1. A Prospective Analysis of Genetic Variants Associated with Human Lifespan.
- Author
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Wright KM, Rand KA, Kermany A, Noto K, Curtis D, Garrigan D, Slinkov D, Dorfman I, Granka JM, Byrnes J, Myres N, Ball CA, and Ruby JG
- Subjects
- Aged, Aged, 80 and over, Apolipoproteins E genetics, Carrier Proteins genetics, Databases, Genetic, Female, Humans, Male, Nuclear Proteins genetics, Pedigree, Polymorphism, Single Nucleotide, Prospective Studies, Proto-Oncogene Proteins genetics, Genome-Wide Association Study methods, Longevity genetics
- Abstract
We present a massive investigation into the genetic basis of human lifespan. Beginning with a genome-wide association (GWA) study using a de-identified snapshot of the unique AncestryDNA database - more than 300,000 genotyped individuals linked to pedigrees of over 400,000,000 people - we mapped six genome-wide significant loci associated with parental lifespan. We compared these results to a GWA analysis of the traditional lifespan proxy trait, age, and found only one locus, APOE , to be associated with both age and lifespan. By combining the AncestryDNA results with those of an independent UK Biobank dataset, we conducted a meta-analysis of more than 650,000 individuals and identified fifteen parental lifespan-associated loci. Beyond just those significant loci, our genome-wide set of polymorphisms accounts for up to 8% of the variance in human lifespan; this value represents a large fraction of the heritability estimated from phenotypic correlations between relatives., (Copyright © 2019 Wright et al.)
- Published
- 2019
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