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Fine particulate matter (PM 2.5 ) can damage airway epithelial barriers. The anion transport system plays a crucial role in airway epithelial barriers. However, the detrimental effect and mechanism of PM 2.5 on the anion transport system are still unclear. In this study, airway epithelial cells and ovalbumin (OVA)-induced asthmatic mice were used. In transwell model, the adenosine triphosphate (ATP)-induced transepithelial anion short-circuit current (I sc ) and airway surface liquid (ASL) significantly decreased after PM 2.5 exposure. In addition, PM 2.5 exposure decreased the expression levels of P2Y2R, CFTR and cytoplasmic free-calcium, but ATP can increase the expressions of these proteins. PM 2.5 exposure increased the levels of Th2-related cytokines of bronchoalveolar lavage fluid, lung inflammation, collagen deposition and hyperplasisa of goblet cells. Interestingly, the administration of ATP showed an inhibitory effect on lung inflammation induced by PM 2.5 . Together, our study reveals that PM 2.5 impairs the ATP-induced transepithelial anion I sc through downregulating P2Y2R/CFTR pathway, and this process may participate in aggravating airway hyperresponsiveness and airway inflammation. These findings may provide important insights on PM 2.5 -mediated airway epithelial injury., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

CdZnTe (CZT) is a new type of compound semiconductor that has emerged in recent years. Compared to other semiconductor materials, it possesses an ideal bandgap, high density, and high electron mobility, rendering it an excellent room-temperature composite semiconductor material for X-ray and γ-ray detectors. Due to the exceptional performance of CZT material, detectors manufactured using it exhibit high energy resolution, spatial resolution, and detection efficiency. They also have the advantage of operating at room temperature. CZT array detectors, furthermore, demonstrate outstanding spatial detection and three-dimensional imaging capabilities. Researchers worldwide have conducted extensive studies on this subject. This paper, building upon this foundation, provides a comprehensive analysis of CZT crystals and CZT array detectors and summarizes existing research to offer valuable insights for envisioning new detector methodologies.

Low-carbon innovation plays an essential role in carbon reduction worldwide. This study investigates the nexus between low-carbon innovation, economic growth, and carbon emissions by the dynamic spatial Durbin model from 2007 to 2020. First, the Moran index results verify the provincial spatial agglomeration of carbon emissions. High-emission provinces concentrate in major economic zones and energy extraction areas. Second, the effect decomposition results show that long-term and short-term effects are consistent. Low-carbon innovation has a significant mitigation effect on carbon emissions in local regions, which effect, however, is not significant in the adjacent areas. The environmental Kuznets curve hypothesis is validated locally, but all provinces and cities have not reached the inflection point of the environmental Kuznets curve, and the linkage effect in adjacent regions remains insignificant. The above results have been tested to be robust. Third, the results of the mechanism analysis show that environmental policies, absorptive capacity, and financial development play a moderating role in the relationship between low-carbon innovation and carbon emissions. Finally, the heterogeneity test showed significant differences between Eastern, Central, and Western. The direct effect of low-carbon innovation exists in Eastern and central regions; the spillover effect of low-carbon innovation is only in the eastern region. In addition, corresponding measures are proposed based on the conclusions., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Carbon dioxide (CO 2 ) emission reduction has become an important concern worldwide. During the past century, human activities have been a significant cause of the increase in the level of greenhouse gases. Past research mainly focuses on evaluating the nexus between unidimensional population factors and CO 2 emissions, while few prior studies in a developing country have reported the impact of multidimensional demographic factors on CO 2 emissions. As an initial attempt, this study investigates the short- and long-run associations between population factors, low-carbon innovation, and carbon dioxide emissions (CO 2 ) for a panel consisting of 285 cities by employing the pooled mean group (PMG) estimator under the framework of the panel autoregressive distributed lag (ARDL) model. Our main findings are as follows: (1) Population size and population density could increase CO 2 emissions, while population quality and low-carbon innovation were essential factors that alleviate carbon emission pressure in the long run. (2) Economic development, foreign direct investment, and industrial development were found to be factors causing the increase in carbon emissions. (3) The split-sample analysis demonstrated that the improvement of population quality still has a positive and significant long-run effect on environmental quality. Simultaneously, low-carbon innovation could realize the enormous dividends of carbon emission reduction in the long run, especially in existing relatively larger CO 2 emission areas. Finally, the paper presents important policy implications., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Background: Tracheal fistulas (TF) can be dangerous and even fatal in patients. The current treatment is really challenging. Previous studies reported that mesenchymal stem cells (MSCs) could be used to treat respiratory tract fistulas. Stem cells from human exfoliated deciduous teeth (SHED) are considered to be MSC-like cells that may also have the potential to treat the tracheal fistulas. In this study, we investigated the therapeutic effects of SHED in rat tracheal fistula models., Methods: A total of 80 SD rats were randomly divided into five groups: a sham-operated group, a local PBS group (L-PBS), an intravenous PBS group (I-PBS), a local SHED treatment group (L-SHED), and an intravenous SHED treatment group (I-SHED). The L-SHED and I-SHED groups were given a topical application around the fistula or an intravenous injection of 1*10 7 SHED via the tail vein, respectively, while the L-PBS and I-PBS groups were given an equivalent volume of PBS through local or intravenous administration. A stereomicroscope was used to observe fistula healing on the 2nd, 3rd, and 5th days following transplantation. On the 7th day, the survival of SHED was observed by immunofluorescence. The pathology of the lungs and fistulas was observed by hematoxylin and eosin (H&E) and Masson staining. The expression levels of the Toll-like receptor 4 (TLR4), interleukin (IL)-1β, IL-33, and IL-4 were measured using immunohistochemistry. The expression levels of TLR4, high mobility group box 1 (HMGB1), and myeloid differentiation factor 88 (MYD88) were studied using western blotting. On day 14, airway responsiveness of rats was detected and analyzed., Results: Fistula healing in the L-SHED and I-SHED groups was faster than that in their respective PBS groups after transplantation. The fistula diameters in the L-SHED and I-SHED groups were significantly smaller than those in the L-PBS and I-PBS groups on the 3rd day. Moreover, the phenomenon of fibroblast proliferation and new blood vessel growth around the fistula seemed more pronounced in the L-SHED and I-SHED groups. Although no discernible difference was found in airway responsiveness after SHED treatment, the degree of inflammation in the lungs was reduced by intravenous SHED treatment. However, there was no significant reduction in lung inflammation by local SHED treatment. The expression levels of IL-1β and IL-33 were decreased in the I-SHED group, while IL-4 was elevated compared with the I-PBS group. Interestingly, intravenous SHED treatment inhibited the activation of HMGB1/TLR4/MYD88 in the lung tissues of TF rats., Conclusions: SHED transplantation accelerated the rate of fistula healing in rats. Intravenous SHED treatment reduced lung inflammation. Thus, SHED may have potential in the treatment of tracheal fistula, providing hope for future therapeutic development for TF., (© 2022. The Author(s).)

This study first attempts to use the parameterized quadratic directional distance function (DDF) approach to calculate China's provincial carbon abatement cost and carbon reduction potential (CRP) under different scenarios from 2000 to 2017. Afterward, considering three different scenarios, we analyze the spatio-temporal characteristics and the dynamic evolution pattern of CRP. We also employ spatial Durbin model (SDM) to investigate the influencing factors of CRP. The results are obtained as follows: (1) CRP across the three scenarios varies considerably across provinces and different-located groups. CRP higher areas are mainly located in the economically developed eastern coastal regions, while most provinces with low CRP are concentrated in the western region. (2) Provinces with a similar CRP showed a significant geographic agglomeration, and the agglomeration effect was strengthened first and then weakened. Simultaneously, the local spatial distribution of moderation carbon reduction potential (MCRP), fairness carbon reduction potential (FCRP), and efficiency carbon reduction potential (ECRP) shows a slight spatial polarization feature. (3) Through the SDM analysis and spillover effect decomposition, we find that improvement of regional CRP not only depends on economic development, industrial structure adjustment, and energy efficiency elevation, but also involves energy structure optimization, low-carbon innovation, and population. The low-carbon innovation provides critical support for local CRP under the efficiency scenario but restrains the local CRP under the fairness scenario. Therefore, the central government should emphasize local conditions and the ex-ante scenario assessment, strengthen regional interactive governance, optimize energy efficiency, and promote the application of clean energy to enhance CRP., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)