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Objectives: To evaluate the effects on vascular enhancement of either a fixed rate (FR) or a fixed injection duration (FID) in single-pass (SP) contrast-enhanced abdominal multi-detector CT (CE-MDCT)., Materials & Methods: Ninety-nine (54M; 45F; aged 18-86 yrs) patients with nontraumatic acute abdomen underwent a SP CE-MDCT after i.v. injection of 1.7 cc/Kg of a nonionic iodinated contrast-media (370 mgI/ml) performed with either a FR (2 cc/sec; Group A) or a FID (55 sec; Group B). In both groups, patients were further stratified according to total body weight (Kg) as follows: 40-60 (L); 61-80 (M); 81-100 (H). Signal- (SNR) and contrast-to-noise ratios (CNR) were calculated for the liver and for both abdominal aorta (AA) and main portal vein (MPV). Statistical analysis was performed by Student's T or Chi-square test for continuous and categorical data, respectively, whereas post-hoc analysis was performed by the Mann-Whitney test (p < 0.05)., Results: There were no significant differences in demographic and physical characteristics between Group A (n = 50; 53 ± 20 yrs; BMI = 23.4 ± 4.4) and B (n = 50; 51 ± 17 yrs; BMI 22.7 ± 4.2). Whereas overlapping findings were observed in the M sub-groups (n = 40), SNR and CNR were significantly higher (p < 0.01) in Group B for both AA and MPV in the high (H) weight sub-groups (n = 20) while not significant differences were observed in the low (L) weight sub-groups (n = 40) despite a significantly lower injection rate (1.6 ± 0.2 cc/sec, p < 0.01) in Group B., Conclusion: A FID results in an overall better vascular enhancement than a FR in SP CE-MDCT., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Quantum interference is a central resource in many quantum-enhanced tasks, from computation to communication. While usually occurring between identical photons, it can also be enabled by performing projective measurements that render the photons indistinguishable, a process known as quantum erasing. Structured light forms another hallmark of photonics, achieved by manipulating the degrees of freedom of light, and enables a multitude of applications in both classical and quantum regimes. By combining these ideas, we design and experimentally demonstrate a simple and robust scheme that tailors quantum interference to engineer photonic states with spatially structured coalescence along the transverse profile, a type of quantum mode with no classical counterpart. To achieve this, we locally tune the distinguishability of a photon pair by spatially structuring the polarization and creating a structured quantum eraser. We believe that these spatially engineered multiphoton quantum states may be of significance in fields such as quantum metrology, microscopy, and communication.

Background: In classical electrodynamics, light-matter interactions are modelled using Maxwell equations. The solution of Maxwell equations, which is typically given by means of the electric and magnetic field, is vectorial in nature. Yet it is well known that light-matter interactions can be approximately described in a scalar (polarization independent) way for many optical applications. While the accuracy of the scalar approximation can be theoretically computed, to the best of our knowledge, it has never been determined experimentally. Here, we introduce Vortex Circular Dichroism ( VCD), an optical measurement that has the required features to assess the vectoriality of diffraction., Methods: VCD is measured as the differential transmission (or absorption) of left and right circularly polarized vortex beams. We test the VCD measurement with two different systems: i) an experimental set of single circular nano-apertures drilled in a gold film with diameters ranging from 150 to 1950 nm; and ii) a theoretical set of golden spheres with the same diameters as the nano-apertures., Results: We observe that in both systems, VCD > 0 for smaller diameters, VCD ≲ 0 for intermediate values and VCD ≈ 0 for larger values of the diameter. Furthermore, the simulations show that a diffraction process characterized by a VCD ≈ 0 ( VCD ≠ 0) is polarization-independent (polarization-dependent). As a result, we relate VCD ≠ 0 to a vectorial diffraction, and VCD ≈ 0 to a scalar one., Conclusions: Overall, our results show compelling evidence that it is possible to experimentally assess the scalar/vectorial regime of a diffraction process, and that the VCD technique possesses the required features to measure the vectoriality of diffraction processes involving plasmonic cylindrically symmetric structures., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Zambrana-Puyalto X et al.)

Background: The focus-based integrated model (FBIM) is a form of psychotherapy that integrates psychodynamic and cognitive psychotherapy and Erikson's life cycle model. Although there are many studies on the effectiveness of integrated models of psychotherapy, few have examined the efficacy of FBIM., Objective: This pilot study explores clinical outcome measures concerning individual wellbeing, the presence/absence of symptoms, life functioning, and risk in a cohort of subjects after they received FBIM therapy., Methods: A total of 71 participants were enrolled at the CRF Zapparoli Center in Milan, 66.2% of whom were women ( N = 47). The mean age of the total sample was 35.2 years (SD = 12.8). We used the Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) to test treatment efficacy., Results: The results revealed that participants improved in all four dimensions of CORE-OM (i.e., wellbeing, symptoms, life functioning, and risk), women improved more than men, and in most cases (64%), the change was clinically reliable., Conclusion: The FBIM model seems to be effective for treating several patients. Most of the participants saw significant changes in symptoms, life functioning, and general wellbeing., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Gislon, Sattin, Cis, Fiaschi, Tognasso, D’Ambrosio, Villa, Ruffino and Bergamaschi.)

Background: Hand dexterity impairment is a key feature of disability in people with primary progressive multiple sclerosis (PPMS). So far, ocrelizumab, a recombinant humanized monoclonal antibody that selectively depletes CD20-expressing B cells, is the only therapy approved for PPMS and recent analysis reported its ability to reduce the risk of upper limb disability progression. However, the neural mechanisms underlying hand impairment in PPMS and the brain networks behind the effect of ocrelizumab on manual dexterity are not fully understood., Objective: Main aims of our study were: (i) to investigate neurophysiological and behavioural correlates of hand function impairment in subjects with PPMS, and (ii) to use neurophysiologic and behavioural measures to track the effects of ocrelizumab therapy on manual dexterity., Methods: Seventeen PPMS patients and 17 healthy-controls underwent routine neurophysiological protocols assessing the integrity of cortico-spinal and somatosensory pathways and advanced transcranial magnetic stimulation (TMS) protocols evaluating inhibitory (short and long interval intracortical inhibition, short-latency afferent inhibition) and facilitatory (motor thresholds, intracortical facilitation, short-interval intracortical facilitation) circuits in the primary motor cortex. All subjects also underwent behavioural analysis of hand dexterity by means of nine-hole peg test and finger movement analysis, and hand strength with handgrip and three-point pinch test. Neurophysiological and clinical assessments of hand functionality were also performed after 1 year of ocrelizumab therapy., Results: At baseline PPMS patients displayed a significant impairment of hand dexterity and strength compared to healthy controls (all p < 0.03). Neurophysiological study disclosed prolonged latencies of standard somatosensory and motor evoked potentials (all p < 0.025) and an overall reduction of intracortical excitability at TMS protocols, involving both excitatory and inhibitory circuits. Importantly, hand dexterity impairment, indexed by delayed 9HPT, correlated with TMS protocols investigating cortical sensorimotor integration (short-latency afferent inhibition, SAI), p = 0.009. Both parameters, 9HPT (p = 0.01) and SAI (p = 0.01), displayed a significant improvement after 1 year of therapy with ocrelizumab., Conclusion: Intracortical sensorimotor networks are involved in hand dexterity dysfunction of PPMS. Ocrelizumab therapy displays a beneficial effect on hand dexterity impairment most likely through intracortical networks implicated in fast sensorimotor integration., (© 2022. The Author(s).)

Accurately measuring mechanical displacements is essential for a vast portion of current technologies. Several optical techniques accomplish this task, allowing for non-contact sensing even below the diffraction limit. Here we introduce an optical encoding technique, dubbed "linear photonic gears", that enables ultra-sensitive measurements of a transverse displacement by mapping it into the polarization rotation of a laser beam. In ordinary ambient conditions, we measure the relative shift between two objects with a resolution of 400 pm. We argue that a resolution of 50 pm should be achievable with existing state-of-the-art technologies. Our single-optical-path scheme is intrinsically stable and it could be implemented as a compact sensor, using cost effective integrated optics. We anticipate it may have a strong impact on both research and industry., (© 2022. The Author(s).)

Background: Geographic isolates are the ideal setting to study the genetic background and the epidemiology of epilepsy. There are only few published reports on the epidemiology of pediatric epilepsy in geographic isolates., Methods: This study was performed in the Ischia island, district of Napoli (Southern Italy). The local population includes 61,086 individuals, 8381 of them aged from 0 to 14 years. We included children with two or more unprovoked seizures or one unprovoked seizure associated to a high risk of relapse, observed from 2004 to 2017. Neonatal, febrile and acute symptomatic seizures were excluded. Eligible patients were identified through the local pediatricians' medical records. All probands and their parents underwent a face-to-face interview. Clinical charts were reviewed and electroclinical diagnoses were confirmed by two authors (AC, VB)., Results: Thirty-six children and adolescents were included. Overall, the prevalence of epilepsy in the Ischia island was 4.3 per 1,000 (95% CI 3.0-5.9). Incidence was 51.7 per 100,000 person-years (95% CI 36.2-71.6). Sixteen (44.4%) patients had a genetic (idiopathic) origin and 20 (55.6%) a symptomatic (structural/metabolic) etiology. Nine probands (25%) had at least one family member with epilepsy (including third-degree relatives). Their pedigrees were suggestive of dominant inheritance in six and of recessive inheritance in three families., Conclusions: The epidemiological features of pediatric epilepsy in this geographic isolate are similar to the general population. A family history was reported in one fourth of the patients with a wide clinical heterogeneity, likely reflecting genetic heterogeneity in this population., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Structured photons are nowadays an important resource in classical and quantum optics due to the richness of properties they show under propagation, focusing, and in their interaction with matter. Vectorial modes of light in particular, a class of modes where the polarization varies across the beam profile, have already been used in several areas ranging from microscopy to quantum information. One of the key ingredients needed to exploit the full potential of complex light in the quantum domain is the control of quantum interference, a crucial resource in fields like quantum communication, sensing, and metrology. Here we report a tunable Hong-Ou-Mandel interference between vectorial modes of light. We demonstrate how a properly designed spin-orbit device can be used to control quantum interference between vectorial modes of light by simply adjusting the device parameters and no need of interferometric setups. We believe our result can find applications in fundamental research and quantum technologies based on structured light by providing a new tool to control quantum interference in a compact, efficient, and robust way.

In this work, we experimentally show that quantum entanglement can be symmetry protected in the interaction with a single subwavelength plasmonic nanoaperture, with a total volume of V∼0.2λ^{3}. In particular, we experimentally demonstrate that two-photon entanglement can be either completely preserved or completely lost after the interaction with the nanoaperture, solely depending on the relative phase between the quantum states. We achieve this effect by using specially engineered two-photon states to match the properties of the nanoaperture. In this way we can access a symmetry protected state, i.e., a state constrained by the geometry of the interaction to retain its entanglement. In spite of the small volume of interaction, we show that the symmetry protected entangled state retains its main properties. This connection between nanophotonics and quantum optics probes the fundamental limits of the phenomenon of quantum interference.

Quantum teleportation establishes a correspondence between an entangled state shared by two separate parties that can communicate classically and the presence of a quantum channel connecting the two parties. The standard benchmark for quantum teleportation, based on the average fidelity between the input and output states, indicates that some entangled states do not lead to channels which can be certified to be quantum. It was recently shown that if one considers a finer-grained witness, then all entangled states can be certified to produce a nonclassical teleportation channel. Here we experimentally demonstrate a complete characterization of a new family of such witnesses, of the type proposed in Phys. Rev. Lett. 119, 110501 (2017)PRLTAO0031-900710.1103/PhysRevLett.119.110501 under different conditions of noise. We report nonclassical teleportation using quantum states that cannot achieve average fidelity of teleportation above the classical limit. We further use the violation of these witnesses to estimate the negativity of the shared state. Our results have fundamental implications in quantum information protocols and may also lead to new applications and quality certification of quantum technologies.

In classical physics, properties of objects exist independently of the context, i.e., whether and how measurements are performed. Quantum physics showed this assumption to be wrong, and that Nature is indeed "contextual". Contextuality has been observed in the simplest physical systems, such as single particles, and plays fundamental roles in quantum computation advantage. Here, we demonstrate for the first time quantum contextuality in an integrated photonic chip. The chip implements different combinations of measurements on a single photon delocalized on four distinct spatial modes, showing violations of a Clauser-Horne-Shimony-Holt (CHSH)-like noncontextuality inequality. This paves the way to compact and portable devices for contextuality-based quantum-powered protocols., Competing Interests: The authors declare no competing financial interest.

Greenberger-Horne-Zeilinger (GHZ) states and their mixtures exhibit fascinating properties. A complete basis of GHZ states can be constructed by properly choosing local basis rotations. We demonstrate this experimentally for the Hilbert space [Formula: see text] by entangling two photons in polarization and orbital angular momentum. Mixing GHZ states unmasks different entanglement features based on their particular local geometrical connectedness. In particular, a specific GHZ state in a complete orthonormal basis has a "twin" GHZ state for which equally mixing leads to full separability in opposition to any other basis-state. Exploiting these local geometrical relations provides a toolbox for generating specific types of multipartite entanglement, each providing different benefits in outperforming classical devices. Our experiment investigates these GHZ's properties exploiting the HMGH framework which allows us to study the geometry for the different depths of entanglement in our system and showing a good stability and fidelity thus admitting a scaling in degrees of freedom and advanced operational manipulations.

When a phase singularity is suddenly imprinted on the axis of an ordinary Gaussian beam, an optical vortex appears and starts to grow radially, by effect of diffraction. This radial growth and the subsequent evolution of the optical vortex under focusing or imaging can be well described in general within the recently introduced theory of circular beams, which generalize the hypergeometric-Gaussian beams and which obey novel kinds of ABCD rules. Here, we investigate experimentally these vortex propagation phenomena and test the validity of circular-beam theory. Moreover, we analyze the difference in radial structure between the newly generated optical vortex and the vortex obtained in the image plane, where perfect imaging would lead to complete closure of the vortex core.

The full structuration of light in the transverse plane, including intensity, phase and polarization, holds the promise of unprecedented capabilities for applications in classical optics as well as in quantum optics and information sciences. Harnessing special topologies can lead to enhanced focusing, data multiplexing or advanced sensing and metrology. Here we experimentally demonstrate the storage of such spatio-polarization-patterned beams into an optical memory. A set of vectorial vortex modes is generated via liquid crystal cell with topological charge in the optic axis distribution, and preservation of the phase and polarization singularities is demonstrated after retrieval, at the single-photon level. The realized multiple-degree-of-freedom memory can find applications in classical data processing but also in quantum network scenarios where structured states have been shown to provide promising attributes, such as rotational invariance.

Recent schemes to encode quantum information into the total angular momentum of light, defining rotation-invariant hybrid qubits composed of the polarization and orbital angular momentum degrees of freedom, present interesting applications for quantum information technology. However, there remains the question as to how detrimental effects such as random spatial perturbations affect these encodings. Here, we demonstrate that alignment-free quantum communication through a turbulent channel based on hybrid qubits can be achieved with unit transmission fidelity. In our experiment, alignment-free qubits are produced with q-plates and sent through a homemade turbulence chamber. The decoding procedure, also realized with q-plates, relies on both degrees of freedom and renders an intrinsic error-filtering mechanism that maps errors into losses.

Vectorial vortex light beams, also referred to as spirally polarized beams, are of particular interest since they can be exploited in several applications ranging from quantum communication to spectroscopy and microscopy. In particular, symmetric pairs of vector beams define two-dimensional spaces which are described as "hybrid Poincaré spheres" (HPS). While generation of vortex beams has been demonstrated by various techniques, their manipulation, in particular in order to obtain transformations describing curves entirely contained on a given HPS, is quite challenging, as it requires a simultaneous action on both polarization and orbital angular momentum degrees of freedom. Here, we demonstrate experimentally this kind of manipulation by exploiting electrically-tuned q-plates: an arbitrary transformation on the HPS can be obtained, by controlling two parameters of the q-plate, namely the initial optic axis orientation α0 and the uniform birefringent phase retardation δ. Upon varying such parameters, one can determine both the rotation axis and the rotation angle on the HPS, obtaining the desired state manipulation with high fidelity.

"Twisted photons" are photons carrying a well-defined nonzero value of orbital angular momentum (OAM). The associated optical wave exhibits a helical shape of the wavefront (hence the name) and an optical vortex at the beam axis. The OAM of light is attracting a growing interest for its potential in photonic applications ranging from particle manipulation, microscopy, and nanotechnologies to fundamental tests of quantum mechanics, classical data multiplexing, and quantum communication. Hitherto, however, all results obtained with optical OAM were limited to laboratory scale. Here, we report the experimental demonstration of a link for free-space quantum communication with OAM operating over a distance of 210 m. Our method exploits OAM in combination with optical polarization to encode the information in rotation-invariant photonic states, so as to guarantee full independence of the communication from the local reference frames of the transmitting and receiving units. In particular, we implement quantum key distribution, a protocol exploiting the features of quantum mechanics to guarantee unconditional security in cryptographic communication, demonstrating error-rate performances that are fully compatible with real-world application requirements. Our results extend previous achievements of OAM-based quantum communication by over 2 orders of magnitude in the link scale, providing an important step forward in achieving the vision of a worldwide quantum network.

An important problem in quantum information processing is the certification of the dimension of quantum systems without making assumptions about the devices used to prepare and measure them, that is, in a device-independent manner. A crucial question is whether such certification is experimentally feasible for high-dimensional quantum systems. Here we experimentally witness in a device-independent manner the generation of six-dimensional quantum systems encoded in the orbital angular momentum of single photons and show that the same method can be scaled, at least, up to dimension 13.

In quantum mechanics, observing is not a passive act. Consider a system of two quantum particles A and B: if a measurement apparatus M is used to make an observation on B, the overall state of the system AB will typically be altered. When this happens, no matter which local measurement is performed, the two objects A and B are revealed to possess peculiar correlations known as quantum discord. Here, we demonstrate experimentally that the very act of local observation gives rise to an activation protocol which converts discord into distillable entanglement, a stronger and more useful form of quantum correlations, between the apparatus M and the composite system AB. We adopt a flexible two-photon setup to realize a three-qubit system (A, B, M) with programmable degrees of initial correlations, measurement interaction, and characterization processes. Our experiment demonstrates the fundamental mechanism underpinning the ubiquitous act of observing the quantum world and establishes the potential of discord in entanglement generation.

In quantum information, complementarity of quantum mechanical observables plays a key role. The eigenstates of two complementary observables form a pair of mutually unbiased bases (MUBs). More generally, a set of MUBs consists of bases that are all pairwise unbiased. Except for specific dimensions of the Hilbert space, the maximal sets of MUBs are unknown in general. Even for a dimension as low as six, the identification of a maximal set of MUBs remains an open problem, although there is strong numerical evidence that no more than three simultaneous MUBs do exist. Here, by exploiting a newly developed holographic technique, we implement and test different sets of three MUBs for a single photon six-dimensional quantum state (a "qusix"), encoded exploiting polarization and orbital angular momentum of photons. A close agreement is observed between theory and experiments. Our results can find applications in state tomography, quantitative wave-particle duality, quantum key distribution.

Background: The effectiveness of screening for lung cancer (LC) in smokers on a population level, as distinct from the special circumstances that may apply in a randomized trial of selected volunteers, has not been thoroughly investigated. Here we evaluate by the standardized mortality ratio (SMR) indicator the impact of a chest X-ray (CXR) screening programme carried out at community level on LC mortality in smokers., Methods: All smokers of >10 pack-years, of both genders, ages 45-75 years, resident in 50 communities of the Province of Varese, Italy, screening-eligible, in 1997 were invited by their National Health Service (NHS) general practitioner physicians to a nonrandomized programme of five annual CXR screenings. The entire invitation-to-screen cohort (n=5815 subjects) received NHS usual care, with the addition of CXR exams in volunteer participants (21% of invitees), and was observed through December 2006. To overcome participants' selection bias of LC mortality assessment, for the entire invitation-to-screen cohort we estimated the LC-specific SMR, based on the local reference population receiving the NHS usual care., Results: Over the 8-year period 1999-2006, a total of 172 cumulative LC deaths were observed in the invitation-to-screen cohort; 210 were expected based on the reference population. Each year in the invited cohort the observed LC deaths were fewer than expected. The cumulative LC SMR was 0.82 (95% CI, 0.67-0.99; p=0.048), suggesting that LC mortality was reduced by 18% with CXR screening., Conclusion: Implementation of a CXR screening programme at community level was associated with a significant reduction of LC mortality in smokers., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Quantum metrology bears a great promise in enhancing measurement precision, but is unlikely to become practical in the near future. Its concepts can nevertheless inspire classical or hybrid methods of immediate value. Here we demonstrate NOON-like photonic states of m quanta of angular momentum up to m=100, in a setup that acts as a 'photonic gear', converting, for each photon, a mechanical rotation of an angle θ into an amplified rotation of the optical polarization by mθ, corresponding to a 'super-resolving' Malus' law. We show that this effect leads to single-photon angular measurements with the same precision of polarization-only quantum strategies with m photons, but robust to photon losses. Moreover, we combine the gear effect with the quantum enhancement due to entanglement, thus exploiting the advantages of both approaches. The high 'gear ratio' m boosts the current state of the art of optical non-contact angular measurements by almost two orders of magnitude.

Quantum communication employs the counter-intuitive features of quantum physics for tasks that are impossible in the classical world. It is crucial for testing the foundations of quantum theory and promises to revolutionize information and communication technologies. However, to execute even the simplest quantum transmission, one must establish, and maintain, a shared reference frame. This introduces a considerable overhead in resources, particularly if the parties are in motion or rotating relative to each other. Here we experimentally show how to circumvent this problem with the transmission of quantum information encoded in rotationally invariant states of single photons. By developing a complete toolbox for the efficient encoding and decoding of quantum information in such photonic qubits, we demonstrate the feasibility of alignment-free quantum key-distribution, and perform proof-of-principle demonstrations of alignment-free entanglement distribution and Bell-inequality violation. The scheme should find applications in fundamental tests of quantum mechanics and satellite-based quantum communication.

Quantum resources outperform classical ones for certain communication and computational tasks. Remarkably, in some cases, the quantum advantage cannot be improved using hypothetical postquantum resources. A class of tasks with this property can be singled out using graph theory. Here we report the experimental observation of an impossible-to-beat quantum advantage on a four-dimensional quantum system defined by the polarization and orbital angular momentum of a single photon. The results show pristine evidence of the quantum advantage and are compatible with the maximum advantage allowed using postquantum resources.

Background: Case-control studies of mass screening for lung cancer (LC) by chest x-rays (CXR) performed in the 1990s in scarcely defined Japanese target populations indicated significant mortality reductions, but these results are yet to be confirmed in western countries. To ascertain whether CXR screening decreases LC mortality at community level, we studied a clearly defined population-based cohort of smokers invited to screening. We present here the LC detection results and the 10-year survival rates., Methods: The cohort of all smokers of > 10 pack-years resident in 50 communities of Varese, screening-eligible (n = 5,815), in July 1997 was invited to nonrandomized CXR screening. Self-selected participants (21% of cohort) underwent screening in addition to usual care; nonparticipants received usual care. The cohort was followed-up until December 2010. Kaplan-Meier LC-specific survival was estimated in participants, in nonparticipants, in the whole cohort, and in an uninvited, unscreened population (control group)., Results: Over the initial 9.5 years of study, 67 LCs were diagnosed in screening participants (51% were screen-detected) and 178 in nonparticipants. The rates of stage I LC, resectability and 5-year survival were nearly twice as high in participants (32% stage I; 48% resected; 30.5% 5-year survival) as in nonparticipants (17% stage I; 27% resected; 13.5% 5-year survival). There were no bronchioloalveolar carcinomas among screen-detected cancers, and median volume doubling time of incidence screen-detected LCs was 80 days (range, 44-318), suggesting that screening overdiagnosis was minimal. The 10-year LC-specific survival was greater in screening participants than in nonparticipants (log-rank, p = 0.005), and greater in the whole cohort invited to screening than in the control group (log-rank, p = 0.001). This favourable long-term effect was independently related to CXR screening exposure., Conclusion: In the setting of CXR screening offered to a population-based cohort of smokers, screening participants who were diagnosed with LC had more frequently early-stage resectable disease and significantly enhanced long-term LC survival. These results translated into enhanced 10-year LC survival, independently related to CXR screening exposure, in the entire population-based cohort. Whether increased long-term LC-specific survival in the cohort corresponds to mortality reduction remains to be evaluated., Trial Registration Number: ISRCTN90639073.

In this work we experimentally implement a deterministic transfer of a generic qubit initially encoded in the orbital angular momentum of a single-photon to its polarization. Such a transfer of quantum information, which is completely reversible, has been implemented adopting an electrically tunable q-plate device and a Sagnac interferometer with a Dove prism. The adopted scheme exhibits high fidelity and low losses.

The extraction of information from a quantum system unavoidably implies a modification of the measured system itself. In this framework partial measurements can be carried out in order to extract only a portion of the information encoded in a quantum system, at the cost of inducing a limited amount of disturbance. Here we analyze experimentally the dynamics of sequential partial measurements carried out on a quantum system, focusing on the trade-off between the maximal information extractable and the disturbance. In particular we implement two sequential measurements observing that, by exploiting an adaptive strategy, is possible to find an optimal trade-off between the two quantities.

Background: We hypothesize that mortality risk profile of participants and nonparticipants in nonrandomized lung cancer (LC) screening of smokers may be different., Methods: In 1997, a population-based cohort of 5815 smokers of Varese Province was invited to nonrandomized LC screening by annual chest x-ray examination for 4 years. LC risk factors and screening participation rate were recorded. Except for screening, the whole cohort received usual care. After 9.5-year observation, we compared mortality of participants versus nonparticipants by assessing age-standardized all-cause mortality rate ratio (MRR) and disease group-specific MRR with 95% confidence intervals (95% CI)., Results: Self-selected screening participants were 21% of cohort. Participants were younger (p < 0.001), were more frequently current smokers (p = 0.019), had more pack-years of smoking (p < 0.0001), and had higher rate of LC family history (p < 0.0001) and of occupational LC risk (p < 0.0001) relative to nonparticipants. In logistic regression analysis familial LC, occupational risk and pack-years smoked were significant predictors of participation in screening and of developing LC. Participants displayed a healthy effect, as shown by all-cause MRR = 0.67 (95% CI, 0.53-0.84), all cancers except LC MRR = 0.61 (95% CI, 0.41-0.91), cardiovascular diseases MRR = 0.38 (95% CI, 0.22-0.63), and noncancer disease other than cardiovascular or respiratory MRR = 0.57 (95% CI, 0.34-0.92). The LC mortality (MRR = 1.40; 95% CI, 1.03-1.91) was higher in participants relative to nonparticipants (p = 0.031)., Conclusion: The selection effect in LC screening participants was dual: healthy effect and higher LC mortality. In assessing the overall effectiveness of LC screening on a population level, a higher LC mortality risk in participants should be considered.