1. Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics.
- Author
-
Hsu YW, Wong HS, Huang WC, Yeh YH, Hsiao CD, Chang WC, and Hsieh SL
- Subjects
- Alleles, Genome-Wide Association Study, Humans, Lectins, C-Type genetics, Phenotype, Polymorphism, Single Nucleotide, Genetic Pleiotropy, Polymorphism, Genetic
- Abstract
Background: Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genetic variation impacts molecular or cellular behaviours of a gene, and subsequently leads to such variability remain poorly understood., Methods: Here, in addition to phenome-wide correlations, we leveraged multiomics to exploit mechanistic links, from genetic polymorphism to protein structural or functional changes and a cross-omics perturbation landscape of a germline variant., Results: We identified a missense cis-acting expression quantitative trait locus in CLEC18A (rs75776403) in which the altered residue (T
151 →M151 ) disrupts the lipid-binding ability of the protein domain. The altered allele carriage led to a metabolic and proliferative shift, as well as immune deactivation, therefore determines human anthropometrics (body height), kidney, and hematological traits., Conclusions: Collectively, we uncovered genetic pleiotropy in human complex traits and diseases via CLEC18A rs75776403-regulated pathways., (© 2022. The Author(s).)- Published
- 2022
- Full Text
- View/download PDF