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Objective: Stress-only myocardial perfusion imaging protocol has a prognostic value similar to that of a stress-rest protocol. The aim of the study was to assess stress myocardial perfusion by gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (GSMPI) in patients who had a normal stress-only study 4.9 years (mean time) before and assess the possible influence of various factors on the results., Subjects and Methods: Three hundred and forty patients who had a normal stress-only study in the past, were reexamined with GSMPI after a mean period of 4.9 years., Results: Thirty out of 340 patients (8.8%) had an ischemic result on stress and were therefore submitted to a rest study. Differences between normal and pathological results across levels of potential prognostic factors (age, gender, diabetes mellitus, dyslipidemia, arterial hypertension, smoking and family history), symptoms,left ventricular ejection fraction (LVEF) on ultrasound (U/S), coronary angiography and pre-test probability did not prove statistically significant. On multivariable analysis patients with the combination of family history, diabetes mellitus and hypertension had a 10.7 times higher risk of a pathological scan than the patients without., Discussion: The information delivered by stress-only GSMPI proved to be a prognostically reliable method for follow-up of low and intermediate pretest probability coronary artery disease (CAD) patients., Conclusion: The 91.2% of the patients with an initial normal stress-only GSMPI had a repeat normal stress-only GSMPI after a mean period of 4.9 years. The combination of family history, diabetes mellitus and hypertension increases the risk of a pathological scan significantly.

Purpose: To evaluate differences in side-effects and hemodynamic response between men and women undergoing regadenoson-stress SPECT myocardial perfusion imaging (MPI)., Methods: The initial population of the study included 858 consecutive patients who underwent regadenoson-stress MPI at our institution. These patients underwent prospective assessment and classification of regadenoson-induced side-effects in six categories and recording of heart rate (HR) and blood pressure (BP) before and after regadenoson administration. From this initial population, after adjustment with 1:1 propensity matching using gender as the dependent variable and age, BMI, diabetes mellitus, hypertension, smoking, presence of coronary artery disease, LVEF, baseline systolic and diastolic blood pressure (BP) and HR, on-going use of cardio-active medications during test, and abnormal MPI scan as independent variables, a population of 279 pairs of opposite gender was formed and studied., Results: Compared with men, women had a significantly higher rate of any side-effect (71% vs. 58%, p = 0.002), chest pain (23% vs. 12%, p < 0.001), gastrointestinal discomfort (20% vs. 12%, p = 0.01), dizziness (12% vs. 5%, p = 0.002), and headache (20% vs. 13%, p = 0.03) and similar rates of dyspnea and other side-effects. Women demonstrated a higher median HR-response compared with men (41% (- 8, 127) vs. 34% (- 5, 106), p = 0.001) while men demonstrated a lower median systolic BP response (- 3% (- 27, 48) vs. 0% (- 36, 68), p = 0.02) compared with women., Conclusions: Gender is independently associated with a differential response to regadenoson with regard to overall side-effects and HR-response. These observations have the potential of important management and prognostic implications respectively.

The objective of this study was to investigate the patient and staff doses in the most frequent interventional cardiology (IC) procedures performed in Onassio, the largest Cardiac Centre in Greece. Data were collected from three digital X-ray systems for 212 coronary angiographies, 203 percutaneous transluminal coronary angioplasties (PTCA) and 134 various electrophysiological studies. Patient skin dose was measured using suitably calibrated slow radiotherapy films and cardiologist dose using suitably calibrated thermoluminescent dosemeters placed on left arm, hand and foot. Patient median dose area product (DAP) (all examinations) ranged between 6.7 and 83.5 Gy cm2. Patient median skin dose in PTCA was 799 mGy (320-1660 mGy) and in RF ablation 160 mGy (35-1920 mGy). Median arm, hand and foot dose to the cardiologist were 12.6, 27 and 13 microSv, respectively, per procedure. The great range of radiation doses received by both patients and operators confirms the need for continuous monitoring of all IC techniques.

Aim: To explore the factors that may influence the radiation dose imparted to the patient in PCI, and investigate whether the use of the latest digital X-ray system based on FP detector technology can have an impact on dose., Materials and Method: Demographic and clinical data such as number of lesions treated, number of stents placed, grade of tortuosity, and stage of occlusion, as well as use of double wire and double balloon technique, ostial stenting or bifurcation stenting, and presence of major complications were recorded, together with radiation parameters., Results: The factors that increased patient radiation dose were (1) patient gender, as men exhibited higher doses than women; (2) complex lesion; (3) increasing number of stents; (4) position of stent; (5) grade of tortuosity; and (6) stage of occlusion. The FP digital system appeared to be settled in a lower-dose rate for fluoroscopy (a factor of 6) and higher for dose per frame in cine (a factor of 3) in comparison with the image intensifier (II) system. There was a marked reduction of DAP when the FP technology was introduced., Conclusion: More extensive studies should be performed in the future so as to further investigate the influence of the FP detector in IC.

The purpose of this study was to collect information on the practice and patient doses in a major Greek cardiac centre, investigate differences between senior cardiologists of various levels of experience and compare results with the literature, in order to optimize angiographic and interventional cardiology procedures. Radiation doses from 292 patients have been studied, 195 of which had undergone coronary angiography and 97 percutaneous transluminal coronary angioplasty. All procedures were undertaken on a Siemens Angioscop X-ray equipment. The system performed under automatic exposure control using pulsed fluoroscopy of 12.5 pulses s(-1) and cine frame rate of 25 frames s(-1). Dose-area product values, fluoroscopy times, total number of cine frames as well as operator's name were collected for each patient. Only senior cardiologists have participated in the study. Median values for dose-area product were 39.1 Gy cm(2) for coronary angiography and 58.3 Gy cm(2) for percutaneous transluminal coronary angioplasty. Median fluoroscopy time was 5.0 min and 9.7 min and median number of frames was 1588 and 1823 for coronary angiography and percutaneous transluminal coronary angioplasty, respectively. Comparison showed that patient dose-area product values were lower than other studies and fluoroscopy time values were comparable. However, the total number of frames used was much higher than other published results. Differences between cardiologists with increased experience have been found. Analysis of the patient dose values obtained initiated a program of radiation protection optimization. The need for continuous training in radiation protection for interventionalists has been verified.

In a substantial number of patients, AF recurs after successful electrical cardioversion. The purpose of this study was to investigate if the atrial arrhythmias recorded immediately after cardioversion are associated with the risk of recurrence of the arrhythmia and to compare the prognostic significance of this parameter with that of other established risk factors. In a series of 71 patients, the risk factors for recurrence of AF during the first year after successful electrical cardioversion were analyzed. A new parameter that was investigated was the frequency of atrial premature beats and the presence of runs of supraventricular tachycardia in the Holter recording started immediately after the cardioversion. Age, left atrial size, left ventricular systolic function, duration of the arrhythmia before cardioversion, underlying cardiac disease, or medication taken were not found to be predictive of recurrence of the arrhythmia. However, the natural logarithm of the number of atrial premature complexes per hour of the Holter recording in the 37 patients in whom AF recurred was higher compared to that of the 34 patients who maintained sinus rhythm (P < 0.0005). The same was true if only the first 6 hours of the recording were analyzed (P < 0.0005). There was a trend for more frequent arrhythmia recurrence if runs of supraventricular tachycardia were present. The finding of > 10 atrial premature complexes per hour in the recording had a relative risk of 2.57 (1.51-4.37), a positive predictive accuracy of 76.5%, and a negative predictive accuracy of 70.3% for subsequent arrhythmia recurrence. We can conclude that frequent (> 10/hour) atrial premature complexes in the Holter recording after electrical cardioversion for AF is a significant risk factor for recurrence of the arrhythmia.

Objectives: Increased QT dispersion has been considered as predisposing to ventricular arrhythmias in hypertrophic cardiomyopathy, congestive heart failure, and coronary artery disease. An increased QT dispersion has also been found in hypertensive patients with left ventricular hypertrophy (LVH). The data on the effect of LVH regression on QT dispersion are limited., Methods and Results: To assess the relation of LVH regression and QT dispersion decrease, 68 patients (42 men and 26 women, mean age 56.3+/-9.5 years) with uncomplicated essential hypertension were studied. All underwent full electrocardiographic and echocardiographic studies at baseline and after 6 months of monotherapy, 29 with angiotensin-converting enzyme inhibitors and 39 with calcium antagonists. QT dispersion was calculated by subtracting the shortest QT from the longest QT, in absolute value (QTmax - QTmin). It was also corrected with Bazett's formula (QTc dispersion). Left ventricular mass index was assessed according to the Devereux formula. After treatment, LVH decreased with both angiotensin-converting enzyme inhibitors (from 155 to 130 g/m2, P < .001) and calcium antagonists (156 to 133/92/m2, P < .001). QT dispersion decreased both after angiotensin-converting enzyme inhibitor treatment (from 82 to 63 ms) and calcium antagonist treatment (from 77 to 63 ms, both P < .001 ). There was a significant correlation of QT dispersion and left ventricular mass after therapy (r = 0.36, P < .005). There was a correlation of the degree of LVH and QT dispersion decrease (r = 0.27, P < .05)., Conclusions: It is concluded that LVH regression influences AQT favorably. Its prognostic value has yet to be determined.

In order to test the effect of noise on the various parameters of the SAECG, 83 patients underwent three consecutive recordings at different noise levels. The high noise (HN) recordings had a noise level of 0.60-0.74 microV, the intermediate noise (IN) had 0.31-0.59 microV, and the low noise (LN) had < or = 0.30 microV. For the calculation of noise we used the standard deviation of the mean noise of the composite lead high pass filtered at 40 Hz. The recordings were compared using time-domain, frequency-domain, and spectrotemporal analysis. The time-domain parameters of the LN recordings, using 25-Hz, 40-Hz, and 60-Hz high pass cutoffs, were significantly different from those of the HN or IN recordings (P < 0.05). In the frequency-domain analysis, significant differences were found in some of the parameters of the LN compared to the HN. The spectrotemporal analysis of the X and Z leads also showed significant differences among the LN and the other recordings. In the time-domain analysis, both at 40 Hz and 25 Hz, there were more abnormal LN compared to the HN recordings (P < 0.05). In the spectrotemporal analysis, there were significantly more abnormal HN and IN recordings compared to the LN (P < 0.001 and P < 0.01, respectively). Therefore, the level of noise, even within the acceptable range, can significantly affect the SAECG. In the time domain at the lower noise levels the parameters become more abnormal, while the opposite seems to occur in the spectral and the spectrotemporal analysis.