1. Water-dispersible glycosylated poly(2,5'-thienylene)porphyrin-based nanoparticles for antibacterial photodynamic therapy.
- Author
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Khan R, Özkan M, Khaligh A, and Tuncel D
- Subjects
- Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Glycosylation, Microbial Sensitivity Tests, Molecular Structure, Photosensitizing Agents chemical synthesis, Photosensitizing Agents chemistry, Polymers chemical synthesis, Polymers chemistry, Porphyrins chemical synthesis, Porphyrins chemistry, Anti-Bacterial Agents pharmacology, Bacillus subtilis drug effects, Escherichia coli drug effects, Nanoparticles chemistry, Photochemotherapy, Photosensitizing Agents pharmacology, Polymers pharmacology, Porphyrins pharmacology, Water chemistry
- Abstract
Here we report the preparation of water-dispersible glycosylated poly(2,5'-thienylene)porphyrin based nanoparticles by a nanoprecipitation method and demonstrate the application of these nanoparticles in antibacterial photodynamic therapy. The diameter of the nanoparticles is in the range of 50-80 nm and the resulting nanoparticles are stable in water without precipitation at least for a month. They have high singlet oxygen efficiency and display light-triggered biocidal activity against both Gram negative bacteria (Escherichia coli, E. coli) and Gram positive bacteria (Bacillus subtilis, B. subtilis). Upon white light irradiation for 10 min with a flux of 22 mW cm-2 of the E. coli suspension incubated with NPs (18 μg mL-1), a killing efficiency of 99% is achieved, whereas in the dark the effect is recorded as only around 8%.
- Published
- 2019
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