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Running economy is an important determinant of endurance running performance, yet insights into characteristics contributing to its inter-individual variability remain limited. Although slow-twitch muscle fibers are more energy-efficient than fast-twitch fibers during the (near-)isometric contractions common during submaximal running, current literature lacks a consensus on whether a relationship between muscle fiber-type distribution and running economy exists. This study aims to resolve the ongoing debate by addressing potential confounding factors often overlooked in prior research, such as the effect of different running speeds, the homogeneity of investigated groups, and the potential impact of the adopted running gait. We selected two groups with predetermined distinct muscle fiber-type distribution in their triceps surae muscle by measurement of carnosine via 1 H-MRS, one predominantly slow (ST; n = 11; carnosine z-score = -1.31) and the other predominantly fast (FT; n = 10; z-score = 0.83). Across a range of running speeds (2-4 m/s), we measured running economy (W/kg) through indirect calorimetry, along with running kinematics, kinetics and muscle activity of the lower limb. The ST-group exhibited, on average, 7.8% better running economy than the FT-group (p = 0.01) and this difference was consistent across speeds. Both groups demonstrated almost identical kinematics, kinetics, and muscle activity patterns across submaximal running speeds. Overall, our findings indicate that distinct muscle fiber-type distribution explains some of the observed variability in running economy, for which a predominance of energy-efficient slow-twitch fibers appear beneficial. In contrast, muscle fiber-type distribution does not affect running gait substantially., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

The effects of occlusal splints on sport performance have already been studied, although their biomechanical impacts are often overlooked. We investigated the kinematical changes during running until exhaustion at severe intensity while wearing a mandibular advancement occlusal splint. Twelve trained runners completed (i) an incremental protocol on a track to determine their velocity corresponding to maximal oxygen uptake and (ii) two trials of square wave transition exercises at their velocity corresponding to maximal oxygen until exhaustion, wearing two occlusal splints (without and with mandibular advancement). Running kinematics were compared within laps performed during the square wave transition exercises and between splint conditions. The mandibular advancement occlusal splint increased the running distance covered (~1663 ± 402 vs. 1540 ± 397 m, p = 0.03), along with a noticeable lap effect in decreasing stride frequency ( p = 0.04) and increasing stride length ( p = 0.03) and duty factor ( p < 0.001). No spatiotemporal differences were observed between splints, except for improved balance foot contact times in the mandibular advancement condition. An increased knee flexion angle at initial contact ( p = 0.017) was noted along laps in the non-advancement condition, despite the fact that no differences between splints were found. Running patterns mainly shifted within laps rather than between conditions, indicating that a mandibular advancement occlusal splint had a trivial kinematical effect.

This study investigated the coactivation of plantar flexor and dorsiflexor muscles and oxygen uptake during running with forefoot and rearfoot strikes at 15 and 19 km/h. We included 16 male runners in this study. The participants ran each foot strike pattern for 5 min at 15 and 19 km/h on a treadmill. During the running, respiratory gas exchange data and surface electromyographic (EMG) activity of the medial gastrocnemius (MG), lateral gastrocnemius (LG), soleus, and tibialis anterior muscles of the right lower limb were continuously recorded. The indices of oxygen uptake, energy expenditure (EE), and muscle activation were calculated during the last 2 min in each condition. During the stance phase of running at 15 and 19 km/h, activation of the tibialis anterior and MG muscles was lower and higher, respectively, with forefoot strike than with rearfoot strike. The foot strike pattern did not influence the oxygen uptake. These results suggest that the foot strike pattern has no clear effect on the oxygen uptake when running at 15 and 19 km/h. However, forefoot strike leads to plantar flexion dominance during co-contraction of the tibialis anterior and MG muscles, which are an antagonist and agonist for plantar flexion, respectively, during the stance phase., (© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)

Background: The metabolic cost of locomotion is a key factor in walking and running performance. It has been studied by analysing the activation and co-activation of the muscles of the lower limbs. However, these measures do not comprehensively address muscle mechanics, in contrast to approaches using muscle moments and co-contraction., Research Question: What is the effect of speed and type of locomotion on muscle moments and co-contraction, and their relationship with metabolic cost during walking and running?, Methods: Eleven recreational athletes (60.5 ± 7.1 kg; 169.0 ± 6.6 cm; 23.6 ± 3.3 years) walked and ran on a treadmill at different speeds, including a similar speed of 1.75 m.s -1 . Metabolic cost was estimated from gas exchange measurements. Muscle moments and co-contraction of ankle and knee flexors and extensors during the stance and swing phases were estimated using an electromyographic-driven model., Results: Both the slowest and fastest walking speeds had significantly higher metabolic costs than intermediate ones (p < 0.05). The metabolic cost of walking was correlated with plantarflexors moment during swing phase (r = 0.62 at 0.5 m.s -1 , r = 0.67 at 1,25 m.s -1 ), dorsiflexors moment during stance phase (r = 0.65 at 1.25 m.s -1 , r = 0.67 at 1.5 and 1.75 m.s -1 ), and ankle co-contraction during the stance phase (r = 0.63 at 1.25 and 1.75 m.s -1 ). The metabolic cost of running at 3.25 m.s -1 during the swing phase was correlated with the dorsiflexors moment (r = 0.63), plantarflexors moment (r = 0.61) and ankle co-contraction (r = 0.60)., Discussion and Conclusion: Fluctuations in metabolic cost of walking and running could be explained, at least in part, by increased ankle antagonist moments and co-contraction., Competing Interests: Declaration of Competing Interest All the authors confirm that there is no financial interest, personal interest or belief that could affect the objectivity in any way of the following article: Relationship between metabolic cost, muscle moments and co-contraction during walking and running., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

This study aimed to identify the aerobic and anaerobic metabolic performance capacities contributing to Yo-Yo Intermittent Recovery level 2 (Yo-Yo IR2) test performance. Nineteen recreational Australian footballers completed a Yo-Yo IR2 test, and on another day a treadmill peak oxygen uptake (VO 2peak ) and maximal accumulated oxygen deficit test in a randomised counter-balanced order. The maximal accumulated oxygen deficit (MAOD) procedures included 5 × 5 min sub-maximal continuous runs at progressively higher speeds whilst VO 2 was recorded; thereafter, speed was incrementally increased to elicit VO 2peak . After 35 min of rest, participants ran at a speed equivalent to 115% of VO 2peak until exhaustion, at which point expired air was collected to determine maximal accumulated oxygen deficit. Relationships between variables were assessed using Pearson's correlation and partial correlations. Maximum aerobic speed, relative intensity, and VO 2peak were significantly correlated with Yo-Yo IR2 performance. High Yo-Yo IR2 performers also had higher MAS, relative intensity, and VO 2peak levels. However, when higher maximum aerobic speed, relative intensity, and VO 2peak were controlled for each other and analysed independently, neither maximal aerobic speed nor VO 2peak correlated with Yo-Yo IR2 performance. Yo-Yo IR2 performance is the result of a complex interaction between several variables. Training programs should primarily focus on improving VO 2peak, maximal aerobic speed, and relative intensity to optimize Yo-Yo IR2 test performance.

The modern era of running shoes began in the 1960s with the introduction of simple polymer midsole foams, and it ended in the late 2010s with the introduction of advanced footwear technology (AFT). AFT is characterized by highly compliant, resilient, and lightweight foams with embedded, rigid, longitudinal architecture. This footwear complex improves a runner's efficiency, and it introduced a step change in running performance. Purpose: This review serves to examine the current state of knowledge around AFT-what it is and what we know about its ingredients, what benefits it confers to runners, and what may or may not mediate that benefit. We also discuss the emerging science around AFT being introduced to track-racing spikes and how it is currently regulated in sporting contexts. Conclusions: AFT has changed running as a sport. The construction of AFT is grossly understood, but the nature of the interacting elements is not. The magnitude of the enhancement of a runner's economy and performance has been characterized and modeled, but the nuanced factors that mediate those responses have not. With these knowns and unknowns, we conclude the review by providing a collection of best practices for footwear researchers, advice for runners interested in AFT, and a list of pertinent items for further investigation.

Purpose: We evaluated (1) whether participating in middle- and long-distance running races augments muscle soreness, oxygen cost, respiration, and exercise exertion during subsequent running, and (2) if post-race menthol application alleviates these responses in long-distance runners., Methods: Eleven long-distance runners completed a 1500-m race on day 1 and a 3000-m race on day 2. On day 3 (post-race day), either a 4% menthol solution (Post-race menthol) or a placebo solution (Post-race placebo) serving as a vehicle control, was applied to their lower leg skin, and their perceptual and physiological responses were evaluated. The identical assessment with the placebo solution was also conducted without race participation (No-race placebo)., Results: The integrated muscle soreness index increased in the Post-race placebo compared to the No-race placebo (P < 0.001), but this response was absent in the Post-race menthol (P = 0.058). Oxygen uptake during treadmill running tended to be higher (4.3%) in the Post-race placebo vs. No-race placebo (P = 0.074). Oxygen uptake was 5.4% lower in the Post-race menthol compared to the Post-race placebo (P = 0.018). Minute ventilation during treadmill running was 6.7-7.6% higher in the Post-race placebo compared to No-race placebo, whereas it was 6.6-9.0% lower in the Post-race menthol vs. Post-race placebo (all P ≤ 0.001). The rate of perceived exertion was 7.0% lower in the Post-race menthol vs. Post-race placebo (P = 0.007)., Conclusions: Middle- and long-distance races can subsequently elevate muscle soreness and induce respiratory and metabolic stress, but post-race menthol application to the lower legs can mitigate these responses and reduce exercise exertion in long-distance runners., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

AbstractMuscle-tendon unit (MTU) morphology and physiology are likely major determinants of locomotor performance and therefore Darwinian fitness. However, the relationships between underlying traits, performance, and fitness are complicated by phenomena such as coadaptation, multiple solutions, and trade-offs. Here, we leverage a long-running artificial selection experiment in which mice have been bred for high levels of voluntary running to explore MTU adaptation, as well as the role of coadaptation, multiple solutions, and trade-offs, in the evolution of endurance running. We compared the morphological and contractile properties of the triceps surae complex, a major locomotor MTU, in four replicate selected lines to those of the triceps surae complex in four replicate control lines. All selected lines have lighter and shorter muscles, longer tendons, and faster muscle twitch times than all control lines. Absolute and normalized maximum shortening velocities and contractile endurance vary across selected lines. Selected lines have similar or lower absolute velocities and higher endurance than control lines. However, normalized shortening velocities are both higher and lower in selected lines than in control lines. These findings potentially show an interesting coadaptation between muscle and tendon morphology and muscle physiology, highlight multiple solutions for increasing endurance running performance, demonstrate that a trade-off between muscle speed and endurance can arise in response to selection, and suggest that a novel physiology may sometimes allow this trade-off to be circumvented.

The goal of the study was to determine the effect of altering running strategy on predicted running performance in distance runners through application of a novel prediction model. Fifteen male ( n = 10; Age: 22.2 ± 4.9 years; Height: 177.7 ± 7.4 cm; Mass: 68.6 ± 6.7 kg) and female ( n = 5; Age: 21.8 ± 4.1 years; Height: 167.4 ± 7.8 cm; Mass: 59.3 ± 8.1 kg) long distance runners were recruited to participate in the study. Participants' oxygen consumption (VO 2 ) and carbon dioxide (VCO 2 ) were measured by a metabolic cart using a face mask. After a brief warm-up, participants rested for the initial five minutes then ran at their preferred speed for five minutes. Participants rested for another five minutes while their oxygen consumption returned to baseline measurements and ran for five minutes while increasing step rate by 7.5%. There was no significant difference between conditions for VO 2 measurements and energetic cost ( p > 0.05). There was also no significant difference in the baseline, self-selected speed and predicted speed resulting from the increase in step rate (p > 0.05). Increasing stride rate 7.5% resulted in an average decrease in predicted running speed of 1%. While statistically insignificant, small decrements in running speed can accrue over time and negatively impact running performance.

Introduction/purpose: Shoe longitudinal bending stiffness (LBS) is often considered to influence running economy (RE) and thus, running performance. However, previous results are mixed and LBS levels have not been studied in advanced footwear technology (AFT). The purpose of this study was to evaluate the effects of increased LBS from curved carbon fiber plates embedded within an AFT midsole compared to a traditional running shoe on RE and spatiotemporal parameters., Methods: Twenty-one male trained runners completed three times 4 min at 13 km/h with two experimental shoe models with a curved carbon fiber plate embedded in an AFT midsole with different LBS values (Stiff: 35.5 N/mm and Stiffest: 43.1 N/mm), and a Control condition (no carbon fiber plate: 20.1 N/mm). We measured energy cost of running (W/kg) and spatiotemporal parameters in one visit., Results: RE improved for the Stiff shoe condition (15.71 ± 0.95 W/kg; p < 0.001; n 2  = 0.374) compared to the Control condition (16.13 ± 1.08 W/kg; 2.56%) and Stiffest condition (16.03 ± 1.19 W/kg; 1.98%). However, we found no significant differences between the Stiffest and Control conditions. Moreover, there were no spatiotemporal differences between shoe conditions., Conclusion: Changes in LBS in AFT influences RE suggesting that moderately stiff shoes have the most effective LBS to improve RE in AFT compared to very stiff shoes and traditional, flexible shoe conditions while running at 13 km/h., (© 2024 The Author(s). Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.)

Purpose: Long-distance running performance has been reported to be associated with sprint performance in highly trained distance runners. Therefore, we hypothesized that sprint training could enhance distance running and sprint performance in long-distance runners. This study examined the effect of 6-week sprint training on long-distance running and sprint performance in highly trained distance runners., Methods: Nineteen college runners were divided into control (n = 8) and training (n = 11) groups. Participants in the training group performed 12 sprint training sessions in 6 weeks, while those in the control group performed 12 distance training sessions. Before and after the interventions, maximal oxygen uptake (V˙O2max), O2 cost during submaximal running (290 m·min-1 and 310 m·min-1 of running velocity), and time to exhaustion (starting at 290 m·min-1 and increased 10 m·min-1 every minute) were assessed on a treadmill. Additionally, the 100-m and 400-m sprinting times and 3000-m running time were determined on an all-weather track., Results: In the control group, no measurements significantly changed after the intervention. In the training group, the time to exhaustion, 100-m and 400-m sprinting times, and 3000-m running time improved significantly, while V˙O2max and O2 cost did not change., Conclusions: These results showed that 6-week sprint training improved both sprint and long-distance running performance in highly trained distance runners without a change in aerobic capacity. Improvement in the time to exhaustion without a change in V˙O2max suggests that the enhancement of long-distance running performance could be attributable to improved anaerobic capacity.

Ratio-scaled VO 2 is the widely used method for quantifying running economy (RE). However, this method should be criticized due to its theoretical defect and curvilinear relationship indicated by the allometric scaling, although no consensus has been achieved on the generally accepted exponent b value of body weight. Therefore, this study aimed to provide a quantitative synthesis of the reported exponents used to scale VO 2 to body weight. Six electronic databases were searched based on related terms. Inclusion criteria involved human cardiopulmonary testing data, derived exponents, and reported precision statistics. The random-effects model was applied to statistically analyze exponent b. Subgroup and meta-regression analyses were conducted to explore the potential factors contributing to variation in b values. The probability of the true exponent being below 1 in future studies was calculated. The estimated b values were all below 1 and aligned with the 3/4 power law, except for the 95 % prediction interval of the estimated fat-free body weight exponent b. A publication bias and a slightly greater I 2 and τ statistic were also observed in the fat-free body weight study cohort. The estimated probabilities of the true body weight exponent, full body weight exponent, and fat-free body weight exponent being lower than 1 were 93.8 % (likely), 95.1 % (very likely), and 94.5 % (likely) respectively. 'Sex difference', 'age category', 'sporting background', and 'testing modality' were four potential but critical variables that impacted exponent b. Overall, allometric-scaled RE should be measured by full body weight with exponent b raised to 3/4., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Recent improvements in elite running performances across all distances have been largely attributed to the introduction of advanced footwear technology (AFT), which features a curved and stiff plate working synergistically with a new generation of midsole foams demonstrating enhanced resilience and compliance. These recent improvements appear to be considerably more pronounced in women's events, highlighted by improvements in road racing world records by an average of 3.7% (range: 2.6%-5.2%) compared to mean progressions of 1.5% (range: 1.3%-1.9%) in the same men's events. Although there is a growing body of research investigating the mechanisms underpinning running performance enhancements derived from AFT, there remains no explanation for potential sex-based differences in their benefits. We overview the currently available evidence and highlight why the recent direction of AFT research provides a barrier to progress by focusing primarily on male athletes. We subsequently provide our perspective on why women may be benefiting from the new generation of shoes more than men, suggest potential mechanisms leading to hypotheses that need to be further investigated in upcoming studies, and finally propose that factors outside of footwear innovation may have concurrently driven the recently observed performance evolutions., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Mason, Starc, Morin, McClelland and Zech.)

We sought to assess the effects of repeated cold-water immersions (CWI) on respiratory, metabolic, and sympathoadrenal responses to graded exercise in hypoxia. Sixteen (2 female) participants (age: 21.2 ±   1.3 years; body fat: 12.3 ± 7.7%; body surface area 1.87 ± 0.16 m 2 , VO 2peak : 48.7 ± 7.9 mL/kg/min) underwent 6 CWI in 12.0 ± 1.2 °C. Each CWI was 5 min, twice daily, separated by ≥4 h, for three consecutive days, during which metabolic data were collected. The day before and after the repeated CWI intervention, participants ran in normobaric hypoxia (F I O 2  = 0.135) for 4 min at 25%, 40%, 60%, and 75% of their sea level peak oxygen consumption (VO 2peak ). CWI had no effect on VO 2 ( p  > 0.05), but reduced the V E (CWI #1: 27.1 ± 17.8 versus CWI #6: 19.9 ± 12.1 L/min) ( p  < 0.01), V T (CWI #1: 1.3 ± 0.4 vs CWI #6: 1.1 ± 0.4 L) ( p  < 0.01), and V E :VO 2 (CWI #1: 53.5 ± 24.1 vs CWI #6: 41.6 ± 20.5) ( p  < 0.01) during subsequent CWI. Further, post exercise plasma epinephrine was lower after CWI compared to before (103.3 ± 43.1; 73.4 ± 34.6 pg/mL) ( p  = 0.03), with no change in pre-exercising values (75.4 ± 30.7; 72.5 ± 25.9 pg/mL). While these changes were noteworthy, it is important to acknowledge there were no changes in pulmonary ( V E , V T , and V E :VO 2 ) or metabolic (VO 2 , SmO 2 , and SpO 2 ) variables across multiple hypoxic exercise workloads following repeated CWI. CWI habituated participants to cold water, but this did not lead to adaptations during exercise in normobaric hypoxia., Competing Interests: The authors have declared no conflicts of interest.

During running, the mechanical energy of the centre of mass of the body (COM) oscillates throughout the step like a spring-mass system, where part of its mechanical energy is stored during negative phases to be released during the following positive phases. This storage-release of energy improves muscle-tendon efficiency, which is related to lower-limb stiffness. This study explores the effect of sports background on the bouncing mechanism, by examining differences in stiffness and step spatiotemporal parameters between swimmers and football athletes. All athletes performed three consecutive running bouts on an instrumented treadmill at three different speeds (3.9, 4.4 and 5.0 m·s -1 ). The ground reaction forces were recorded. Vertical stiffness and step spatiotemporal parameters were analysed and compared using a two-way ANOVA. Vertical stiffness of football players was on average 21.0 ± 1.1% higher than swimmers. The modification of step spatiotemporal parameters also suggests a more elastic rebound by increasing the stretch of tendons relative to muscle within muscle-tendon units in football players. Compared to swimmers, they (1) decrease the effective contact time by 9.7 ± 2.4% and (2) decrease the duration of the push by 15.0 ± 6.4%, suggesting that background training adaptations influence spring-mass behaviour during running.

In a randomized controlled cross-over study ten male runners (26.7 ± 4.9 years; recent 5-km time: 18:37 ± 1:07 min:s) performed an incremental treadmill test (ITT) and a 3-km time trial (3-km TT) on a treadmill while wearing either carbon fiber insoles with downwards curvature or insoles made of butyl rubber (control condition) in light road racing shoes (Saucony Fastwitch 9). Oxygen uptake, respiratory exchange ratio, heart rate, blood lactate concentration, stride frequency, stride length and time to exhaustion were assessed during ITT. After ITT, all runners rated their perceived exertion, perceived shoe comfort and perceived shoe performance. Running time, heart rate, blood lactate levels, stride frequency and stride length were recorded during, and shoe comfort and shoe performance after, the 3-km TT. All parameters obtained during or after the ITT did not differ between the two conditions [range: p  = 0.188 to 0.948 (alpha value: 0.05); Cohen's d = 0.021 to 0.479] despite the rating of shoe comfort showing better scores for the control insoles ( p  = 0.001; d = -1.646). All parameters during and after the 3-km TT showed no differences ( p  = 0.200 to 1.000; d = 0.000 to 0.501) between both conditions except for shoe comfort showing better scores for control insoles ( p  = 0.017; d = -0.919). Running with carbon fiber insoles with downwards curvature did not change running performance or any submaximal or maximal physiological or biomechanical parameter and perceived exertion compared to control condition. Shoe comfort is impaired while running with carbon fiber insoles. Wearing carbon fiber insoles with downwards curvature during treadmill running is not beneficial when compared to running with control insoles., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Engel, Zehnter, Yona, Mai, Willwacher, Düking and Sperlich.)

Introduction: The present study investigated the role of training intensity in the dose-response relationship between endurance training and cardiorespiratory fitness (CRF). The hypothesis was that beginners would benefit from an increase in training intensity after an initial training phase, even if the energy expenditure was not altered. For this purpose, 26 weeks of continuous moderate training (control group, CON) was compared to training with gradually increasing intensity (intervention group, INC) but constant energy expenditure., Methods: Thirty-one healthy, untrained subjects (13 men, 18 women; 46 ± 8 years; body mass index 25.4 ± 3.3 kg m -2 ; maximum oxygen uptake, VO 2max 34 ± 4 ml min -1  kg -1 ) trained for 10 weeks with moderate intensity [3 days/week for 50 min/session at 55% heart rate reserve (HR reserve )] before allocation to one of two groups. A minimization technique was used to ensure homogeneous groups. While group CON continued with moderate intensity for 16 weeks, the INC group trained at 70% HR reserve for 8 weeks and thereafter participated in a 4 × 4 training program (high-intensity interval training, HIIT) for 8 weeks. Constant energy expenditure was ensured by indirect calorimetry and corresponding adjustment of the training volume. Treadmill tests were performed at baseline and after 10, 18, and 26 weeks., Results: The INC group showed improved VO 2max (3.4 ± 2.7 ml kg -1  min -1 ) to a significantly greater degree than the CON group (0.4 ± 2.9 ml kg -1  min -1 ) ( P  = 0.020). In addition, the INC group exhibited improved V max (1.7 ± 0.7 km h -1 ) to a significantly greater degree than the CON group (1.0 ± 0.5 km h -1 ) ( P  = 0.001). The reduction of resting HR was significantly larger in the INC group (7 ± 4 bpm) than in the CON group (2 ± 6 bpm) ( P  = 0.001). The mean heart rate in the submaximal exercise test was reduced significantly in the CON group (5 ± 6 bpm; P  = 0.007) and in the INC group (8 ± 7 bpm; P  = 0.001), without a significant interaction between group and time point., Conclusion: Increasing intensity leads to greater adaptations in CRF than continuing with moderate intensity, even without increased energy expenditure. After 26 weeks of training in the moderate- and higher-intensity domain, energy-matched HIIT elicited further adaptations in cardiorespiratory fitness. Thus, training intensity plays a crucial role in the dose-response relationship between endurance training and fitness in untrained but healthy individuals., Clinical Trial Registration: https://www.drks.de/DRKS00031445, identifier DRKS00031445., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Reuter, Rosenberger, Barz, Venhorst, Blanz, Roecker and Meyer.)

Objective: The aim of the present study was to examine whether 10-20-30 training (consecutive 1-min intervals consisting of 30 s at low-speed, 20 s at moderate-speed, and 10 s at high-speed), performed with submaximal effort during the 10-s high-speed runs, would lead to improved performance as well as increased maximum oxygen uptake (VO 2 -max) and muscle oxidative phosphorylation (OXPHOS). In addition, to examine to what extent the effects would compare to 10-20-30 running conducted with maximal effort., Design: Nineteen males were randomly assigned to 10-20-30 running performed with either submaximal (SUBMAX; n = 11) or maximal (MAX; n = 8) effort, which was conducted three times/week for 6 weeks (intervention; INT). Before and after INT, subjects completed a 5-km running test and a VO 2 -max test, and a biopsy was obtained from m. vastus lateralis., Results: After compared to before INT, SUBMAX and MAX improved (p < 0.05) 5-km performance by 3.0% (20.8 ± 0.4 (means±SE) vs. 21.5 ± 0.4 min) and 2.3% (21.2 ± 0.4 vs. 21.6 ± 0.4 min), respectively, and VO 2 -max was ~7% higher (p < 0.01) in both SUBMAX (57.0 ± 1.3 vs. 53.5 ± 1.1 mL/min/kg) and MAX (57.8 ± 1.2 vs. 53.7 ± 0.9 mL/min/kg), with no difference in the changes between groups. In SUBMAX, muscle OXPHOS was unchanged, whereas in MAX, muscle OXPHOS subunits (I-IV) and total OXPHOS (5.5 ± 0.3 vs 4.7 ± 0.3 A.U.) were 9%-29% higher (p < 0.05) after compared to before INT., Conclusion: Conducting 10-20-30 training with a non-maximal effort during the 10-s high-speed runs is as efficient in improving 5-km performance and VO 2 -max as maximal effort exercise, whereas increase in muscle OXPHOS occur only when the 10-s high-speed runs are performed with maximal effort., (© 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.)

We sought to determine the utility of Stryd, a commercially available inertial measurement unit, to quantify running intensity and aerobic fitness. Fifteen (eight male, seven female) runners (age = 30.2 [4.3] years; V·O 2 max = 54.5 [6.5] ml·kg -1 ·min -1 ) performed moderate- and heavy-intensity step transitions, an incremental exercise test, and constant-speed running trials to establish the maximal lactate steady state (MLSS). Stryd running power stability, sensitivity, and reliability were evaluated near the MLSS. Stryd running power was also compared to running speed, V·O 2 , and metabolic power measures to estimate running mechanical efficiency (EFF) and to determine the efficacy of using Stryd to delineate exercise intensities, quantify aerobic fitness, and estimate running economy (RE). Stryd running power was strongly associated with V·O 2 (R 2 = 0.84; p < 0.001) and running speed at the MLSS (R 2 = 0.91; p < 0.001). Stryd running power measures were strongly correlated with RE at the MLSS when combined with metabolic data (R 2 = 0.79; p < 0.001) but not in isolation from the metabolic data (R 2 = 0.08; p = 0.313). Measures of running EFF near the MLSS were not different across intensities (~21%; p > 0.05). In conclusion, although Stryd could not quantify RE in isolation, it provided a stable, sensitive, and reliable metric that can estimate aerobic fitness, delineate exercise intensities, and approximate the metabolic requirements of running near the MLSS.

Half-marathon (HM) is a running sport of increasing popularity in both sexes and in all age groups worldwide during the last years. Many studies have examined several aspects of HM, such as performance and participation trends, sex and age differences, physiological correlates, and training; however, no comprehensive review has ever been contacted to summarize the recently accumulated knowledge. Therefore, the aim of the present study was to review all previous research in this sport, focusing on participation and performance aspects. It was shown that HM runners had similar anthropometric and physiological characteristics as full-marathon runners which should be attributed to the affinity of these two races in terms of metabolic demands. Performance in HM was related with superior scores in aerobic capacity (maximal oxygen uptake, anaerobic threshold and running economy) and training characteristics (sport experience, weekly distance, training speed, frequency of sessions and long single endurance run distance), and lower scores in adiposity-related scores (e.g. body mass, body mass index, body fat percentage and skinfold thickness). Considering the popularity of HM race and the lack of many original studies (compared to FM race), this is an exciting field for scientific research with a large potential for practical applications, since the majority of HM runners are amateur runners in need of sex-, age- and performance-tailored exercise prescription., (© 2022. The Author(s).)

Introduction: The relationship between the Achilles tendon moment arm length (AT MA ) and the energy cost of running (E run ) has been disputed. Some studies suggest a short AT MA reduces E run while others claim a long AT MA reduces E run . For a given ankle joint moment, a short AT MA permits a higher tendon strain energy storage, whereas a long AT MA reduces muscle fascicle force and muscle energy cost but shortening velocity is increased, elevating the metabolic cost. These are all conflicting mechanisms to reduce E run , since AT energy storage comes at a metabolic cost. Neither of these proposed mechanisms have been examined together., Methods: We measured AT MA using the tendon travel method in 17 males and 3 females (24 ± 3 years, 75 ± 11 kg, 177 ± 7 cm). They ran on a motorized treadmill for 10 min at 2.5 m · s -1 while E run was measured. AT strain energy storage, muscle lengths, velocities and muscle energy cost were calculated during time-normalized stance from force and ultrasound data. A short (SHORT n  = 11, AT MA  = 29.5 ± 2.0 mm) and long (LONG, n  = 9, AT MA  = 36.6 ± 2.5 mm) AT MA group was considered based on a bimodal distribution of measured AT MA., Results: Mean E run was 4.9 ± 0.4 J · kg -1  · m -1 . The relationship between AT MA and E run was not significant ( r 2  = 0.13, p  = 0.12). Maximum AT force during stance was significantly lower in LONG (5,819 ± 1,202 N) compared to SHORT (6,990 ± 920 N, p  = 0.028). Neither AT stretch nor AT strain energy storage was different between groups (mean difference: 0.3 ± 1 J · step -1 , p  = 0.84). Fascicle force was significantly higher in SHORT (508 ± 93 N) compared to LONG (468 ± 84 N. p  = 0.02). Fascicle lengths and velocities were similar between groups ( p  > 0.72). Muscle energy cost was significantly lower in LONG (0.028 ± 0.08 J · kg · step -1 ) compared to SHORT (0.045 ± 0.14 J · kg · step -1 p  = 0.004). There was a significant negative relationship between AT MA and total muscle energy cost relative to body mass across the stance phase ( r  = -0.699, p  < 0.001)., Discussion: Together these results suggest that a LONG AT MA serves to potentially reduce E run by reducing the muscle energy cost of the plantarflexors during stance. The relative importance of AT energy storage and return in reducing E run should be re-considered., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Bennett, Machado and Fletcher.)

Purpose: To determine whether kinetic chain pattern during knee extensor strength training influences quadriceps femoris center of mass and moment of inertia about the hip in a predictable manner as such changes can affect running economy. Methods: Twelve participants completed 8 weeks of both unilateral open (OKC) and closed (CKC) kinetic chain resistance training on opposing legs. Changes in quadriceps femoris muscle volume (VOL QF ), center of mass location (CoM QF ), and moment of inertia ( I QF ) about the hip were determined from magnetic resonance images scans. Regional hemodynamics of the vastus lateralis taken at 30% and 70% of muscle length during OKC and CKC bouts early in the training program were measured using near-infrared spectroscopy (NIRS) and used post hoc to predict changes in CoM QF . Results: While increases in VOL QF were similar between OKC (Δ79.5 ± 87.9 cm 3 ) and CKC (Δ60.2 ± 110.5 cm 3 , p = 0.29), the patterns of hypertrophy differed; a distal shift in CoM QF (Δ2.4 ± 0.4 cm, p < 0.001) and increase in I QF (Δ0.017 ± 0.014 kg m 2 , p < 0.001) occurred in OKC but not in CKC (CoM QF : Δ-2.2 ± 2.0 cm, I QF : Δ-0.022 ± 0.020 kg m 2 , p > 0.05). Regional hemodynamics assessed by NIRS during a single training session displayed similar exercise and regional differences and predicted 39.6% of observed changes in CoM QF . Conclusions: is inversely related to running economy and since CKC exercise provides a more proximal pattern of hypertrophy than OKC, it may be more preferential for running. The results from the present study also highlight the potential of NIRS as a tool for predicting patterns of hypertrophy between different exercises and exercise conditions.QF and I QF , and these changes may be predicted in part from NIRS measurements during a single workout. Given I QF is inversely related to running economy and since CKC exercise provides a more proximal pattern of hypertrophy than OKC, it may be more preferential for running. The results from the present study also highlight the potential of NIRS as a tool for predicting patterns of hypertrophy between different exercises and exercise conditions., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Earp, Angelino, Hatfield, Colantuono, Jackson, Morgan, Adami, Melanson and Blazevich.)

The objectives of this study were to first determine whether a newly designed 3D-printed midsole, configured with a mechanism to increase anterior-posterior deformation, could increase anterior midsole shear during the stance phase of running. We then wanted to determine whether these shoes could affect running economy and smoothness. Two footwear conditions, differing in midsole technology, were used in this study. The control condition consisted of a thermoplastic polyurethane midsole (TPU-Control), whereas the prototype shoes (3D-Shear) were constructed with a 3D-printed lattice midsole designed for greater anterior foot displacement during early to mid-stance. Twenty male participants ran on a treadmill for 6 min in each condition, and data were collected during the final 2 min. Midsole shear was measured using 3D kinematic data; running smoothness was quantified with peak acceleration and jerk magnitudes from the foot, sacrum, and head; and running economy was determined with oxygen consumption data. As hypothesised, the anterior midsole shear was greater in the 3D-Shear condition compared to the TPU-Control. The 3D-Shear did not improve running economy. Runners exhibited significantly lower peak accelerations at the sacrum, along with lower magnitudes of jerk at the foot, sacrum, and head in the 3D-Shear condition, indicating smoother running patterns.

Purpose: The aim of the study was to compare the effects of isometric strength (IST) and plyometric training (PT) on endurance running performance. Methods: Twenty-six endurance runners (18 males and 8 females; age 36 ± 6 years, stature 1.69 ± 0.05 m body mass 61.6 ± 8.0 kg, VO 2max 50.4 ± 5.8 ml·kg -1 ·min -1 ) completed the countermovement jump (CMJ), isometric mid-thigh pull (IMTP), 2.4 km run time trial (2.4kmTT), running economy test (RE) and a graded exercise test measures at baseline. They were then randomly assigned to three groups, the control (CON), PT or IST group, and completed the circuit, plyometric or isometric training, respectively, twice a week for 6 weeks, while still continuing to perform their planned running training. They then completed the same set of measures performed at baseline post-intervention. Results: Significant time x group interactions and time main effect were observed for 2.4kmTT ( P = .002, ƞ 2 p  = .45 and P < .001, ƞ 2   =0.72), maximal aerobic speed (MAS) ( P = .006, ƞ 2 p  = .39), CMJ height ( P < .001, ƞ 2 p  = .55) and IMTP relative peak force ( P = .001, ƞ 2 p  = .50) in favor of PT and IST. Significant main effect for time was observed for 2.4kmTT ( P < .001, ƞ 2 p  = .72), RE ( P = .048, ƞ 2 p  = .17), VO 2max ( P = .047, ƞ 2 p  = .18), MAS ( P < .001, ƞ 2 p  = .63), CMJ height ( P < .001, ƞ 2 p  = .51) and IMTP relative peak force ( P < .001, ƞ 2 p  = .58). Conclusion: In conclusion, both PT and IST were similarly effective at enhancing running endurance performance. However, IST resulted in greater improvement to RE.

Purpose: This study aimed to investigate: 1. The influence of sex and age on the accuracy of the classical model of endurance performance, including maximal oxygen uptake ([Formula: see text]), its fraction (LT2 % ), and cost of running (C R ), for calculating running speed at lactate threshold 2 (vLT2) in young athletes. 2. The impact of different C R determination methods on the accuracy of the model. 3. The contributions of [Formula: see text], LT2 % , and C R to vLT2 in different sexes., Methods: 45 male and 55 female young squad athletes from different sports (age: 15.4 ± 1.3 years; [Formula: see text]: 51.4 ± 6.8 [Formula: see text]) performed an incremental treadmill test to determine [Formula: see text], LT2 % , C R , and vLT2. C R was assessed at a fixed running speed (2.8 [Formula: see text]), at lactate threshold 1 (LT1), and at 80% of [Formula: see text], respectively., Results: Experimentally determined and modeled vLT2 were highly consistent independent of sex and age (ICC [Formula: see text] 0.959). The accuracy of vLT2 modeling was improved by reducing random variation using individualized C R at 80% [Formula: see text] (± 4%) compared to C R at LT1 (± 7%) and at a fixed speed (± 8%). 97% of the total variance of vLT2 was explained by [Formula: see text], LT2 % , and C R . While [Formula: see text] and C R showed the highest unique (96.5% and 31.9% of total [Formula: see text], respectively) and common (- 31.6%) contributions to the regression model, LT2 % made the smallest contribution (7.5%)., Conclusion: Our findings indicate: 1. High accuracy of the classical model of endurance performance in calculating vLT2 in young athletes independent of age and sex. 2. The importance of work rate selection in determining C R to accurately predict vLT2. 3. The largest contribution of [Formula: see text] and C R to vLT2, the latter being more important in female athletes than in males, and the least contribution of LT2 % ., (© 2022. The Author(s).)

Introduction: The research examines the relationship between marathon performance and muscle stiffness changes from pre to marathon in recreational runners aged 50+ years., Methods: Thirty-one male long-distance runners aged 50-73 years participated in the experiment. The muscle stiffness of quadriceps and calves was measured in two independent sessions: the day before the marathon and 30 min after the completed marathon run using a Myoton device., Results and Discussion: The 42.195-km run was completed in 4.30,05 h ± 35.12 min, which indicates an intensity of 79.3% ± 7.1% of HRmax. The long-term, low-intensity running exercise (marathon) in older recreational runners and the low level of HRmax and VO2max showed no statistically significant changes in muscle stiffness (quadriceps and calves). There was reduced muscle stiffness ( p = 0.016), but only in the triceps of the calf in the dominant (left) leg. Moreover, to optimally evaluate the marathon and adequately prepare for the performance training program, we need to consider the direct and indirect analyses of the running economy, running technique, and HRmax and VO2max variables. These variables significantly affect marathon exercise., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Mackala, Mroczek, Chmura, Konefał, Pawlik, Ochman, Chmura, Paleczny, Seredyński, Wyciszkiewicz, Nowicka-Czudak, Łopusiewicz, Adamiec, Wiecha, Ponikowski and Ponikowska.)

Purpose: This study assessed the body composition, cardiorespiratory fitness, fiber type and mitochondrial function, and training characteristics of a 71-year-old runner who broke the world record marathon of the men's 70-74 age category and held several other world records. The values were compared to those of the previous world-record holder. Methods: Body fat percentage was assessed using air-displacement plethysmography. V ˙ O 2 max , running economy, and maximum heart rate were measured during treadmill running. Muscle fiber typology and mitochondrial function were evaluated using a muscle biopsy. Results: Body fat percentage was 13.5%, V ˙ O 2 max was 46.6 ml kg -1  min -1 , and maximum heartrate was 160 beats∙min -1 . At the marathon pace (14.5 km h -1 ), his running economy was 170.5 ml kg -1  km -1 . The gas exchange threshold and respiratory compensation point occurred at 75.7% and 93.9% of the V ˙ O 2 max , i.e., 13 km h -1 and 15 km h -1 , respectively. The oxygen uptake at the marathon pace corresponded to 88.5% of V ˙ O 2 max . Vastus lateralis fiber content was 90.3% type I and 9.7% type II. Average distance was 139 km∙w -1 in the year prior to the record. Conclusion: The 71-year-old world-record holder marathon showed a relatively similar V ˙ O 2 max , lower percentage of V ˙ O 2 max at marathon pace, but a substantially better running economy than his predecessor. The better running economy may result from an almost double weekly training volume compared to the predecessor and a high type I fiber content. He trained every day in the last ∼1.5 years and achieved international performance in his age group category with a small (<5% per decade) age-related decline in marathon performance., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Van Hooren and Lepers.)

Purpose: Previous research has shown that maximal oxygen uptake (VO2max) significantly influences performance in trail-running races up to 120 km but not beyond. Similarly, the influence of running economy on performance in ultratrail remains unclear. The aim of our study was, therefore, to determine the physiological predictors of performance in a 166-km trail-running race., Methods: Thirty-three experienced trail runners visited the laboratory 4 to 8 weeks before the race to undergo physiological testing including an incremental treadmill test and strength assessments. Correlations and regression analyses were used to determine the physiological variables related to performance., Results: Average finishing time was 37:33 (5:52) hours. Performance correlated significantly with VO2max (r = -.724, P < .001), velocity at VO2max (r = -.813, P < .001), lactate turn point expressed as percentage of VO2max (r = -.510, P = .018), cost of running (r = -.560, P = .008), and body fat percentage (r = .527, P = .012) but was not related to isometric strength. Regression analysis showed that velocity at VO2max predicted 65% of the variability in performance (P < .001), while a model combining VO2max and cost of running combined predicted 62% of the variability (P = .008)., Conclusion: This is the first study to show that VO2max and velocity at VO2max are significant predictors of performance in a 166-km trail-running race. This suggests that ultratrail runners should focus on the development of these 2 qualities to optimize their race performance.

Running power is a popular measure to gauge objective intensity. It has recently been shown, though, that foot-worn sensors alone cannot reflect variations in the exerted energy that stems from changes in the running economy. In order to support long-term improvement in running, these changes need to be taken into account. We propose leveraging the presence of two additional sensors worn by the most ambitious recreational runners for improved measurement: a watch and a heart rate chest strap. Using these accelerometers, which are already present and distributed over the athlete's body, carries more information about metabolic demand than a single foot-worn sensor. In this work, we demonstrate the mutual information between acceleration data and the metabolic demand of running by leveraging the information bottleneck of a constrained convolutional neural network. We perform lab measurements on 29 ambitious recreational runners (age = 28 ± 7 years, weekly running distance = 50 ± 25 km, V˙O2max = 60.3 ± 7.4 mL · min -1 ·kg -1 ). We show that information about the metabolic demand of running is contained in kinetic data. Additionally, we prove that the combination of three sensors (foot, torso, and lower arm) carries significantly more information than a single foot-worn sensor. We advocate for the development of running power systems that incorporate the sensors in watches and chest straps to improve the validity of running power and, thereby, long-term training planning.

Maximal oxygen uptake (V̇O 2max ) may be the single most important factor for long-distance running performance. Interval training, enabling high intensity, is forwarded as the format that yields the largest increase in V̇O 2max . However, it is uncertain if an optimal outcome on V̇O 2max , anaerobic capacity, and running performance is provided by training with a high aerobic intensity or high overall intensity. Thus, we randomized 48 aerobically well-trained men (23 ± 3 years) to three commonly applied interval protocols, one with high aerobic intensity (HIIT) and two with high absolute intensity (sprint interval training; SIT), 3× week for 8 weeks: (1) HIIT: 4 × 4 min at ~95% maximal aerobic speed (MAS) with 3 min active breaks. (2) SIT: 8 × 20 s at ~150% MAS with 10 s passive breaks. (3) SIT: 10 × 30 s at ~175% MAS with 3.5 min active breaks. V̇O 2max increased more (p < 0.001) following HIIT, 4 × 4 min (6.5 ± 2.4%, p < 0.001) than SIT, 8 × 20 s (3.3 ± 2.4%, p < 0.001) and SIT, 10 × 30 s (n.s.). This was accompanied by a larger (p < 0.05) increase in stroke volume (O 2 -pulse) following HIIT, 4 × 4 min (8.1 ± 4.1%, p < 0.001) compared with SIT, 8 × 20 s (3.8 ± 4.2%, p < 0.01) and SIT, 10 × 30 (n.s.). Anaerobic capacity (maximal accumulated oxygen deficit) increased following SIT, 8 × 20 s (p < 0.05), but not after HIIT, 4 × 4 min, nor SIT, 10 × 30 s. Long-distance (3000-m) endurance performance increased (p < 0.05-p < 0.001) in all groups (HIIT, 4 × 4 min: 5.9 ± 3.2%; SIT, 8 × 20 s: 4.1 ± 3.7%; SIT, 10 × 30 s: 2.2 ± 2.2%), with HIIT increasing more than SIT, 10 × 30 s (p < 0.05). Sprint (300-m) performance exhibited within-group increases in SIT, 8 × 20 s (4.4 ± 2.0%) and SIT, 10 × 30 s (3.3 ± 2.8%). In conclusion, HIIT improves V̇O 2max more than SIT. Given the importance of V̇O 2max for most endurance performance scenarios, HIIT should typically be the chosen interval format., (© 2022 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.)

There is current scientific interest in naturally sourced phenolic compounds and their potential benefits to health, as well as the effective role polyphenols may provide in an exercise setting. This study investigated the chronic effects of supplementation with a biodynamic and organic olive fruit water phytocomplex (OliPhenolia® [OliP]), rich in hydroxytyrosol (HT), on submaximal and exhaustive exercise performance and respiratory markers of recovery. Twenty-nine recreationally active participants (42 ± 2 yrs; 71.1 ± 2.1 kg; 1.76 ± 0.02 m) consumed 2 × 28 mL∙d−1 of OliP or a taste- and appearance-matched placebo (PL) over 16 consecutive days. Participants completed a demanding, aerobic exercise protocol at ~75% maximal oxygen uptake (V˙O2max) for 65 min 24 h before sub- and maximal performance exercise tests prior to and following the 16-day consumption period. OliP reduced the time constant (τ) (p = 0.005) at the onset of exercise, running economy (p = 0.015) at lactate threshold 1 (LT1), as well as the rating of perceived exertion (p = 0.003) at lactate turnpoint (LT2). Additionally, OliP led to modest improvements in acute recovery based upon a shorter time to achieve 50% of the end of exercise V˙O2 value (p = 0.02). Whilst OliP increased time to exhaustion (+4.1 ± 1.8%), this was not significantly different to PL (p > 0.05). Phenolic compounds present in OliP, including HT and related metabolites, may provide benefits for aerobic exercise and acute recovery in recreationally active individuals. Further research is needed to determine whether dose-response or adjunct use of OliP alongside longer-term training programs can further modulate exercise-associated adaptations in recreationally active individuals, or indeed support athletic performance.

Purpose: Carbon plates have been used to increase running shoes' longitudinal bending stiffness (LBS), leading to reductions in the energy cost of level running (Cr). However, whether or not this is true during uphill (UH) running remains unknown. The aim of our study was to identify the effect of LBS on Cr during UH running., Methods: Twenty well-trained male runners participated in this study. Cr was determined using gas exchange during nine 4-minute bouts performed using 3 different LBS shoe conditions at 2.22 and 4.44 m/s on level and 2.22 m/s UH (gradient: + 15%) running. All variables were compared using 2-way analyses of variance (LBS × speed/grade effects)., Results: There was no significant effect of LBS (F = 2.04; P = .14, ηp2=.11) and no significant LBS × grade interaction (F = 0.31; P = .87, ηp2=.02). Results were characterized by a very large interindividual variability in response to LBS changes., Conclusions: The current study contributes to a growing body of literature reporting no effect of LBS on Cr during level and UH running. Yet, the very large interindividual differences in response to changes in LBS suggest that increasing shoe LBS may be beneficial for some runners.

Footwear with or without custom foot orthotics have the potential to improve comfort, but the link with running performance needs further investigation. We systematically reviewed the association of footwear comfort on running economy in recreational runners. Nine electronic databases were searched from inception to March 2020. Eligible studies investigated both direct outcome measures of running performance (e.g. running speed) and/or physiological measures (e.g. running economy (RE)) alongside comfort for each footwear condition tested. Methodological quality was assessed using the "Effective Public Health Practice Project" (EPHPP). RE during submaximal running was the most common physiological outcome reported in 4 of the 6 eligible studies. The absolute difference in RE between the most and least comfortable footwear condition was computed, and meta-analysis was conducted using a random effect model. The most comfortable footwear is associated with a reduction in oxygen consumption (MD: -2.06 mL.kg -1 .min -1 , 95%CI: -3.71, -0.42, P  = 0.01) while running at a set submaximal speed. There was no significant heterogeneity ( I 2 = 0.82). EPHPP quality assessment demonstrated weak quality of the studies, due to reporting bias and failing to disclose the psychometric properties of the outcome measures. It can be concluded with moderate certainty that improved RE in recreational athletes is associated with wearing more comfortable footwear compared to less comfortable footwear.HighlightsThis systematic review reports on the association of footwear comfort with running economy in recreational runners.Running economy during constant submaximal running is likely improved in recreational runners wearing more comfortable compared to less comfortable footwear.This finding is based on a meta-analysis, including four studies, showing a small but statistically significant decreased oxygen consumption at steady state speeds while wearing the most comfortable footwear.P = 0.82). EPHPP quality assessment demonstrated weak quality of the studies, due to reporting bias and failing to disclose the psychometric properties of the outcome measures. It can be concluded with moderate certainty that improved RE in recreational athletes is associated with wearing more comfortable footwear compared to less comfortable footwear.HighlightsThis systematic review reports on the association of footwear comfort with running economy in recreational runners.Running economy during constant submaximal running is likely improved in recreational runners wearing more comfortable compared to less comfortable footwear.This finding is based on a meta-analysis, including four studies, showing a small but statistically significant decreased oxygen consumption at steady state speeds while wearing the most comfortable footwear.

Introduction: The maximum oxygen uptake (V˙O 2 max), the maximum rate of oxygen that can be sustained before the onset of blood lactate accumulation, and the metabolic cost of locomotion are the main physiological factors associated with long-distance running performance. The latter is known as the running economy. Generally, runners reach peak performance in long races between 25 and 30 years of age, with a progressive decline occurring thereafter. However, it is not known whether the running economy is affected or how it is affected by aging., Aim: To investigate the effect of age and years of running experience on the running economy of amateur long-distance runners aged 20-80 years., Methods: Sixty-nine recreational long-distance runners, divided into five age groups according to decade of life, participated in this study: Group 1 (n= 9) 27.2 ± 1.3 years, Group 2 (n= 18) 35.9 ± 2.2 years, Group 3 (n= 17) 43.4 ± 2.8 years, Group 4 (n= 17) 53.0 ± 2.3 years, and Group 5 (n= 8) 65.5 ± 2.9 years. For running economy assessment, oxygen cost (OC) and energy cost (EC) were measured. Furthermore, the participants were interviewed on their running experience., Results: For EC, the two independent variables composing the regression model were age (ß = 0.703, t= 5.443, p < 0.001) and running experience (ß = -0.230, t = -1.785, p= 0.07), and 34% of the energy cost variation can be explained by these two factors. EC and OC were compared among the groups. There were no significant differences between Groups 1 and 2 (p= 0.999), Groups 1 and 3 (p= 1.000), and Groups 1 and 4 (p= 0.528). However, Group 5 had a significantly higher energy cost than Group 1 (p < 0.001), Group 2 (p < 0.001), Group 3 (p < 0.001) and Group 4 (p < 0.001)., Conclusion: The number of years of running experience has a positive effect on running economy, but it is insufficient to overcome the negative effect of the aging process. Furthermore, running economy was significantly worse in participants aged ≥60 years compared with that in younger athletes., (Copyright © 2022 Elsevier Inc. All rights reserved.)

The effects of plyometric training (PT) on middle- and long-distance running performances are well established. However, its influence on pacing behaviour is still unclear. The aim of this study was to evaluate the effects of PT on pacing behaviour. In addition, verify whether the adaptations induced by PT would change ratings of perceived exertion (RPE) and/or affective feelings during the race. Twenty-eight male runners were assigned to two groups: control (C) and PT. PT held two weekly PT sessions for eight weeks. Drop jump (DJ) performance, 10-km running performance, pacing behaviour, RPE and affective feelings, VO 2peak , ventilatory thresholds (VT1 and VT2), peak treadmill speed (PTS), and running economy (RE) were measured. For group comparisons, a mixed model analysis for repeated measures, effect size (ES) and 90% confidence interval (90% CI) were calculated for all dependent variables. Significant differences pre-to-post was observed for PT group in DP (7.2%; p  ≤ 0.01; ES = 0.56 (0.28-0.85)) and RE (4.5%; p  ≤ 0.05; ES = -0.52 ((-0.73 to -0.31)) without changes in pacing behaviour. While PT was effective for improving DJ and RE, there is no evidence that pacing behaviour, RPE or affective feelings are directly affected by these adaptations during a 10-km time trial run.

The study aimed to investigate the effect of flywheel accentuated eccentric loading (AEL) training on the running economy (RE) of young male well-trained distance runners. Twenty-two runners participated and were randomly assigned to the flywheel (FG, n = 12) and the control group (CG, n = 10). Traditional endurance training was performed in both groups three times a week for 6-week, while traditional resistance and flywheel AEL training was added to the CG and FG respectively. Subjects performed the incremental exercise test, squat jump, and countermovement jump (CMJ) before and after training. The results showed that 1) the RE at 65% of peak oxygen consumption (VO 2 peak), 75% VO 2 peak, and 85% VO 2 peak improved significantly after 6 weeks of training ( p < 0.01, Effect size (ES) = 0.76; p < 0.01, ES = 1.04; p < 0.01, ES = 1.85) in FG, and the RE of 85% VO 2 peak in FG was significantly lower than CG ( p < 0.05, ES = 0.30); 2) in post-training, both squat jump ( p < 0.01, ES = 0.73) and CMJ ( p < 0.01, ES = 1.15) performance, eccentric utilization ratio ( p < 0.04, ES = 0.44), the rate of force development (RFD) of squat jump ( p < 0.05, ES = 0.46), and CMJ RFD ( p < 0.01, ES = 0.66) were significantly improved in FG. And there are no significant differents in CG group because it was maintain training for our participants. Our findings showed that 1) flywheel AEL training improves the muscles' explosive strength and other neuromuscular functions, and improves the athlete's running economy under 65%, 75%, and 85% VO 2 peak, which potentially increases endurance performance. 2) Flywheel AEL training can improve the height, RFD, and the eccentric utilization ratio of squat jump and CMJ, and other lower limb elastic potential energy indicators of the young male, well-trained distance runners., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Weng, Liu, Ruan, Yang, Wei, Cui, Ho and Li.)

It is not fully understood how supplementation with omega-3 fatty acids affects the metabolism of amino acids required for the bioavailability/synthesis of NO, i.e., L-arginine (L-arg), asymmetric dimethylarginine (ADMA), their metabolites, and the L-arg/ADMA ratio and their impact on running economy (RE) in runners. Thus, 26 male amateur endurance runners completed a twelve-week study in which they were divided into two supplemented groups: the OMEGA group (n = 14; 2234 mg and 916 mg of eicosapentaenoic and docosahexaenoic acid daily) or the MCT group (n = 12; 4000 mg of medium-chain triglycerides daily). At the same time, all participants followed an endurance training program. Before and after the 12-week intervention, blood was collected from participants at two time points (at rest and immediately post-exercise) to determine EPA and DHA in red blood cells (RBCs) and plasma levels of L-arg, ADMA, and their metabolites. RBC EPA and DHA significantly increased in the OMEGA group (p < 0.001), which was related to the resting increase in L-arg (p = 0.001) and in the L-arg/ADMA ratio (p = 0.005) with no changes in the MCT group. No differences were found in post-exercise amino acid levels. A total of 12 weeks of omega-3 fatty acid supplementation at a dose of 2234 mg of EPA and 916 mg of DHA daily increased levels of L-arg and the L-arg/ADMA ratio, which indirectly indicates increased bioavailability/NO synthesis. However, these changes were not associated with improved RE in male amateur endurance runners.

Peak oxygen uptake (VO 2peak ) is one of the most reliable parameters of exercise capacity; however, maximum effort is required to achieve this. Therefore, alternative, and repeatable submaximal parameters, such as running economy (RE), are needed. Thus, we evaluated the suitability of oxygen uptake efficiency (OUE), oxygen uptake efficiency plateau (OUEP) and oxygen uptake efficiency at the ventilatory anaerobic threshold (OUE@VAT) as alternatives for VO 2peak and RE. Moreover, we evaluated how these parameters are affected by endurance training and supplementation with omega-3 fatty acids. A total of 26 amateur male runners completed a 12-week endurance program combined with omega-3 fatty acid supplementation or medium-chain triglycerides as a placebo. Before and after the intervention, the participants were subjected to a treadmill test to determine VO 2peak , RE, OUE, OUEP and OUE@VAT. Blood was collected at the same timepoints to determine eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes. OUE correlated moderately or weakly with VO 2peak (R 2 = 0.338, p = 0.002) and (R 2 = 0.226, p = 0.014) before and after the intervention, respectively. There was a weak or no correlation between OUEP, OUE@VAT, VO 2peak and RE despite steeper OUE, increased OUEP and OUE@VAT values in all participants. OUE parameters cannot be treated as alternative parameters for VO 2peak or RE and did not show changes following supplementation with omega-3 fatty acids in male amateur endurance runners.

Running has become increasingly popular worldwide. Among runners, there exists a wide range of expertise levels. Investigating the differences between runners at two extreme levels, that is novices and experts, is crucial to understand the changes that occur as a result of multiple years of training. Vertical oscillation of center of mass (CoM), stride frequency normalized to the leg length, and duty factor, which describes the step time relative to the flight time, are key biomechanical parameters that have been shown to be closely related to the running economy and are used to characterize the running style. The variability characteristics of these parameters may reveal valuable information concerning the control of human locomotion. However, how the expertise level and running speed affect the variability of these key biomechanical parameters has not yet been investigated. The aim of this study was to analyze the effects of expertise level (novice vs. expert) and running speed (10 km/h vs. 15 km/h) on these parameters and their variability. It was hypothesized that expert runners would have lower vertical oscillation of CoM, normalized stride frequency, and duty factor and show less variability in these parameters. The parameters' variability was operationalized by the coefficient of variation. The mean values and variability of these key biomechanical parameters according to expertise level and running speed were compared with rmANOVAs. The results showed that the experts had a lower duty factor and less variable vertical oscillation of CoM and normalized stride frequency, independently of the running speed. At a higher running speed, the variability of vertical oscillation of CoM was higher, whereas that of normalized stride frequency and duty factor did not change significantly. To the best of our knowledge, this is the first study analyzing the effects of expertise level and running speed on the variability of key biomechanical parameters.

The purpose of the present study was to investigate whether and how dynamic stretching of the plantarflexors may influence running economy. A crossover design with a minimum of 48 h between experimental (dynamic stretching) and control conditions was used. Twelve recreational runners performed a step-wise incremental protocol to the limit of tolerance on a motorised instrumented treadmill. The initial speed was 2.3 m/s, followed by increments of 0.2 m/s every 3 min. Dynamic joint stiffness, vertical stiffness and running kinematics during the initial stage of the protocol were calculated. Running economy was evaluated using online gas-analysis. For each participant, the minimum number of stages completed before peak O 2 uptake (V̇O 2peak ) common to the two testing conditions was used to calculate the gradient of a linear regression line between V̇O 2 ( y -axis) and speed ( x -axis). The number of stages, which ranged between 4 and 8, was used to construct individual subject regression equations. Non-clinical forms of magnitude-based decision method were used to assess outcomes. The dynamic stretching protocol resulted in a possible decrease in dynamic ankle joint stiffness (-10.7%; 90% confidence limits ±16.1%), a possible decrease in vertical stiffness (-2.3%, ±4.3%), a possibly beneficial effect on running economy (-4.0%, ±8.3%), and very likely decrease in gastrocnemius medialis muscle activation (-27.1%, ±39.2%). The results indicate that dynamic stretching improves running economy, possibly via decreases in dynamic joint and vertical stiffness and muscle activation. Together, these results imply that dynamic stretching should be recommended as part of the warm-up for running training in recreational athletes examined in this study., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Pamboris, Noorkoiv, Baltzopoulos, Powell, Howes and Mohagheghi.)

Background: Running is a common recreational activity, and the number of long-distance-race participants is continuously growing. It is well-established that regular physical activity can prevent and manage non-communicable diseases and benefit public health. Training for a long-distance race requires development of specific aerobic abilities and should generate the desired race performance. The purpose of this study was to support the training design and motivation of recreational endurance runners, by investigating whether a 14.5 km race performance of long-distance runners correlates with their cardiopulmonary indices measured in the laboratory., Methods: To examine the relationships of a 14.5 km running performance with the cardiopulmonary parameters of amateur runners, a cross-sectional study design was applied. Fifteen (eleven men and four women) recreational long-distance runners (aged 41.3 ± 9.2 years) from Northern Greece were included in the study and were evaluated in the laboratory within one week before an endurance running race-the 14.5 km Philip Road race, in Greece. The laboratory-based examinations of the athletes consisted of a comprehensive medical pre-participation screening and maximal cardiopulmonary exercise testing., Results: The results showed that the 14.5 km race performance time (73.8 ± 9.7 min) significantly correlated with the cardiopulmonary-exercise-testing speed-related indices at specific submaximal and maximal workloads ( p < 0.01, p < 0.05), while the cardiopulmonary indices of oxygen uptake did not reliably predict race running time ( p > 0.05)., Conclusions: There is a better correlation of the 14.5 km running performance of recreational long-distance runners with the cardiopulmonary-exercise-testing speed-related indices at specific workloads than with the indices of oxygen uptake, running economy or respiratory economy. When preparing a training strategy, amateur long-distance runners should mostly rely on specific running-speed-related laboratory data rather than on oxygen-uptake values.

When will women run a sub-4-minute mile? The answer seems to be a distant future given how women's progress has plateaued in the mile, or its better studied metric placeholder, the 1500 m. When commonly accepted energetics principles of running, along with useful field validation equations of the same, are applied to probe the physiology underpinning the 10 all-time best women's mile performances, insights gained may help explain the present 12.34-second shortfall. Insights also afford estimates of how realistic improvements in the metabolic cost of running could shrink the difference and bring the women's world record closer to the fabled 4-minute mark. As with men in the early 1950s, this might stir greater interest, excitement, participation, and depth in the women's mile, the present absence of which likely contributes to more pessimistic mathematical modeling forecasts. The purpose of this invited commentary is to provide a succinct, theoretical, but intuitive explanation for how women might get closer to their own watershed moment in the mile.

Traditional movement economy (ME) measures the energetic cost of in-line running. However, it is debatable whether such a measure is representative of movement efficiency for team sport athletes who are required to run and change direction repeatedly. This study evaluated ME during both in-line running and runs with directional changes and provided a preliminary exploration as to whether these abilities discriminate soccer players according to playing position, level, and sex. Forty-three soccer players were assessed for ME as extrapolated from oxygen uptake during in-line running (RE) and running with changes of directions (using 20 and 10 m shuttle runs [SRE 20 and SRE 10 ]) at 8.4 km/h mean speed. ME worsened with change of direction frequency ( p  < 0.001). Coefficient of determination was high between RE and SRE 20 ( r 2  =   0.601) but dropped below 0.5 for RE and SRE 10 ( r 2  = 0.280) as change of direction frequency increased. No significant differences were observed between different player positions, however, centre midfielders reported the best ME across any position and running mode, with the largest differences observed in centre backs over SRE 10 (41.9 ± 2.7 ml/kg/min [centre midfielders] vs 45 ± 1.8 ml/kg/min [centre backs]; ES = 1.19). No significant differences were observed for ME over any running condition for male players of different playing levels. Female players exhibited better ME than male players with significant differences observed for SRE 10 (41.5 ± 2.6 ml/kg/min [females] vs 44 ± 2.6 ml/kg/min [males]; p  = 0.013; ES = 0.94). RE does not adequately account for efficiency during activities that involve changes of direction. SRE 10 is a stronger discriminator of ME between soccer players of different position and sex.

Background: A significant challenge that non-elite collegiate triathletes encounter during competition is the decline in running performance immediately after cycling. Therefore, the purpose of this study was to determine if performing a 40-km bout of cycling immediately before running would negatively influence running economy and mechanical efficiency of running during simulated race conditions in collegiate triathletes., Methods: Eight competitive club-level collegiate triathletes randomly performed two trials: cycling for 40 km (Cycle-Run) or running for 5 km (Run-Run), immediately followed by a four-minute running economy and mechanical efficiency of running test at race pace on an instrumented treadmill. Blood lactate, respiratory exchange ratio, mechanical work, energy expenditure, and muscle glycogen were also measured during the four-minute running test., Results: Mechanical efficiency of running, but not running economy, was significantly lower in Cycle-Run, compared to Run-Run (42.1 ± 2.5% vs. 48.1 ± 2.5%, respectively; p = 0.027). Anaerobic energy expenditure was significantly higher in the Cycle-Run trial, compared to the Run-Run trial (16.3 ± 2.4 vs. 7.6 ± 1.1 kJ; p = 0.004); while net (151.0 ± 12.3 vs. 136.6 ± 9.6 kJ; p = 0.204) and aerobic energy expenditure (134.7 ± 12.3 vs. 129.1 ± 10.5 kJ; p = 0.549) were not statistically different between trials. Analysis of blood lactate, respiratory exchange ratio, mechanical work, and changes in muscle glycogen revealed no statistically significant differences between trials., Conclusions: These results suggest that mechanical efficiency of running, but not running economy, is decreased and anaerobic energy expenditure is increased when a 40-km bout of cycling is performed immediately before running in collegiate triathletes., (© 2022. The Author(s).)

The prediction of running performance at different competitive distances is a challenge, since it can be influenced by several physiological, morphological and biomechanical factors. In experienced male runners heterogeneous for maximal oxygen uptake (VO 2 max), endurance running performance can be well predicted by several key parameters of aerobic fitness such as VO 2 max and its respective velocity (vVO 2 max), running economy, blood lactate response to exercise, oxygen uptake kinetics and critical velocity. However, for a homogeneous group of well-trained endurance runners, the relationship between aerobic fitness parameters and endurance running performance seems to be influenced by the duration of the race (i.e., middle vs. long). Although middle-distance and ultramarathon runners present high aerobic fitness levels, there is no accumulating evidence showing that the aerobic key parameters influence both 800-m and ultramarathon performance in homogeneous group of well-trained runners. The vVO 2 max seems to be the best predictor of performance for 1500 m. For 3000 m, both vVO 2 max and blood lactate response to exercise are the main predictors of performance. Finally, for long distance events (5000 m, 10,000 m, marathon and ultramarathon), blood lactate response seems to be main predictor of performance. The different limiting/determinants factors and/or training-induced changes in aerobic parameters can help to explain this time- or distance-dependent pattern., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 The Authors.)

Introduction: Breast pain is a major barrier to running for women. While breast support through the use of sports bras reduces breast-related discomfort, the effect of breast support on running performance is less understood. Therefore, the purpose of the current study was to evaluate the effect of greater breast support on oxygen consumption and running economy during a treadmill running task., Methods: Fifteen female recreational runners performed a 10-min treadmill running task at their preferred running speed in each of two sports bra conditions: low support and high support. Participants ran on an instrumented treadmill (1,200 Hz, Bertec) while indirect calorimetry was performed using a metabolic measurement system (100 Hz, TrueOne, ParvoMedics). Average VO 2 (absolute and relative) from the third to 10th minutes was used to evaluate oxygen consumption. Running economy was calculated as the distance traveled per liter of oxygen consumed. Paired samples t -tests were used to compare mean oxygen consumption and running economy values between breast support conditions. Correlation analysis was performed to evaluate the relationship between breast size and change in running performance., Results: Greater breast support was associated with reductions in absolute ( p < 0.001) and relative oxygen consumption ( p < 0.001; LOW: 30.9 ± 7.1 ml/kg/min; HIGH: 28.7 ± 6.7 ml/kg/min). Greater breast support was associated with increases in running economy ( p < 0.001; LOW: 88.6 ± 29.1 m/L O 2 ; HIGH: 95.2 ± 31.1 m/L O 2 ). No changes in temporospatial characteristics of running were observed including cadence ( p = 0.149), step length ( p = 0.300) or ground contact time ( p = 0.151). Strong positive linear correlations were observed between the change in running performance metrics and breast size (Oxygen Consumption: p < 0.001, r = 0.770; Relative Oxygen Consumption: p < 0.001, r = 0769; Running Economy: p < 0.001, r = 0.807)., Conclusions: Greater breast support was associated with reduced oxygen consumption and increased running economy. These findings demonstrate that greater breast support is not only associated with improved comfort but also improved running performance., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Fong and Powell.)

The purpose of this study was to examine the changes in metabolic heat production (Hprod), evaporative heat loss (Hevap), and dry heat loss (Hdry), following heat acclimatization (HAz) and heat acclimation (HA). Twenty-two male endurance athletes (mean ± standard deviation; age, 37 ± 12 y; body mass, 73.4 ± 8.7 kg; height, 178.7 ± 6.8 cm; and VO2max, 57.1 ± 7.2 mL·kg−1·min−1) completed three trials (baseline; post-HAz; and post-HA), which consisted of 60 min steady state exercise at 59 ± 2% velocityVO2max in the heat (ambient temperature [Tamb], 35.2 ± 0.6 °C; relative humidity [%rh] 47.5 ± 0.4%). During the trial, VO2 and RER were collected to calculate Hprod, Hevap, and Hdry. Following the baseline trial, participants completed self-directed outdoor summer training followed by a post-HAz trial. Then, five days of HA were completed over eight days in the heat (Tamb, 38.7 ± 1.1 °C; %rh, 51.2 ± 2.3%). During the HA sessions, participants exercised to maintain hyperthermia (38.50 °C and 39.75 °C) for 60 min. Then, a post-HA trial was performed. There were no differences in Hprod between the baseline (459 ± 59 W·m−2), post-HAz (460 ± 61 W·m−2), and post-HA (464 ± 55 W·m−2, p = 0.866). However, Hevap was significantly increased post-HA (385 ± 84 W·m−2) compared to post-HAz (342 ± 86 W·m−2, p = 0.043) and the baseline (332 ± 77 W·m−2, p = 0.037). Additionally, Hdry was significantly lower at post-HAz (125 ± 8 W·m−2, p = 0.013) and post-HA (121 ± 10 W·m−2, p < 0.001) compared to the baseline (128 ± 7 W·m−2). Hdry at post-HA was also lower than post-HAz (p = 0.049). Hprod did not change following HAz and HA. While Hdry was decreased following HA, the decrease in Hdry was smaller than the increases in Hevap. Adaptations in body heat exchange can occur by HA following HAz.

Background: Compared to conventional racing shoes, Nike Vaporfly 4% running shoes reduce the metabolic cost of level treadmill running by 4%. The reduction is attributed to their lightweight, highly compliant, and resilient midsole foam and a midsole-embedded curved carbon-fiber plate. We investigated whether these shoes also could reduce the metabolic cost of moderate uphill (+3°) and downhill (-3°) grades. We tested the null hypothesis that, compared to conventional racing shoes, highly cushioned shoes with carbon-fiber plates would impart the same ∼4% metabolic power (W/kg) savings during uphill and downhill running as they do during level running., Methods: After familiarization, 16 competitive male runners performed six 5-min trials (2 shoes × 3 grades) in 2 Nike marathon racing-shoe models (Streak 6 and Vaporfly 4%) on a level, uphill (+3°), and downhill (-3°) treadmill at 13 km/h (3.61 m/s). We measured submaximal oxygen uptake and carbon dioxide production during Minutes 4-5 and calculated metabolic power (W/kg) for each shoe model and grade combination., Results: Compared to the conventional shoes (Streak 6), the metabolic power in the Vaporfly 4% shoes was 3.83% (level), 2.82% (uphill), and 2.70% (downhill) less (all p < 0.001). The percent of change in metabolic power for uphill running was less compared to level running (p = 0.04; effect size (ES) = 0.561) but was not statistically different between downhill and level running (p = 0.17; ES = 0.356)., Conclusion: On a running course with uphill and downhill sections, the metabolic savings and hence performance enhancement provided by Vaporfly 4% shoes would likely be slightly less overall, compared to the savings on a perfectly level race course., Competing Interests: Competing interests WH has received research grants from Puma and Saucony; RK is a paid consultant for Nike. Puma, Saucony, and Nike were not involved in the study design, the writing of the manuscript, or the decision to submit it for publication. CSW has no conflicts of interest relevant to the content of this article., (Copyright © 2022. Production and hosting by Elsevier B.V.)