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In this study, water dispersible fluorescent carbon quantum dot (CQD) has been synthesised, having an average size of 8.6 ± 0.4 nm using Cynodon dactylon (CD) following microwave assisted green synthetic one-step method. As-prepared CQD fluoresces strongly at 444 nm having a quantum yield of 1% in water when excited at 350 nm. This fluorescence of CQD is sensitive toward As 3+ and Fe 3+ metal ions. These CQD are utilized for dual metal ion fluorescence sensing; turn-on fluorescence sensing for As 3+ and turn-off fluorescence sensing for Fe 3+ ions. Limit of detection for As 3+ and Fe 3+ ions has been found to be 19 nM and 0.10 μM respectively, which is the lowest value reported for As 3+ without any functionalization. The adsorption kinetics of As 3+ and Fe 3+ ions on CQD have been examined using pseudo-first-order-kinetic model revealing that physical adsorption is dominant over chemical processes in this work. For 0.41 g/L and 1.90 g/L dose of CQD, the equilibrium adsorption capacity was found to be 1.57 × 10 -6  mg/g, 2.91 × 10 -7  mg/g, and 1.01 × 10 -5  mg/g, 1.69 × 10 -6  mg/g respectively for As 3+ and Fe 3+ ions. Despite having low quantum yield in water, as-prepared CQD showed low cytotoxicity and good tolerance against photodegradation of biological cells at concentrations lower than 62.5 μg/mL and when the cells are illuminated up to 12 h. Owing to this, the synthesised CQD have been utilized as fluorescent probes for in itro cell imaging., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Curcumin has antioxidant properties resulting from its radical scavenging ability and inhibition of inflammation-associated factors. However, its lack of solubility, instability, and poor bioavailability are impediments to its therapeutic use. As potential alternatives, we synthesized and performed chemical analysis of thirty diarylidene-N-methyl-4-piperidone (DANMP), diheteroarylidene-N-methyl-4-piperidone (DHANMP), and spirobibenzopyran (SBP) derivatives, one of which was also characterized by single crystal X-ray diffraction. All compounds were evaluated for antioxidant activity via 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and for drug-like properties in silico. A subset of five compounds was investigated in terms of aqueous solubilities, which were significantly improved compared to that of curcumin. In vitro assessments of cellular and anti-inflammatory effects were conducted via real time polymerase chain reaction (RT-PCR) and Griess assays to evaluate the presence of inflammatory/activated (M1) markers and production of nitric oxide (NO) species, which are associated with inflammation. The five compounds reduced levels of markers and NO to extents similar to or better than curcumin in inflamed cells, and showed no adverse effects on cell viability. We show that these compounds possess anti-inflammatory properties and may be used as curcumin-substitutes with improved characteristics., (© 2023 Wiley-VHCA AG, Zurich, Switzerland.)

Himalaya, the highest mountain system in the world and house of important biodiversity hotspot, is sensitive to projected warming by climate change. Rhizocarpon geographicum (map lichen), a crustose lichen, grows in high mountain ranges, is a potential indicator species of climate change. In the present study, MaxEnt species distribution modeling algorithm was used to predict the suitable habitat for R. geographicum in current and future climate scenarios. Nineteen bioclimatic variables from WorldClim database, along with elevation, were used to predict the current distribution and three representative concentration pathway (RCP) scenarios by integrating three general circulation models (GCMs) for future distribution of species covering years 2050 and 2070. Furthermore, we performed change analysis to identify the precise difference between the current and future distribution of suitable areas of the species for delineating habitat range expansion (gain), habitat contraction (loss), and stable habitats. The final ensemble model obtained had average test value 0.968, and its predicted ~ 27.5% of the geographical area in the Indian Himalayan Region is presently climatically suitable for the species. The predicted highly suitable area for R. geographicum is observed to be declining in Northwestern Himalaya, and it is shifting towards the higher elevation areas of the Eastern Himalaya. The projected distribution in future under the RCP scenarios (RCP 4.5, 6.0, and 8.5) showed the range expansion towards higher elevations, and it is more pronounced for the extreme future scenarios (RCP 8.5) than for the moderate and intermediate climate scenarios (RCP 4.5 and RCP 6.0). However, assuming that species can migrate to previously unoccupied areas, the model forecasts a habitat loss of 10.86-16.51% for R. geographicum, which is expected due to increase in mean annual temperature by 1.5-3.7 °C. The predictive MaxEnt modeling approach for mapping lichen will contribute significantly to the understanding of the impact of climate change in Himalayan ecosystems with wide implications for drawing suitable conservation plans and to take adaptation and mitigation measures., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

A strategy of "Nature-to-new" with iterative scaffold-hopping was considered for investigation of privileged ring/functional motif-elaborated analogs of natural aurones. An organocatalyzed umpolung chemistry based method was established for molecular-diversity feasible synthesis of title class of chemotypes i.e. (Z)-2-Arylideneimidazo[1,2-a]pyridinones and (Z)-2-Arylidenebenzo[d]imidazo[2,1-b]thiazol-3-ones. Various biophysical experiments indicated their important biological properties. The analogs showed characteristic anticancer activities with efficiency more than an anticancer drug. The compounds induced apoptosis with arrest in the S phase of the cell cycle regulation. The compounds' significant effect in up/down-regulation of various apoptotic proteins, an apoptosis cascade, and the inhibition of topoisomerases-mediated DNA relaxation process was identified. The analysis of the structure-activity relationship, interference with biological events and the drug-likeness physicochemical properties of the compounds in the acceptable window indicated distinctive medicinal molecule-to-properties of the investigated chemotypes., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

A palladium(II) complex [(κ 4 -{1,2-C 6 H 4 (NCH-C 6 H 4 O) 2 }Pd] (1) supported by a dianionic salen ligand [1,2-C 6 H 4 (NCH-C 6 H 4 O) 2 ] 2- (L) was synthesised and used as a molecular pre-catalyst in the hydroboration of aldehydes and ketones. The molecular structure of Pd(II) complex 1 was established by single-crystal X-ray diffraction analysis. Complex 1 was tested as a competent pre-catalyst in the hydroboration of aldehydes and ketones with pinacolborane (HBpin) to produce corresponding boronate esters in excellent yields at ambient temperature under solvent-free conditions. Further, the complex 1 proved to be a competent catalyst in the reductive amination of aldehydes with HBpin and primary amines under mild and solvent-free conditions to afford a high yield (up to 97%) of corresponding secondary amines. Both protocols provided high conversion, superior selectivity and broad substrate scope, from electron-withdrawing to electron-donating and heterocyclic substitutions. A computational study based on density functional theory (DFT) revealed a reaction mechanism for Pd-catalysed hydroboration of carbonyl species in the presence of HBpin. The protocols also uncovered the dual role of HBpin in achieving the hydroboration reaction.

The advent of d-d type complex salts for designing smart functional materials with versatile utility inspired us to develop a novel type of M(II)-Ce(IV) complex salts [M(II) = Cu and Zn ions]. In this study, we present for the first time a holistic approach to design and prepare metal complex salts of the novel hybrid d-f block type, [Cu(bpy) 2 ] 2 [Ce(NO 3 ) 6 ] 2 (1), [Cu(phen) 2 (NO 3 )] 2 [Ce(NO 3 ) 6 ](HNO 3 ) (2), [Zn(bpy) 2 (NO 3 )][ClO 4 ] (3), and [Zn(phen) 2 (NO 3 )] 2 [Ce(NO 3 ) 6 ] (4); [bpy = 2,2'-bipyridine; phen = 1,10-phenanthroline]. The intrinsic structural and morphological properties of the compounds have been revealed by employing a suite of analytical and spectroscopic methods. X-ray structural analysis reveals that the copper(II) centres in the cationic complex units of 1 and 2 adopt a highly distorted tetrahedral and a rare bicapped square pyramidal coordination geometry, respectively. The zinc(II) ions in both 3 and 4 adopt the rare bicapped square pyramidal geometry while the cerium(IV) ions in 1, 2 and 4 exist in a dodecahedral geometry. Investigation of supramolecular interactions reveals that intermolecular O⋯H and O⋯π short contacts bind the complex units in 1, while predominant π⋯π interactions, along with O⋯H and O⋯π short contacts, produce the binding force among the complex units in 2. We further employed the complex salts (1-4) to construct Schottky devices to reveal the role of these new complex salts in the charge-transport phenomenon. The carrier mobilities ( μ ) for salts 1-4 were determined to be 1.76 × 10 -6 , 9.02 × 10 -6 , 1.86 × 10 -8 , and 4.31 × 10 -8 m 2 V -1 s -1 , with respective transit times ( τ ) of 439, 85, 4.17 × 10 3 , and 1.79 × 10 3 ns, which suggest that complex salt 2 is the best candidate with the highest transport properties among all the complex salts. A crystal engineering perspective sheds light on the charge-transport properties of the complex salts, emphasizing the attribution of the best performance of 2 to its predominant π⋯π interactions. The synthesis of this new type of complex salts, their physicochemical properties and their charge-transport applications envisage great promise for the development of novel crystalline materials with smart functionalities.

Base-metal catalysts Co1, Co2 and Co3 were synthesized from designed pincer ligands L1, L2 and L3 having NNN donor atoms respectively. Co1, Co2 and Co3 were characterized by IR, UV-Vis. and ESI-MS spectroscopic studies. Single crystal X-ray diffraction studies were investigated to authenticate the molecular structures of Co1 and Co3. Catalysts Co1, Co2 and Co3 were utilized to study the dehydrogenative activation of alcohols for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines. Under optimized reaction conditions, a broad range of substrates including alcohols, anilines and ketones were exploited. A series of control experiments for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines were examined to understand the reaction pathway. ESI-MS spectral studies were investigated to characterize cobalt-alkoxide and cobalt-hydride intermediates. Reduction of styrene by evolved hydrogen gas during the reaction was investigated to authenticate the dehydrogenative nature of the catalysts. Probable reaction pathways were proposed for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines on the basis of control experiments and detection of reaction intermediates.

Detection and mapping of landslides is one of the most important techniques used for reducing the impact of natural disasters especially in the Himalaya, owing to its high amount of tectonic deformation, seismicity, and unfavorable climatic conditions. Moreover, the northeastern part of the Himalaya, severely affected by landslides every monsoon, is poorly studied. The information on the inventories is inhomogeneous and lacking. In this context, satellite-based earth observation data, which has significantly advanced in the last decade and often serves as a potential source for data collection, monitoring, and damage assessment for disasters in a short time span, has been implemented. Keeping in mind the above framework, this study aims to exploit the potentials of Sentinel-1 synthetic aperture radar (SAR) and Sentinel-2 optical imagery for identifying new landslides in vegetated and hilly areas of the northeastern part of India. In order to assess the potentials of our data and methodology, a landslide event which occurred on 13 August 2016 13:30 h (IST) in North Sikkim, India, triggered due to rainfall has been explored in detail. The landslide also resulted in the formation of a lake, 2.2 km in length and 290 m in width. Difficulty in procurement of cloud-free datasets immediately after the event led us to the use of Sentinel-1 SAR backscatter data, to assess its potential for this purpose. It is observed that the potential of SAR amplitude imagery is limited to different aspects as per the sensor look direction during the mode of acquisition. Furthermore, the present study also incorporates a change detection algorithm to evaluate the performance of the Sudden Landslide Identification Product (SLIP) model to identify new landslides using Sentinel-2 multispectral imagery. Overall, the results exhibit that integrated usage of both optical and SAR amplitude imagery may provide a plethora of information for identification and mapping of new landslides for damage assessment and early warning. All the above results combined together suggest this method for rapid identification of landslides in the Himalayan terrain with special emphasis on the northeastern part of the Himalaya. The automation of this method for future operational usage is also suggested.

A unique strategy for the attainment of a discotic nematic (N D ) mesophase is reported consisting of a central benzene core to which are attached two 4-alkylphenyl and two 4-pentylbiphenyl moieties diagonally via alkynyl linkers. The rotational nature and incompatibility of unequal phenylethynyl units led to the disruption of π-π interactions within cores that aids to the realization of N D phase and favors high solid-state emission. When used in OLEDs, compounds act as an efficient solid-state pure deep-blue emitter with Commission Internationale de L'Eclairage (CIE x , y ) coordinates of (0.16, 0.07).

The objective of pharmaceutical cocrystallization is to create crystalline analogues that have vastly different properties, such as solubility, melting point, stability, and bioavailability from that observed in the pure active pharmaceutical ingredients (APIs). Amoxapine is a benzoxazepine derivative and exhibits antidepressant properties. Amoxapine has very low solubility in water, so it was cocrystallized with natural acids in a 1:1 ratio in appropriate solvents by the solvent-drop grinding method. Single crystals of cocrystals were grown by the solvent evaporation method in water, ethanol, and methanol. Crystal structures of API salts were determined by single-crystal X-ray diffraction. Salts were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction. Solubility of salts was determined in water by the shake-flask method at 37 °C using UV-vis spectroscopy. Salts of amoxapine with different acids were successfully developed, and their crystal structure was determined. Enhanced solubility was found in the salts of amoxapine for pharmaceutical application in drug formulation., Competing Interests: The authors declare no competing financial interest.

A metal-free highly diastereoselctive [3 + 2] cycloaddition reaction has been developed between N-phenacylbenzothiazolium bromides and prochiral cyclopentene-1,3-diones. The active 1,3 dipole benzothiazolium N-phenacylide was generated in situ with the treatment of DIPEA, and the corresponding cycloaddition products were obtained in excellent yields under mild reaction conditions. The scope of the reaction is quite broad, tolerating a variety of aryl and heteroaromatic groups. A catalytic asymmetric approach was also studied preliminarily, and moderate enantioselectivity was achieved.

The purpose of study was to conjugate and evaluate methotrexate with C 60 -fullerenes and multi-walled carbon nanotubes (MWCNTs) for better drug delivery to cancer cells, and also to compare these two systems. C 60 -fullerenes and MWCNTs were functionalized by 1,3-dipolar cycloaddition using glycine and paraformaldehyde. Methotrexate (MTX) was esterified and conjugated to the functionalized carbon-based carriers. The conjugates were characterized for micromeritics and drug conjugation. The systems were evaluated for drug release in various pH, MTT cytotoxicity assay, protein binding, cellular uptake, haemolytic profile and pharmacokinetics. Spectroscopic studies confirmed the successful conjugation of drug to the aminated carbon-based carriers. The developed systems released more drug at the pH of cancer cells to that of the pH of plasma. The carriers were compatible with erythrocytes and offered substantial cytotoxicity. Better cellular uptake was confirmed by confocal laser scanning microscopy. C 60 -fullerenes/MWCNTs modulated the pharmacokinetic profile of drug in desired manner, resulting in better retention and compartment availability. However, the results from C 60 -fullerenes were observed to be better than that from MWCNTs. The present findings established the potential of carbon-based aminated nanocarriers for delivery of methotrexate in safer and effective manner., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Docetaxel has always attracted the researchers owing to its promises and challenges. Despite marked efficacy, concerns like poor aqueous solubility, lower bioavailability, poor tissue penetration and dose related side-effects offer further scope of research on docetaxel. The present study aims to explore the potential of C60-fullerenes in the delivery of docetaxel to cancerous cells. C60-fullerenes were carboxylated, acylated and conjugated with the drug. The chemical processes were monitored by UV, FT-IR and NMR spectroscopy. The conjugate was further characterized for drug loading, micromeritics, drug release, morphology and evaluated for in-vitro cytotoxicity, haemolysis and in-vivo pharmacokinetic profile. The developed nanoconstruct was able to enhance the bioavailability of docetaxel by 4.2 times and decrease the drug clearance by 50%. The developed system was able to control the drug release and was found to be compatible with erythrocytes. The cytotoxic potential on studied MCF-7 and MDA-MB231 cell lines was also enhanced by many folds, indicating marked promise in efficacy enhancement and dose reduction. The present findings are encouraging and offer a technique to enhance the delivery and efficacy potential of anticancer agents, especially belonging to BCS class IV., (Copyright © 2015 Elsevier B.V. All rights reserved.)

1. The aim of the present study was to understand the benefit of liposomal dry powder for inhalation (LDPI) of ketotifen fumarate (KF) over plain drug dry powder for inhalation as a pulmonary targetted drug-delivery system. 2. The KF liposomes, composed of egg phosphatidyl choline and cholesterol, were prepared by the lipid film hydration technique. The liposomal dispersion was freeze dried and formulated to a dry powder for inhalation. Values of 89.0-65.3% drug entrapment of freeze-dried liposomes were estimated in prepared batches. 3. Rehydrated KF liposomes formed by the hydration of LDPI or the plain KF solution was delivered to rat lungs by intratracheal instillation. Simultaneous monitoring of drug levels in the bronchoalveolar lavage and lung tissue enabled assessment of pulmonary drug disposition. 4. Cumulative drug levels in lung tissue after intratracheal administration revealed that with liposomes targetting factors were between 1.36 and 1.54. The maximal drug concentration in lung homogenate for LDPI was 42.0 micro g compared with 73.6 micro g for plain drug solution. 5. Similarly, the time to reach maximum drug concentration in the lung homogenate for liposomal dry powder was 9-12 h compared with 3 h for plain drug. 6. Hence, the use of LDPI of KF was found to provide desired drug levels in the lung for a long time and thereby increased pulmonary targetting 7. This is expected to enhance the therapeutic index of the drug and probably reduce the dose administered and the cost of therapy.