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We establish the irreversibility of renormalization group flows on a pointlike defect inserted in a d-dimensional Lorentzian conformal field theory. We identify the impurity entropy g with the quantum relative entropy in two equivalent ways. One involves a null deformation of the Cauchy surface, and the other is given in terms of a local quench protocol. Positivity and monotonicity of the relative entropy imply that g decreases monotonically along renormalization group flows, and provides a clear information-theoretic meaning for this irreversibility.