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Background: Breast cancer (BRCA) is one of the most common malignant tumors. The structural maintenance of chromosome (SMC) gene family has been shown to play an important role in human cancers. However, the role of SMC families in BRCA is unclear. This study aimed to explore the role and potential clinical value of whole SMCs in BRCA., Methods: TIMER and UALCAN database were used to analysis the expression level. Genetic variations were analyzed by cBioPortal. Promoter methylation and protein level were analyzed by UCLCAN. GO and KEGG were analyzed by Metascape database. Prognostic value of SMCs was analyzed by Kaplan-Meier and multivariate cox regression analyses. Immune infiltration analysis was conducted by CIBERSORT. Immunotherapy outcome prediction was conducted by Cancer Immunome Atlas. Targeted drug therapy outcome prediction was taken by GDSC and R language. The cell viability was tested by CCK8 and migration was tested by wound healing assay. Xenograft model was used to investigate the in vivo role of SMC2., Results: Expression levels of SMC1A, SMC2, SMC4, SMC5 and SMC6 mRNA were increased in BRCA tissues, and negatively correlated with promoter methylation. Overexpression of SMC2 and SMC4 was negatively correlated with survival. Function of SMCs family regulatory genes was mainly related to ATPase activity. Expression of most SMCs was negatively correlated with immunotherapy and drug therapy outcomes. Interfere SMC2 and SMC4 decreased IC 50 values of 5-fluorouracil and oxaliplatin and inhibited the migration of MCF7 cells. Tumor growth and weights were significantly decreased in si-SMC2 groups., Conclusions: Combined bioinformatics and clinical specimen analysis verified SMC2 and SMC4 as independent prognostic factors in BRCA, suggesting their significance for the diagnosis and treatment of BRCA., Competing Interests: Declarations Conflict of interests The authors declare that they have no competing interests. Consent for publication Not applicable., (© 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).)

Mental health problems among college students are increasingly prominent. The negative effects of emotional distress on college students' mental health have been supported empirically. It is important to understand the psychological processes underlying this relationship. Using a longitudinal design, the present study aimed to reveal the explanatory mechanism of the association between dimensions of dispositional mindfulness and mental health problems among Chinese college students by testing the mediating effects of experiential avoidance and intolerance of uncertainty. A total of 907 Chinese college students (57% male; Mage = 20.33 years) were invited to complete self-report questionnaires at two time points. Mindful awareness, acceptance and mental health problems (depression, anxiety and stress) were assessed at baseline (T0). Experiential avoidance, intolerance of uncertainty and mental health problems were assessed at the 6 month follow-up (T1). Following structural equation modeling (SEM) analyses, the results show that high levels of mindful awareness and acceptance may diminish mental health problems by decreasing the levels of experiential avoidance among college students. However, only mindful acceptance diminished mental health problems through decreased intolerance of uncertainty. In addition, our study found that mindful awareness and acceptance may have different functions when working alone. Specifically, these two constructs may have different relationships with mental health. Identifying these mechanisms by which dispositional mindfulness is associated with college students' mental health over time has potential value for the prevention of potential mental health issues and timely interventions.

Large quantities of microplastics are found in the East China Sea (ECS), however, the impacts of complicated terrestrial input on the distribution characteristics of microplastics have not been studied. Hence, we aimed to characterize the microplastic distribution in the ECS combined with the fluorescence characteristics of chromophoric dissolved organic matter (CDOM), a sensitive technique to trace terrestrial substances in seawater. The average microplastic abundance in the surface seawater of ECS was 34.73 ± 4.05 items/m 3 and sites in the north ECS had a higher microplastic abundance (55.90 ± 2.47 items/m 3 ) than those in the southern region (11.22 ± 4.01 items/m 3 ), due to its proximity to the Yangtze River estuary and Hangzhou Bay. Polyethylene (PE, 44.2 %) was the most abundant microplastic type in the northern region, whereas polyethylene terephthalate (PET, 28.4 %) had a higher proportion in the south ECS. Besides, sites in the north ECS had a higher diversity index of microplastics, suggesting various sources of microplastic pollution. Interestingly, a stronger correlation with the diversity index was found for protein-like component C3 (R 2 = 0.56) in northern regions compared to fulvic-like component C1 (R 2 = 0.32) and humic-like component C2 (R 2 = 0.28), suggesting the significant impact of anthropogenic discharge. Moreover, no correlation between fluorescence components and microplastic diversity index was found in the south ECS, indicating that CDOM can reflect the impact range of terrestrial input on the distribution characteristics of microplastics. This research might be useful in assessing and reducing the impact of terrestrial input on the distribution characteristics of microplastics in the ECS., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Recently, the degradation of non-chlorinated organic pollutants in saline pharmaceutical wastewater by SO 4 ˙ - -based advanced oxidation processes (AOPs) has received widespread attention. However, little is known about the oxidation of chlorinated compounds in SO 4 ˙ - -based AOPs. This study chose clofibric acid (CA) as a chlorinated pollutant model; the oxidation kinetics and mechanistic pathway were explored in the Co 2+ /peroxymonosulfate (PMS) system. Notably, a high removal efficiency (81.0%) but low mineralization rate (9.15%) of CA within 120 min were observed at pH 3.0 during Co 2+ /PMS treatment. Exogenic Cl - had a dual effect (inhibitory then promoting) on CA degradation. Several undesirable chlorinated by-products were formed in the Co 2+ /PMS system. This demonstrated endogenic chlorine and exogenic Cl - both reacted with SO 4 ˙ - to generate chlorine radicals, which participated in the dechlorination and rechlorination of CA and its by-products. Furthermore, SO 4 ˙ - was the dominant species responsible for CA degradation at low Cl - concentrations (≤1 mM), whereas Cl 2 ˙ - was the predominant radical at [Cl - ] 0 > 1 mM. A possible degradation pathway of CA was proposed. Our findings suggested that chlorinated compounds in highly saline pharmaceutical wastewater will be more resistant and deserve more attention., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Trace copper ion (Cu(II)) in water and wastewater can trigger peroxymonosulfate (PMS) activation to oxidize organic compounds, but it only works under alkaline conditions. In this work, we found that the presence of chloride could significantly accelerate the oxidation of Acid Orange 7 (AO7) by the Cu(II)/PMS process at a wide pH range (4.0-9.0). The observed pseudo-first-order rate constant k for AO7 oxidation was linearly correlated with the increased Cl - concentration (0-300 mM). An increase in mineralization rate was observed in the presence of Cl - , while the overall mineralization was quite low. Decomposition of PMS facilitated when Cl - concentration or pH value increased. Based on the scavenger experiments and electron paramagnetic resonance (EPR) measurement, the mechanism of Cu(II)-catalyzed PMS oxidation process in the presence of Cl - was proposed as both the radical and non-radical pathway, and 1 O 2 was the reactive oxygen species in the Cu(II)/PMS system. Finally, a possible degradation pathway of AO7 was elucidated. The feasibility of in situ utilizing high salinity and trace cupric species to accelerate the degradation of organic pollutants by the Cu(II)/PMS process in water and wastewater was demonstrated. However, the identification of undesired chlorinated by-products reminds us of cautiousness in assessing the application of Cu(II)/PMS system under chloride-rich environment. The findings of this work provide a simple and efficient approach to apply PMS in the remediation of refractory organic contaminants in the presence of trace cupric species under a high salinity environment with a wide range of pH., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Cigarette smoke-induced airway inflammationmucus over-production is one of the most important pathogenic features of chronic airway diseases. This study aimed to investigate the effect of berberine, a plant alkaloid with strong anti-inflammatory property, on cigarette smoke-induced airway inflammation and mucushypersecretion in mice. Mice with exposure to cigarette smoke wereintraperitonealy injected with berberin (5, 10 mg/kg·d). Inflammatory cytokines TNF-α, IL-1β and MCP-1 levels in bronchoalveolar lavage fluid were determined by ELISA.Lung tissue was examined for histopathological lesions and goblet cell hyperplasia. The expression of signaling proteins in lung tissue, ERK and P38 were detected using Western Blot. Cigarette smoke exposure significantly increased the release of inflammatory cytokines TNF-α, IL-1β, MCP-1 and inflammatory cells in bronchoalveolar lavage fluid, and it also induced goblet cell hyperplasiaand the expression of mucin-5ac in the airway of mice. Pretreatment of berberineinhibited cigarette smoke-induced airway inflammation and mucus production. Cigarette smoke exposure also increased the expression of ERK and P38, meanwhile, berberineintervention can inhibit such changes. In summary, berberine inhibits cigarette smoke exposure-induced airway inflammation and mucus hypersecretion in mice, which may partly act through inhibition of ERK and P38.