1. Semi-Automated Analysis of Dome-Shaped Macula in Preterm and Full-Term Infants Using Handheld Swept-Source Optical Coherence Tomography.
- Author
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Dang JN, Wu J, Zheng Y, Bunk JJ, Tam EK, Lee KE, Lawson SE, Monger TR, Legocki AT, Kelly JP, Egeolu O, Ding L, Wang RK, Tarczy-Hornoch K, and Cabrera MT
- Subjects
- Humans, Female, Prospective Studies, Male, Infant, Newborn, Term Birth, Macular Edema diagnosis, Macular Edema diagnostic imaging, Tomography, Optical Coherence methods, Macula Lutea diagnostic imaging, Macula Lutea pathology, Infant, Premature, Gestational Age, Retinopathy of Prematurity diagnosis
- Abstract
Purpose: Dome-shaped macula (DSM) is known to occur in highly myopic adults and, recently, preterm infants. This study uses investigational handheld swept-source optical coherence tomography (SS-OCT) to further characterize infantile DSM., Methods: In this prospective, observational study, preterm infants undergoing retinopathy of prematurity screening and full-term infants within 72 hours of birth were imaged. Two trained graders assessed macular features, including DSM, subretinal fluid, and macular edema. A semi-automated program measured foveal immaturity, dome height, and diameter., Results: Two hundred seventeen imaging sessions from 50 full-term and 30 preterm infants were included (46% female, preterm birth weight 1038 ± 335 g, and gestational age 28.7 ± 3.1 weeks). DSM occurred in 40% preterm versus 14% full-term infants (P = 0.01). Mean postmenstrual age at first DSM diagnosis was 38.4 ± 0.0 weeks among preterm and 40.4 ± 1.1 weeks among full-term infants (P < 0.001). Dome height and diameter measured 55.67 ± 44.22 µm and 3583.15 ± 1090.35 µm for preterm versus 88.37 ± 44.73 µm and 3581.97 ± 355.07 µm for full-term infants (P = 0.24 and P = 0.96, respectively). All 27 images (11 preterm and 7 full-term infants) with 3-dimensional analysis had round dome configuration. No other associations were seen, including macular fluid (P = 0.17)., Conclusions: Infants frequently exhibit DSM without an association with macular fluid. Preterm infants were more likely than full-term infants to have DSM. Unlike DSM in children and adults, infantile DSM configuration is mostly round rather than ridge-shaped.
- Published
- 2024
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