1. Volumetric alterations in the basal ganglia in autism Spectrum disorder: A systematic review.
- Author
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de Medeiros Marcos GVT, Feitosa DDM, Paiva KM, Oliveira RF, da Rocha GS, de Medeiros Guerra LM, de Araújo DP, Goes HM, Costa S, de Oliveira LC, Guzen FP, de Souza Júnior JE, de Moura Freire MA, de Aquino ACQ, de Gois Morais PLA, and de Paiva Cavalcanti JRL
- Subjects
- Humans, Autism Spectrum Disorder diagnostic imaging, Autism Spectrum Disorder pathology, Autism Spectrum Disorder physiopathology, Basal Ganglia pathology, Basal Ganglia diagnostic imaging
- Abstract
Introduction: Recent research indicates that some brain structures show alterations in conditions such as Autism Spectrum Disorder (ASD). Among them, are the basal ganglia that are involved in motor, cognitive and behavioral neural circuits., Objective: Review the literature that describes possible volumetric alterations in the basal ganglia of individuals with ASD and the impacts that these changes have on the severity of the condition., Methodology: This systematic review was registered in the design and reported according to the PRISMA Items and registered in PROSPERO (CRD42023394787). The study analyzed data from published clinical, case-contemplate, and cohort trials. The following databases were consulted: PubMed, Embase, Scopus, and Cochrane Central Register of Controlled Trials, using the Medical Subject Titles (MeSH) "Autism Spectrum Disorder" and "Basal Ganglia". The last search was carried out on February 28, 2023., Results: Thirty-five eligible articles were collected, analyzed, and grouped according to the levels of alterations., Conclusion: The present study showed important volumetric alterations in the basal ganglia in ASD. However, the examined studies have methodological weaknesses that do not allow generalization and correlation with ASD manifestations., (© 2024 International Society for Developmental Neuroscience.)
- Published
- 2024
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