1. A prospective multi-center study quantifying visual inattention in delirium using generative models of the visual processing stream.
- Author
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Al-Hindawi A, Vizcaychipi M, and Demiris Y
- Subjects
- Humans, Male, Female, Aged, Prospective Studies, Middle Aged, Eye-Tracking Technology, Aged, 80 and over, Eye Movements physiology, Delirium physiopathology, Delirium diagnosis, Attention physiology, Visual Perception physiology
- Abstract
The visual attentional deficits in delirium are poorly characterized. Studies have highlighted neuro-anatomical abnormalities in the visual processing stream but fail at quantifying these abnormalities at a functional level. To identify these deficits, we undertook a multi-center eye-tracking study where we recorded 210 sessions from 42 patients using a novel eye-tracking system that was made specifically for free-viewing in the (ICU); each session lasted 10 min and was labeled with the delirium status of the patient using the Confusion Assessment Method in ICU (CAM-ICU). To analyze this data, we formulate the task of visual attention as a hierarchical generative process that yields a probabilistic distribution of the location of the next fixation. This distribution can then be compared to the measured patient fixation producing a correctness score which is tallied compared across delirium status. This analysis demonstrated that the visual processing system of patients suffering from delirium is functionally restricted to a statistically significant degree. This is the first study to explore the potential mechanisms underpinning visual inattention in delirium and suggests a new target of future research into a disease process that affects one in four hospitalized patients with severe short and long-term consequences., (© 2024. The Author(s).)
- Published
- 2024
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