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Aim: Limited data are available on the fitting properties of prototyped occlusal appliances. The aim of the present study was to assess the fitting of prototyped splints digitally designed with different offset values and generated with two different biocompatible resins., Materials and Methods: Ten dental digital models were included, and occlusal splints were designed with different offset values (0.0, 0.05, 0.10, 0.15, 0.20, and 0.25 mm). Each splint was 3D printed using two different biocompatible resins, and the gap between the splint and the teeth was recorded by placing impression material. A specific 3D technology was used to assess the gap volume between the splint and the teeth and to calculate the Euclidean distance between the surface points of two digital models, with and without the gap volume., Results: The splints with a 0.20-mm offset value showed smaller gap volume and deviation analysis values compared with those with offset values of 0.15 and 0.25 mm (P < 0.05). These results were consistent with both types of biocompatible resins used. For each offset value tested, the gap volume and deviation value analysis did not significantly differ between the splints printed with the two different resins., Conclusion: According to the present findings, the 0.20-mm offset value would be the best choice when digitally designing occlusal appliances.

Background: Maxillary transverse discrepancy is often diagnosed in childhood. The evaluation of morphological characteristics of the maxilla is crucial for appropriate treatment of this condition, however conventional diagnostic method is based on visual inspection and transversal linear parameters. In this paper, we described a user-friendly diagnostic digital workflow based on the surface-to-surface analysis. We also described a case report., Case Report: A 6-year-old female patient presenting mild transversal maxillary deficiency associated with functional posterior crossbite was treated by using maxillary removable appliance. In this respect, the appliance was designed in accordance to the morphological characteristics of the maxilla obtained by using the diagnostic digital work-flow and the maxillary surface-to-surface analysis., Conclusion: The present user-friendly diagnostic digital workflow based on surface-to-surface analysis helps clinicians to detect specific morphological characteristics of the maxilla, such as shape and area of asymmetry, in order to reach a comprehensive diagnosis and choose the correct biomechanics for treating the condition.

Introduction: The goal of this study was to compare the size and morphologic symmetry of the maxillary teeth in subjects with and without unilateral palatally displaced canines (PDCs)., Methods: Plaster casts of 38 subjects (mean age 14.75 ± 0.95 y) with unilateral PDCs were selected (study group [SG]) and compared with casts from an age- and sex-matched control group (CG). Then dental casts of both groups were scanned into 3-dimensional (3D) models. Tooth sizes (mesiodistal [MD] and buccolingual [BL] widths and volumes) for SG and CG were measured. Afterward, 3D deviation analysis was carried out with the use of Geomagic Control X software. All of the data were normally distributed according to parametric tests., Results: All of the maxillary tooth diameters were smaller in SG than in CG. Statistically significant differences (P ≤ 0.001) were obtained when comparing the widths and volumes of the PDC quadrant and the unaffected quadrant of the same patient. Morphologic tooth symmetry by surface-to-surface matching for SG (PDC side vs non-PDC side) and CG (right vs left quadrant) demonstrated significant (P ≤ 0.001) but small differences, except for the lateral upper incisors (71.27%)., Conclusions: Unlike control subjects, PDC patients showed high mismatching of lateral incisor crowns of ∼30%., (Copyright © 2018. Published by Elsevier Inc.)

Background and Objectives: Some authors have recently postulated the possibility of a unilateral contraction of the palate in patients with crossbite. This study aimed to investigate palatal dimension size and morphology in subjects with functional posterior crossbite and to localize location of the contraction through a 3D analysis procedure., Materials and Methods: A study sample (SS) of 35 subjects (mean age 9.2 ± 0.8 years), diagnosed with functional crossbite, and a control sample (CS) of 35 subjects (mean age 9.4 ± 0.9 years) without crossbite were selected for this study. The digital models of each patient were analysed to assess palatal dimension size and symmetry by measuring linear distances between primary canines (D1) and fist molars (D2) to the median palatine plane and by performing and analysing the 3D deviation between the two specular models of the palatal vault for each patient., Results: Our findings demonstrate a significantly narrower dimension of D2 for the crossbite side than at the non-crossbite side. The 3D deviation analysis demonstrates a lower matching percentage of the palatal vault models in the SS (83.36%) compared with the CS (92.82%) and a location of that the palatal contraction is at the alveolar bone level., Conclusions: It can be assumed that there is a bilateral symmetrical contraction of the palatal vault and an asymmetric contraction of the alveolar process, but further studies are needed to corroborate this hypothesis.

Motivation: High-throughput sequencing technologies provide access to an increasing number of bacterial genomes. Today, many analyses involve the comparison of biological properties among many strains of a given species, or among species of a particular genus. Tools that can help the microbiologist with these tasks become increasingly important., Results: Insyght is a comparative visualization tool whose core features combine a synchronized navigation across genomic data of multiple organisms with a versatile interoperability between complementary views. In this work, we have greatly increased the scope of the Insyght public dataset by including 2688 complete bacterial genomes available in Ensembl thus vastly improving its phylogenetic coverage. We also report the development of a virtual machine that allows users to easily set up and customize their own local Insyght server., Availability and Implementation: http://genome.jouy.inra.fr/Insyght, Contact: Thomas.Lacroix@jouy.inra.fr., (© The Author 2015. Published by Oxford University Press.)