1. [Macro-AST and myeloma: An incidental association?]
- Author
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Lartigau-Roussin C, Paclet MH, Audin H, Toussaint B, Henni T, and Raffray L
- Subjects
- Female, Humans, Liver Diseases blood, Middle Aged, Multiple Myeloma blood, Paraproteinemias blood, Paraproteinemias complications, Paraproteinemias diagnosis, Up-Regulation, Aspartate Aminotransferases blood, Liver Diseases complications, Liver Diseases diagnosis, Multiple Myeloma complications, Multiple Myeloma diagnosis
- Abstract
Introduction: Macro-AST is recognized as a classical aetiology of isolated and persistent increase of serum aspartate aminotransferase (AST) levels. Macro-AST are high molecular weight complexes associating AST and a macromolecule, often an immunoglobulin. Although those macroenzymes of unknown pathogenesis are usually non-pathogenic, association with several diseases, including autoimmune diseases and liver diseases has been described., Case Report: We report here the case of a 45-year-old patient with previously normal liver enzymes in whom an AST elevation and an IgA monoclonal gammopathy were discovered concomitantly. Following the diagnosis of multiple myeloma, we could evidence in the patient's serum a complex between AST and the monoclonal IgA. AST levels course followed closely the progression of monoclonal gammopathy., Conclusion: This is the first report demonstrating a clear link between macro-AST and a monoclonal gammopathy., (Copyright © 2016 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.)
- Published
- 2017
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