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To enhance sustainability and resilience against climate change in infrastructure, a quantitative evaluation of both environmental impact and cost is important within a life cycle framework. Climate change effects can lead performance deterioration in bridge components during their operational phase, highlighting the necessity for a risk-based evaluation process aligned with maintenance strategies. This study employs a two-phase life cycle assessments (LCA) framework. First, risk assessments are conducted to evaluate the impact of climate change on steel plate girder bridges and prestressed concrete (PSC) girder bridges under identical structural conditions. The reduction in flexural strength of steel plate girders and PSC girders due to changes in environmental variables such as temperature and relative humidity, induced by various climate change scenarios, was evaluated analytically. Subsequently, life cycle environmental impact and cost assessments were performed, including maintenance outcomes derived from risk assessments. The findings revealed that the environmental impact and cost could increase by approximately 12.4% when climate change is considered, compared to scenarios where it is not taken into account. Sensitivity analyses were performed to identify the key factors influencing environmental impact and cost. The analysis determined that the frequency of preventive maintenance, the recycling rate, and environmental cost coefficient weight in the life cycle assessment significantly affected the results., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

The feasibility of single-exposure dual-energy imaging (DEI) was investigated in pursuit of motion-artifact-free subtraction angiography. To acquire low- and high-energy images simultaneously from a single X-ray exposure, a sandwich-like multilayered detector was fabricated by configuring two phosphor-coupled photodiode array layers in tandem. A simple analytic model describing the signal in DE-reconstructed images was derived. For the feasibility test, two plastic phantoms with linear arrays of cylindrical holes were prepared to contain iodinated water. One consisted of the same-diameter cylinders with different iodine concentrations, whereas the other had the different-diameter cylinders with the same iodine concentration. The concentration and size discrimination capabilities of single-exposure DEI were evaluated by investigating the phantom images. While the image noise relative to the signal was almost independent of the mass thickness of iodine, the iodine detectability improved with the mass thickness. The detectability performance at a lower tube voltage (e.g. 60 kV) outperformed those at higher voltages, as expected from the model. The results obtained in this study demonstrate the potential applicability of the single-exposure approach to motion-artifact-free subtraction angiography., (Copyright © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)

Recent tragedies around the world have shown how accidents in the cable-stayed bridges can wreak havoc on the society. To ensure the safety of the cable-stayed bridges, several studies have estimated the cable tension force using the vibration of cables. Most of these methods for estimating the tension of a cable start with measuring the displacement of the cable. Recent development of commercial cameras provide opportunity for more convenient and efficient method for measuring the displacement of cable. However, traditional vision-based displacement measurement methods require the assumption that the movement of the cable should be measured in parallel to the camera plane. This assumption limits the installation location of the camera when measuring the displacement of a cable. Therefore, this study introduces a new vision-based cable displacement measurement system that can measure the displacement of a cable in various locations even when the camera is installed in the side of the cable. The proposed method consists of three phases: (1) camera projection matrix estimation, (2) cable tracking in the image coordinate, and (3) cable displacement estimation in the world coordinate. To validate the performance of the proposed method, a simulation-based validation test, a lab-scale validation test, and an on-site validation test were conducted. The simulation-based validation test verified the performance of the proposed method in an ideal condition, and the lab-scale validation test showed the performance of the method in physical environment. Finally, the on-site validation test showed that the proposed method can measure the cable displacement with a side view camera.

For the purpose of real-time scan-protocol optimisation and patient-specific dose management in cone-beam computed tomography, we introduce a numerical algorithm that estimates the primary dose distributions in reconstructed images. The proposed algorithm is based on the ray-tracing technique and utilises reconstructed voxel data and scanning protocol. The algorithm is validated with the Monte Carlo (MC) and conventional model-based dose reconstruction methods for the simple cylindrical water and anthropomorphic head phantoms. The algorithm shows good agreement with both methods in terms of the zeroth-order x-ray interactions, which exclude the higher-order x-ray interactions at sites distant from the first interactions, and it consumes a significantly lower computational cost compared with the MC method. The differences between the proposed algorithm and the model-based dose reconstruction method as well as the improvement strategies of the algorithm are discussed in detail., (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Purpose: Dedicated breast CT is an emerging volumetric X-ray imaging modality for diagnosis that does not require any painful breast compression. To improve the detection rate of weakly enhanced lesions, an adaptive image rescaling (AIR) technique was proposed., Materials and Methods: Two disks containing five identical holes and five holes of different diameters were scanned using 60/100 kVp to obtain single-energy CT (SECT), dual-energy CT (DECT), and AIR images. A piece of pork was also scanned as a subclinical trial. The image quality was evaluated using image contrast and contrast-to-noise ratio (CNR). The difference of imaging performances was confirmed using student's t test., Results: Total mean image contrast of AIR (0.70) reached 74.5% of that of DECT (0.94) and was higher than that of SECT (0.22) by 318.2%. Total mean CNR of AIR (5.08) was 35.5% of that of SECT (14.30) and was higher than that of DECT (2.28) by 222.8%. A similar trend was observed in the subclinical study., Conclusion: The results demonstrated superior image contrast of AIR over SECT, and its higher overall image quality compared to DECT with half the exposure. Therefore, AIR seems to have the potential to improve the detectability of lesions with dedicated breast CT., Competing Interests: Conflicts of Interest: The authors have no potential conflicts of interest to disclose., (Copyrights © 2021 The Korean Society of Radiology.)

Purpose: We present a new framework for theoretical analysis of the noise power spectrum (NPS) of photon-counting x-ray detectors, including simple photon-counting detectors (SPCDs) and spectroscopic x-ray detectors (SXDs), the latter of which use multiple energy thresholds to discriminate photon energies., Methods: We show that the NPS of SPCDs and SXDs, including spatio-energetic noise correlations, is determined by the joint probability density function (PDF) of deposited photon energies, which describes the probability of recording two photons of two different energies in two different elements following a single-photon interaction. We present an analytic expression for this joint PDF and calculate the presampling and digital NPS of CdTe SPCDs and SXDs. We calibrate our charge sharing model using the energy response of a cadmium zinc telluride (CZT) spectroscopic x-ray detector and compare theoretical results with Monte Carlo simulations., Results: Our analysis shows that charge sharing increases pixel signal-to-noise ratio (SNR), but degrades the zero-frequency signal-to-noise performance of SPCDs and SXDs. In all cases considered, this degradation was greater than 10%. Comparing the presampling NPS with the sampled NPS showed that degradation in zero-frequency performance is due to zero-frequency noise aliasing induced by charge sharing., Conclusions: Noise performance, including spatial and energy correlations between elements and energy bins, are described by the joint PDF of deposited energies which provides a method of determining the photon-counting NPS, including noise-aliasing effects and spatio-energetic effects in spectral imaging. Our approach enables separating noise due to x-ray interactions from that associated with sampling, consistent with cascaded systems analysis of energy-integrating systems. Our methods can be incorporated into task-based assessment of image quality for the design and optimization of spectroscopic x-ray detectors., (© 2020 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicineehalf of American Association of Physicists in Medicine.)

Polycrystalline cadmium telluride (CdTe) X-ray photodetector with advanced performance was fabricated in a Schottky diode form by direct thermal deposition (evaporation) on pixelized complementary metal oxide semiconductor (CMOS) readout panel. Our CdTe X-ray detector shows such a variety of benefits as relatively low process temperature, low cost, low operation voltage less than 40 V, and higher sensitivity and spatial resolution than those of commercial a-Se detectors. CdTe has cubic Zinc Blende structure and maintains p-type conduction after growth in general. For low voltage operation, we succeeded in Cl doping at all stage of CdTe film deposition, and as a result, hole concentration of p-type CdTe was reduced to ~10 12  cm -3 from ~10 15  cm -3 , and such concentration reduction could enable our Schottky diode with Ti electrode to operate at a reverse bias of less than 40 V. Our CdTe Schottky diode/CMOS pixel array as a direct conversion type imager demonstrates much higher resolution X-ray imaging in 7 × 9 cm 2 large scale than that of CsI/CMOS array, an indirect conversion imager. To our limited knowledge, our results on polycrystalline CdTe Schottky diode/CMOS array would be very novel as a first demonstration of active pixel sensor system equipped with directly deposited large scale X-ray detector.

Purpose: Acquisition of high-quality x-ray images using low patient exposures requires detectors with high detective quantum efficiency (DQE). We describe a novel apodized-aperture pixel (AAP) design that increases high-frequency modulation transfer function (MTF) and DQE values. The AAP design makes a separation of physical sensor elements from image pixels by using very small sensor elements (e.g., 0.010-0.025 mm) to synthesize desired larger image pixels (e.g., 0.1-0.2 mm)., Methods: A cascaded systems model of signal and noise propagation is developed to describe the benefits of the AAP approach in terms of the MTF, Wiener noise power spectrum (NPS), and DQE. The theoretical model was validated experimentally using a CMOS/CsI detector with 0.05 mm sensor elements to synthesize 0.20 mm image pixels and a clinical Se detector with 0.07 mm sensor elements to synthesize 0.28 mm pixels. A Monte Carlo study and x-ray images of a star-pattern and rat leg are used to visually compare AAP images., Results: When used with a high-resolution converter layer and sensor elements one quarter the size of image pixels, the MTF is increased by 53% and the DQE by a factor of 2.3× at the image sampling cut-off frequency. Both simulated and demonstration images show improved detectability of high-frequency content and removal of aliasing artifacts. Evidence of Gibbs ringing is sometimes seen near high-contrast edges., Conclusions: It is shown that the AAP approach preserves the MTF of the small sensor elements and attenuates frequencies above the image sampling cut-off frequency. This has the double benefit of improving the MTF while reducing both signal and noise aliasing, resulting in an increase of the DQE at high spatial frequencies. For optimal implementation, the converter layer must have very high spatial resolution and the detector must have low readout noise., (© 2017 American Association of Physicists in Medicine.)

Goal: We investigate the signal and noise performance of an x-ray microtomography system that incorporates a complementary metal-oxide-semiconductor flat-panel detector as a projection image receptor., Methods: Signal and noise performance is analyzed in the Fourier domain using modulation-transfer function (MTF), noise-power spectrum (NPS), and noise-equivalent number of quanta (NEQ) with respect to magnification and different convolution kernels for image reconstruction., Results: Higher magnification provides lower NPS, and thus, higher NEQ performance in the transaxial planes from microtomography. A window function capable of smoothing the ramp filter edge to below one-half of the Nyquist limit results in better performance in terms of NPS and NEQ. The characteristics of convolution kernels do not affect signal and noise performance in longitudinal planes; hence, MTF performance mainly dominates the NEQ performance. The signal and noise performances investigated in this study are demonstrated with images obtained from the contrast phantom and postmortem mouse., Conclusion: The results of our study could be helpful in developing x-ray microtomography systems based on flat-panel detectors.

Purpose: The overall goal of this study is to restore kilovoltage computed tomography (kV-CT) images which are disfigured by patients' metal prostheses. By generating a hybrid sinogram that is a combination of kV and megavoltage (MV) projection data, the authors suggest a novel metal artifact-reduction (MAR) method that retains the image quality to match that of kV-CT and simultaneously restores the information of metal prostheses lost due to photon starvation., Methods: CT projection data contain information about attenuation coefficients and the total length of the attenuation. By normalizing raw kV projections with their own total lengths of attenuation, mean attenuation projections were obtained. In the same manner, mean density projections of MV-CT were obtained by the normalization of MV projections resulting from the forward projection of density-calibrated MV-CT images with the geometric parameters of the kV-CT device. To generate the hybrid sinogram, metal-affected signals of the kV sinogram were identified and replaced by the corresponding signals of the MV sinogram following a density calibration step with kV data. Filtered backprojection was implemented to reconstruct the hybrid CT image. To validate the authors' approach, they simulated four different scenarios for three heads and one pelvis using metallic rod inserts within a cylindrical phantom. Five inserts describing human body elements were also included in the phantom. The authors compared the image qualities among the kV, MV, and hybrid CT images by measuring the contrast-to-noise ratio (CNR), the signal-to-noise ratio (SNR), the densities of all inserts, and the spatial resolution. In addition, the MAR performance was compared among three existing MAR methods and the authors' hybrid method. Finally, for clinical trials, the authors produced hybrid images of three patients having dental metal prostheses to compare their MAR performances with those of the kV, MV, and three existing MAR methods., Results: The authors compared the image quality and MAR performance of the hybrid method with those of other imaging modalities and the three MAR methods, respectively. The total measured mean of the CNR (SNR) values for the nonmetal inserts was determined to be 14.3 (35.3), 15.3 (37.8), and 25.5 (64.3) for the kV, MV, and hybrid images, respectively, and the spatial resolutions of the hybrid images were similar to those of the kV images. The measured densities of the metal and nonmetal inserts in the hybrid images were in good agreement with their true densities, except in cases of extremely low densities, such as air and lung. Using the hybrid method, major streak artifacts were suitably removed and no secondary artifacts were introduced in the resultant image. In clinical trials, the authors verified that kV and MV projections were successfully combined and turned into the resultant hybrid image with high image contrast, accurate metal information, and few metal artifacts. The hybrid method also outperformed the three existing MAR methods with regard to metal information restoration and secondary artifact prevention., Conclusions: The authors have shown that the hybrid method can restore the overall image quality of kV-CT disfigured by severe metal artifacts and restore the information of metal prostheses lost due to photon starvation. The hybrid images may allow for the improved delineation of structures of interest and accurate dose calculations for radiation treatment planning for patients with metal prostheses.

Purpose: Single-photon-counting (SPC) x-ray imaging has the potential to improve image quality and enable novel energy-dependent imaging methods. Similar to conventional detectors, optimizing image SPC quality will require systems that produce the highest possible detective quantum efficiency (DQE). This paper builds on the cascaded-systems analysis (CSA) framework to develop a comprehensive description of the DQE of SPC detectors that implement adaptive binning., Methods: The DQE of SPC systems can be described using the CSA approach by propagating the probability density function (PDF) of the number of image-forming quanta through simple quantum processes. New relationships are developed to describe PDF transfer through serial and parallel cascades to accommodate scatter reabsorption. Results are applied to hypothetical silicon and selenium-based flat-panel SPC detectors including the effects of reabsorption of characteristic/scatter photons from photoelectric and Compton interactions, stochastic conversion of x-ray energy to secondary quanta, depth-dependent charge collection, and electronic noise. Results are compared with a Monte Carlo study., Results: Depth-dependent collection efficiency can result in substantial broadening of photopeaks that in turn may result in reduced DQE at lower x-ray energies (20-45 keV). Double-counting interaction events caused by reabsorption of characteristic/scatter photons may result in falsely inflated image signal-to-noise ratio and potential overestimation of the DQE., Conclusions: The CSA approach is extended to describe signal and noise propagation through photoelectric and Compton interactions in SPC detectors, including the effects of escape and reabsorption of emission/scatter photons. High-performance SPC systems can be achieved but only for certain combinations of secondary conversion gain, depth-dependent collection efficiency, electronic noise, and reabsorption characteristics.

X-ray computed laminography is widely used in nondestructive testing of relatively flat objects using an oblique scanning configuration for data acquisition. In this work, a new scanning scheme is proposed in conjunction with the compressive-sensing-based image reconstruction for reducing imaging radiation dose and scanning time. We performed a numerical study comparing image qualities acquired by various scanning configurations that are practically implementable: single-arc, double-arc, oblique, and spherical-sinusoidal trajectories. A compressive-sensing-inspired total-variation (TV) minimization algorithm was used to reconstruct the images from the data acquired at only 40 projection views in those trajectories. It was successfully demonstrated that the proposed scanning scheme outperforms the others in terms of image contrast and spatial resolution, although the oblique scanning scheme showed a comparable resolution property. We believe that the proposed scanning method may provide a solution to fast and low-dose nondestructive testing of radiation-sensitive and highly integrated devices such as multilayer microelectronic circuit boards.

A bioassay-guided fractionation and chemical investigation of the MeOH extract from the twigs of Lindera glauca (SIEB. et ZUCC.) BLUME resulted in the isolation and identification of six lignans (1-6) including three new lignan derivatives, named linderuca A (1), B (2), and C (3). The structures of the new compounds (1-3) were determined on the basis of spectroscopic analyses, including two dimensional NMR and circular dichroism (CD) spectroscopy studies. The cytotoxic activities of the isolates (1-6) were evaluated by determining their inhibitory effects on human tumor cell lines. Compounds 1-5 showed antiproliferative activities against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 7.79-29.42 µM. Based on the understanding that inflammation is a crucial cause of tumor progression, we also investigated the anti-inflammatory activities of the isolates (1-6) in the lipopolysaccharide-stimulated murine microglia BV-2 cell line by measuring nitric oxide (NO) levels. The new lignans (1-3) significantly inhibited NO production with IC50 values of 12.10, 9.48, and 9.87 µM, respectively, without cytotoxicity.

The absorbed energy distribution (AED) in X-ray imaging detectors is an important factor that affects both energy resolution and image quality through the Swank factor and detective quantum efficiency. In the diagnostic energy range (20-140 keV), escape of characteristic photons following photoelectric absorption and Compton scatter photons are primary sources of absorbed-energy dispersion in X-ray detectors. In this paper, we describe the development of an analytic model of the AED in compound X-ray detector materials, based on the cascaded-systems approach, that includes the effects of escape and reabsorption of characteristic and Compton-scatter photons. We derive analytic expressions for both semi-infinite slab and pixel geometries and validate our approach by Monte Carlo simulations. The analytic model provides the energy-dependent X-ray response function of arbitrary compound materials without time-consuming Monte Carlo simulations. We believe this model will be useful for correcting spectral distortion artifacts commonly observed in photon-counting applications and optimal design and development of novel X-ray detectors.

Purpose: Single-photon counting (SPC) x-ray imaging has the potential to improve image quality and enable new advanced energy-dependent methods. The purpose of this study is to extend cascaded-systems analyses (CSA) to the description of image quality and the detective quantum efficiency (DQE) of SPC systems., Methods: Point-process theory is used to develop a method of propagating the mean signal and Wiener noise-power spectrum through a thresholding stage (required to identify x-ray interaction events). The new transfer relationships are used to describe the zero-frequency DQE of a hypothetical SPC detector including the effects of stochastic conversion of incident photons to secondary quanta, secondary quantum sinks, additive noise, and threshold level. Theoretical results are compared with Monte Carlo calculations assuming the same detector model., Results: Under certain conditions, the CSA approach can be applied to SPC systems with the additional requirement of propagating the probability density function describing the total number of image-forming quanta through each stage of a cascaded model. Theoretical results including DQE show excellent agreement with Monte Carlo calculations under all conditions considered., Conclusions: Application of the CSA method shows that false counts due to additive electronic noise results in both a nonlinear image signal and increased image noise. There is a window of allowable threshold values to achieve a high DQE that depends on conversion gain, secondary quantum sinks, and additive noise.

Purpose: Theoretical models of the detective quantum efficiency (DQE) of x-ray detectors are an important step in new detector development by providing an understanding of performance limitations and benchmarks. Previous cascaded-systems analysis (CSA) models accounted for photoelectric interactions only. This paper describes an extension of the CSA approach to incorporate coherent and incoherent interactions, important for low-Z detectors such as silicon and selenium., Methods: A parallel-cascade approach is used to describe the three types of x-ray interactions. The description of incoherent scatter required developing expressions for signal and noise transfer through an "energy-labeled reabsorption" process where the parameters describing reabsorption are random functions of the scatter photon energy. The description of coherent scatter requires the use of scatter form factors that may not be accurate for some crystalline detector materials. The model includes the effects of scatter reabsorption and escape, charge collection, secondary quantum sinks, noise aliasing, and additive noise. Model results are validated by Monte Carlo calculations for Si and Se detectors assuming free-atom atomic form factors., Results: The new signal and noise transfer expressions were validated by showing agreement with Monte Carlo results. Coherent and incoherent scatter can degrade the DQE of Si and sometimes Se detectors depending on detector thickness and incident-photon energy. Incoherent scatter can produce a substantial low-frequency drop in the modulation transfer function and DQE., Conclusions: A generally useful CSA model of the DQE is described that is believed valid for any single-Z material up to 10 cycles/mm at both mammographic and radiographic energies within the limitations of Fourier-based linear-systems models and the use of coherent-scatter form factors. The model describes a substantial low-frequency drop in the DQE of Si systems due to incoherent scatter above 20-40 keV.

On the search for anti-cancer compounds from natural Korean medicinal sources, a bioassay-guided fractionation and chemical investigation of the MeOH extract from the rhizomes of Acorus gramineus resulted in the isolation and identification of thirteen phenolic derivatives (1-13) including two new 8-O-4'-neolignans, named surinamensinols A (1) and B (2) and a new phenolic compound, named acoramol (9). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic data analyses as well as circular dichroism (CD) spectroscopy studies. The cytotoxic activities of the isolates (1-13) were evaluated by determining their inhibitory effects on human tumor cell lines. The new 8-O-4'-neolignans, compounds 1 and 2, showed moderate antiproliferative activities against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC(50) values in the range of 4.17-26.18μM. On the basis of the expanded understanding that inflammation is a crucial cause of tumor progression, anti-inflammatory activities of these compounds were determined by measuring nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. Compounds 1, 2, 4, 7 and 10 inhibited NO production in BV-2 stimulated by lipopolysaccharide with IC(50) values of 8.17-18.73μM via NO scavenging, inhibition of iNOS activity, and/or suppression of iNOS expression., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Purpose: This study investigates the fundamental signal and noise performance limitations imposed by the stochastic nature of x-ray interactions in selected photoconductor materials, such as Si, a-Se, CdZnTe, HgI(2), PbI(2), PbO, and TlBr, for x-ray spectra typically used in mammography., Methods: It is shown how Monte Carlo simulations can be combined with a cascaded model to determine the absorbed energy distribution for each combination of photoconductor and x-ray spectrum. The model is used to determine the quantum efficiency, mean energy absorption per interaction, Swank noise factor, secondary quantum noise, and zero-frequency detective quantum efficiency (DQE)., Results: The quantum efficiency of materials with higher atomic number and density demonstrates a larger dependence on convertor thickness than those with lower atomic number and density with the exception of a-Se. The mean deposited energy increases with increasing average energy of the incident x-ray spectrum. HgI(2), PbI(2), and CdZnTe demonstrate the largest increase in deposited energy with increasing mass loading and a-Se and Si the smallest. The best DQE performances are achieved with PbO and TlBr. For mass loading greater than 100 mg cm(-2), a-Se, HgI(2), and PbI(2) provide similar DQE values to PbO and TlBr., Conclusions: The quantum absorption efficiency, average deposited energy per interacting x-ray, Swank noise factor, and detective quantum efficiency are tabulated by means of graphs which may help with the design and selection of materials for photoconductor-based mammography detectors. Neglecting the electrical characteristics of photoconductor materials and taking into account only x-ray interactions, it is concluded that PbO shows the strongest signal-to-noise ratio performance of the materials investigated in this study.

Purpose: Compressed sensing theory has enabled an accurate, low-dose cone-beam computed tomography (CBCT) reconstruction using a minimal number of noisy projections. However, the reconstruction time remains a significant challenge for practical implementation in the clinic. In this work, we propose a novel gradient projection algorithm, based on the Gradient-Projection-Barzilai-Borwein formulation (GP-BB), that handles the total variation (TV)-norm regularization-based least squares problem for the CBCT reconstruction in a highly efficient manner, with speed acceptable for routine use in the clinic., Methods: CBCT is reconstructed by minimizing an energy function consisting of a data fidelity term and a TV-norm regularization term. Both terms are simultaneously minimized by calculating the gradient projection of the energy function with the step size determined using an approximate Hessian calculation at each iteration, based on the Barzilai-Borwein formulation. To speed up the process, a multiresolution optimization is used. In addition, the entire algorithm was designed to run with a single graphics processing unit (GPU) card. To evaluate the performance, the Shepp-Logan numerical phantom, the CatPhan 600 physical phantom, and a clinically-treated head-and-neck patient were acquired from the TrueBeam™ system (Varian Medical Systems, Palo Alto, CA). For each scan, in total, 364 projections were acquired in a 200° rotation. The imager has 1024 × 768 pixels with 0.388 × 0.388-mm resolution. This was down-sampled to 512 × 384 pixels with 0.776 × 0.776-mm resolution for reconstruction. Evenly spaced angles were subsampled and used for varying the number of projections for the image reconstruction. To assess the performance of our GP-BB algorithm, we have implemented and compared with three compressed sensing-type algorithms, the two of which are popular and published (forward-backward splitting techniques), and the other one with a basic line-search technique. In addition, the conventional Feldkamp-Davis-Kress (FDK) reconstruction of the clinical patient data is compared as well., Results: In comparison with the other compressed sensing-type algorithms, our algorithm showed convergence in ≤30 iterations whereas other published algorithms need at least 50 iterations in order to reconstruct the Shepp-Logan phantom image. With the CatPhan phantom, the GP-BB algorithm achieved a clinically-reasonable image with 40 projections in 12 iterations, in less than 12.6 s. This is at least an order of magnitude faster in reconstruction time compared with the most recent reports utilizing GPU technology given the same input projections. For the head-and-neck clinical scan, clinically-reasonable images were obtained from 120 projections in 34-78 s converging in 12-30 iterations. In this reconstruction range (i.e., 120 projections) the image quality is visually similar to or better than the conventional FDK reconstructed images using 364 projections. This represents a dose reduction of nearly 67% (120∕364 projections) while maintaining a reasonable speed in clinical implementation., Conclusions: In this paper, we proposed a novel, fast, low-dose CBCT reconstruction algorithm using the Barzilai-Borwein step-size calculation. A clinically viable head-and-neck image can be obtained within ∼34-78 s while simultaneously cutting the dose by approximately 67%. This makes our GP-BB algorithm potentially useful in an on-line image-guided radiation therapy (IGRT).

Purpose: X-ray digital subtraction angiography (DSA) is widely used for vascular imaging. However, the need to subtract a mask image can result in motion artifacts and compromised image quality. The current interest in energy-resolving photon-counting (EPC) detectors offers the promise of eliminating motion artifacts and other advanced applications using a single exposure. The authors describe a method of assessing the iodine signal-to-noise ratio (SNR) that may be achieved with energy-resolved angiography (ERA) to enable a direct comparison with other approaches including DSA and dual-energy angiography for the same patient exposure., Methods: A linearized noise-propagation approach, combined with linear expressions of dual-energy and energy-resolved imaging, is used to describe the iodine SNR. The results were validated by a Monte Carlo calculation for all three approaches and compared visually for dual-energy and DSA imaging using a simple angiographic phantom with a CsI-based flat-panel detector., Results: The linearized SNR calculations show excellent agreement with Monte Carlo results. While dual-energy methods require an increased tube heat load of 2× to 4× compared to DSA, and photon-counting detectors are not yet ready for angiographic imaging, the available iodine SNR for both methods as tested is within 10% of that of conventional DSA for the same patient exposure over a wide range of patient thicknesses and iodine concentrations., Conclusions: While the energy-based methods are not necessarily optimized and further improvements are likely, the linearized noise-propagation analysis provides the theoretical framework of a level playing field for optimization studies and comparison with conventional DSA. It is concluded that both dual-energy and photon-counting approaches have the potential to provide similar angiographic image quality to DSA.

As a part of our ongoing search for bioactive constituents from natural Korean sources, the investigation of rhizomes of Acorus gramineus afforded five new lignans, named ligraminols A-E (1-5), together with seven known ones (6-12). The structures of 1-5 were determined by a combination of 1D and 2D NMR, HRMS, CD, and enzymatic hydrolysis. Compounds 1-12 were tested for their antiproliferative activities toward a panel of human-derived normal and cancer cell lines. Moreover, compounds 1-12 were evaluated for their inhibitory activities on nitric oxide production in an activated murine microglial cell line.

The performance of a specialized dual γ-ray imager using both mechanical and electronic collimation was evaluated by Monte Carlo simulation (MCNP5). The dual imager consisted of an active collimator and a planar detector that were made from scintillators. The active collimator served not only as a coded aperture for mechanical collimation but also as a first detector for electronic collimation. Therefore, a single system contained both mechanical and electronic collimation. Various types of scintillators were tested and compared with each other in terms of their angular resolution, efficiency, and background noise. In general, a BGO active collimator had the best mechanical collimation performance, and an LaCl₃(Ce) active collimator provided the best electronic collimation performance. However, for low radiation energies, the mechanical collimation images made from both scintillators showed the same quality, and, for high radiation energies, electronic collimation images made from both scintillators also show similar quality. Therefore, if mechanical collimation is used to detect low-energy radiation and electronic collimation is applied to reconstruct a high-energy source, either LaCl₃(Ce) or BGO would be appropriate for the active collimator of a dual γ-ray imager. These results broaden the choice of scintillators for the active collimator of the dual γ-ray imager, which makes it possible to consider other factors, such as machinability and cost, in making the imager. As a planar detector, BGO showed better performance than other scintillators since its radiation detection efficiency was highest of all., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

The purpose of this work is to demonstrate an ultra-fast reconstruction technique for digital tomosynthesis (DTS) imaging based on the algorithm proposed by Feldkamp, Davis, and Kress (FDK) using standard general-purpose graphics processing unit (GPGPU) programming interface. To this end, the FDK-based DTS algorithm was programmed "in-house" with C language with utilization of 1) GPU and 2) central processing unit (CPU) cards. The GPU card consisted of 480 processing cores (2 x 240 dual chip) with 1,242 MHz processing clock speed and 1,792 MB memory space. In terms of CPU hardware, we used 2.68 GHz clock speed, 12.0 GB DDR3 RAM, on a 64-bit OS. The performance of proposed algorithm was tested on twenty-five patient cases (5 lung, 5 liver, 10 prostate, and 5 head-and-neck) scanned either with a full-fan or half-fan mode on our cone-beam computed tomography (CBCT) system. For the full-fan scans, the projections from 157.5°-202.5° (45°-scan) were used to reconstruct coronal DTS slices, whereas for the half-fan scans, the projections from both 157.5°-202.5° and 337.5°-22.5° (2 x 45°-scan) were used to reconstruct larger FOV coronal DTS slices. For this study, we chose 45°-scan angle that contained ~80 projections for the full-fan and ~160 projections with 2 x 45°-scan angle for the half-fan mode, each with 1024 x 768 pixels with 32-bit precision. Absolute pixel value differences, profiles, and contrast-to-noise ratio (CNR) calculations were performed to compare and evaluate the images reconstructed using GPU- and CPU-based implementations. The time dependence on the reconstruction volume was also tested with (512 x 512) x 16, 32, 64, 128, and 256 slices. In the end, the GPU-based implementation achieved, at most, 1.3 and 2.5 seconds to complete full reconstruction of 512 x 512 x 256 volume, for the full-fan and half-fan modes, respectively. In turn, this meant that our implementation can process > 13 projections-per-second (pps) and > 18 pps for the full-fan and half-fan modes, respectively. Since commercial CBCT system nominally acquires 11 pps (with 1 gantry-revolution-per-minute), our GPU-based implementation is sufficient to handle the incoming projections data as they are acquired and reconstruct the entire volume immediately after completing the scan. In addition, on increasing the number of slices (hence volume) to be reconstructed from 16 to 256, only minimal increases in reconstruction time were observed for the GPU-based implementation where from 0.73 to 1.27 seconds and 1.42 to 2.47 seconds increase were observed for the full-fan and half-fan modes, respectively. This resulted in speed improvement of up to 87 times compared with the CPU-based implementation (for 256 slices case), with visually identical images and small pixel-value discrepancies (< 6.3%), and CNR differences (< 2.3%). With this achievement, we have shown that time allocation for DTS image reconstruction is virtually eliminated and that clinical implementation of this approach has become quite appealing. In addition, with the speed achievement, further image processing and real-time applications that was prohibited prior due to time restrictions can now be tempered with.

Purpose: Energy-resolved x-ray imaging has the potential to improve contrast-to-noise ratio by measuring the energy of each interacting photon and applying optimal weighting factors. The success of energy-resolving photon-counting (EPC) detectors relies on the ability of an x-ray detector to accurately measure the energy of each interacting photon. However, the escape of characteristic emissions and Compton scatter degrades spectral information. This article makes the theoretical connection between accuracy and imprecision in energy measurements with the x-ray Swank factor for a-Se, Si, CdZnTe, and HgI2-based detectors., Methods: For a detector that implements adaptive binning to sum all elements in which x-ray energy is deposited for a single interaction, energy imprecision is shown to depend on the Swank factor for a large element with x rays incident at the center. The response function for each converter material is determined using Monte Carlo methods and used to determine energy accuracy, Swank factor, and relative energy imprecision in photon-energy measurements., Results: For each material, at energies below the respective K edges, accuracy is close to unity and imprecision is only a few percent. Above the K-edge energies, characteristic emission results in a drop in accuracy and precision that depends on escape probability. In Si, and to some extent a-Se, Compton-scatter escape also degrades energy precision with increasing energy. The influence of converter thickness on energy accuracy and imprecision is modest for low-Z materials but becomes important when using high-Z materials at energies greater than the K-edge energies., Conclusions: Accuracy and precision in energy measurements by EPC detectors are determined largely by the energy-dependent x-ray Swank factor. Modest decreases in the Swank factor (5%-15%) result in large increases in relative imprecision (30%-40%).

A flexible microdome-grooved Gd(2)O(2)S:Tb scintillator is simulated, fabricated, and characterized for digital radiography applications. According to Monte Carlo simulation results, the dome-grooved structure has a high spatial resolution, which is verified by X-ray image performance of the scintillator. The proposed scintillator has lower X-ray sensitivity than a nonstructured scintillator but almost two times higher spatial resolution at high spatial frequency. Through evaluation of the X-ray performance of the fabricated scintillators, we confirm that the microdome-grooved scintillator can be applied to next-generation flexible digital radiography systems requiring high spatial resolution.

A dedicated small-animal x-ray micro computed tomography (micro-CT) system has been developed to screen laboratory small animals such as mice and rats. The micro-CT system consists of an indirect-detection flat-panel x-ray detector with a field-of-view of 120 x 120 mm2, a microfocus x-ray source, a rotational subject holder and a parallel data processing system. The flat-panel detector is based on a matrix-addressed photodiode array fabricated by a CMOS (complementary metal-oxide semiconductor) process coupled to a CsI:T1 (thallium-doped caesium iodide) scintillator as an x-ray-to-light converter. Principal imaging performances of the micro-CT system have been evaluated in terms of image uniformity, voxel noise and spatial resolution. It has been found that the image non-uniformity mainly comes from the structural non-uniform sensitivity pattern of the flat-panel detector and the voxel noise is about 48 CT numbers at the voxel size of 100 x 100 x 200 microm3 and the air kerma of 286 mGy. When the magnification ratio is 2, the spatial resolution of the micro-CT system is about 14 1p/mm (line pairs per millimetre) that is almost determined by the flat-panel detector showing about 7 1p/mm resolving power. Through low-contrast phantom imaging studies, the minimum resolvable contrast has been found to be less than 36 CT numbers at the air kerma of 95 mGy. Some laboratory rat imaging results are presented.