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1. Rifalazil and derivative compounds show potent efficacy in a mouse model of H. pylori colonization.

Author

Rothstein DM, Mullin S, Sirokman K, Söndergaard KL, Johnson S, Gwathmey JK, van Duzer J, and Murphy CK

Subjects
Animals, Disease Models, Animal, Helicobacter Infections microbiology, Helicobacter pylori drug effects, Mice, Mice, Inbred C57BL, Microbial Sensitivity Tests, Antibiotics, Antitubercular pharmacology, Helicobacter Infections drug therapy, Helicobacter pylori growth & development, Rifamycins pharmacology
Abstract

The rifamycin rifalazil (RFZ), and derivatives (NCEs) were efficacious in a mouse model of Helicobacter pylori colonization. Select NCEs were more active in vitro and showed greater efficacy than RFZ. A systemic component contributes to efficacy.

Published
2008
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