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Mental health disorders and substance use disorders (SUDs) in particular, contribute greatly to the global burden of disease. Psychedelics, including entactogens and dissociative substances, are currently being explored for the treatment of SUDs, yet with less empirical clinical evidence than for other mental health disorders, such as depression or post-traumatic stress disorder (PTSD). In this narrative review, we discuss the current clinical research evidence, therapeutic potential and safety of psilocybin, lysergic acid diethylamide (LSD), ketamine, 3,4-methylenedioxymethamphetamine (MDMA) and ibogaine, particularly in the context of the SUD treatment. Our aim was to provide a balanced overview of the current research and findings on potential benefits and harms of psychedelics in clinical settings for SUD treatment. We highlight the need for more clinical research in this particular treatment area and point out some limitations and challenges to be addressed in future research., (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

In 2010 the American Community Survey (ACS) replaced the long form of the United States decennial census. The ACS is now the principal source of high-resolution geographic information about the U.S. population. The margins of error on ACS census tract-level data are on average 75 percent larger than those of the corresponding 2000 long-form estimate. The practical implications of this increase is that data are sometimes so imprecise that they are difficult to use. This paper explains why the ACS tract and block group estimates have large margins of error. Statistical concepts are explained in plain English. ACS margins of error are attributed to specific methodological decisions made by the Census Bureau. These decisions are best seen as compromises that attempt to balance financial constraints against concerns about data quality, timeliness, and geographic precision. In addition, demographic and geographic patterns in ACS data quality are identified. These patterns are associated with demographic composition of census tracts. Understanding the fundamental causes of uncertainty in the survey suggests a number of geographic strategies for improving the usability and quality ACS.

This procedure, used since some years because of its easy application and effectiveness, is spreading nowadays in the management of posterior epistaxis either in primary assistance centers or specialized. The method is actually advantageous in polytrauma, chronic bronchitis patients or in some postoperative cases. Nevertheless the device should close controlled in order to prevent injuries of the nose structures.