1. Higher relative risk of spondyloarthropathies among B27 positive Indonesian Chinese than native Indonesians.
- Author
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Nasution AR, Mardjuadi A, Suryadhana NG, Daud R, and Muslichan S
- Subjects
- Adolescent, Adult, Aged, Child, China ethnology, Cross-Sectional Studies, Ethnicity genetics, Female, Gene Frequency, Humans, Indonesia epidemiology, Male, Middle Aged, Rheumatic Diseases epidemiology, Rheumatic Diseases immunology, Risk Factors, Spinal Diseases epidemiology, Spinal Diseases immunology, Spondylitis, Ankylosing genetics, HLA-B27 Antigen genetics, Spondylitis, Ankylosing epidemiology, Spondylitis, Ankylosing immunology
- Abstract
We assessed the prevalence of HLA-B27 among ethnic Indonesian and Indonesian Chinese patients with ankylosing spondylitis (AS) or related spondyloarthropathies, and also among healthy controls. HLA-B27 was found in 23 (62.2%) of 37 Chinese patients and 4% of 176 Chinese healthy controls (p < 0.001). In contrasts only 2 (8.3%) of 24 native Indonesian patients and 13 (9%) of 145 healthy controls were HLA-B27+, indicating the lack of association of HLA-B27 with spondyloarthropathies in native Indonesians. These findings also suggest that HLA-B27 Chinese Indonesians carry a greater relative risk of developing AS and related spondyloarthropathies than native Indonesians, although the prevalence of HLA-B27 in the general population is more than 2 times higher in native Indonesians.
- Published
- 1993