and non-linear models for the thickness of the friction linings and the average coefficient of friction based on the effective value of vibration acceleration. The vibration acceleration signals were analyzed in the amplitude and frequency domains. In both cases, satisfactory values of the dynamics of changes above 6 dB were obtained. In the case of spectral analysis using a mid-band filter, more accurate models of the friction lining thickness and the average coefficient of friction were obtained. However, the spectral analysis does not allow the estimation of the lining thickness and the friction coefficient at low braking speeds, i.e., 50 and 80 km/h. The analysis of amplitudes leads to the determination of models in the entire braking speed range from 50 to 200 km/h, despite the lower accuracy compared to the model, based on the spectral analysis. The vibroacoustic literature presents methods of diagnosis of the wear of various machine elements such as bearings or friction linings, based on amplitude or frequency analysis of vibrations. These signal analysis methods have their limitations with regard to their scope of use and the accuracy of diagnosis. There are no cases of simultaneous use of different methods of analysis. This article presents the simultaneous application of the amplitude and frequency methods in the analysis of vibroacoustic signals generated by brake linings. Moreover, algorithms for assessing the wear of friction linings and the average coefficient of friction were presented. The algorithm enables determination of the time at which the friction linings should be replaced with new ones. The final algorithm analyzes the vibration acceleration signals using both amplitude analysis for low braking speeds, as well as spectral analysis for medium and high braking speeds.

This article presents the results of tests conducted on the average and instantaneous friction coefficients of railway vehicle disc brakes. The tests were carried out independently of various states of wear on the friction linings and the brake disc. The requirements of the International Union of Railways (UIC) regarding the approval of brake linings for use were taken into account. Based on many years of research using a brake bench to test railway disc brakes, the authors developed multiple regression models for the average friction coefficient and fluctuations (tolerances) in the instantaneous friction coefficient and achieved 870 results. The models proposed three types of variables: the input braking parameters (speed, pressure, and mass to be braked), operational parameters (the wear on the friction linings and the brake disc), and design parameters (perforations in the form of holes on the disc surface). The above two models were validated on the basis of 384 brakes, and in subsequent stages a further evaluation was performed. The coefficients were determined to be, respectively, 0.99 for the model of the average friction coefficient and 0.71 for the model of tolerance (fluctuations) of the instantaneous friction coefficient.

The article presents the state of knowledge and research in the field of surface cracks occurring in disc braking systems of rail and car vehicles. The craze formed during the operation of vehicles is particularly dangerous and leads to breaking the disc into several pieces. It may lead to a loss of braking force and damage to the entire disc brake caliper. The main aim of the research is to identify surface cracks in brake discs made of cast iron and use experimental methods to estimate their depth. Research were conducted on the disc braking system developed by the authors. In examining the location and depth of cracks, the penetration method, ultrasound, as well as a special probe were used. This device measures the crack depth based on the electrical resistance between two points on the surface of the metallic object. The tests showed that the first microcracks on the brake discs appeared after 309 braking tests on the test stand. In addition, it was observed that the surface cracks length of the disc increased linearly to depth until they reached about 11.5-12 mm with corresponded to crack lengths in the range of 65-70 mm. However, determination of the regression functions presented in the article allows to estimate the depth of surface cracks up to 70 mm long on cast iron brake discs by measuring their length.

The Hsp90 molecule, one of the most abundant heat shock proteins in mammalian cells, maintains homeostasis and prevents stress-induced cellular damage. Hsp90 is expressed under normal conditions at a level of about 1-2 Percent of total proteins, while its expression increases 2-10 fold in cancer cells. The two main constitutively expressed isoforms of Hsp90 are known as Hsp90-alpha and Hsp90-beta, and their upregulation is associated with tumor progression, invasion and formation of metastases, as well as development of drug resistance. The Hsp90 is a key target for many newly established, potent anticancer agents containing Hsp90 N-terminal ATP binding inhibitors, such as geldanamycin, and its analogues 17AAG and 17DMAG. The therapeutic usage of geldanamycin has been limited due to its poor water solubility and severe hepatotoxicity. Therefore, its analogues, including 17AAG, 17DMAG, Tanespimycin and Retaspimycin hydrochloride, with improved pharmacokinetic profiles, have been developed.