1. Antimicrobial and in silico studies of the triterpenoids of Dichapetalum albidum.
- Author
-
Chama MA, Dziwornu GA, Popli E, Mas-Claret E, Egyir B, Ayine-Tora DM, Owusu KB, Reid DG, Osei-Safo D, Duer M, Mulholland D, and Bender A
- Abstract
Here we report a new polyhydroxylated triterpene, 2β,6β,21α-trihydroxyfriedelan-3-one ( 4 ) isolated from the root and stem bark of Dichapetalum albidum A. Chev (Dichapetalaceae), along with six known triterpenoids ( 1 - 3 , 5 , 6 , 8 ), sitosterol-3β- O -D-glucopyranoside ( 9 ), a dipeptide ( 7 ), and a tyramine derivative of coumaric acid ( 10 ). Friedelan-3-one ( 2 ) showed an antimicrobial activity (IC
50 ) of 11.40 μg/mL against Bacillus cereus , while friedelan-3α-ol ( 1 ) gave an IC50 of 13.07 μg/mL against Staphylococcus aureus with ampicillin reference standard of 19.52 μg/mL and 0.30 μg/mL respectively. 3β-Acetyl tormentic acid ( 5 ) showed an IC50 of 12.50 μg/mL against Trypanosoma brucei brucei and sitosterol-3β- O -d-glucopyranoside ( 9 ) showed an IC50 of 5.06 μg/mL against Leishmania donovani with respective reference standards of IC50 5.02 μg/mL for suramin and IC50 0.27 μg/mL for amphotericin B. Molecular docking of the isolated compounds on the enzyme glucose-6-phosphate dehydrogenase (G6PDH) suggested 3β-acetyl tormentic acid ( 5 ) and sitosterol-3β- O -D-glucopyranoside ( 9) as plausible inhibitors of the enzyme in accordance with the experimental biological results observed., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 Published by Elsevier Ltd.)- Published
- 2023
- Full Text
- View/download PDF