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1. Inguinal swelling unveiling biphasic synovial sarcoma: A case report.

Author

Limaiem F, Hajri M, Kammoun N, Laabidi T, Hadrich Z, and Kchir N

Abstract

Introduction and Importance: Synovial sarcoma is a high-grade soft tissue sarcoma primarily affecting teenagers and young adults. Inguinal region involvement is rare, making diagnosis and treatment challenging., Case Presentation: A 35-year-old Tunisian man presented with a progressively enlarging right inguinal swelling. Imaging revealed a mass behind the inguinal ligament, confirmed as biphasic synovial sarcoma through biopsy. The patient underwent successful surgery with clear resection margins. Histopathological examination revealed a biphasic sarcoma with spindle cell and glandular components, supporting the diagnosis of synovial sarcoma. Following surgery, the patient received adjuvant radiotherapy. Regular outpatient follow-up is being conducted to monitor progress., Clinical Discussion: Synovial sarcoma is characterized by slow growth and local invasiveness, with potential for metastasis. It typically presents as a solid mass that can compress nearby structures such as blood vessels. Imaging studies offer valuable insights into tumor location, size, invasiveness, and potential metastases. Local tumor staging relies on MRI, while distant metastases are detected using chest CT or bone scans. Diagnosis is confirmed through histopathological examination and immunohistochemical analysis., Conclusions: This case report highlights a rare presentation of inguinal synovial sarcoma and emphasizes the importance of individualized multimodal therapy in its management., Competing Interests: Declaration of competing interest None declared., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2024
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2. Secondary xanthogranulomatous hypophysitis mimicking a pituitary macroadenoma: a case report.

Author

Salhi S, Oueslati I, Mouelhi Y, Zehani A, Kchir N, Kamoun E, Yazidi M, and Chihaoui M

Subjects
Humans, Female, Pregnancy, Middle Aged, Adrenocorticotropic Hormone, Eye, Pituitary Neoplasms diagnosis, Galactorrhea, Cysts
Abstract

Hypophysitis is an extremely rare inflammatory disease that can mimic the clinical and radiological features of a pituitary adenoma. In this case report, we describe a 45-year-old woman with secondary xanthogranulomatous hypophysitis (XGH) who presented with signs of a pituitary macroadenoma. The patient complained of headaches, visual impairment, and amenorrhea-galactorrhea syndrome. Her physical examination was normal. Laboratory investigation revealed corticotropin, thyrotropin, and gonadotropin deficiencies. She also had low visual acuity in her right eye and an altered visual field. Pituitary magnetic resonance imaging revealed an intra and suprasellar mass measuring 13 × 11 × 16 mm, with hemorrhagic necrosis, that was having a discrete mass effect on the patient's optic chiasm and pituitary stalk. The patient was treated with hydrocortisone and levothyroxine, and then transferred to the Neurosurgery department for total transsphenoidal resection of the mass. Histological examination of the tumor permitted a diagnosis of XGH of a remodeled Rathke's pouch cyst to be made. Systemic conditions such as tuberculosis, sarcoidosis, and other granulomatous diseases were excluded. The etiopathogenesis of XGH remains poorly characterized, but it may be a progressive form of lymphocytic hypophysitis or a remodeled Rathke's pouch cyst. Screening for autoimmune pathology and systemic diseases is essential to guide appropriate management., Competing Interests: Declaration of conflicting interestThe authors declare that there is no conflict of interest.

Published
2024
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4. Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.

Author

Hendaoui I, Lahmar A, Campo L, Mebarki S, Bichet S, Hess D, Degen M, Kchir N, Charrada-Ben Farhat L, Hefaiedh R, Ruiz C, Terracciano LM, Tucker RP, Hendaoui L, and Chiquet-Ehrismann R

Subjects
Biliary Tract Neoplasms pathology, Cell Line, Tumor, Humans, Stromal Cells immunology, Stromal Cells pathology, Biliary Tract Neoplasms immunology, Biomarkers, Tumor immunology, Neoplasm Proteins immunology, Tenascin immunology
Abstract

Extrahepatic cancers of the biliary system are typically asymptomatic until after metastasis, which contributes to their poor prognosis. Here we examined intrahepatic cholangiocarcinomas (n = 8), carcinomas of perihilar bile ducts (n = 7), carcinomas of the gallbladder (n = 11) and hepatic metastasis from carcinomas of the gallbladder (n = 4) for the expression of the extracellular matrix glycoproteins tenascin-C and tenascin-W. Anti-tenascin-C and anti-tenascin-W immunoreactivity was found in all biliary tract tumors examined. Unlike tenascin-C, tenascin-W was not detected in normal hepatobiliary tissue. Tenascin-W was also expressed by the cholangiocarcinoma-derived cell line Huh-28. However, co-culture of Huh-28 cells with immortalized bone marrow-derived stromal cells was necessary for the formation and organization of tenascin-W fibrils in vitro . Our results indicate that tenascin-W may be a novel marker of hepatobiliary tumor stroma, and its absence from many normal tissues suggests that it may be a potential target for biotherapies., Competing Interests: Some of the results showed herein have been used in the patent “Tenascin-W and biliary tract cancers” (WO2017072669). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Hendaoui, Lahmar, Campo, Mebarki, Bichet, Hess, Degen, Kchir, Charrada-Ben Farhat, Hefaiedh, Ruiz, Terracciano, Tucker, Hendaoui and Chiquet-Ehrismann.)

Published
2021
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5. Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification.

Author

Monette A, Bergeron D, Ben Amor A, Meunier L, Caron C, Mes-Masson AM, Kchir N, Hamzaoui K, Jurisica I, and Lapointe R

Subjects
Feasibility Studies, Female, Gene Expression Regulation, Neoplastic, Humans, Immunotherapy, Male, Neoplasms drug therapy, Prognosis, Protein Interaction Maps, Survival Analysis, Biomarkers, Tumor metabolism, Neoplasms immunology, Neoplasms pathology, Tissue Array Analysis methods
Abstract

Background: Permanence of front-line management of lung cancer by immunotherapies requires predictive companion diagnostics identifying immune-checkpoints at baseline, challenged by the size and heterogeneity of biopsy specimens., Methods: An innovative, tumor heterogeneity reducing, immune-enriched tissue microarray was constructed from baseline biopsies, and multiplex immunofluorescence was used to profile 25 immune-checkpoints and immune-antigens., Results: Multiple immune-checkpoints were ranked, correlated with antigen presenting and cytotoxic effector lymphocyte activity, and were reduced with advancing disease. Immune-checkpoint combinations on TILs were associated with a marked survival advantage. Conserved combinations validated on more than 11,000 lung, breast, gastric and ovarian cancer patients demonstrate the feasibility of pan-cancer companion diagnostics., Conclusions: In this hypothesis-generating study, deepening our understanding of immune-checkpoint biology, comprehensive protein-protein interaction and pathway mapping revealed that redundant immune-checkpoint interactors associate with positive outcomes, providing new avenues for the deciphering of molecular mechanisms behind effects of immunotherapeutic agents targeting immune-checkpoints analyzed.

Published
2019
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6. Desmoplastic infantile ganglioglioma.

Author

Kamoun S, Azouz H, Zemmali M, Haouet S, and Kchir N

Subjects
Brain Neoplasms surgery, Child, Female, Ganglioglioma surgery, Humans, Seizures etiology, Brain Neoplasms diagnostic imaging, Craniotomy methods, Ganglioglioma diagnostic imaging, Magnetic Resonance Imaging methods
Abstract

The term desmoplastic infantile ganglioglioma was coined by VandenBerg et al in 1987. In their first report these authors referred to a rare, distinct brain tumor. About 60 cases of desmoplastic infantile ganglioglioma have been described in the literature since its first description. We report a case of a 6-year-old girl who was admitted for seizure without family history. Magnetic resonance imaging scan showed a hypodense area in the right temporal region. A right temporal craniotomy was performed and the tumor was excised. The pathologic examination revealed the diagnosis of desmoplastic infantile ganglioglioma., Competing Interests: The authors declare no competing interest.

Published
2019
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8. 46th Medical Maghrebian Congress. November 9-10, 2018. Tunis.

Author

Alami Aroussi A, Fouad A, Omrane A, Razzak A, Aissa A, Akkad A, Amraoui A, Aouam A, Arfaoui A, Belkouchi A, Ben Chaaben A, Ben Cheikh A, Ben Khélifa A, Ben Mabrouk A, Benhima A, Bezza A, Bezzine A, Bourrahouat A, Chaieb A, Chakib A, Chetoui A, Daoudi A, Ech-Chenbouli A, Gaaliche A, Hassani A, Kassimi A, Khachane A, Labidi A, Lalaoui A, Masrar A, McHachi A, Nakhli A, Ouakaa A, Siati A, Toumi A, Zaouali A, Condé AY, Haggui A, Belaguid A, El Hangouche AJ, Gharbi A, Mahfoudh A, Bouzouita A, Aissaoui A, Ben Hamouda A, Hedhli A, Ammous A, Bahlous A, Ben Halima A, Belhadj A, Bezzine A, Blel A, Brahem A, Banasr A, Meherzi A, Saadi A, Sellami A, Turki A, Ben Miled A, Ben Slama A, Daib A, Zommiti A, Chadly A, Jmaa A, Mtiraoui A, Ksentini A, Methnani A, Zehani A, Kessantini A, Farah A, Mankai A, Mellouli A, Zaouali A, Touil A, Hssine A, Ben Safta A, Derouiche A, Jmal A, Ferjani A, Djobbi A, Dridi A, Aridhi A, Bahdoudi A, Ben Amara A, Benzarti A, Ben Slama AY, Oueslati A, Soltani A, Chadli A, Aloui A, Belghuith Sriha A, Bouden A, Laabidi A, Mensi A, Ouakaa A, Sabbek A, Zribi A, Green A, Ben Nasr A, Azaiez A, Yeades A, Belhaj A, Mediouni A, Sammoud A, Slim A, Amine B, Chelly B, Jatik B, Lmimouni B, Daouahi B, Ben Khelifa B, Louzir B, Dorra A, Dhahri B, Ben Nasrallah C, Chefchaouni C, Konzi C, Loussaief C, Makni C, Dziri C, Bouguerra C, Kays C, Zedini C, Dhouha C, Mohamed C, Aichaouia C, Dhieb C, Fofana D, Gargouri D, Chebil D, Issaoui D, Gouiaa D, Brahim D, Essid D, Jarraya D, Trad D, Ben Hmida E, Sboui E, Ben Brahim E, Baati E, Talbi E, Chaari E, Hammami E, Ghazouani E, Ayari F, Ben Hariz F, Bennaoui F, Chebbi F, Chigr F, Guemira F, Harrar F, Benmoula FZ, Ouali FZ, Maoulainine FMR, Bouden F, Fdhila F, Améziani F, Bouhaouala F, Charfi F, Chermiti Ben Abdallah F, Hammemi F, Jarraya F, Khanchel F, Ourda F, Sellami F, Trabelsi F, Yangui F, Fekih Romdhane F, Mellouli F, Nacef Jomli F, Mghaieth F, Draiss G, Elamine G, Kablouti G, Touzani G, Manzeki GB, Garali G, Drissi G, Besbes G, Abaza H, Azzouz H, Said Latiri H, Rejeb H, Ben Ammar H, Ben Brahim H, Ben Jeddi H, Ben Mahjouba H, Besbes H, Dabbebi H, Douik H, El Haoury H, Elannaz H, Elloumi H, Hachim H, Iraqi H, Kalboussi H, Khadhraoui H, Khouni H, Mamad H, Metjaouel H, Naoui H, Zargouni H, Elmalki HO, Feki H, Haouala H, Jaafoura H, Drissa H, Mizouni H, Kamoun H, Ouerda H, Zaibi H, Chiha H, Kamoun H, Saibi H, Skhiri H, Boussaffa H, Majed H, Blibech H, Daami H, Harzallah H, Rkain H, Ben Massoud H, Jaziri H, Ben Said H, Ayed H, Harrabi H, Chaabouni H, Ladida Debbache H, Harbi H, Yacoub H, Abroug H, Ghali H, Kchir H, Msaad H, Ghali H, Manai H, Riahi H, Bousselmi H, Limem H, Aouina H, Jerraya H, Ben Ayed H, Chahed H, Snéne H, Lahlou Amine I, Nouiser I, Ait Sab I, Chelly I, Elboukhani I, Ghanmi I, Kallala I, Kooli I, Bouasker I, Fetni I, Bachouch I, Bouguecha I, Chaabani I, Gazzeh I, Samaali I, Youssef I, Zemni I, Bachouche I, Youssef I, Bouannene I, Kasraoui I, Laouini I, Mahjoubi I, Maoudoud I, Riahi I, Selmi I, Tka I, Hadj Khalifa I, Mejri I, Béjia I, Bellagha J, Boubaker J, Daghfous J, Dammak J, Hleli J, Ben Amar J, Jedidi J, Marrakchi J, Kaoutar K, Arjouni K, Ben Helel K, Benouhoud K, Rjeb K, Imene K, Samoud K, El Jeri K, Abid K, Chaker K, Abid K, Bouzghaîa K, Kamoun K, Zitouna K, Oughlani K, Lassoued K, Letaif K, Hakim K, Cherif Alami L, Benhmidoune L, Boumhil L, Bouzgarrou L, Dhidah L, Ifrine L, Kallel L, Merzougui L, Errguig L, Mouelhi L, Sahli L, Maoua M, Rejeb M, Ben Rejeb M, Bouchrik M, Bouhoula M, Bourrous M, Bouskraoui M, El Belhadji M, El Belhadji M, Essakhi M, Essid M, Gharbaoui M, Haboub M, Iken M, Krifa M, Lagrine M, Leboyer M, Najimi M, Rahoui M, Sabbah M, Sbihi M, Zouine M, Chefchaouni MC, Gharbi MH, El Fakiri MM, Tagajdid MR, Shimi M, Touaibia M, Jguirim M, Barsaoui M, Belghith M, Ben Jmaa M, Koubaa M, Tbini M, Boughdir M, Ben Salah M, Ben Fraj M, Ben Halima M, Ben Khalifa M, Bousleh M, Limam M, Mabrouk M, Mallouli M, Rebeii M, Ayari M, Belhadj M, Ben Hmida M, Boughattas M, Drissa M, El Ghardallou M, Fejjeri M, Hamza M, Jaidane M, Jrad M, Kacem M, Mersni M, Mjid M, Sabbah M, Serghini M, Triki M, Ben Abbes M, Boussaid M, Gharbi M, Hafi M, Slama M, Trigui M, Taoueb M, Chakroun M, Ben Cheikh M, Chebbi M, Hadj Taieb M, Kacem M, Ben Khelil M, Hammami M, Khalfallah M, Ksiaa M, Mechri M, Mrad M, Sboui M, Bani M, Hajri M, Mellouli M, Allouche M, Mesrati MA, Mseddi MA, Amri M, Bejaoui M, Bellali M, Ben Amor M, Ben Dhieb M, Ben Moussa M, Chebil M, Cherif M, Fourati M, Kahloul M, Khaled M, Machghoul M, Mansour M, Abdesslem MM, Ben Chehida MA, Chaouch MA, Essid MA, Meddeb MA, Gharbi MC, Elleuch MH, Loueslati MH, Sboui MM, Mhiri MN, Kilani MO, Ben Slama MR, Charfi MR, Nakhli MS, Mourali MS, El Asli MS, Lamouchi MT, Cherti M, Khadhraoui M, Bibi M, Hamdoun M, Kassis M, Touzi M, Ben Khaled M, Fekih M, Khemiri M, Ouederni M, Hchicha M, Kassis M, Ben Attia M, Yahyaoui M, Ben Azaiez M, Bousnina M, Ben Jemaa M, Ben Yahia M, Daghfous M, Haj Slimen M, Assidi M, Belhadj N, Ben Mustapha N, El Idrissislitine N, Hikki N, Kchir N, Mars N, Meddeb N, Ouni N, Rada N, Rezg N, Trabelsi N, Bouafia N, Haloui N, Benfenatki N, Bergaoui N, Yomn N, Ben Mustapha N, Maamouri N, Mehiri N, Siala N, Beltaief N, Aridhi N, Sidaoui N, Walid N, Mechergui N, Mnif N, Ben Chekaya N, Bellil N, Dhouib N, Achour N, Kaabar N, Mrizak N, Mnif N, Chaouech N, Hasni N, Issaoui N, Ati N, Balloumi N, Haj Salem N, Ladhari N, Akif N, Liani N, Hajji N, Trad N, Elleuch N, Marzouki NEH, Larbi N, M'barek N, Rebai N, Bibani N, Ben Salah N, Belmaachi O, Elmaalel O, Jlassi O, Mihoub O, Ben Zaid O, Bouallègue O, Bousnina O, Bouyahia O, El Maalel O, Fendri O, Azzabi O, Borgi O, Ghdes O, Ben Rejeb O, Rachid R, Abi R, Bahiri R, Boulma R, Elkhayat R, Habbal R, Rachid R, Tamouza R, Jomli R, Ben Abdallah R, Smaoui R, Debbeche R, Fakhfakh R, El Kamel R, Gargouri R, Jouini R, Nouira R, Fessi R, Bannour R, Ben Rabeh R, Kacem R, Khmakhem R, Ben Younes R, Karray R, Cheikh R, Ben Malek R, Ben Slama R, Kouki R, Baati R, Bechraoui R, Fakhfakh R, Fradi R, Lahiani R, Ridha R, Zainine R, Kallel R, Rostom S, Ben Abdallah S, Ben Hammamia S, Benchérifa S, Benkirane S, Chatti S, El Guedri S, El Oussaoui S, Elkochri S, Elmoussaoui S, Enbili S, Gara S, Haouet S, Khammeri S, Khefecha S, Khtrouche S, Macheghoul S, Mallouli S, Rharrit S, Skouri S, Helali S, Boulehmi S, Abid S, Naouar S, Zelfani S, Ben Amar S, Ajmi S, Braiek S, Yahiaoui S, Ghezaiel S, Ben Toumia S, Thabeti S, Daboussi S, Ben Abderahman S, Rhaiem S, Ben Rhouma S, Rekaya S, Haddad S, Kammoun S, Merai S, Mhamdi S, Ben Ali R, Gaaloul S, Ouali S, Taleb S, Zrour S, Hamdi S, Zaghdoudi S, Ammari S, Ben Abderrahim S, Karaa S, Maazaoui S, Saidani S, Stambouli S, Mokadem S, Boudiche S, Zaghbib S, Ayedi S, Jardek S, Bouselmi S, Chtourou S, Manoubi S, Bahri S, Halioui S, Jrad S, Mazigh S, Ouerghi S, Toujani S, Fenniche S, Aboudrar S, Meriem Amari S, Karouia S, Bourgou S, Halayem S, Rammeh S, Yaïch S, Ben Nasrallah S, Chouchane S, Ftini S, Makni S, Manoubi S, Miri S, Saadi S, Manoubi SA, Khalfallah T, Mechergui T, Dakka T, Barhoumi T, M'rad TEB, Ajmi T, Dorra T, Ouali U, Hannachi W, Ferjaoui W, Aissi W, Dahmani W, Dhouib W, Koubaa W, Zhir W, Gheriani W, Arfa W, Dougaz W, Sahnoun W, Naija W, Sami Y, Bouteraa Y, Elhamdaoui Y, Hama Y, Ouahchi Y, Guebsi Y, Nouira Y, Daly Y, Mahjoubi Y, Mejdoub Y, Mosbahi Y, Said Y, Zaimi Y, Zgueb Y, Dridi Y, Mesbahi Y, Gharbi Y, Hellal Y, Hechmi Z, Zid Z, Elmouatassim Z, Ghorbel Z, Habbadi Z, Marrakchi Z, Hidouri Z, Abbes Z, Ouhachi Z, Khessairi Z, Khlayfia Z, Mahjoubi Z, and Moatemri Z

Subjects
Africa, Northern epidemiology, Anatomy education, Education, Medical history, Education, Medical methods, Education, Medical organization & administration, History, 21st Century, Humans, Internship and Residency standards, Internship and Residency trends, Job Satisfaction, Pathology, Clinical education, Tunisia epidemiology, Education, Medical trends, Medicine methods, Medicine organization & administration, Medicine trends
Published
2019

9. [A misleading oncocytic tumor of the pituitary gland].

Author

Zehani A, Chelly I, Ben Said I, Jmel H, Haouet S, and Kchir N

Subjects
Adenoma, Oxyphilic complications, Adenoma, Oxyphilic diagnostic imaging, Adenoma, Oxyphilic pathology, Headache etiology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Paresis etiology, Pituitary Neoplasms complications, Pituitary Neoplasms diagnostic imaging, Pituitary Neoplasms pathology, Vision Disorders etiology, Adenoma, Oxyphilic diagnosis, Pituitary Neoplasms diagnosis
Published
2018
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10. Kaposi's varicelliform eruption revealing Darier's disease.

Author

Souissi A, Karray M, Chelly I, Ben Tanfous A, Zaraa I, El Euch D, Kchir N, and Mokni M

Subjects
Darier Disease complications, Humans, Kaposi Varicelliform Eruption etiology, Kaposi Varicelliform Eruption pathology, Male, Young Adult, Darier Disease diagnosis, Kaposi Varicelliform Eruption diagnosis
Published
2018

11. Poster abstracts of the 18th Pan Arab Cancer Congress. TUNISIA. April 19-21, 2018.

Author

Aarab J, Abbess I, Abdalla F, Abdelaziz Z, Abdelfattah S, Abdelli I, Abdelmajid K, Abdelsselem Z, Abdelwahed N, Abdessayed N, Abid B, Abid K, Abidi R, Abudabbous A, Abujanah S, Aburwais A, Acacha E, Acharfi N, Affes N, Aftis R, Ahalli I, Aid M, Aissaoui D, Alaoui A, Alaoui M, Albatran S, Mamdouh A, Alkikkli R, Allam A, Aloulou S, Alqawi O, Alragig MA, Alsharksi A, Amaadour KOL, Amaadour L, Ameziane N, Ammari A, Ammour H, Amrane R, Annad N, Aouati E, Aouichat S, Aouragh S, Arifi S, Astra M, Atassi M, Ati N, Atoui K, Atreche L, Ayachi S, Ayadi I, Ayadi MA, Ayadi M, Ayari J, Ayed H, Ayed K, Ayedi H, Ayedi I, Azegrar M, Azzouz H, Babdalla F, Bachiri R, Bachiri Z, Baghdad M, Bahloul R, Bahouli A, Bahri M, Baississ I, Bakkali H, Balti M, Baraket O, Bargaoui H, Batti R, Bedioui A, Begag R, Behourah Z, Belaid I, Belaïd A, Ben Abdallah A, Ben Abdallah I, Ben Ahmed S, Ben Ahmed T, Ben Azaiz M, Ben Chehida MA, Ben Fatma L, Ben Ghachem D, Ben Ghachem T, Ben Hassouna J, Ben Hmida S, Ben Nasr S, Ben Nejima D, Ben Rahal K, Ben Rejeb M, Ben Rhouma S, Ben Safta I, Ben Salem A, Ben Zargouna Y, Benabdallah I, Benabdella H, Benabdessalem MZ, Benahmed K, Benahmed S, Benameur H, Benasr S, Benbrahim F, Benbrahim W, Benbrahim Z, Benchehida M, Bencheikh Y, Bendhiab T, Benfatma L, Bengueddach A, Benhami M, Benhassouna J, Benhbib W, Benjaafar N, Benkali R, Benkridis W, Benlaloui A, Benmaitig M, Benmansour A, Benmouhoub M, Benna F, Benna H, Benna M, Benna M, Bennabdellah H, Benrahal K, Bensafta I, Bensalah H, Bensalem A, Bensaud M, Benslama R, Benyoub M, Benzid K, Bergaoui H, Beroual M, Berrad S, Berrazaga Y, Bezzaz Z, Bhiri H, Bibi M, Binous MY, Blel A, Boder JM, Bouaouina N, Bouaziz H, Bouchoucha S, Boudawara T, Boudawara Z, Bouderbala A, Bouhali R, Bouhani M, Boujarnija R, Boujelben S, Boujelbene N, Boukerzaza I, Boukhari H, Boulfoul W, Boulma R, Boumansour N, Bouned A, Bounedjar A, Bouraoui I, Bouraoui S, Bourigua R, Bourmech M, Bousaffa H, Bousahba A, Bousrih C, Boussarsar A, Boussen H, Boutayeb S, Bouzaidi K, Bouzaiene F, Bouzaiene H, Bouzerzour Z, Bouzid K, Bouzid N, Bouzidi D, Bouzidi W, Bouzouita A, Brahimi S, Brahmia A, Buhmeida A, Chaaben K, Chaabouni H, Chaabouni M, Chaabène K, Chaari H, Chaari I, Chaari M, Chabchoub I, Chabeene K, Chaker K, Chakroun M, Charfi M, Charfi S, Chargui R, Charles M, Chebil M, Cheikchouk K, Chelly B, Chelly I, Cheraiet N, Cherif A, Cherif M, Cherifi A, Chikhrouhou T, Chikouche A, Chirouf A, Chraiet N, Collan Y, Cui Z, Dabbebi H, Daldoul A, Damouche I, Daoud H, Daoud N, Daoued J, Darif K, Darwish DO, Derbouz Z, Derouiche A, Dhibe TT, Dhibet T, Djallaoui A, Djami N, Djebbes K, Djedi H, Djeghim S, Djellali L, Djellaoui A, Djilat K, Djouabi R, Doumbia H, Drah M, Dridi M, Hsairi M, Elabbassi S, Elallia F, Elati Z, Elattassi M, Elbenna H, Elfagieh MA, Elfaitori O, Elfannas H, Elghali A, Elghali MA, Elgonti S, Elhadj OE, Elhazzaz R, Elkacemi H, Elkinany K, Elkissi Y, Elloumi F, Elmaalel O, Elmajjaou IS, Elmajjaoui S, Elmhabrech H, Elmrabet F, Elsaghayer WA, Elzagheid A, Emaetig F, Erraichi H, Essid M, Ewshah N, Ezzairi F, Faleh R, Fallah S, Farag AL, Farhat L, Fehri R, Feki J, Fendri S, Fendri S, Fessi Z, Filali T, Fissah A, Fourati M, Fourati N, Frikha M, Fuchs CS, Gabssi A, Gachi F, Gadria S, Gammoudi A, Ganzoui I, Gargoura A, Ghaddabb I, Gharbi I, Gharbi M, Ghazouani E, Gheriani N, Ghorbel A, Ghorbel L, Ghozi A, Ghrissi R, Gouader A, Goucha A, Guebsi A, Guellil I, Guermazi F, Guesmi S, Guetari W, Habak N, Haddad A, Haddad S, Haddaoui A, Hadef I, Hader AF, Hadiji A, Hadjarab F, Hadoussa M, Hadoussa N, Hafsa C, Hafsia M, Hajji A, Hajmansour M, Hamdi S, Hamici Z, Hamida S, Hamila F, Hamissa S, Hammouda B, Haouet S, Harhira I, Haroun A, Hassouni K, Hdiji A, Hechiche M, Hejjane L, Hellal C, Henni M, Herbegue K, Hichami L, Hikem M, Hmad A, Hmida L, Hmissa S, Hochlaf M, Houas A, Houhani M, Huwidi A, Ian C, Ibrahim BN, Ibrahim NY, Idir H, Issaoui D, Itaimi A, Izem AE, Jaidane O, Jamel D, Jamous H, Jarrar M, Jarrar MS, Jarray S, Jebsi M, Jmal H, Juwid A, Kaabia O, Kablouti A, Kacem I, Kacem K, Kaid MY, Kallel M, Kallel R, Kammoun H, Kari S, Karrit S, Kchir H, Kchir N, Kebdani T, Kechad N, Kehili H, Kerboua E, Keskes H, Kessi NN, Khababa N, Khaldi H, Khanfir A, Khater B, Khelif A, Khemiri S, Khennouf K, Khouni H, Khrouf S, Kmira Z, Kochbati L, Korbi A, Kouadri N, Kouhen F, Krarti M, Handoussa M, Hsu Y, Laakom O, Laato M, Labidi S, Lahlali F, Lahmidi A, Lalaoui A, Lamia N, Lamri A, Letaief F, Letaief MR, Aldehmani M, Rafael A, Liepa AM, Limaiem F, Limam K, Loughlimi H, Ltaief F, Maamouri N, Mabrouk M, Madouri R, Mahjoub N, Mahjoubi Z, Mahrsi M, Makrem H, Mallek W, Manitta M, Mansoura L, Mansouri H, Maoua M, Maoui W, Marouene C, Marzouk K, Masmoudi S, May F, Meddeb I, Meddeb K, Meddour S, Medhioub F, Mejri N, Melizi MR, Mellas N, Melliti R, Melzi A, Merair N, Merrouki FZ, Mersali C, Messalbi O, Messaoudi L, Messioud S, Messoudi K, Mestiri S, Mezlini A, Mezlini A, Mghirbi F, Mhabrech H, Mhiri A, Midoun N, Milud R, Missaoui B, Mnasser A, Mnejja W, Mokni M, Mokrani A, Mokrani M, Moujahed R, Moukasse Y, Mouzount A, Mrad K, Mraidha MH, Mrizak N, Mzali R, Mzid Y, M'ghirbi F, Nakhli A, Nasr C, Nasri S, Noubigh G, Nouha D, Nouia L, Nouira Y, Noureddine A, Nouri O, Ohtsu A, Ouahbi H, Oualla K, Ouanes Y, Ouaz H, Ouikene A, Ouldbessi N, Parker I, Pyrhonen S, Rachdi H, Rahal K, Rahal K, Rahoui M, Raies H, Rameh S, Reguieg K, Rejab H, Rejiba R, Rhim MS, Riahi S, Rouimel N, Saad Saoud N, Saadi K, Saadi M, Sadou A, Saguem I, Sahnoun T, Sahnoune H, Sakhri S, Sallemi A, Sassi A, Sbika W, Sedkaoui C, Sefiane S, Sellami A, Seppo P, Sfaoua H, Sghaier S, Shagan A, Siala W, Slim I, Slimene M, Soltani S, Souilah S, Souissi M, Sriha Badreddine B, Swaisi Y, Taibi A, Taktak T, Talbi G, Talha SW, Talima SM, Tbessi S, Tebani N, Tebra S, Tebramrad S, Telaijia D, Tenni A, Tolba A, Topov Y, Touil K, Toumi N, Toumi W, Tounsi N, Trigui A, Trigui R, Triki W, Walha M, Werda I, Yacoub H, Yahyaoui Y, Yaich A, Yaici R, Yamouni M, Yeddes I, Yekrou D, Yousfi M, Yousfi N, Youssfi MA, Zaabar L, Zaied S, Zaim I, Zakhama W, Zayed S, Zehani A, Zemni I, Zenzri Y, Zeraoula S, Zouiten O, Zoukar O, Zrafi W, Zribi A, and Zubia N

Published
2018

12. Papillary thyroid tumors: Diagnostic value of CD56 and Cytokeratin 19.

Author

Zehani A, Bani A, Chelly I, Rejaibi S, Besbes G, Haouet S, and Kchir N

Subjects
Adenoma diagnosis, Adenoma pathology, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor analysis, Biomarkers, Tumor metabolism, Biopsy, Fine-Needle, CD56 Antigen analysis, Carcinoma, Papillary metabolism, Carcinoma, Papillary pathology, Diagnosis, Differential, Female, Humans, Immunohistochemistry, Keratin-19 analysis, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Thyroid Cancer, Papillary diagnosis, Thyroid Cancer, Papillary metabolism, Thyroid Cancer, Papillary pathology, Thyroid Neoplasms metabolism, Thyroid Neoplasms pathology, Young Adult, CD56 Antigen metabolism, Carcinoma, Papillary diagnosis, Keratin-19 metabolism, Thyroid Neoplasms diagnosis
Abstract

Introduction: Noninvasive Follicular Thyroid Neoplasm With Papillary-like Nuclear Features (NIFTP) is a tumor composed exclusively of follicles lined by cells having nuclear characteristics of papillary carcinoma. Morphological diagnosis is often difficult especially in the cases in which these nuclear abnormalities are focal., Aim: To investigate the contribution of the immunohistochemical study with anti CD56 and anti cytokeratin 19 in the positive diagnosis of NIFTP., Methods: This is a diagnostive, retrospective study of 40 thyroid specimens including 15 NIFTP, 10 classical form papillary carcinoma (CPC) and 15 vesicular adenomas (AV), collected over a period of eighteen months (December 2013-May 2015)., Results: Negativity with anti-CD56 was noted in 16 cases: 9 cases of NIFTP and 7 cases of CPC. A diffuse staining was noted in 14 cases of AV. Positivity with anti-Cytokeratin19 was noted in 38 cases: 14 NIFTP, 10 CPC and 14 AV. For the diagnosis of NIFTP, the sensitivity of CD56 was 60% and specificity of 100%. The sensitivity of the Cytokeratin 19 was 93,3 % and specificity of 33,3%., Conclusions: Considering the good sensitivity and specificity of the CD56, it is possible to apply immunohistochemistry for definitive diagnosis of NIFTP and to differentiate it from adenoma. The cytokeratin 19 does not have a big contribution to distinguish between benign and malignant lesions.

Published
2018

13. Tumor budding is a prognostic factor linked to epithelial mesenchymal transition in pancreatic ductal adenocarcinoma. Study report and literature review.

Author

Chouat E, Zehani A, Chelly I, Njima M, Maghrebi H, Bani MA, Njim L, Zakhama A, Haouet S, and Kchir N

Subjects
Humans, Observer Variation, Predictive Value of Tests, Retrospective Studies, Carcinoma, Pancreatic Ductal pathology, Epithelial-Mesenchymal Transition, Pancreatic Neoplasms pathology
Abstract

Background: Pancreatic ductal adenocarcinoma (PDAC) has a devastatingly poor prognosis. Surgical resection is undertaken in only 20% of patients. Most of well-known prognostic factors reflect tumor stage more than its biology. So it is important to identify new biological indicators related to survival in order to develop new therapies., Objective: To determine the relation between tumor budding and Epithelial Mesenchymal Transition (EMT) and to evaluate their impact on survival for patients after resection of PDAC., Methods: We herein report a retrospective study of 50 patients with resected PDAC. Tumor budding, immunohistochemical expression of vimentin and other standard factors were correlated with survival using the Kaplan-Meier method and Cox multivariable survival analysis. For tumor budding assessment, an inter-observer variability study was performed using 100 images of tumor slides stained with Hematoxylin & Eosin and Pan-Cytokeratin., Results: Tumor budding was present in all tumors. A substantial agreement between six pathologists was established in distinguishing high-grade from low-grade budding (κ = 0.6 and 0.73 for H&E and PCK images respectively). High-grade budding was identified in 56% of tumors (28/50). It was an adverse prognostic factor independent of tumor size, resection margins status, nodal status and vascular invasion (p = 0.008). Tumor budding was significantly associated with vimentin expression (p = 0.002)., Conclusions: The association of tumor budding with vimentin expression supported the idea that EMT is a key process in PDAC responsible for progression and drug resistance. Consequently, the elucidation of EMT molecular biology and development of new targeted therapy may improve disease outcome., (Copyright © 2017 IAP and EPC. Published by Elsevier B.V. All rights reserved.)

Published
2018
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14. Intracranial grade I meningiomas: Confrontation between histological examination and magnetic resonance imaging.

Author

Zehani A, Houcine Y, Chelly I, Arous A, Drissi C, Haouet S, and Kchir N

Subjects
Adolescent, Adult, Aged, Diagnosis, Differential, Female, Histological Techniques, Humans, Magnetic Resonance Imaging methods, Male, Meningeal Neoplasms epidemiology, Meningeal Neoplasms pathology, Meningioma epidemiology, Meningioma pathology, Middle Aged, Neoplasm Grading, Pathology, Clinical methods, Retrospective Studies, Young Adult, Meningeal Neoplasms diagnosis, Meningioma diagnosis
Abstract

Introduction: Meningiomas are tumors derived from arachnoid cells. More than 90% of cases have a benign clinical course and are classified as grade I according to the World Health Organization. A confrontation between radiologic findings and pathological examination is necessary to predict the grading of meningiomas., Objectives: To study the radiological presentation by magnetic resonance imaging (MRI) and pathological features of intracranial meningiomas grade I., Methods: This was a retrospective descriptive study of a series of 35 cases of grade I meningiomas. A review of MRI images was performed in this study., Results: Our series consisted of 25 female and 10 male patients with a mean age of 49.2 years.The tumor was localized at the base of the skull in 20 cases (57.14%). The average size was 49 mm. At MRI, all meningiomas were solid showing enhancement after injection of contrast agent. This enhancement was homogeneous in 21 cases and heterogeneous in 14 cases. The edema was broad and extended in 15 cases, reduced in 8 cases and absent in 12 cases. The mean minimum apparent diffusion coefficient was 0.77 and the mean maximum average diffusion coefficient was 0,8. On histological examination, the meningioma was of meningotheliomatous type in 23 cases (65.7%), fibroblastic in 8 cases (22.9%), transitional 3 cases (8.6%) and angiomatous in one case (2,8%)., Conclusion: Although the final diagnosis of meningioma is mainly based on pathological examination, comparison with imaging is also important to orient the pathologist.

Published
2018

15. Round cell sarcoma of the colon with CIC rearrangement.

Author

Maghrebi H, Batti R, Zehani A, Chrait N, Rais H, Makni A, Haddad A, Ayadi M, Daghfous A, Jrad M, Kchir N, Bensafta Z, and Mezlini A

Subjects
Adolescent, Colonic Neoplasms pathology, Colonic Neoplasms surgery, Fatal Outcome, Humans, Male, Repressor Proteins genetics, Sarcoma, Small Cell pathology, Sarcoma, Small Cell surgery, Translocation, Genetic, Colonic Neoplasms diagnosis, Sarcoma, Small Cell diagnosis
Abstract

Background: The CIC-rearranged sarcoma is a very rare highly aggressive malignant soft tissue group of tumors. It has recently been described as highly aggressive soft tissue tumors of children and young adults sharing similar morphological features with the Ewing sarcoma. The digestive localization is exceptional., Case Presentation: A 14-year-old male presented with a history of abdominal pain for 1 year, which increased in intensity over the last 2 months. Imaging findings showed a large heterogeneous mesenteric mass on the left flank of the abdomen. Exploratory laparotomy was performed and revealed a large cystic hypervascularized mass depending on the transverse colon and mesocolon. A wide excision of the lesion was performed with segmental colectomy. No postoperative complications were noted. The microscopic examination revealed a vaguely nodular growth of undifferentiated small round cells, arranged in solid sheets separated by thin fibrous septa with a scarce stroma. After an uncomplicated post-operative course, the patient was referred for chemotherapy. The patient died 2 months later with a peritoneal and pleural progression., Conclusions: The CIC-rearranged sarcoma is an aggressive tumor. There is no standard therapy for this rare disease. Their treatment includes surgery and chemotherapy. Resistance to chemotherapy is common. Further publications and studies will help to determine a standard therapy for this rare disease.

Published
2017
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16. Summaries of the papers of the 4th National Congress of the Tunisian Society of Medical Oncology attached to the 4th Maghreb Congress of Oncology.

Author

Abbes I, Abdelhak S, Abdelhedi C, Abid K, Abidi R, Acacha E, Achour S, Achour A, Adouni O, Afrit M, Ahlem A, Akik I, Akremi M, Aloui R, Aloulou S, Ammar N, Arem S, Athimni S, Attia L, Attia M, Ayadi M, Ayadi A, Ayadi K, Ayadi H, Ayadi L, Ayadi I, Ayari J, Azzouz H, Bacha D, Bahloul R, Bahri I, Bahri M, Bakir D, Balti M, Bargaoui H, Batti R, Bayar R, Bdioui Thabet A, Beji M, Bel Hadj Hassen S, Bel Haj Ali A, Belaid I, Belaid A, Beldjiilali Y, Belkacem O, Bellamlih O, Ben Abdallah W, Ben Abdallah M, Ben Abdellah H, Ben Abderrahmen S, Ben Ahmed S, Ben Ahmed K, Ben Ayache M, Ben Ayoub W, Ben Azaiz M, Ben Azouz M, Ben Daly A, Ben Dhia S, Ben Dhiab M, Ben Dhiab T, Ben Fatma L, Ben Ghachem D, Ben Hammadi S, Ben Hassen M, Ben Hassena R, Ben Hassouna J, Ben Kridis W, Ben Leila F, Ben Mahfoudh KH, Ben Mustapha N, Ben Nasr S, Ben Othman F, Ben Rejeb M, Ben Rekaya M, Ben Rhouma S, Ben Safta Z, Ben Safta I, Ben Said A, Ben Salah M, Ben Salah H, Ben Slama S, Ben Temime R, Ben Youssef Y, Ben Zid K, Benabdella H, Benasr S, Bengueddach A, Benna M, Benna F, Bergaoui H, Berrazaga Y, Besbes M, Bhiri H, Bibi M, Blel A, Bohli M, Bouali S, Bouaouina N, Bouassida K, Bouaziz H, Boubaker J, Boudaouara T, Boudaouara Z, Boudaouara O, Boughanmi F, Boughattas W, Boughizane S, Bouguila H, Bouhani M, Bouhlel B, Boujelbane N, Boujemaa M, Boulma R, Bouraoui S, Bouriga R, Bourmech M, Bousrih C, Boussen H, Boussen N, Bouzaien F, Bouzayene F, Brahem I, Briki R, Chaabene K, Chaabouni M, Chaari H, Chabchoub I, Chachia S, Chaker K, Chamlali M, Charfi L, Charfi M, Charfi S, Charradi H, Cheffai I, Chelly B, Chelly I, Chenguel A, Cherif A, Cherif O, Chiboub A, Chouchene A, Chraiet N, Daghfous A, Daldoul A, Daoud N, Daoud J, Daoud R, Daoud E, Debaibi M, Dhaouadi S, Dhief R, Dhouib F, Dimassi S, Djebbi A, Doghri R, Doghri Y, Doudech B, Dridi M, El Amine O, El Benna H, El Khal MC, Eladeb M, Elloumi M, Elmeddeb K, Enaceur F, Ennouri S, Essoussi M, Ezzairi F, Ezzine A, Faleh R, Fallah S, Faouzi N, Fathallah K, Fehri R, Feki J, Fekih M, Fendri S, Fessi Z, Fourati N, Fourati M, Frikha I, Frikha M, Gabsi A, Gadria S, Gamoudi A, Gargoura A, Gargouri W, Ghariani N, Ghazouani E, Ghorbal A, Ghorbel L, Ghorbel S, Ghozzi A, Glili A, Gmadh K, Goucha A, Gouiaa N, Gritli S, Guazzah K, Guebsi A, Guermazi Z, Guermazi F, Gueryani N, Guezguez M, Hacheni F, Hachicha M, Haddad A, Haddaoui A, Hadoussa M, Haj Mansour M, Hajjaji A, Hajji A, Hamdi A, Hamdi Y, Hammemi R, Haouet S, Hdiji A, Hechiche M, Hedfi M, Helali AJ, Henchiri H, Heni S, Hentati A, Herbegue K, Hidar S, Hlaf M, Hmida W, Hmida I, Hmida L, Hmila Ben Salem I, Hochlef M, Hsairi M, Jaffel H, Jaidane M, Jarraya H, Jebsi M, Jedidi M, Jlassi A, Jlassi H, Jmal H, Jmour O, Jouini M, Kabtni W, Kacem M, Kacem S, Kacem I, Kaid M, Kairi H, Kallel M, Kallel R, Kallel F, Kammoun H, Kamoun S, Kanoun Belajouza S, Karray W, Karrit S, Karrou M, Kchir N, Kdous S, Kehili H, Keskes H, Khairi H, Khalfallah MT, Khalifa MB, Khanfir A, Khanfir F, Khechine W, Khemiri S, Khiari H, Khlif A, Khouni H, Khrouf S, Kochbati L, Korbi I, Korbi A, Krir MW, Ksaier I, Ksantini R, Ksantini M, Ksantini F, Ktari K, Laabidi S, Laamouri B, Labidi A, Lahmar A, Lahouar R, Lamine O, Letaief F, Limaiem F, Limayem I, Limem S, Limem F, Loghmari A, M'ghirbi F, Maamouri F, Magherbi H, Mahjoub N, Mahjoub M, Mahjoubi K, Majdoub S, Makhlouf T, Makni A, Makni S, Mallat N, Manai MH, Mansouri H, Maoua M, Marghli I, Masmoudi T, Mathlouthi N, Meddeb K, Medini B, Mejri N, Merdessi A, Mesali C, Mezlini E, Mezlini A, Mezni E, Mghirbi F, Mhiri N, Mighri N, Mlika M, Mnejja W, Mnif H, Mokni M, Mokrani A, Mosbah F, Moujahed R, Mousli A, Moussa A, Mrad Dali K, Mrizak N, Msakni I, Mzabi S, Mzali R, Mzoughi Z, Naimi Z, Najjar S, Nakkouri R, Nasr C, Nasrallah D, Nasri M, Njim L, Noubigh GEF, Nouira Y, Nouri O, Omrani S, Osmane W, Ouanes Y, Ouanna N, Oubich F, Oumelreit Belamlih G, Rachdi H, Rafraf F, Rahal K, Raies H, Rammeh S, Rebaii N, Rekik W, Rekik H, Rhim MS, Rhim S, Rihab D, Rjiba R, Rziga T, Saad H, Saad A, Saadi M, Said N, Salah R, Sallemi N, Sassi A, Sassi K, Sassi Mahfoudh A, Sbika W, Sellami A, Serghini M, Sghaier S, Sh Zidi Y, Siala W, Slimane M, Slimani O, Soltani S, Souguir MK, Sridi A, Tabet Zatla A, Tajina D, Talbi G, Tbessi S, Tebra Mrad S, Temessek H, Tlili G, Toumi N, Toumi O, Toumia N, Tounsi H, Trigui E, Triki M, Triki A, Turki M, Werda I, Yahyaoui S, Yahyaoui Y, Yaich A, Yamouni M, Yazid D, Yousfi A, Zaghouani H, Zaied S, Zairi F, Zaraa S, Zehani A, Zenzri Y, Zidi A, Znaidi N, Zouari K, Zouari S, Zoukar O, and Zribi A

Published
2017

18. Prognostic value of Ki67: comparison of the proliferation index between meningiomas with and without infiltration of glial tissue.

Author

Zehani A, Chelly I, Haouet S, and Kchir N

Subjects
Aged, Female, Humans, Male, Middle Aged, Mitotic Index, Neoplasm Grading, Retrospective Studies, Brain Neoplasms chemistry, Brain Neoplasms pathology, Cell Proliferation, Ki-67 Antigen analysis, Meningioma chemistry, Meningioma pathology, Neuroglia pathology, Prognosis
Abstract

Background: Although generally considered benign, meningiomas can cause significant morbidity and mortality.  Histologic grade is the most useful morphologic predictor of recurrence., Objectives: To compare Ki67 labeling index between meningioma grade I and meningioma grade II with brain invasion., Methods: We analyzed 20 primary meningioma, 10 of which were grade I and 10 of which were grade II. Ki67 proliferative indices were determined in all cases., Results: The patient population consisted of 9 males and 11 females with mean age of 60 years. For meningioma grade I, the Ki67 labeling index varied between 1 and 15% with an average of 3.1%. A diagnosis of gradeII meningiomas was made solely on the basis of brain invasion. The immunohistochemical study noted that the Ki67 index varied between 1 and 20% with an average of 6,8%., Conclusion: The Ki67 labeling index shows a significant increase from grade I to grade II.  It may provide useful prognostic information.

Published
2017

20. Malignant transformation of nasal inverted papilloma into sarcomatoid carcinoma.

Author

Zehani A, Chelly I, Marrakchi J, Chouat E, Besbes G, Haouet S, and Kchir N

Subjects
Cell Transformation, Neoplastic, Humans, Male, Middle Aged, Carcinoma pathology, Nose Neoplasms pathology, Papilloma, Inverted pathology
Abstract

A 57 year-old, male presented with a chronic unilateral nasal obstruction and epistaxis. Intranasal endoscopy showed multiple polypoid lesions. The computed tomography exam revealed a heterogeneous mass that occupied the right nasal cavity with osteolysis of the middle and lower cone causing fluid retention of the right maxillary sinus. He underwent resection of these lesions. Pathological examination revealed malignant transformation of nasal inverted papilloma into sarcomatoid carcinoma. This case report highlights the importance of considering malignant transformation in the differential diagnosis of polypoid lesions.

Published
2017

21. Gastrointestinal neuro-endocrine tumors: retrospective study of 36 cases.

Author

Zehani A, Aloui S, Chelly I, Haouet S, and Kchir N

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Female, Gastrointestinal Neoplasms classification, Humans, Male, Middle Aged, Neoplasm Grading, Neuroendocrine Tumors classification, Prognosis, Retrospective Studies, Young Adult, Gastrointestinal Neoplasms pathology, Neuroendocrine Tumors pathology
Abstract

Background: Neuroendocrine tumors (NETs) of the gastrointestinal tract are a heterogeneous group of tumors which have different malignant potential and evolution. The World Health Organization (WHO) has set up a new classification of gastrointestinal NETs in 2010. However, it does not evaluate the risk of malignancy for each tumor., Aim: To evaluate the prognostic impact of the WHO classification in 2010 by reclassifying the tumor according to new recommendations and to identify histoprognostic factors to better predict changes., Methods: This is a descriptive retrospective study of 36 cases of gastrointestinal NETs, collected at the pathological anatomy department in Rabta hospital, over a period of 11 years from 2003 to 2013., Results: Our series included 11 NETs of Appendix, nine of the pancreas, seven of the small bowel, four of the stomach, three of the rectum, one of the colon and one of the esophagus. The mean age of patients across all sites, was 50.3 years old and the sex ratio was 0,44. The tumors were classified according to the 2010 WHO classification. They were divided into: G1 in 27 cases (75%); G2 in three cases (8.3%); G3 small cell carcinoma in two cases (5.6%); G3 large cell carcinoma in one case (2.8%) and mixed adeno-neuroendocrine carcinoma in three cases (8.3%)., Conclusion: Our study has shown limits of the latest 2010 WHO classification of NETs. The prognosis of these tumors could be better predicted by the evaluation of other histoprognostic factors and by the improvement of criteria defining histological degrees including tumor size.

Published
2017

22. [Misleading ventricular tumor].

Author

Zehani A, Bouali S, Chelly I, Bouhoula A, Jemel H, Haouet S, and Kchir N

Subjects
Adult, Cerebral Ventricle Neoplasms complications, Cerebral Ventricle Neoplasms diagnostic imaging, Cerebral Ventricle Neoplasms surgery, Diagnosis, Differential, Feeding and Eating Disorders etiology, Glioma complications, Glioma diagnostic imaging, Glioma surgery, Humans, Infertility, Male etiology, Magnetic Resonance Imaging, Male, Meningioma diagnosis, Papilledema etiology, Sleep Initiation and Maintenance Disorders etiology, Third Ventricle diagnostic imaging, Vision Disorders etiology, Cerebral Ventricle Neoplasms pathology, Glioma pathology, Hypogonadism etiology, Third Ventricle pathology
Published
2017
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23. Agressive infection following a dental extraction in a diabetic patient :Rhinocerebral mucormycosis.

Author

Zehani A, Smichi I, Marrakchi J, Besbes G, Haouet S, and Kchir N

Subjects
Adult, Central Nervous System Fungal Infections etiology, Diabetes Complications microbiology, Diabetes Mellitus microbiology, Humans, Immunocompromised Host, Invasive Fungal Infections etiology, Male, Mucormycosis etiology, Postoperative Complications diagnosis, Postoperative Complications microbiology, Rhinitis complications, Rhinitis microbiology, Central Nervous System Fungal Infections diagnosis, Diabetes Complications diagnosis, Invasive Fungal Infections diagnosis, Mucormycosis diagnosis, Rhinitis diagnosis, Tooth Extraction adverse effects
Abstract

Mucormycosis is a rare and acute fungal infection which is frequently lethal, usually observed in non-controlled diabetic patients. The infection usually begins in the nose but it can invade the lung, the digestive tract, and the skin. Rhinocerebral mucormycosis accounts for 40 to 49% of mucormycosis cases. We report the case of a 44-year-old diabetic man, presenting with rhinocerebral mucormycosis. Our patient was treated by an association of amphotericin B and surgical debridement.

Published
2017

25. [An unusual glial tumor].

Author

Khadhar A, Zehani A, Chelly I, Ben Said I, Haouet S, and Kchir N

Subjects
Biomarkers, Tumor analysis, Choroid Plexus Neoplasms chemistry, Choroid Plexus Neoplasms epidemiology, Choroid Plexus Neoplasms surgery, Glioma chemistry, Glioma epidemiology, Glioma surgery, Humans, Male, Middle Aged, Neoplasm Proteins analysis, Choroid Plexus Neoplasms pathology, Glioma pathology
Published
2017
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26. A confusing lesion of thyroid papillary carcinoma.

Author

Zehani A, Chelly I, Marrakchi J, Besbes G, Haouet S, and Kchir N

Subjects
Adenocarcinoma, Follicular diagnosis, Adenocarcinoma, Follicular pathology, Adult, Diagnosis, Differential, Female, Humans, Thyroid Cancer, Papillary pathology, Thyroid Neoplasms diagnosis, Thyroid Neoplasms pathology, Thyroid Nodule diagnosis, Thyroid Nodule pathology, Thyroid Cancer, Papillary diagnosis, Thyroid Epithelial Cells pathology
Published
2017

27. Tumor of the kidney associated to acquired cystic renal disease.

Author

Zehani A, Smichi I, Chelly I, Nouira Y, Haouet S, and Kchir N

Subjects
Carcinoma, Renal Cell diagnosis, Humans, Kidney Diseases, Cystic diagnosis, Kidney Diseases, Cystic therapy, Kidney Failure, Chronic complications, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic therapy, Kidney Neoplasms diagnosis, Male, Middle Aged, Renal Dialysis, Carcinoma, Renal Cell etiology, Kidney Diseases, Cystic complications, Kidney Neoplasms etiology
Published
2017

28. Neuroendocrine differentiation in basal cell carcinoma.

Author

Houcine Y, Chelly I, Zehani A, Belhaj Kacem L, Azzouz H, Rekik W, C H, Haouet S, and Kchir N

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell immunology, Chromogranin A analysis, Chromogranin A immunology, Female, Humans, Immunohistochemistry, Male, Middle Aged, Neurosecretory Systems, Skin Neoplasms immunology, Synaptophysin analysis, Synaptophysin immunology, Young Adult, Carcinoma, Basal Cell pathology, Cell Differentiation, Skin Neoplasms pathology
Abstract

Basal cell carcinoma (BCC) is the prototypical basaloid tumor of the skin. It may show various patterns simulating other cutaneous tumors due to its pleomorphism. It may have an unusal pattern of differentiation such as squamous, sebaceous, apocrine, eccrine, pilar, and endocrine differentiation. In order to establish the relative frequency of neuroendocrine differentiation in BCC, we performed a retrospective study of 33 consecutive BCCs using conventional immunohistochemistry with two neuroendocrine antibodies: Chromogranine A and synaptophysine. The age of the patients ranged from 17-83 years with mean of 65 years. The male to female ratio was 16:17. In immunohistochimestry, Chromogranine A was seen in 72.2% (24/33) while Synaptophysine was positive in 9.09% (3/33). Their expression was cytoplasmic and membranous and was seen in the periphery of these tumors in the overlying cells. Positive staining of chromogranine A was high (75-100% of tumors cells) in 9%, intermediate (25-75% of tumors cells) in 33% of cases and relatively low (<25%) in 30.3% of cases.

Published
2017
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29. Abstracts of the 40th National Congress of Medicine Tunis, 19-20 October 2017.

Author

Abdallah M, Abdelaziz A, Abdelaziz O, Abdelhedi N, Abdelkbir A, Abdelkefi M, Abdelmoula L, Abdennacir S, Abdennadher M, Abidi H, Abir Hakiri A, Abou El Makarim S, Abouda M, Achour W, Aichaouia C, Aissa A, Aissa Y, Aissi W, Ajroudi M, Allouche E, Aloui H, Aloui D, Amdouni F, Ammar Y, Ammara Y, Ammari S, Ammous A, Amous A, Amri A, Amri M, Amri R, Annabi H, Antit S, Aouadi S, Arfaoui A, Assadi A, Attia L, Attia M, Attia L, Ayadi I, Ayadi Dahmane I, Ayari A, Azzabi S, Azzouz H, B Mefteh N, B Salah C, Baccar H, Bachali A, Bahlouli M, Bahri G, Baïli H, Bani M, Bani W, Bani MA, Bassalah E, Bawandi R, Bayar M, Bchir N, Bechraoui R, Béji M, Beji R, Bel Haj Yahia D, Belakhel S, Belfkih H, Belgacem O, Belgacem N, Belhadj A, Beltaief N, Beltaief N, Ben Abbes M, Ben Abdelaziz A, Ben Ahmed I, Ben Aissia N, Ben Ali M, Ben Ammar H, Ben Ammou B, Ben Amor A, Ben Amor M, Benatta M, Ben Ayed N, Ben Ayoub W, Ben Charrada N, Ben Cheikh M, Ben Dahmen F, Ben Dhia M, Ben Fadhel S, Ben Farhat L, Ben Fredj Ismail F, Ben Hamida E, Ben Hamida Nouaili E, Ben Hammamia M, Ben Hamouda A, Ben Hassine L, Ben Hassouna A, Ben Hasssen A, Ben Hlima M, Ben Kaab B, Ben Mami N, Ben Mbarka F, Ben Mefteh N, Ben Kahla N, Ben Mrad M, Ben Mustapha N, Ben Nacer M, Ben Neticha K, Ben Othmen E, Ben Rhouma S, Ben Rhouma M, Ben Saadi S, Ben Safta A, Ben Safta Z, Ben Salah C, Ben Salah N, Ben Sassi S, Ben Sassi J, Ben Tekaya S, Ben Temime R, Ben Tkhayat A, Ben Tmim R, Ben Yahmed Y, Ben Youssef S, Ben Ali M, Ben Atta M, Ben Safta Z, Ben Salah M, Berrahal I, Besbes G, Bezdah L, Bezzine A, Bezzine A, Bokal Z, Borsali R, Bouasker I, Boubaker J, Bouchekoua M, Bouden F, Boudiche S, Boukhris I, Bouomrani S, Bouraoui S, Bouraoui S, Bourgou S, Boussabeh E, Bouzaidi K, Chaker K, Chaker L, Chaker A, Chaker F, Chaouech N, Charfi M, Charfi MR, Charfi F, Chatti L, Chebbi F, Chebbi W, Cheikh R, Cheikhrouhou S, Chekir J, Chelbi E, Chelly I, Chelly B, Chemakh M, Chenik S, Cheour M, Cheour M, Cherif E, Cherif Y, Cherif W, Cherni R, Chetoui A, Chihaoui M, Chiraz Aichaouia C, Dabousii S, Daghfous A, Daib A, Daib N, Damak R, Daoud N, Daoud Z, Daoued N, Debbabi H, Demni W, Denguir R, Derbel S, Derbel B, Dghaies S, Dhaouadi S, Dhilel I, Dimassi K, Dougaz A, Dougaz W, Douik H, Douik El Gharbi L, Dziri C, El Aoud S, El Hechmi Z, El Heni A, ELaoud S, Elfeleh E, Ellini S, Ellouz F, Elmoez Ben O, Ennaifer R, Ennaifer S, Essid M, Fadhloun N, Farhat M, Fekih M, Fourati M, Fteriche F, G Hali O, Galai S, Gara S, Garali G, Garbouge W, Garbouj W, Ghali O, Ghali F, Gharbi E, Gharbi R, Ghariani W, Gharsalli H, Ghaya Jmii G, Ghédira F, Ghédira A, Ghédira H, Ghériani A, Gouta EL, Guemira F, Guermazi E, Guesmi A, Hachem J, Haddad A, Hakim K, Hakiri A, Hamdi S, Hamed W, Hamrouni S, Hamza M, Haouet S, Hariz A, Hendaoui L, Hfaidh M, Hriz H, Hsairi M, Ichaoui H, Issaoui D, Jaafoura H, Jazi R, Jazia R, Jelassi H, Jerraya H, Jlassi H, Jmii G, Jouini M, Kâaniche M, Kacem M, Kadhraoui M, Kalai M, Kallel K, Kammoun O, Karoui M, Karouia S, Karrou M, Kchaou A, Kchaw R, Kchir N, Kchir H, Kechaou I, Kerrou M, Khaled S, Khalfallah N, Khalfallah M, Khalfallah R, Khamassi K, Kharrat M, Khelifa E, Khelil M, Khelil A, Khessairi N, Khezami MA, Khouni H, Kooli C, Korbsi B, Koubaa MA, Ksantini R, Ksentini A, Ksibi I, Ksibi J, Kwas H, Laabidi A, Labidi A, Ladhari N, Lafrem R, Lahiani R, Lajmi M, Lakhal J, Laribi M, Lassoued N, Lassoued K, Letaif F, Limaïem F, Maalej S, Maamouri N, Maaoui R, Maâtallah H, Maazaoui S, Maghrebi H, Mahfoudhi S, Mahjoubi Y, Mahjoubi S, Mahmoud I, Makhlouf T, Makni A, Mamou S, Mannoubi S, Maoui A, Marghli A, Marrakchi Z, Marrakchi J, Marzougui S, Marzouk I, Mathlouthi N, Mbarek K, Mbarek M, Meddeb S, Mediouni A, Mechergui N, Mejri I, Menjour MB, Messaoudi Y, Mestiri T, Methnani A, Mezghani I, Meziou O, Mezlini A, Mhamdi S, Mighri M, Miled S, Miri I, Mlayeh D, Moatemri Z, Mokaddem W, Mokni M, Mouhli N, Mourali MS, Mrabet A, Mrad F, Mrouki M, Msaad H, Msakni A, Msolli S, Mtimet S, Mzabi S, Mzoughi Z, Naffeti E, Najjar S, Nakhli A, Nechi S, Neffati E, Neji H, Nouira Y, Nouira R, Omar S, Ouali S, Ouannes Y, Ouarda F, Ouechtati W, Ouertani J, Ouertani J, Ouertani H, Oueslati A, Oueslati J, Oueslati I, Oueslati A, Rabai B, Rahali H, Rbia E, Rebai W, Regaïeg N, Rejeb O, Rhaiem W, Rhimi H, Riahi I, Ridha R, Robbena L, Rouached L, Rouis S, Safer M, Saffar K, Sahli H, Sahraoui G, Saidane O, Sakka D, Salah H, Sallami S, Salouage I, Samet A, Sammoud K, Sassi Mahfoudh A, Sayadi C, Sayhi A, Sebri T, Sedki Y, Sellami A, Serghini M, Sghaier I, Skouri W, Skouri W, Slama I, Slimane H, Slimani O, Souhail O, Souhir S, Souissi A, Souissi R, Taboubi A, Talbi G, Tbini M, Tborbi A, Tekaya R, Temessek H, Thameur M, Touati A, Touinsi H, Tounsi A, Tounsia H, Trabelsi S, Trabelsi S, Triki A, Triki M, Turki J, Turki K, Twinsi H, Walha Y, Wali J, Yacoub H, Yangui F, Yazidi M, Youssef I, Zaier A, Zainine R, Zakhama L, Zalila H, Zargouni H, Zehani A, Zeineb Z, Zemni I, Zghal M, Ziadi J, Zid Z, Znagui I, Zoghlami C, Zouaoui C, Zouari B, Zouiten L, and Zribi H

Published
2017

30. Renal carcinoma associated to acquired cystic renal disease.

Author

Zehani A, Bani MA, Chelly I, Smichi I, Nouira Y, Azzouz H, Haouet S, and Kchir N

Subjects
Carcinoma, Renal Cell diagnosis, Carcinoma, Renal Cell pathology, Diagnosis, Differential, Humans, Kidney Diseases, Cystic diagnosis, Kidney Diseases, Cystic pathology, Kidney Diseases, Cystic therapy, Kidney Failure, Chronic complications, Kidney Failure, Chronic pathology, Kidney Failure, Chronic therapy, Kidney Neoplasms diagnosis, Kidney Neoplasms pathology, Male, Middle Aged, Renal Dialysis, Urography, Carcinoma, Renal Cell etiology, Kidney Diseases, Cystic complications, Kidney Neoplasms etiology
Published
2017

31. Adult granulosa cell tumor of the testis: a case report.

Author

Bani MA, Zehani A, Chelly I, Fethi A, Haouet S, and Kchir N

Subjects
Granulosa Cell Tumor diagnostic imaging, Humans, Male, Testicular Neoplasms diagnostic imaging, Testis diagnostic imaging, Testis pathology, Ultrasonography, Young Adult, Granulosa Cell Tumor pathology, Testicular Neoplasms pathology
Published
2016

32. [A new variant of digestive round cell sarcoma in a child].

Author

Zehani A, Chelly I, Coindre JM, Haouet S, and Kchir N

Subjects
Abdominal Pain diagnostic imaging, Abdominal Pain etiology, Adolescent, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Colectomy, Colonic Neoplasms diagnosis, Colonic Neoplasms genetics, Colonic Neoplasms therapy, Gastrointestinal Hemorrhage etiology, Humans, Incidental Findings, Male, Martial Arts injuries, Oncogene Proteins, Fusion genetics, Peritoneal Neoplasms secondary, Sarcoma, Small Cell diagnosis, Sarcoma, Small Cell genetics, Sarcoma, Small Cell secondary, Sarcoma, Small Cell therapy, Colonic Neoplasms pathology, Sarcoma, Small Cell pathology
Published
2016
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33. Gastric metastasis from malignant meningeal hemangiopericytoma.

Author

Khadhar A, Zehani A, Ben Safta Y, Bani MA, Chelly I, Haouet S, and Kchir N

Subjects
Hemangiopericytoma pathology, Humans, Male, Meningeal Neoplasms pathology, Middle Aged, Stomach Neoplasms pathology, Stomach Neoplasms secondary, Hemangiopericytoma diagnosis, Meningeal Neoplasms diagnosis, Stomach Neoplasms diagnosis
Published
2016

34. [A confusing swelling of the buccal mucosa].

Author

Zehani A, Chelly I, Chahed H, Besbes G, Haouet S, and Kchir N

Subjects
Adult, Biomarkers, Tumor, Humans, Lymphoma, B-Cell, Marginal Zone chemistry, Lymphoma, B-Cell, Marginal Zone diagnostic imaging, Lymphoma, B-Cell, Marginal Zone pathology, Magnetic Resonance Imaging, Male, Mouth Mucosa chemistry, Mouth Mucosa pathology, Mouth Neoplasms chemistry, Mouth Neoplasms diagnostic imaging, Mouth Neoplasms pathology, Lymphoma, B-Cell, Marginal Zone diagnosis, Mouth Mucosa diagnostic imaging, Mouth Neoplasms diagnosis
Published
2016
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35. Gliosarcoma with smooth muscle cell differentiation: a case report.

Author

Bani MA, Zehani A, Chelly I, Khadhar A, Azouz H, Jemel H, Haouet S, and Kchir N

Subjects
Adult, Brain Neoplasms diagnostic imaging, Female, Gliosarcoma diagnostic imaging, Humans, Magnetic Resonance Imaging, Brain Neoplasms pathology, Cell Differentiation, Gliosarcoma pathology, Myocytes, Smooth Muscle cytology
Published
2016

36. Methotrexate-induced necrolysis in tumoral-stage mycosis fungoides: a challenging diagnosis.

Author

Mna AB, Souissi A, Halouani S, El Euch D, Zahani A, Kchir N, Zaraa I, and Mokni M

Subjects
Humans, Male, Middle Aged, Mycosis Fungoides diagnosis, Skin drug effects, Skin Neoplasms diagnosis, Lymphoma, T-Cell, Cutaneous drug therapy, Methotrexate adverse effects, Mycosis Fungoides chemically induced, Neoplasm Staging, Skin pathology, Skin Neoplasms chemically induced
Abstract

Methotrexate-induced cutaneous ulceration is a rare but potentially serious drug adverse reaction. This adverse reaction of methotrexate therapy has been initially described in psoriasis patients and is unusual in patients with cutaneous T-cell lymphoma. In 1978, Mc Donald et al reported the first three cases of cutaneous ulcerations in patients treated for a mycosis fungoides with intravenous infusions of methotrexate. Since then, few cases of methotrexate-induced skin ulcers in patients with mycosis fungoides have been published. We report an additional patient with erythrodermic mycosis fungoides who developed cutaneous ulcerations as a sole manifestation of methotrexate toxicity.

Published
2016

37. A Challenging Cutaneous T-Cell Lymphoma.

Author

Khadhar A, Chelly I, Zehani A, Litaiem N, Zaraa I, Azouz H, Bellil K, de Mascarel A, Haouet S, and Kchir N

Subjects
Antigens, CD analysis, Chemokine CXCL13 analysis, Granzymes analysis, Humans, Male, Middle Aged, Perforin analysis, Poly(A)-Binding Proteins analysis, Programmed Cell Death 1 Receptor analysis, T-Cell Intracellular Antigen-1, Lymphoma, T-Cell, Cutaneous chemistry, Lymphoma, T-Cell, Cutaneous pathology
Abstract

Cutaneous peripheral T-cell lymphomas not otherwise specified (CPTL-NOS) are rare neoplasms accounting for just 2% of cutaneous peripheral T-cell lymphomas (CPTL). Only very few case series have been reported. They represent a phenotypically and prognostically heterogenous group of CPTL that do not fit into any of CPTL well-defined subtypes. The authors report a case of a 64-year-old man with simultaneous plaque-like lesions and disseminated nodules growing rapidly on the face, trunk, and extremities over a 6-month period. There was no a history of preceding patches, erythematous plaques, rash, or pruritic lesions. These lesions were extending over 80% of the skin surface. Histopathologic analysis revealed dense diffuse infiltrates composed of mostly medium-sized to large lymphoid cells throughout the entire dermis without epidermotropism. Neoplastic cells were atypical with markedly pleomorphic nuclei. Immunohistochemistry showed that the tumor cells were positive for CD3, CD4, and CD5 with a loss of CD7. They were negative for CD20, CD8, CD56, CXCL13, PD1, TIA-1, granzyme-B, perforin, CD25, and CD30. The proliferative fraction was low, with MIB-1 labeling less than 10% of cells. The authors diagnosed the patient with primary CPTL-NOS. Despite the rarity of these tumors, clinicians as well as dermatopathologists and pathologists should be familiar with these rare CPTL especially because most of these lymphomas have an aggressive behavior and exhibit an unfavorable prognosis.

Published
2016
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38. [A rare splenic lesion].

Author

Zehani A, Chelly I, Ben Rejeb H, Parrens M, de Mascarel A, and Kchir N

Subjects
Biomarkers, Tumor analysis, Diagnosis, Differential, Epstein-Barr Virus Infections diagnosis, Granuloma, Plasma Cell diagnosis, Herpesvirus 4, Human isolation & purification, Humans, Immunoglobulin G analysis, Male, Middle Aged, Sarcoma chemistry, Sarcoma pathology, Splenic Neoplasms chemistry, Splenic Neoplasms pathology, Tumor Virus Infections diagnosis, Sarcoma diagnosis, Splenic Neoplasms diagnosis
Published
2015
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39. [Cystic mass of the kidney].

Author

Khadhar A, Zehani A, Chelly I, Smichi I, Haouet S, and Kchir N

Subjects
Biomarkers, Tumor, Diagnosis, Differential, Epithelial Cells pathology, Female, Humans, Kidney Diseases, Cystic diagnosis, Kidney Diseases, Cystic diagnostic imaging, Kidney Diseases, Cystic surgery, Kidney Neoplasms diagnosis, Kidney Neoplasms diagnostic imaging, Kidney Neoplasms surgery, Neoplasms, Complex and Mixed diagnosis, Neoplasms, Complex and Mixed diagnostic imaging, Neoplasms, Complex and Mixed surgery, Nephrectomy, Sarcoma, Synovial diagnosis, Stromal Cells pathology, Tomography, X-Ray Computed, Young Adult, Kidney Diseases, Cystic pathology, Kidney Neoplasms pathology, Neoplasms, Complex and Mixed pathology
Published
2015
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40. [Calcified cerebral hydatid cyst].

Author

Bouali S, Boubaker A, Bouhoula A, Abderrahmen K, Ben Said I, Kallel J, Kchir N, and Jemel H

Subjects
Brain Diseases pathology, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Brain Diseases parasitology, Calcinosis pathology, Echinococcosis pathology
Published
2015

41. Multiple spinal metastases from a well-differentiated liposarcoma of the iliac wing: a case report.

Author

Ben Nsir A, Boubaker A, Kassar AZ, Abderrahmen K, Kchir N, and Jemel H

Abstract

Study Design: A case report., Objectives: To report an unusual case of multiple spinal metastases from an undiagnosed well-differentiated liposarcoma (WDLPS) of the iliac wing and to stress the need of a meticulous clinical examination and further screening of patients with chronic and asymptomatic bony lesions., Setting: University of medicine of Monastir, Department of neurological surgery, Fattouma Bourguiba University Hospital, Monastir, Tunisia and University of Medicine of Tunis EL Manar, Department of neurological surgery, Tunisian National Institute of Neurology, Tunis, Tunisia., Methods: A 39-year-old man presented with signs of spinal cord compression for the past 2 weeks. His medical history was consistent for an asymptomatic right iliac wing mass that appeared 3 years ago and for which he has not consulted. Magnetic resonance imaging revealed multiple bony lesions of the thoraco-lumbar spine associated with a 6-cm right paravertebral mass at the T4 level extending posteriorly through the intervertebral foramina to the spinal canal causing major spinal cord compression. An emergent T2-T6 laminectomy allowed for a complete resection of the epidural mass. Pathological examination confirmed the diagnosis of well-differentiated liposarcoma. Adjunctive radiation therapy was administered., Results: The patient's neurological status improved remarkably under an intensive care and rehabilitation program. He was ambulatory without assistance in the second postoperative week., Conclusion: The case reported in this paper represents a genuine example of the possible metastatic potential of WDLPSs of the bone and underscores the importance of examining patients thoroughly, especially when they have chronic and asymptomatic lesions.

Published
2015
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42. [About a rare tumor of the kidney: Malignant mixed epithelial and stromal tumor].

Author

Smichi I, Zehani A, Chelly I, Khadhar A, Azouz H, Nouira Y, Haouet S, and Kchir N

Subjects
Adult, Female, Humans, Rare Diseases, Kidney Neoplasms pathology, Kidney Neoplasms surgery, Mixed Tumor, Malignant pathology, Mixed Tumor, Malignant surgery
Abstract

Mixed epithelial and stromal tumor of the kidney is a recently described neoplasm that predominantly affects perimenopausal women. Few cases with malignant features have been reported. Here, we report the case of malignant mixed epithelial and stromal tumor of the kidney with sarcomatous transformation arising in a 27-year-old female. She presented with abdominal discomfort. Computed tomography of the abdomen revealed a large compressive mass arisen from the left kidney with solid and focal cystic components. The patient underwent left radical nephrectomy. Histologic sections showed benign and malignant components. The benign component consisted of multiple tubules and variably sized cysts lined by benign epithelium. The malignant component was composed of undifferentiated cellular spindle cell sarcoma. By immunohistochemical studies, the epithelial component was positive for cytokeratins and epithelial membrane antigen (EMA). The stromal component displayed strong immunohistochemical expression of vimentin, CD99, bcl2; and was negative for cytokeratins, desmin, SMA, S-100, estrogen receptor (ER) and progesterone receptor (PR). Analysis by reverse transcriptase polymerase chain reaction (RT-PCR) failed to identify the SYT-SSX1 or SYT-SSX2 fusion transcripts characteristic of synovial sarcoma., (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)

Published
2015
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44. Unusual presentation of sarcoidosis: solitary intracranial mass lesion mimicking an intracranial neoplasm: a case report.

Author

Ghozzi A, Azouz H, Chelly I, Nfoussi H, Jemal H, Kchir N, Haouet S, and Zitouna M

Subjects
Adult, Brain Neoplasms diagnosis, Diagnosis, Differential, Female, Glioma diagnosis, Humans, Magnetic Resonance Imaging, Central Nervous System Diseases diagnosis, Sarcoidosis diagnosis
Abstract

Sarcoidosis is a multisystem disease of unknown cause and with a worldwide distribution. Involvement of the central nervous system occurs in a relatively small number of patients with sarcoidosis. Isolated neurosarcoidosis without signs of systemic disease however is a rare. In this report, we present an unusual case of neurosarcoidosis with intra cranial mass mimicking radiologically a glioma. Pathological examination revealed intraparenchymatous necrotising granulomatous lesions. After clinicopathological correlation, the diagnosis of a necrotizing cerebral granulomatosis (neurosarcoidosis) with atypical systemic involvement was made. Because of its non-specific clinical presentation and neuroradiological imaging characteristics, intracranial neurosarcoidosis remains a very difficult diagnosis, particularly in the absence of systemic signs of the disease.

Published
2014
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45. [A rare form of primary cutaneous lymphoma].

Author

Zehani A, Chelly I, Berjeb H, Vergier B, De Mascarel A, and Kchir N

Subjects
Adult, Antigens, CD analysis, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Tumor analysis, Cyclophosphamide administration & dosage, Diabetes Mellitus, Type 1 complications, Doxorubicin administration & dosage, Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor, Granzymes analysis, Humans, Lymphomatoid Papulosis complications, Lymphomatoid Papulosis drug therapy, Lymphomatoid Papulosis pathology, Male, Perforin analysis, Poly(A)-Binding Proteins analysis, Prednisone administration & dosage, Skin Neoplasms chemistry, Skin Neoplasms complications, Skin Neoplasms drug therapy, Skin Neoplasms pathology, Skin Ulcer etiology, T-Cell Intracellular Antigen-1, Tuberculosis, Pulmonary complications, Vincristine administration & dosage, Lymphomatoid Papulosis diagnosis, Skin Neoplasms diagnosis
Published
2014
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46. Ureteral spread of a primary cutaneous diffuse large B-cell lymphoma, leg type.

Author

Salem AB, Nfoussi H, and Kchir N

Abstract

We report a case of 76-year-old man, with a past medical history of primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), who presented with ureteral tumor diagnosed as urothelial carcinoma on imaging investigations. Histological examination showed an unusual finding. The tumor was a ureteral localization of the PCDLBCL-LT previously diagnosed. To the best of our knowledge, this is the first case of PCDLBCL-LT with ureteral spread described in the literature.

Published
2014
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48. [Uncommon antral polypoid lesion!].

Author

Zehani A, Chelly I, Nfoussi H, Ksantini R, Azzouz H, Haouet S, Zitouna M, and Kchir N

Subjects
Diagnosis, Differential, Disease Progression, Gastrointestinal Neoplasms pathology, Gastrointestinal Stromal Tumors pathology, Humans, Male, Middle Aged, Polyps pathology, Stomach Neoplasms pathology, Gastrointestinal Neoplasms diagnosis, Gastrointestinal Stromal Tumors diagnosis, Polyps diagnosis, Stomach Neoplasms diagnosis
Published
2014

49. [Unusual tumor of bile duct].

Author

Zehani A, Chelly I, Nfoussi H, Azzouz H, Haouet S, and Kchir N

Subjects
Aged, Bile Duct Neoplasms pathology, Carcinosarcoma pathology, Duodenal Neoplasms diagnosis, Duodenal Neoplasms secondary, Humans, Intra-Abdominal Fat pathology, Male, Neoplasm Invasiveness, Pancreatic Neoplasms diagnosis, Pancreatic Neoplasms secondary, Bile Duct Neoplasms diagnosis, Carcinosarcoma diagnosis
Published
2014

50. [Paraganglioma of spermatic cord].

Author

Majdoub W, Nfoussi H, Rhouma SB, Chelly I, Zehani A, Haouet S, and Kchir N

Subjects
Humans, Male, Middle Aged, Genital Neoplasms, Male pathology, Paraganglioma pathology, Spermatic Cord
Abstract

Paragangliomas can exist anywhere in the distribution of neural crest derived cells. In the spermatic cord, they are exceedingly rare. We report a case of histologically discovery, occurring in a man of 50 years who had a para-testicular mass, painless, firm without other signs associated. In view of this observation and a review of the literature, we propose to establish the epidemiological profile and study the prognostic and the clinicopathologic features of this tumor., (Copyright © 2013. Published by Elsevier Masson SAS.)

Published
2013
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