1. Correlation with sympathetic skin response, 123 I-MIBG scintigraphy, and 123 I-FP-CIT SPECT in Parkinson's disease.
- Author
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Ozawa M, Morishima R, Shimizu T, and Takahashi K
- Subjects
- Humans, Male, Female, Aged, Middle Aged, Supranuclear Palsy, Progressive diagnostic imaging, Supranuclear Palsy, Progressive physiopathology, Sympathetic Nervous System physiopathology, Sympathetic Nervous System diagnostic imaging, Radiopharmaceuticals, Galvanic Skin Response physiology, Parkinson Disease diagnostic imaging, Parkinson Disease physiopathology, Tomography, Emission-Computed, Single-Photon methods, 3-Iodobenzylguanidine, Tropanes, Multiple System Atrophy diagnostic imaging, Multiple System Atrophy physiopathology
- Abstract
Background: Parkinson's disease (PD), and other parkinsonian syndromes are known to cause striatonigral dopaminergic system dysfunction and autonomic disturbances, including the vasomotor and sudomotor nervous systems. The detection of
123 I-FP-CIT SPECT (DaT scan) imaging and autonomic dysfunction helps differentiate PD from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). The sympathetic skin response (SSR) is a simple, non-invasive electrophysiological test that assesses the sympathetic sudomotor nervous system. It is reported that the SSR is impaired in patients with PD, MSA, and PSP., Objective: To study the relationship between SSR,123 I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy and DaT scan imaging parameters in patients with PD, MSA, and PSP., Methods: The study included 62, 25, and 19 patients with PD, MSA, and PSP, respectively. The SSR, MIBG cardiac scintigraphy, and DaT scan imaging were examined. The amplitude and latency of the SSR were measured in all limbs and were compared with the results of MIBG cardiac scintigraphy and DAT scan imaging., Results: The SSR amplitudes were lower than reported normal subjects' reference values in PD, MSA, and PSP. The SSR amplitude only correlated with MIBG cardiac scintigraphy and DaT scan imaging parameters in PD. Multiple regression analyses also showed a significant relationship between the amplitudes of SSR and DaT scan imaging in PD., Conclusion: Unlike MSA, and PSP, the sudomotor nervous system is parallelly involved with cardiac sympathetic and central dopaminergic dysfunction from the early stage of PD., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest relevant to this work., (Copyright © 2024 Elsevier Masson SAS. All rights reserved.) more...- Published
- 2024
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