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Slovakia belongs to the group of European countries with a low prevalence of HIV infection. The major proportion of HIV-positive cases in Slovakia is still represented by MSM, followed by heterosexuals infected through unprotected sexual intercourse. This study was conducted to update the description of HIV subtypes circulating in Slovakia. HIV-1 partial pol gene sequences from 143 individuals were prospectively collected from 2004 to 2008 and analyzed. Phylogenetic analysis based on HIV-1 partial pol gene sequences revealed the highest prevalence of HIV-1 B subtype (93.0 %), predominantly associated with the MSM group. Ten (7.0%) individuals were infected with HIV-1 non-B subtypes. The pure subtypes were more frequent (7; 4.9%) than CRFs (3; 2.1%) and their occurrence was as follows: subtype C (3; 2, 1%), subtype A (2; 1.4%), subtype F (2; 1.4%), CRF_01AE (1; 0.7%), CRF_02AG (1; 0.7%), and CRF08_BC (1; 0.7%). Data show slightly increasing HIV-1 subtype diversity, with HIV-1 subtype B still having the highest prevalence in the Slovak-infected population.

Objective: To evaluate clinical care for HIV positive pregnant women who delivered in Slovakia from 1985 till 2008., Background: National guidelines for the prevention of mother-to-child transmission of HIV have not yet been established., Method: Retrospective analysis of 14 HIV-infected pregnant women and their infants. Factors examined include maternal social, demographic, immunological and virological characteristics, method of HIV testing, antiretroviral therapy during pregnancy, delivery and puerperium, mode of delivery, mode of infant feeding, pregnancy outcomes and HIV status of infants., Conclusions: Due to the increase in cases of HIV-infected pregnant women within the last several years, it would be advisable to create National Guidelines for PMTCT (Prevention of Mother-to-Child Transmission) in order to consolidate the care management in all HIV/AIDS care centers around Slovakia (Fig. 4, Ref. 7).