1. [Pharmacological treatment of posttraumatic stress disorder].
- Author
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Roepke S, Schellong J, Bergemann N, Frommberger U, and Schmidt U
- Subjects
- Humans, Treatment Outcome, Sertraline therapeutic use, Evidence-Based Medicine, Sleep Wake Disorders drug therapy, Sleep Wake Disorders therapy, Paroxetine therapeutic use, Combined Modality Therapy, Sleep Initiation and Maintenance Disorders therapy, Sleep Initiation and Maintenance Disorders drug therapy, Stress Disorders, Post-Traumatic therapy, Stress Disorders, Post-Traumatic drug therapy, Stress Disorders, Post-Traumatic psychology
- Abstract
In addition to trauma-focussed psychotherapy, pharmacological treatment is often unavoidable, especially in patients with severe posttraumatic stress disorder (PTSD). As long as comorbid disorders do not dictate the pharmacotherapy approach, sertraline and paroxetine, along with other off-label prescribable substances approved in Germany, can be used for the treatment of PTSD. Venlafaxine, in particular, has shown good effectiveness in studies, whereas risperidone has shown lower effectiveness in augmentation. Overall, only a small to medium effect size is to be expected for all substances. Psychopharmacotherapy plays an important role in addressing sleep disorders, which are highly prevalent in PTSD. Treatment of trauma-related nightmares can be attempted with doxazosin or clonidine. In contrast, there are limited empirical data available for sleep disorders associated with PTSD, but the pharmacological treatment of insomnia can provide some guidance., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2024
- Full Text
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