1. Detection of glucose in the human brain with 1 H MRS at 7 Tesla.
- Author
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Kaiser LG, Hirokazu K, Fukunaga M, and B Matson G
- Subjects
- Adult, Brain anatomy & histology, Humans, Male, Reproducibility of Results, Sensitivity and Specificity, Tissue Distribution, Algorithms, Brain metabolism, Glucose metabolism, Magnetic Resonance Imaging methods, Molecular Imaging methods, Proton Magnetic Resonance Spectroscopy methods
- Abstract
Purpose: A new method is proposed for noninvasive detection of glucose in vivo using proton MR spectroscopy at 7 Tesla., Theory and Methods: The proposed method utilizes J-difference editing to uncover the resonance of beta-glucose (β-glc) at 3.23 ppm, which is strongly overlapped with choline. Calculations using the density matrix formalism are used to maximize the signal-to-noise ratio of the β-glc resonance at 3.23 ppm. The calculations are verified using phantom and in vivo data collected at 7 Tesla., Results: The proposed method allows observation of the glucose signal at 3.23 ppm in the human brain spectrum. Additional co-edited resonances of N-acetylaspartylglutamatate and glutathione are also detected in the same experiment., Conclusion: The proposed method does not require carbon (
13 C)- labeled glucose injections and13 C hardware; as such, it has a potential to provide valuable information on intrinsic glucose concentration in the human brain in vivo. Magn Reson Med 76:1653-1660, 2016. © 2016 International Society for Magnetic Resonance in Medicine., (© 2016 International Society for Magnetic Resonance in Medicine.)- Published
- 2016
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