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Background: Total ankle arthroplasty (TAA) is used to treat symptomatic end-stage ankle arthritis (AA). However, little is known about TAA's effects on gait symmetry., Research Question: Determine if symmetry changes from before surgery through two years following TAA utilizing the normalized symmetry index (NSI) and statistical parametric mapping (SPM)., Methods: 141 patients with end-stage unilateral AA were evaluated from a previously collected prospective database, where each participant was tested within two weeks of surgery (Pre-Op), one year and two years following TAA. Walking speed, hip extension angle and moment, hip flexion angle, ankle plantarflexion angle and moment, ankle dorsiflexion angle, weight acceptance (GRF1), and propulsive (GRF2) vertical ground reaction forces were calculated for each limb. Gait symmetry was assessed using the NSI. A linear mixed effects model with a single response for each gait symmetry variable was used to examine the fixed effect of follow-up time (Pre-Op, Post-1 yr, Post-2 yr) and the random effect of participant with gait speed as a covariate in the model. A one-dimensional repeated measures analysis of variance (ANOVA) statistical parameter mapping (SPM) was completed to examine differences in the time-series NSI to determine regions of significant differences between follow-up times., Results: Relative to Pre-Op values, GRF1, and GRF2 showed increased symmetry for discrete metrics and the time-series NSI across sessions. Hip extension moment had the largest symmetry improvement. Ankle plantarflexion angle was different between Pre-Op and Post-2 yr (p=0.010); and plantarflexion moment was different between Pre- Op and each post-operative session (p<0.001). The time-series Ankle Angle NSI was greater during the early stance phase in the Pre-Op session compared to Post-2 yr., Significance: Symmetry across most of the stance phase improved following TAA indicating that TAA successfully improves gait symmetry and future work should determine if these improvements restore symmetry to levels equivalent with health age-match controls., Competing Interests: Declaration of Competing Interest None of the authors declare any competing interests, (Copyright © 2024 Elsevier B.V. All rights reserved.)

Upper extremity kinematics are important for understanding functional ability and performance improvements. The Box and Blocks test (BBT) is a standardized functional test used to measure manual dexterity when evaluating children or patients following a stroke. The BBT measures the number of blocks moved in one minute and therefore, kinematic measures and compensatory strategies cannot be assessed. This study examined the correlation between upper extremity kinematics and cycle time per block movement during the BBT in three age groups (7-, 9-, and 11-year-olds). Participants completed one BBT session while test scores and kinematic measures (hand velocity and position and shoulder, elbow, and wrist range of motion and peak joint angles) were captured using standard three-dimensional motion capture techniques. Kinematic measures were determined for block movements during the middle of each BBT trial. A mixed-effects model was used to identify group differences (α = 0.05). BBT score was different (p = 0.005) between the 7- (44.88 ± 6.03) and the 11-year-old age group (56.95 ± 8.37) along with peak shoulder flexion (p = 0.024) and abduction (p = 0.022). Peak elbow flexion was different (p = 0.049) between the 9- and 11-year-old age groups. No differences were seen between the 7- and 9-year-old age groups. Pearson's Correlation Coefficients were determined between cycle time and each significant kinematic measure, where the cycle time is specific to each block movement (BBT score) and is correlated to the BBT score. This resulted in weak correlations for all the comparisons. Therefore, using BBT score alone is not representative of UE kinematics and both should be collected during this task to provide insight into movement mechanics in a pediatric population., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)