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Your search keyword '"Cunci, S"' showing total 2 results
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2 results on '"Cunci, S"'

1. [AGIRabcd, an association for creating intergenerational exchanges].

Author

Cunci S and Prost G

Subjects
Communication, Cultural Evolution, Developing Countries, France, Health Promotion organization & administration, Humans, Organizational Objectives, Social Values, Aged psychology, Family psychology, Intergenerational Relations, Organizations organization & administration
Published
2001

2. Naproxen kinetics in synovial fluid of patients with osteoarthritis.

Author

Bruno R, Iliadis A, Jullien I, Guego M, Pinhas H, Cunci S, and Cano JP

Subjects
Adult, Aged, Aged, 80 and over, Half-Life, Humans, Middle Aged, Naproxen pharmacokinetics, Osteoarthritis metabolism, Synovial Fluid metabolism
Abstract

1. The kinetics of naproxen in synovial fluid were studied in 407 osteoarthritic outpatients with knee effusion requiring aspiration, following a single 1100 mg oral dose of naproxen sodium. 2. The drug concentration-time profiles were described by a biexponential function. Naproxen entered synovial fluid rapidly, reaching a maximum concentration of 36 mg l-1 (Cmax) at 7.5 h. The first order input rate constant (kOs) was 0.41 +/- 0.15 h-1 with a lag time (tlag) of 0.24 +/- 0.36 h. 3. Elimination from the fluid was slow (t1/2 = 31 +/- 12 h) and appreciable drug concentrations were still measurable (27 mg l-1) after 24 h. 4. During once daily dosing of naproxen sodium, naproxen should accumulate in synovial fluid, a steady-state being achieved within a week of treatment. The predicted accumulation ratio based on trough concentration was 2.4.

Published
1988
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