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A 974 nm laser diode pumped 1120 nm ytterbium (Yb)-doped fiber laser with all fiber components has been experimentally demonstrated. The resonator is composed of a normal single-mode Yb-doped fiber 1 m long and a pair of fiber Bragg gratings. Up to 21.6 mW of continuous-wave output power is generated when the launched pump power is 161 mW with an optical-to-optical conversion efficiency of 13.4%. The central wavelength is 1120.89 nm with a linewidth as narrow as 0.02 nm. Additionally, a similar fiber laser with a 2 m long gain medium displays a broadened linewidth. The results of the two fiber lasers are compared and discussed in the paper.

ECRG-1 (esophageal cancer-related gene 1) has been previously found to be down-regulated in human esophagus cancer. Transient expression of green fluorescent protein (GFP)-tagged ECRG1 showed plasma membrane localization. Treatment of esophagus cancer cell line (NEC) with ECRG-1 fusion protein and over-expression of ECRG-1 in NEC cells can significantly reduce the in vitro proliferation rate of NEC cells. Treatment of established NEC tumors in the nude mice with ECRG-1 fusion protein leads to decreased tumor weight and volume. Over-expression of ECRG-1 in NEC cells can also inhibit tumor formation in nude mice. Cell-cycle analysis showed that over-expression of ECRG-1 in NEC cells results in G(2)/M phase arrest. Our findings indicate that ECRG1 may be a candidate tumor suppressor gene for esophageal cancer (EC) involved in cell-cycle control. Since ECRG-1 gene significantly suppresses the growth of NEC cells both in vitro and in vivo, its loss may contribute to the causation and progression of the EC in Lin-xian county, which is a high incidence area of EC in China.

Summary: The high risk cerebral AVM can do great harm to people in case of hemorrhage .The goal of aathis paper is to discuss the characters of images and the technical manipulate of endovascular embolization for high risk cerebral AVM with bleeding. Fifty-six cases of high risk cerebral AVM with bleeding were confirmed by CT?MRI?and approved by whole cerebral DSA. Depended on the nidus of AVM, the superselective endovascular embolization with NBCA or embolization combined with radiological surgery was chosen. The nidus was eliminated for 100% in 36 cases after embolization for 1 to 3 processes. The rebleeding was found in 2 cases with new growth and survival aneurysm in nidus during the following period and treatment with Y-knife, and cured by second embolization. These are the main causes of brain bleeding composed of aneurysm and aneurysmlike dilation beside and located at the nidus, fine draining veins, and growth in ventricles. It is the favourable for the preference to eliminate the aneurysm in AVM during embolization to prevent brain from bleeding.