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The present work aims to provide the readers with a bird's-eye view of the general domain of cylindrical gear manufacturing technologies, including the cutting tools used, and related topics. The main scientific sources are explored to collect data about the subject. A systematization of the scientific works is completed, to emphasize the main issues the researchers have focused on in the past years in the domain. Several specific aspects are investigated: chip-forming process, cutting tool lifetime, the materials used to produce gear hobs, temperature and lubrication, the cutting tool geometry, cutting parameters, design methods, and optimization. Some gaps in the research have been identified, which are mainly related to the gear hob's design. These gaps, the organization of knowledge, the current requirements of the industry, and the actual socio-economic priorities form the basis for identifying new scientific research directions for the future in the area of spur gears manufacturing technologies and cutting tools. The main output of this work is a frame to guide the development of scientific research in the domain of spur gear production.

Previous literature suggests that correcting ongoing movements is more effective when using the dominant limb and seeing with the dominant eye. Specifically, individuals are more effective at adjusting their movement to account for an imperceptibly perturbed or changed target location (i.e., online movement correction), when vision is available to the dominant eye. However, less is known if visual-motor functions based on monocular information can undergo short-term neuroplastic changes after a bout of practice, to improve online correction processes. Participants ( n  = 12) performed pointing movements monocularly and their ability to correct their movement towards an imperceptibly displaced target was assessed. On the first day, the eye associated with smaller correction amplitudes was exclusively trained during acquisition. While correction amplitude was assessed again with both eyes monocularly, only the eye with smaller correction amplitudes in the pre-test showed significant improvement in delayed retention. These results indicate that monocular visuomotor pathways can undergo short-term neuroplastic changes.

We present the case of an 18-month-old girl, from rural area, admitted to our clinic for fever and cough. The anamnestic data and the clinical and radiological examinations initially suggested the diagnosis of acute interstitial pneumonia. During hospitalization, she repeatedly presented exacerbations with acute respiratory failure, but without fever. Paraclinic examinations revealed anemia, leukocytosis, inflammatory tests with highly increased values, low values of serum iron and serum calcium, hyperproteinemia with hypergammaglobulinemia, the values of IgE and IgG being highly increased. Repeated pulmonary x-rays-peribronchovascular interstitial thickening, at the level of peri-and right infrahilar area. Medullary puncture-increased percentage of eosinophils in several stages of maturity, approximately 20%, normal values for the other medullary series, without atypical cells; the fingertip hemogram showed anemia, leukocytosis, eosinophilia. The diagnosis turned to a possible toxocariasis-atc anti toxocara canis=55.6 NTU. In the third week of hospitalization, the patient presented short crises of nonfebrile seizures. Normal CT and EEG brain. The child was discharged after 5 weeks, the diagnosis being severe toxocariasis with pulmonary and neurological manifestations; she was recommended an antiparasitary treatment and remained in our clinic's records.

The transporter associated with antigen processing (TAP) represents a focal point in the immune recognition of virally or malignantly transformed cells by translocating proteasomal degradation products into the endoplasmic reticulum-lumen for loading of MHC class I molecules. Based on a number of experimental data and the homology to the bacterial ABC exporter Sav1866, we constructed a 3D structural model of the core TAP complex and used it to examine the interface between the transmembrane and nucleotide-binding domains (NBD) by cysteine-scanning and cross-linking approaches. Herein, we demonstrate the functional importance of the newly identified X-loop in the NBD in coupling substrate binding to downstream events in the transport cycle. We further verified domain swapping in a heterodimeric ABC half-transporter complex by cysteine cross-linking. Strikingly, either substrate binding or translocation can be blocked by cross-linking the X-loop to coupling helix 2 or 1, respectively. These results resolve the structural arrangement of the transmission interface and point to different functions of the cytosolic loops and coupling helices in substrate binding, signaling, and transport.

By translocating proteasomal degradation products into the endoplasmic reticulum for loading of major histocompatibility complex I molecules, the ABC transporter TAP plays a focal role in the adaptive immunity against infected or malignantly transformed cells. A key question regarding the transport mechanism is how the quality of the incoming peptide is detected and how this information is transmitted to the ATPase domains. To identify residues involved in this process, we evolved a Trojan horse strategy in which a small artificial protease is inserted into antigenic epitopes. After binding, the TAP backbone in contact is cleaved, allowing the peptide sensor site to be mapped by mass spectrometry. Within this sensor site, we identified residues that are essential for tight coupling of peptide binding and transport. This sensor and transmission interface is restructured during the ATP hydrolysis cycle, emphasizing its important function in the cross-talk between the transmembrane and the nucleotide-binding domains. This allocrite sensor may be similarly positioned in other members of the ABC exporter family.