1. Asperidulins A and B, two new prenylxanthone derivatives from an apple-derived fungus Aspergillus nidulans KIB-HACM-01.
- Author
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Lai P, Wang L, Deng C, Xu Y, Ma XY, Cheng CR, and Huang SX
- Subjects
- Humans, Molecular Structure, Cell Line, Tumor, Drug Screening Assays, Antitumor, Magnetic Resonance Spectroscopy, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Inhibitory Concentration 50, Xanthones chemistry, Xanthones pharmacology, Xanthones isolation & purification, Aspergillus nidulans, Malus microbiology, Malus chemistry
- Abstract
Two new prenylxanthone derivatives, asperidulins A ( 1 ) and B ( 2 ), along with a known emodin analogue ( 3 ) were isolated from an apple-derived fungus Aspergillus nidulans KIB-HACM-01. Their structures were elucidated by interpretation of HRMS, NMR, and comparisons of specific optical rotation. Asperidulin B ( 2 ) exhibited a moderate cytotoxicity against A549 and BEAS-2B with an IC
50 values of 13.62 ± 0.41 and 11.27 ± 0.52 μM, and methyl-averantin ( 3 ) showed moderate cytotoxicities against all six tested cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, SW480, BEAS-2B) with IC50 values ranging from 8.93 ± 0.56 to 35.27 ± 0.25 μM.- Published
- 2024
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