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Objective: HAEMOMASTER system developed by NIKKISO is a feedback control technology that combines blood volume monitoring, which is now increasingly used in many dialysis centers. We investigated the effectiveness and safety of five slopes provided by HAEMOMASTER system., Methods: Patients undergoing hemodialysis with the support of a blood volume monitor (BVM) were enrolled. The NIKKISO DBB-05 Hemodialysis machine had automatically recorded real-time data such as BV and BP. Data from the patients' previous 10 dialysis sessions were collected into the HAEMOMASTER system for data fitting and the calculated target ΔBV. Patients received dialysis treatment with five slopes of the HEAMOMASTER system. We record the actual ΔBV and reverse events of every slope. Relative index to ΔBV of different slopes and sub-analysis was conducted by two-variable Spearman correlation analysis., Results: One hundred participants entered, and 78 completed the study. Slope1 and Slope2 had a lower incidence of adverse reactions (5.3% and 3.8%) and higher correlation coefficients (0.827 and 0.831, P < .001), which means they can reflect dialysis physiology better. HEAMOMASTER system helps the hemodialysis physician develop an optimal individual hemodialysis plan for the patient, reduce adverse effects such as hypotension ,obvious sweating, palpitation, fatigue, and the hemodialysis process is interrupted or the ultrafiltration volume being adjusted., Conclusion: We evaluated the safety and effectiveness of the HAEMOMASTER System in hemodialysis patients. This study serves as a roadmap for the development and widespread use of the HAEMOMASTER system and a resource for the creation of novel biofeedback control strategies. The HAEMOMASTER system has good clinical application prospects in hemodialysis patients and can be used to develop individualized ultrafiltration schemes for patients and improve the comfort and safety of hemodialysis. Slope1 and Slope2 of HAEMOMASTER are more suitable for the majority of patients with a better fit to the actual physiological conditions and lower incidence of adverse events.