1. Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides.
- Author
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Doyle RJ, Elfessi Z, and Kolman K
- Subjects
- Abdominal Pain chemically induced, Aged, Blood Coagulation Disorders chemically induced, Drug Contamination, Drug Dosage Calculations, Hemorrhage drug therapy, Humans, Male, Treatment Outcome, 4-Hydroxycoumarins poisoning, Anticoagulants adverse effects, Blood Coagulation Factors administration & dosage, Hemorrhage chemically induced, Illicit Drugs poisoning, Rodenticides poisoning, Synthetic Drugs adverse effects, Vitamin K administration & dosage
- Abstract
Acute, unintentional drug-related poisonings lead to an estimated 418,313 ED visits in 2014, according to the latest statistics from the Center for Disease Control and Prevention. While most of these were opiate-related poisonings, anticoagulant rodenticides were the most common cause of rodenticide-related poisoning in the United States. Many clinical syndromes and treatment algorithms have been described for patients with anticoagulant rodenticide poisoning. We report a case of an acute ingestion of two anticoagulant rodenticides and successful reversal of coagulation parameters using 4-factor prothrombin complex concentrate in a fixed-dose approach., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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