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Background: Subjective cognitive decline (SCD) is the early predementia syndrome. that occurs even before the development of objective cognitive decline. SCD plus refers to an additional set of criteria that increases the likelihood of developing mild cognitive impairment and further progressing to Alzheimer's disease (AD). Studying the progression of SCD-plus participants will help in understanding the importance of diagnosing this condition at an early stage and delaying its onset., Objective: The present tries to examine neurocognitive changes in individuals who met the criteria of SCD-plus patients. The study also investigated the imaging correlates of these individuals in both cohorts., Methods: This study included 94 participants from Srinivaspura Aging, Neuro Senescence, and COGnition (SANSCOG) and Tata Longitudinal Study of Aging (TLSA) cohorts who satisfy the criteria of SCD plus. Mann-Whitney U test was used to compare the SCD plus participants and healthy controls. Regression analysis was performed to find the association between SCD plus and cognition., Results: The SCD-plus group performed poorer than the healthy group in episodic memory delayed recall (p = 0.049), name face recognition (p = 0.023), and letter fluency (p = 0.004) tasks. The generalized linear model revealed that the SCD-plus group had lower left cerebellar cortex (p = 0.010) and right inferior occipital cortex (p = 0.016) volumes than the healthy control group., Conclusions: The participants in the SCD-plus group performed poorly on memory and language-related tasks, and the volumes of the associated brain regions decreased. This study suggested that the SCD-plus group had characteristics similar to AD group and can help in identifying AD at the earliest., Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Background: Traumatic brain injury (TBI) can be primary/secondary injury which may culminate in cognitive impairment. This study aims to study the prevalence and to evaluate the cognition in participants afflicted with mild/moderate TBI., Methodology: The study considered 1464 participants aged ≥ 45 years from Tata Longitudinal Study of Aging (TLSA). Among them, 48 participants with TBI and 48 age, gender, education-matched healthy controls were included in the study. Based on duration of lack of consciousness (LOC), participants were screened for mild (≤30 mins) or moderate (>30 mins-24 hrs) TBI. After excluding three participants with missing data for LOC and one participant with severe TBI, we considered 44 participants. Cognition was evaluated using COGNITO (Computerized Assessment of Adult Information Processing) neuropsychological test battery. Generalized Linear Model (GLM) was performed to assess the relationship between TBI and cognition (unadjusted (model 1), adjusted for age, gender, education (model 2) and adjusted for age, gender, education Apolipoprotein E E4 (model 3))., Results: Prevalence of TBI is 3.3 %. Model 1 revealed that participants with mild/moderate TBI performed poorer in implicit memory task and had lesser reaction time. Adjusted models (Model 2, 3) revealed that TBI participants had lesser reaction time when compared to healthy controls., Conclusion: TBI did not seem to significantly affect cognitive functioning except implicit memory. Therefore, TBI might act as a risk factor for decline in certain domains of cognition., Competing Interests: Declaration of Competing Interest All the authors considered in the manuscript declare no conflict of interest with respect to the research, authorship and the publication of this article. The authors also declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article., (Copyright © 2025 Elsevier B.V. All rights reserved.)

Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

Competing Interests: There are no conflicts of interest.